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Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors

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Neuroscience Bulletin 2017年第4期33卷 365-372页

作者： he-ren Gao Qian-Xing zhuang Yong-Xiao Zhang Zhang-Peng Chen Bin Li Xiao-Yang Zhang Yi-Ting Zhong Jian-Jun Wang Jing-Ning Zhu State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School ofLife SciencesNanjing UniversityNanjing 210023China

Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion,and cognition. However, the role of orexin in somatic motor control is still little known. here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus（GPi）,a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy. Our results showed that orexin-A induced direct postsynaptic excitation of GPi neurons in a concentration-dependent *** orexin-A-induced excitation was mediated via co-activation of both OX1 and OX2 receptors. Furthermore, the immunostaining results showed that OX1 and OX2 receptors were co-localized in the same GPi neurons. These results suggest that the central orexinergic system actively modulates the motor functions of the basal ganglia via direct innervation on GPi neurons and presumably participates in somatic-non-somatic integration.

关键词： Orexin OX1 receptor OX2 receptor Globus pallidus internus Basal ganglia

Fluoroscopic removal of fractured,retained,embedded Z self-expanding metal stent using a guidewire lasso technique:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2516-2521页

作者： Yong-Hua Bi Jian-zhuang ren Jin-Dong Li Xin-Wei Han Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Thoracic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND There are few reports of a fractured esophageal self-expanding metallic stent(SEMS)and the lasso retrieval technique,forming a guidewire loop by directing the guidewire back up the external stent for *** SUMMARY A 74-year-old man complained of dysphagia approximately 6 mo after radical resection of esophageal *** anastomotic stenosis was diagnosed,and a 20 mm in diameter and 60 mm in length esophageal covered SEMS was inserted after repeated balloon *** 13.5 mo after stenting,dysphagia recurred and esophagography showed severe stenosis above the proximal stent and stent removal was ***-third of the stent was removed and the fractured stent remained in the proximal esophagus.A suction tube was introduced through the guidewire and then the guidewire was grabbed,acting like a“lasso”on *** remaining fractured stent was successfully removed by slowly pulling back the guidewire,with no fragments of stent wires *** The guidewire lasso technique is a simple,effective method of removing esophageal SEMS in rare cases of stent fracture.

关键词： Self-expanding metallic stent Stenosis Guidewire lasso technique Stent removal Esophagus Case report

小剂量复方倍他米松联合富血小板血浆在膝骨关节炎中的应用效果

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中国合理用药探索 2024年第3期21卷 68-74页

作者：任国强明海武董卫兵庄卫生郑州颐和医院骨科郑州450000 河南省人民医院骨科郑州450000

目的:探讨小剂量复方倍他米松联合富血小板血浆(PRP)在膝骨关节炎(KOA)中的应用效果。方法:选取2021年12月~2022年12月期间某院收治的92例KOA患者作为研究对象,采用简单随机抽样法分为对照组和观察组,每组46例。所有患者均给予KOA常规药... 详细信息

目的:探讨小剂量复方倍他米松联合富血小板血浆(PRP)在膝骨关节炎(KOA)中的应用效果。方法:选取2021年12月~2022年12月期间某院收治的92例KOA患者作为研究对象,采用简单随机抽样法分为对照组和观察组,每组46例。所有患者均给予KOA常规药物(硫酸氨基葡萄糖胶囊)治疗,对照组患者给予PRP治疗,观察组在对照组基础上加用小剂量复方倍他米松注射液。比较两组患者疼痛情况[视觉模拟评分法(VAS)]、膝关节功能恢复情况[Lysholm膝关节功能评分表(LKSS)]、膝关节活动度[关节活动度(ROM)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)]、日常生活能力[Barthel指数(BI)]、步行能力、临床疗效及不良反应发生情况。结果:治疗后,两组患者VAS评分均降低(P<0.05),且观察组低于对照组(P<0.05);LKSS评分均升高(P<0.05),且观察组高于对照组(P<0.05);关节主动活动度、关节被动活动度均升高(P<0.05),且观察组高于对照组(P<0.05);WOMAC评分均降低(P<0.05),且观察组低于对照组(P<0.05);BI、步行能力得分均升高(P<0.05),且观察组均高于对照组(P<0.05)。观察组患者治疗总有效率(95.65%)高于对照组(80.43%,P<0.05)。两组患者不良反应发生情况比较无统计学差异(χ^(2)=0.212,P=0.646)。结论:在KOA常规药物治疗基础上联合PRP、小剂量复方倍他米松治疗KOA患者临床疗效较好,可显著减轻患者疼痛,改善膝关节活动情况,促进膝关节功能恢复,提高日常生活能力和步行能力。

关键词：富血小板血浆复方倍他米松膝骨关节炎膝关节功能日常生活能力步行能力

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茶行业标准体系建设状况分析

中国茶叶 2024年第6期46卷 25-32页

作者：高晨曦孙威江任春凤庄长强福建农林大学园艺学院福建福州350002 福建省茶产业工程技术研究中心福建福州350002 福建省产品质量检验研究院国家加工食品质量检验检测中心福建福州350002 六妙白茶股份有限公司福建福鼎355200

随着茶产业的发展,茶叶标准化工作逐步推进。文章介绍了我国茶通用标准、各茶类标准和茶叶国际标准标准化建设的最新情况,其中分类介绍了乌龙茶类标准、白茶类标准、红茶类标准、绿茶类标准、黄茶类标准、黑茶类标准,以及茉莉花茶类标准... 详细信息

随着茶产业的发展,茶叶标准化工作逐步推进。文章介绍了我国茶通用标准、各茶类标准和茶叶国际标准标准化建设的最新情况,其中分类介绍了乌龙茶类标准、白茶类标准、红茶类标准、绿茶类标准、黄茶类标准、黑茶类标准,以及茉莉花茶类标准;现行有效的茶叶国际标准共31项,此外,还有4项正在研制中。为支持中国标准的“走出去”战略,目前有23项国家标准外文版出版,3项正在研制中。文章还对标准建设的未来发展方向进行了展望,对进一步推进我国茶叶标准化工作具有一定参考意义。

关键词：茶行业标准化发展茶叶标准国际标准

Compact auto-stereoscopic display based on directional backlight using side-glowing polymer optical fiber array

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Optoelectronics Letters 2020年第3期16卷 200-204页

作者： he Yong LU Zhao-hong LIU Chu-jia GAO Fei-fei LI Zi-run zhuang Qi-ren Fujian Key Laboratory of Light Propagation and Transformation College of Information Science and EngineeringHuaqiao UniversityXiamen 361021China TPV Display Technology(Xiamen)Co. LtdXiamen 361101China

A compact directional backlight module of time-multiplexed auto-stereoscopic display based on side-glowing polymer optical fiber(SGPOF)is *** optical system is mainly composed of SGPOF array and cylindrical lens *** crosstalk is reduced by inserting a grating film as multi-slit diaphragm between the SGPOF array and the cylindrical lens array.A theoretical model is constructed based on the imaging optics principle of the off-axis *** the experiments,the cylindrical lens array concentrates a small number of views on three different view zones,the display can provide high *** measurement results show that the luminance uniformity of the backlight module is up to 89.6%,and in the viewing zone the crosstalk is lower than 10%.The backlight module is compacted that the thickness being only 7 *** full-resolution and low-crosstalk 3D images are realized by using SGPOF backlight.

关键词： cylindrical directional fiber

Maintenance Decision of Door System Based on PHM-assisted RCM

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Maintenance Decision of Door System Based on PHM-assisted RC...

Microstructure and texture evolution during recrystallization of low-carbon steel sheets

第36届中国控制会议

作者： zhuang Chen Jinbao ren Yong Zhang Zongyi Xing School of Automation Nanjing University of Science and Technology School of Mechanical Engineering Nanjing University of Science and Technology

ISBN: (纸本)9781538629185

The door system is the key systems for the safety of urban rail *** the urban rail vehicle system,the failure of the door system accounts for more than 30%of the total failure of the vehicle system,in order to overcome the subjectivity of the traditional reliability-based door maintenance（RCM） method,a new method of maintenance decision for RCM based on Proportional Hazard Model（PHM） is *** of all,provide preliminary maintenance decisions for the door by traditional RCM *** the proportional hazards model is introduced by considering the life cycle of key components,and the proportional hazards model of the door system is ***,the proportional risk model is applied to the decision-making of RCM door maintenance,and repair interval of the door system is *** case analysis indicates that maintenance cycle gotten by the proposed method is more reasonable than traditional RCM method.

关键词： PHM RCM Maintenance decision Door system

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Journal of Iron and Steel Research International 2017年第1期24卷 84-90页

作者： Dong-dong zhuang Lei-gang Wang Yao Huang Xiao-min Li Hua-yang Zhang De-wei ren School of Material Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina School of Material Science and Engineering Shandong UniversityJinan 250061ShandongChina Metallurgical Corporation of China Group Shanghai 201900China

Aluminum killed low-carbon steel sheets were cold rolled at different reduction ratios and annealed using different temperatures and holding *** Vickers hardness was *** results show that when cold rolling reduction ratios increase from 40% to 81%,recrystallization temperatures decrease from 602℃ to 572℃ during 4hisochronal annealing,as well recrystallization holding time decreases from 117 min to 5min during isothermal annealing at 610℃.All recrystallization temperatures and holding time can be calculated using the annealing experiment *** was examined through electron backscattered diffraction（EBSD）.The results show that as rolling direction preferentially grows,equiaxed grains grow into cake-type during ***-type grains are more beneficial to obtaining ideal〈111〉//ND（normal direcrtion）orientation texture.{111}orientation grains nucleate and grow up *** grains of{111}〈110〉orientations grow into new recrystallization grains of{111}〈123〉and{111}〈112〉during *** formation can be explained by directional nucleation.

关键词： Aluminum killed low-carbon steel sheet Recrystallization Annealing Vickers hardness Texture

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重金属污染土壤原位固定修复研究进展

黑龙江环境通报 2024年第3期37卷 104-106页

作者：安娜王莉庄雨适孙大光任建锋吉林省环境科学研究院长春130000

本文深入研究了原位固定修复技术,它是一项至关重要的土壤治理方法,旨在削减土壤中重金属的生物有效性,减轻其对生态系统和人类的潜在危害。我们探讨了重金属污染的特性和多方面影响,涵盖了重金属的不同形态、生态传播、食物链中的积累... 详细信息

本文深入研究了原位固定修复技术,它是一项至关重要的土壤治理方法,旨在削减土壤中重金属的生物有效性,减轻其对生态系统和人类的潜在危害。我们探讨了重金属污染的特性和多方面影响,涵盖了重金属的不同形态、生态传播、食物链中的积累,以及与此相关的土壤酸化、水体污染和生态系统破坏等问题。此外,我们详细介绍了主要的原位固定修复技术,包括氧化还原法、石灰固化法、生物修复法和离子交换树脂法。特别值得关注的是,新一代高效修复技术如生物炭和石墨烯氧化物也在取得显著进展。这些技术提供了有力的工具,为处理重金属污染土壤问题提供了希望,同时为未来的研究方向开辟了新的前景。

关键词：重金属污染土壤土壤原位固定修复研究

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广东省高分辨率温室气体排放清单及特征

环境科学 2024年第2期45卷 909-919页

作者：卢清唐明双廖彤黄志炯钟庄敏宋佩珊沈劲张智胜梁小明孙家仁陈来国生态环境部华南环境科学研究所广东省水与大气污染防治重点实验室广州510655 广东省生态环境监测中心国家环境保护区域空气质量监测重点实验室广州510308 暨南大学环境与气候研究院广州511443 东莞市生态环保研究院有限公司东莞523000

根据典型城市调查与统计数据收集得到的广东省活动水平数据,采用自上而下和自下而上相结合的排放因子法和GIS技术,建立了广东省2018年3 km×3 km高分辨率温室气体排放清单.估算范围包括能源活动、工业生产过程、农业活动、土地利用变化... 详细信息

根据典型城市调查与统计数据收集得到的广东省活动水平数据,采用自上而下和自下而上相结合的排放因子法和GIS技术,建立了广东省2018年3 km×3 km高分辨率温室气体排放清单.估算范围包括能源活动、工业生产过程、农业活动、土地利用变化和林业、废弃物处理以及电力调入(出)间接排放等6大类CO_(2)、CH4和N_(2)O这3种温室气体.结果表明,广东省2018年CO_(2)、CH4和N_(2)O的排放量分别为8.5×108、1.9×10^(6)和1.1×10^(5)t,以CO_(2)当量计分别为8.5×10^(8)、4.0×10^(7)和3.4×10^(7)t,合计9.2×10^(8)***_(2)是广东省主要的温室气体排放种类,占全省温室气体总排放量的92.0%,能源活动和电力调入(出)间接排放是广东省温室气体排放的主要部门,排放占比分别为77.9%和7.6%,合计占比为85.5%.从温室气体排放的空间分布情况来看,全省大部分地区温室气体表现为排放源,部分区域表现为汇;温室气体排放主要集中在珠三角地区,并呈现一定的沿路网和航道分布的特征;温室气体高排放网格主要为大型电厂、钢铁厂和水泥厂等高耗能企业所在地.

关键词：高分辨率温室气体排放清单广东省排放特征