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负煤柱工作面开采对倾向主断面地表沉陷的影响与预测研究

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煤炭工程 2024年第8期56卷 138-145页

作者：刘润乔凯祝壮王朋飞孙中光马乐张旭邬静玉国能包头能源有限责任公司万利一矿内蒙古鄂尔多斯017000 太原理工大学矿业工程学院山西太原030024 中煤科工集团重庆研究院有限公司重庆400039

为了研究负煤柱工作面布置方式下的地表沉陷规律与机理,通过现场实测和数值模拟的方法,研究了负煤柱工作面时空关系对倾向主断面地表沉陷的影响。研究结果表明:负煤柱工作面地表沉陷曲线在三角煤柱侧较直角煤柱侧更为平缓,上覆岩层下沉... 详细信息

为了研究负煤柱工作面布置方式下的地表沉陷规律与机理,通过现场实测和数值模拟的方法,研究了负煤柱工作面时空关系对倾向主断面地表沉陷的影响。研究结果表明:负煤柱工作面地表沉陷曲线在三角煤柱侧较直角煤柱侧更为平缓,上覆岩层下沉量增加,垮落带相连,导致地表出现平底区;开采时间间隔越久,地表变形越不均匀,岩层整体所受接续工作面扰动程度越小,变形向首采工作面上方集中,最大下沉值出现点向首采工作面方向偏移,最大下沉量先减小后趋向稳定;基于概率积分法,提出了相应的地表沉陷预测方法,并通过与实测数据对比验证了该预测方法的实用性和可靠性。

关键词：多工作面负煤柱开挖间隔时空关系地表沉陷

基于支架和无支架策略在生长板软骨再生治疗中的应用

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中国组织工程研究 2024年第15期28卷 2437-2444页

作者：郭若宜庄汉杰陈修宁贲雨龙范民杰王亦维郑朋飞南京医科大学附属儿童医院骨科江苏省南京市210000

背景:组织工程是一种理想的生长板再生治疗方式,然而目前大多数的再生组织工程研究都是建立在传统支架策略的基础之上,随着传统支架的局限性逐渐显露,研究的方向也逐渐多样化。目的:总结基于支架和无支架策略在生长板软骨再生治疗中的... 详细信息

背景:组织工程是一种理想的生长板再生治疗方式,然而目前大多数的再生组织工程研究都是建立在传统支架策略的基础之上,随着传统支架的局限性逐渐显露,研究的方向也逐渐多样化。目的:总结基于支架和无支架策略在生长板软骨再生治疗中的应用以及各自的优势和不足。方法:检索PubMed、Wiley、Elsevier数据库收录的相关文献,英文检索词为“growth plate injury,regeneration,tissue engineering,scaffold,scaffold-free,biomimetic,cartilage”。检索时限为1990-2023年,最终纳入104篇文献进行综述。结果与结论:仿生支架策略是通过模拟生长板独特的组织结构最大程度上还原每个区域的细胞组成、生物信号和独特力学性能,进而构建能促进组织再生的仿生微环境,因此,仿生支架的设计是尽可能地从成分、结构和力学性能上模拟原生生长板,虽然取得一定的成效,但仍存在再生效果不稳定的问题。无支架策略认为支架的局限性会对再生治疗产生不利影响,因此,无支架构建物的设计是尽可能地依赖于细胞自身产生和维持细胞外基质的能力,不干扰细胞-细胞间的信号,不引入外源性物质,但存在稳定性较差、机械强度低,操作难度较大等问题。仿生策略和无支架策略的出发点不同且均存在各自的优缺点,但它们对于生长板软骨再生均能产生积极的作用。因此,后续的研究不论是采取仿生策略或无支架策略,都将聚焦于对现有技术的不断优化,以期实现有效的生长板软骨再生治疗。

关键词：生长板损伤再生医学组织工程支架仿生无支架

High-entropy Sm_(2)B_(2)O_(7)(B=Ti,Zr,Sn,Hf,Y,Yb,Nb,and Ta) oxides with highly disordered B-site cations for ultralow thermal conductivity

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Journal of Materials Science & Technology 2022年第24期119卷 182-189页

作者： Liang Xu Lei Su Hongjie Wang Hongfei Gao pengfei Guo Min Niu Kang Peng Lei zhuang Zhiwei Dai State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Materials with ultralow thermal conductivity and good thermal stability are of great interest in numerous applications such as energy storage and conversion devices,and thermal insulation *** this work,a family of high-entropy Sm_(2)B_(2)O_(7)(B=Ti,Zr,Sn,Hf,Y,Yb,Nb,and Ta) oxides with highly disordered cations on the B-site has been synthesized by introducing large atomic-size mismatch,mass and charge *** tuning the composition,the high-entropy Sm_(2)B_(2)O_(7) oxides can be engineered from pyrochlore to fluorite structure,accompanied with an order-disorder *** pyrochlore Sm_(2)(Nb_(0.2)Sn_(0.2)Ti_(0.2)Y_(0.2)Zr_(0.2))_(2)O_(7) and fluorite Sm_(2)(Nb_(0.2)Ta_(0.2)Y_(0.2)Yb_(0.2)Zr_(0.2))_(2)O_(7) exhibit low thermal conductivities of 1.35 W·m^(-1)·K^(-1) and 1.23 W·m^(-1)·K^(-1),respectively,indicating their good thermal *** addition,the high-entropy fluorite Sm_(2)(Nb_(0.2)Ta_(0.2)Y_(0.2)Yb_(0.2)Zr_(0.2))_(2)O_(7) also shows average thermal expansion coefficient of 10.2 × 10^(-6)℃^(-1) and high-temperature stability even after thermal exposure at 1600 °C in air for 30 *** results indicate that the high-entropy Sm_(2)B_(2)O_(7)(B=Ti,Zr,Sn,Hf,Y,Yb,Nb,and Ta) can be promising candidates for thermal barrier coatings and thermally insulators.

关键词： High-entropy oxides Atomic sizes mismatch Mass and charge disorder Thermal conductivity Thermal barrier coatings materials

Lateral composition-graded semiconductor nanoribbons for multi-color nanolasers

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Nano Research 2016年第4期9卷 933-941页

作者： Xiujuan zhuang pengfei Guo Qinglin Zhang Huawei Liu Dan Li Wei Hu Xiaoli Zhu Hong Zhou Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education School of Physics and electronics Hunan University Changsha 410082 China

Low-dimensional semiconductor nanostructures have attracted much interest for applications in integrated photonic and optoelectronic devices. Band gap engineering within single semiconductor nanoribbons helps to manipulate photon behavior in two different cavities （in the width and length directions） and realize new photonic phenomena and applications. In this work, lateral composition-graded semiconductor nanoribbons were grown for the first time through an improved source-moving vapor phase route. Along the width of the nanoribbon, the material can be gradually tuned from pure CdS to a highly Se-doped CdSSe alloy with a corresponding band gap modulation from 2.42 to 1.94 eV. The achieved alloy ribbons are overall high-quality crystals, and the position-dependent band-edge photoluminescence （PL） emission had a peak wavelength continuously tuned from -515 to -640 nm. These ribbons can realize multi-color lasing with three groups of lasing modes centered at 519, 557, and 623 run. It was confirmed that the red lasing was from optical resonance along the length direction, while the green and yellow lasing was from optical resonance along the width direction. These novel nanoribbon structures may be applied to many integrated photonic and optoelectronic devices.

关键词： composition grade semiconductor nanoribbon nanolaser multi-color

Greatly enhanced electro-optic modulation efficiency in titanium in-diffusion PIN-PMN-PT waveguide

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Journal of Advanced Ceramics 2023年第7期12卷 1454-1462页

作者： Qingyuan Hu Yuebin Zhang Huimin Liao Xin Liu pengfei Li Yali Feng Lei An Yongyong zhuang Zhuo Xu Xiaoyong Wei Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China

Electro-optic modulators,which convert electrical signals onto the transmission light,are key devices in electro-optic modulating *** efficiency is one of the most important parameters of an electro-optic modulator,which directly determines the footprint and power consumption of the ***,modulation efficiency strongly depends on the electro-optic response of the *** Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIN-PMN-PT)single crystal with giant electro-optic coefficient(λ_(c))and high transparency indicates the potential to achieve greatly enhanced modulation *** this study,a prototype PIN-PMN-PT phase modulator was fabricated based on a titanium(Ti)in-diffusion waveguide,which is reported for the first *** influences of titanium in-diffusion on the composition and domain structure of the PIN-PMN-PT single crystal were studied by transmission electron microscopy(TEM)and piezoelectric force microscopy(PFM),***,a half-wave voltage(V_(π))of 2.3 V was obtained using a device with 6-mm-long(L)***,the electro-optic modulation efficiency(V_(π)L)was calculated as 1.38 V-cm,which was approximately one order of magnitude lower than that of commercial lithium niobate(LiNbO_(3),LN)phase *** enhanced modulation efficiency indicates more compact device and lower power consumption,which is of great significance for electro-optic modulation systems used in micro-fiber gyroscope,integrated photonic devices,etc.

关键词： Pb(In_(1/2)Nb_(1/2))O_(3)-Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)(PIN-PMN-PT)single crystal titanium(Ti)in-diffusion waveguide electro-optic modulator

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碳化硼的制备及其在电池储能和核能中的应用

铁合金 2024年第1期55卷 31-35页

作者：杜文轩王帅孙瑶庄艳歆邢鹏飞东北大学材料电磁过程研究教育部重点实验室辽宁沈阳110819 东北大学冶金学院辽宁沈阳10819 东北大学材料科学与工程学院辽宁沈阳110819

作为硬度值第三的陶瓷材料,碳化硼(B_(4)C)具有硬度高、密度低、物理化学稳定性好及中子吸收性好等特性,使其在轻型装甲、涂层材料、研磨介质、电催化材料及控制核裂变等方面得到广泛应用。碳化硼具有极其稳定的共价键,是制备燃料电池... 详细信息

作为硬度值第三的陶瓷材料,碳化硼(B_(4)C)具有硬度高、密度低、物理化学稳定性好及中子吸收性好等特性,使其在轻型装甲、涂层材料、研磨介质、电催化材料及控制核裂变等方面得到广泛应用。碳化硼具有极其稳定的共价键,是制备燃料电池催化剂的重要基础材料。铝基碳化硼复合材料是综合结构和功能的中子吸收材料,其中子屏蔽性能、力学性能和耐腐蚀性能等方面的应用对于我国核电站建设和安全运行具有重要的科学意义。

关键词：碳化硼制备电池储能核能

蔗糖对参薯块茎形成及DamiR156/DaSPL的调控分析

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分子植物育种 2024年第7期22卷 2098-2103页

作者：庄赛伟刘铭吴晓龙梅朋飞黄小龙夏薇吴文嫱黄东益海南大学生命科学学院海口570228 海南大学热带作物学院海口570228

为了探究蔗糖对不同基因型参薯块茎形成的影响,以及对块茎发育过程中相关的DamiR156及其靶基因DaSPL的调控作用,本研究采用不同蔗糖浓度处理参薯组培苗Da40、Da70、Da207,结果表明高浓度的蔗糖能够促进Da40和Da70的块茎形成。当蔗糖浓度... 详细信息

为了探究蔗糖对不同基因型参薯块茎形成的影响,以及对块茎发育过程中相关的DamiR156及其靶基因DaSPL的调控作用,本研究采用不同蔗糖浓度处理参薯组培苗Da40、Da70、Da207,结果表明高浓度的蔗糖能够促进Da40和Da70的块茎形成。当蔗糖浓度为90 g/L时,Da40的结薯时间提早了22 d,Da70的结薯时间提早了40 d。使用RT-qPCR技术测定不同蔗糖浓度处理下Da70的DamiR156及其靶基因DaSPL6相对表达量。结果表明,在第30天,DamiR156的表达量在蔗糖浓度为70 g/L时表达量最高。在第60天(即块茎形成初期),当蔗糖浓度为0 g/L时,DamiR156的表达量最高,DaSPL6表达量最低,在6个不同蔗糖浓度处理下,DaSPL6的表达量呈现先上升后下降的趋势,DaSPL6在70 g/L时表达量最高。研究结果表明外源蔗糖可促进参薯生长并诱导提前结薯,调节DamiR156/DaSPL6的表达,这为后续研究蔗糖调控参薯块茎形成的分子机制提供了一定的理论依据。

关键词：参薯蔗糖 RT-qPCR DamiR156 DaSPL6

参薯愈伤组织诱导及其悬浮细胞培养体系的建立

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分子植物育种 2024年第3期22卷 840-848页

作者：梅朋飞吴晓龙庄赛伟王颖黄小龙黄东益夏薇吴文嫱海南大学生命科学学院海口570228 海南大学热带作物学院海口570228

为确定参薯愈伤组织诱导的最佳激素浓度及悬浮细胞培养条件,以3种基因型参薯(Dioscorea alata)组培苗的腋芽茎段为材料,采用三因素三水平正交实验来探究不同浓度组合的6-BA、NAA和毒莠定(picloram,PIC)对愈伤组织诱导率的影响;为了初步... 详细信息

为确定参薯愈伤组织诱导的最佳激素浓度及悬浮细胞培养条件,以3种基因型参薯(Dioscorea alata)组培苗的腋芽茎段为材料,采用三因素三水平正交实验来探究不同浓度组合的6-BA、NAA和毒莠定(picloram,PIC)对愈伤组织诱导率的影响;为了初步建立愈伤组织悬浮细胞培养体系,采用单因素实验探讨初始悬浮细胞接种量、蔗糖浓度、摇床转速、酪蛋白浓度和光照时间对其细胞生物量的影响。实验结果表明:在1.0 mg/L 6-BA+1.0 mg/L NAA+0.5 mg/L PIC激素浓度组合下,参薯Da70号组培苗(Da70)的愈伤诱导率为90%,愈伤状态较好,不同激素对愈伤诱导率的影响分别为NAA>PIC>6-BA。在单因素悬浮细胞培养实验中,10 mL的初始悬浮细胞接种量、10 g/L的蔗糖浓度、100 r/min的摇床转速、50 mg/L的酪蛋白浓度和0 h光照有利于细胞生物量的增加。参薯悬浮细胞生长总体上呈现“S”型,且在第18天时,鲜重为0.1593 g,干重为0.0423 g,细胞活力OD值为0.4850,达到峰值。本研究为后续原生质体的分离以及功能基因的亚细胞定位提供依据。

关键词：参薯组培苗愈伤组织悬浮细胞培养条件

LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway

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Oncology Research 2022年第6期30卷 289-300页

作者： YAN zhuang CHUNLAN NING pengfei LIU YANPENG ZHAO YUE LI ZHENCHI MA LULING SHAN YINGZHE PIAO PENG ZHAO XUN JIN Department of Colorectal Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China Department of Biochemistry and Molecular Biology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China Tianjin Medical University Tianjin300070China Department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin300120China Tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.Ltd.Tianjin300381China Department of Gastro Colorectal Oncology Tianjin Cancer Hospital Airport HospitalTianjin300304China Department of Neuro-Oncology and Neurosurgery Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy TianjinTianjin’s Clinical Research Center for CancerTianjin300060China

Aberrant activation of the WNT signaling pathway is a joint event in colorectal cancer(CRC),but the molecular mechanism is still ***,RNA-splicing factor LSM12(like-Sm protein 12)is highly expressed in CRC *** study aimed to verify whether LSM12 is involved in regulating CRC progression via regulating the WNT signaling ***,we found that LSM12 is highly expressed in CRC patient-derived tissues and ***12 is involved in the proliferation,invasion,and apoptosis of CRC cells,similar to the function of WNT signaling in ***,protein interaction simulation and biochemical experiments proved that LSM12 directly binds to CTNNB1(also known asβ-Catenin)and regulates its protein stability to affect the CTTNB1-LEF1-TCF1 transcriptional complex formation and the associated WNT downstream signaling ***12 depletion in CRC cells decreased the in vivo tumor growth through repression of cancer cell growth and acceleration of cancer cell *** together,we suggest that the high expression of LSM12 is a novel factor leading to aberrant WNT signaling activation,and that strategies targeting this molecular mechanism may contribute to developing a new therapeutic method for CRC.

关键词： CRC LSM12 WNT CTNNB1 Apotosis