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Precise control of page cache for containers

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Frontiers of Computer Science 2024年第2期18卷 17-30页

作者： Kun WANG Song WU Shengbang LI zhuo huang Hao FAN Chen YU Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Container-based virtualization isbecoming increasingly popular in cloud computing due to its efficiency and *** isolation is a fundamental property of *** works have indicated weak resource isolation could cause significant performance degradation for containerized applications and enhanced resource ***,current studies have almost not discussed the isolation problems of page cache which is a key resource for *** leverage memory cgroup to control page cache ***,existing policy introduces two major problems in a container-based ***,containers can utilize more memory than limited by their cgroup,effectively breaking memory ***,the Os kernel has to evict page cache to make space for newly-arrived memory requests,slowing down containerized *** paper performs an empirical study of these problems and demonstrates the performance impacts on containerized *** we propose pCache(precise control of page cache)to address the problems by dividing page cache into private and shared and controlling both kinds of page cache separately and *** do so,pCache leverages two new technologies:fair account(f-account)and evict on demand(EoD).F-account splits the shared page cache charging based on per-container share to prevent containers from using memory for free,enhancing memory *** EoD reduces unnecessary page cache evictions to avoid the performance *** evaluation results demonstrate that our system can effectively enhance memory isolation for containers and achieve substantial performance improvement over the original page cache management policy.

关键词： page cache memory cgroup container isolation cloud computing

Structure-regulated fluorine-containing additives to improve the performance of perovskite solar cells

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Nano Research 2024年第7期17卷 6080-6086页

作者： Peiya Chen Xiaoman Bi Hao Yan Yingjie Zhao Yihao Liu zhuo huang Qian Xiao Yongpeng Yang Shasha Zhang Yiqiang Zhang Yanlin Song Henan Institute of Advanced Technology College of ChemistrySchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

Perovskite solar cells(PSCs)have seen remarkable progress in recent years,largely attributed to various additives that enhance both efficiency and *** these,fluorine-containing additives have garnered significant interest because of their unique hydrophobic properties,effective defect passivation,and regulation capability on the crystallization ***,a targeted structural approach to design such additives is necessary to further enhance the performance of ***,fluoroalkyl ethylene with different fluoroalkyl chain lengths(CH_(2)CH(CF_(2))nCF_(3),n=3,5,and 7)as liquid additives is used to investigate influences of fluoroalkyl chain lengths on crystallization regulation and defect *** findings indicate that optimizing the quantity of F groups plays a crucial role in regulating the electron cloud distribution within the additive *** optimization fosters strong hydrogen bonds and coordination effects with FA+and uncoordinated Pb^(2+),ultimately enhancing crystal quality and device ***,1H,1H,2H-perfluoro-1-hexene(PF_(3))with the optimal number of F presents the most effective modulation effect.A PSC utilizing PF_(3)achieves an efficiency of 24.05%,and exhibits exceptional stability against humidity and thermal *** work sheds light on the importance of tailored structure designs in additives for achieving high-performance PSCs.

关键词： perovskite solar cells fluorine number additive structure crystallization regulation defect passivation

Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG Jin-bin LI Long HE Zhen-fan huang zhuo-jian LIU Zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU Heng-li MA Hui-lin DU Qun WU Yong-qiang LI Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

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经济不确定性、个体创业与创业机会不均等

数量经济技术经济研究 2024年第7期41卷 93-112页

作者：杨紫张勋黄卓谭莹中央财经大学统计与数学学院北京师范大学统计学院北京大学国家发展研究院北京大学中国经济研究中心西南财经大学统计学院

党的二十大报告指出,中国发展进入“不确定难预料因素增多的时期”,这对效率和公平的影响巨大且深远。本文利用61个经济变量所构建的中国省级—季度层面的经济不确定性指标,结合中国家庭追踪调查数据(CFPS),在理论分析的基础上,对经济... 详细信息

党的二十大报告指出,中国发展进入“不确定难预料因素增多的时期”,这对效率和公平的影响巨大且深远。本文利用61个经济变量所构建的中国省级—季度层面的经济不确定性指标,结合中国家庭追踪调查数据(CFPS),在理论分析的基础上,对经济不确定性如何影响个体创业与创业机会不均等展开研究。基准回归发现,经济不确定性降低了个体的创业概率。更重要的是,经济不确定性显著减少了以低人力资本、低物质资本和低社会资本为代表的弱势群体的创业机会,加剧了创业机会不均等。就机制分析而言,在需求侧方面,经济不确定性导致了家庭消费降级,降低了市场潜力,减少了创业机会;在供给侧方面,经济不确定性造成银行惜贷,提高了创业的融资成本,抑制了创业活动。在政策思路上,充分发挥中国超大规模市场优势有助于从需求侧的角度缓解经济不确定性对个体创业与创业机会不均等的负面影响,发展数字金融、推动金融普惠则是从供给侧的角度缓解经济不确定性对个体创业与创业机会不均等的负面影响的重要手段。

关键词：经济不确定性个体创业创业机会不均等市场规模数字金融

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang zhuo huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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信息基础设施建设与企业创新

世界经济文汇 2024年第1期37卷 86-104页

作者：陶云清黄卓孔东民北京大学国家发展研究院 100871 北京大学数字金融研究中心 100871 北京大学中国经济研究中心 100871 华中科技大学经济学院 430074

合理评估信息基础设施建设的创新效应对数字经济发展、信息化强国建设以及创新型国家建设具有重要借鉴意义。本研究利用企业所在城市在不同时间入选“宽带中国”试点的准自然实验,采用A股上市公司数据分析信息基础设施建设的创新效应。... 详细信息

合理评估信息基础设施建设的创新效应对数字经济发展、信息化强国建设以及创新型国家建设具有重要借鉴意义。本研究利用企业所在城市在不同时间入选“宽带中国”试点的准自然实验,采用A股上市公司数据分析信息基础设施建设的创新效应。研究发现:第一,在城市入选了“宽带中国”试点后,当地企业的创新行为显著增加。第二,“宽带中国”试点政策通过促进信息化发展和降低交易成本进而促进企业创新。第三,在非国有企业,资本密集度较高、政府补贴较多、融资约束较紧的企业及制造业企业中,“宽带中国”试点政策对企业创新的激励作用更大。本研究支持了“宽带中国”试点政策的及时性和必要性,证实了信息基础设施建设对企业创新的积极作用。

关键词：信息基础设施企业创新信息化发展交易成本

盾构机下穿G1522常台高速公路沉降控制技术研究

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建筑科技 2024年第1期8卷 77-79,92页

作者：黄焯中铁十七局集团市政建设有限公司江苏无锡214111

苏州市轨道交通相城区行政中心南站—徐阳路站区间,盾构下穿G1522常台高速公路,盾构隧道顶部距离公路路基较近且穿越土层种类较多。针对盾构近距离穿越对地层扰动大、施工风险高的特点,通过选取穿越前的一段地层作为试验段,确定穿越期... 详细信息

苏州市轨道交通相城区行政中心南站—徐阳路站区间,盾构下穿G1522常台高速公路,盾构隧道顶部距离公路路基较近且穿越土层种类较多。针对盾构近距离穿越对地层扰动大、施工风险高的特点,通过选取穿越前的一段地层作为试验段,确定穿越期间盾构机的施工参数及控制措施。按照试验所得参数完成盾构穿越后,监测结果显示G1522常台高速公路沉降值控制在要求范围,可为类似穿越工程提供一定的参考经验。

关键词：轨道交通盾构穿越土层沉降控制注浆监测

大城市楔形绿地碳汇能力评估及提升策略研究——以上海张家浜楔形绿地为例

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环境生态学 2024年第3期6卷 44-52页

作者：黄卓荆贝贝上海浦东开发(集团)有限公司上海201204 上海市园林设计研究总院有限公司上海200030

楔形绿地是大城市提升碳汇功能的重要载体。本研究以张家浜楔形绿地为例,探讨上海规模体量最大的楔形绿地碳汇功能及优化提升策略。通过对林地、草地、水域等不同土地利用类型进行碳汇能力评估,并对张家浜绿地的全生命碳汇周期进行了碳... 详细信息

楔形绿地是大城市提升碳汇功能的重要载体。本研究以张家浜楔形绿地为例,探讨上海规模体量最大的楔形绿地碳汇功能及优化提升策略。通过对林地、草地、水域等不同土地利用类型进行碳汇能力评估,并对张家浜绿地的全生命碳汇周期进行了碳中和预估和碳效益计算,预计未来可实现区域碳中和目标并形成持续稳定的碳效益。本研究首次利用碳核算软件对大城市楔形绿地的全生命碳汇周期进行了碳中和预估测算,为碳中和目标下的超大城市绿地碳汇效益的综合评估和绿地的全生命周期建设提供科学指引。

关键词：张家浜楔形绿地碳汇碳中和评估全生命周期

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“物化”释论:当代影视艺术审美教育之思

滁州职业技术学院学报 2024年第1期23卷 86-91页

作者：黄卓杨柏岭安徽师范大学新闻与传播学院安徽芜湖241002

影视美育是当下审美教育建设中的重要一环。针对观众在影视欣赏中出现的泛娱乐、消遣等现象,借鉴庄子“物化”观对审美教育的启示,强调从入乎影视文本审美动机的营造开始,重视沉浸影视文本的审美移情的训练,提高对话影视文本的审美共鸣... 详细信息

影视美育是当下审美教育建设中的重要一环。针对观众在影视欣赏中出现的泛娱乐、消遣等现象,借鉴庄子“物化”观对审美教育的启示,强调从入乎影视文本审美动机的营造开始,重视沉浸影视文本的审美移情的训练,提高对话影视文本的审美共鸣能力,在感知影视作品的思想内容和艺术价值中获得精神的升华。启迪人们领悟艺术活动超越时空的虚拟状态,询唤物我两忘,浑然一体的沉浸式鉴赏体验,在美感中寻找共鸣,在美的体验中升华人格,助推影视艺术审美教育的建设。

关键词：影视艺术审美教育影视批评 “物化”