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Food Science and Human Wellness 2024年第2期13卷 698-708页

作者： Hongyun Zhang Guangqiang Wang Zhiqiang Xiong zhuan liao Yangyan Qian Xin Song Li Sui Lianzhong Ai Yongjun Xia Shanghai Engineering Research Center of Food Microbiology School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterol Digestive Endoscopy CenterShanghai HospitalShanghai 200093China

Probiotics have great potential in regulating intestinal *** this study,the effects of Lactobacillus plantarum AR495 on the visceral sensitivity and gut microbiota of irritable bowel syndrome(IBS)rats were *** results showed that tryptase released after mast cell activation and degranulation plays a key role in visceral pain,and *** AR495 reduced the stimulation of colonic mast cells and the expression of protease-activated receptor 2(PAR2)and TRPV1 in dorsal root *** further showed that supplementation with *** AR495 increased the level of short-chain fatty acids(SCFAs)and enhanced the barrier function of the *** addition,the microbiota analysis of the colon indicated that *** AR495 promoted the proliferation of Bifidobacterium and inhibited the proliferation of Lachnospiraceae,which alleviated the imbalance of the intestinal microbiota caused by IBS to a certain *** total,*** AR495 might reduce visceral sensitivity through the Mast cell-PAR2-TRPV1 signaling pathway by maintaining the homeostasis of the intestinal barrier.

关键词： Lactobacillus plantarum Irritable bowel syndrome Visceral sensitivity Dorsal root ganglia Tryptase Microbiota

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

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Food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian zhuan liao Hui Zhang Lianzhong Ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China Department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is *** major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging *** result showed that pretreatment with *** AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme *** D-galactose induced aging mice,*** AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant *** analysis shown that gavage of *** AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic *** results were also confirmed in H_(2)O_(2)-treated HepG2 *** indicated that *** AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative *** AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 D-galactose Oxidative stress ER stress

Capsule endoscopy in portal hypertension and varices

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Portal Hypertension & Cirrhosis 2024年第3期3卷 171-172页

作者： Jun Pan Zhaoshen Li zhuan liao Department of Gastroenterology National Clinical Research Center for Digestive DiseasesNational Key Laboratory of Immunity and InflammationShanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical DevicesChanghai HospitalNaval Medical UniversityShanghaiChina

1|CAPSULE ENDOSCOPY VERSUS ESOPHAGOGASTRODUODENOSCOPY(EGD)FOR DIAGNOSING GASTROESOPHAGEAL VARICES(GEVs):CENTERS *** is the gold standard for diagnosing GEVs in patients with portal hypertension,but its invasiveness limits patients'*** the nature of noninvasiveness and direct visualization,capsule endoscopy has the potential to be an alternative to EGD for diagnosing varices.

关键词： endoscopy hypertension capsule

A comprehensive review of recent advances in chronic pancreatitis

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Journal of Pancreatology 2024年第1期7卷 45-52页

作者： Sheng-Han Mao Wen-Bin Zou Xiao-Tong Mao Zhao-Shen Li zhuan liao Department of Gastroenterology Changhai HospitalThe Naval Medical UniversityShanghaiChina Shanghai Institute of Pancreatic Diseases ShanghaiChina

Chronic pancreatitis(CP)is a multifaceted disorder influenced by environmental and genetic factors,with smoking and alcohol consumption being major *** developments encompass the advent of innovative transgenic models and the identification of susceptibility genes,shedding light on the genetic aspect of *** pathogenesis of this disease involves a complex interplay of pancreatic acinar cell dysfunction,inflammatory reactions,and *** research delves into understanding these molecular ***,a pivotal symptom of CP,has been increasingly studied to develop effective therapeutic *** advancements,including endoscopic ultrasound,radiomics,and blood-based markers,have shown potential in enhancing early CP ***,recent clinical trials have optimized treatment approaches,such as pancreatic stone fragmentation,stent placement,and decision-making between endoscopic and surgical *** therapies,including chemical pancreatectomy and gene therapy,present promising opportunities for improved CP management.

关键词： Chronic pancreatitis Diagnosis Endoscopy Etiology Mechanism Surgery

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遗传性胰腺炎研究现状及进展

中国实用内科杂志 2024年第7期44卷 532-536页

作者：马国秀王元辰邹文斌廖专海军军医大学附属长海医院消化内科、上海市胰腺病研究所上海200433

随着对胰腺炎机制的深入研究,遗传因素逐渐引起人们的重视。遗传性胰腺炎是一种常染色体遗传病,与多种基因突变相关,其中以PRSS1基因突变最为常见。遗传性胰腺炎的临床表现与其他类型胰腺炎基本相似,但其发病年龄早、疼痛发生率高、病... 详细信息

随着对胰腺炎机制的深入研究,遗传因素逐渐引起人们的重视。遗传性胰腺炎是一种常染色体遗传病,与多种基因突变相关,其中以PRSS1基因突变最为常见。遗传性胰腺炎的临床表现与其他类型胰腺炎基本相似,但其发病年龄早、疼痛发生率高、病程长且无法治愈,同时具有家族聚集性、胰腺癌高风险等特点,严重影响患者及家庭的生活质量。目前该病的临床管理模式以疼痛管理为主,辅以调整生活方式、胰腺癌监测及并发症治疗。近年来,围绕遗传性胰腺炎的临床特征、致病机制、诊断标准、治疗及预后开展了系列研究,现对相关研究进展进行综述。

关键词：遗传性胰腺炎家族性胰腺炎基因突变胰腺癌 PRSS1

Clinical application of magnetically controlled capsule gastroscopy in gastric disease diagnosis: recent advances

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Science China(Life Sciences) 2018年第11期61卷 1304-1309页

作者： zhuan liao Wenbin Zou Zhao-Shen Li Department of Gastroenterology Changhai Hospital the Second Military Medical University

Magnetically controlled capsule gastroscopy(MCCG) is a novel system primarily used for the diagnosis of gastric disease. It consists of an endoscopic capsule with magnetic material inside, external guidance magnet equipment, data recorder and computer workstation. Several clinical trials have demonstrated that MCCG is comparable in accuracy in diagnosing gastric focal disease when compared to conventional gastroscopy. Further clinical studies are needed to test the diagnostic accuracy and improve the functioning of MCCG. This novel MCCG system could be a promising alternative for screening for gastric diseases,with the advantages of no anesthesia required, comfort and high acceptance across populations.

关键词： magnetically controlled capsule endoscopy gastric diseases screening conventional gastroscopy diagnostic accuracy

基于文献计量的全球胶囊内镜研究特征与趋势分析

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中华消化内镜杂志 2024年第8期41卷 647-653页

作者：郝美娟高野程志远辛磊廖专李兆申王洛伟上海理工大学健康科学与工程学院上海200433 贵阳市第四人民医院麻醉手术科贵阳550000 海军军医大学第一附属医院消化内科上海200433 上海交通大学医学院附属第一人民医院消化内科上海200080

目的通过对胶囊内镜领域国际国内发表论文的特征与关键词进行定量分析,阐明胶囊内镜研究发展趋势,为相关研究者提供参考。方法采用文献计量学方法,分别使用Stork文献鸟和CiteSpace可视化工具对PubMed英文数据库和CNKI中文数据库中关于... 详细信息

目的通过对胶囊内镜领域国际国内发表论文的特征与关键词进行定量分析,阐明胶囊内镜研究发展趋势,为相关研究者提供参考。方法采用文献计量学方法,分别使用Stork文献鸟和CiteSpace可视化工具对PubMed英文数据库和CNKI中文数据库中关于“胶囊内镜”的所有发表于2002年至2022年的文献进行检索并分析。结果在此时间段PubMed数据库中共检出6011篇胶囊内镜相关文献,国内外英文论文发表数量和被引频次均呈现上升趋势,全球和国内英文论文的增长率分别为5%和15%。文献发表国家主要集中于美国、日本、中国、意大利和德国。全球研究领域集中于磁控胶囊内镜、结肠胶囊内镜、炎症性肠病、小肠胶囊内镜、胶囊内镜图像、不明原因消化道出血等方向。CNKI数据库中共检索出2027篇文献,研究机构前3名依次为海军军医大学长海医院消化内科、南方医科大学南方医院消化内科、上海交通大学电子信息与电气工程学院,近期最新突现词为人工智能、深度学习、指南。结论目前胶囊内镜领域研究活跃度逐渐增加,我国在国际胶囊内镜领域具有一定学术影响力。

关键词：胶囊内窥镜文献计量学关键词检索趋势分析

新型便携式内镜系统用于动物腹部战创伤救治的可行性与安全性研究

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中华消化内镜杂志 2024年第1期41卷 25-29页

作者：张婷邹文斌姜春晖王震蔡丽萍李兆申廖专海军军医大学第一附属医院消化内科上海200433 海军军医大学第一附属医院肝胆胰脾外科上海200433 海军军医大学第一附属医院临床教学中心上海200433

目的比较新型便携式内镜系统和常规电子内镜系统用于动物腹部战创伤探查与紧急治疗的可行性与安全性。方法将3头健康巴马猪分别编为1号、2号、3号, 术前禁食水8 h。实验前进行诱导麻醉, 从巴马猪的中腹壁逐层切开进入腹腔, 利用腹腔镜... 详细信息

目的比较新型便携式内镜系统和常规电子内镜系统用于动物腹部战创伤探查与紧急治疗的可行性与安全性。方法将3头健康巴马猪分别编为1号、2号、3号, 术前禁食水8 h。实验前进行诱导麻醉, 从巴马猪的中腹壁逐层切开进入腹腔, 利用腹腔镜气腹机建立人工气腹, 置入子弹模型1枚, 建立子弹创伤模型;取出子弹模型后置入弹片模型1枚, 建立弹片创伤模型。分别应用新型便携式内镜系统和常规电子内镜系统对1号巴马猪进行子弹模型和弹片模型的探查及取出操作。上述操作结束后, 两种内镜系统分别对2号、3号巴马猪进行同样操作过程。两种内镜操作的先后顺序根据随机数表法进行分配。分别记录两种内镜系统的手术成功情况、手术时间、内镜管道通畅性、内镜操作满意情况、不良事件和器械缺陷发生情况。结果使用新型便携式内镜系统和常规电子内镜系统进行手术各3次, 手术均成功。新型便携式内镜系统发现及取出子弹模型、发现及取出弹片模型的时间分别为(232.33±11.68)s、(300.33±57.70)s、(170.00±44.44)s、(52.67±2.52)s;常规电子内镜系统相应时间分别为[(232.67±21.20)s, t=-0.054, P=0.962]、[(256.67±67.00)s, t=0.880, P=0.472]、[(176.00±52.42)s, t=-0.111, P=0.922]、[(58.67±14.84)s, t=-0.832, P=0.493], 差异无统计学意义(P>0.05)。实验过程中, 两种内镜系统管道均通畅, 操作者对两种内镜系统的内镜操作过程均满意。两组均无不良事件和器械缺陷发生。结论新型便携式内镜系统用于动物腹部战创伤的救治操作成功情况与常规电子内镜系统相当, 初步证实该系统用于动物腹部战创伤救治安全可行。

关键词：创伤和损伤便携式内镜腹部战创伤动物实验

Study on chronic pancreatitis and pancreatic cancer using MRS and pancreatic juice samples

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World Journal of Gastroenterology 2011年第16期17卷 2126-2130页

作者： Jian Wang Chao Ma zhuan liao Bing Tian Jian-Ping Lu Department of Radiology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Gastroenterology Changhai HospitalThe Second Military Medical University Shanghai 200433 China

AIM:To investigate the markers of pancreatic diseases and provide basic data and experimental methods for the diagnosis of pancreatic ***:There were 15 patients in the present study,among whom 10 had pancreatic cancer and 5,chronic *** all patients,pancreatic cancer or chronic pancreatitis was located on the head of the ***-thology da-ta-of a-ll p-a-tients wa-s confirmed by biopsy and *** the 10 patients with pancreatic cancer,3 people had a medical history of longterm alcohol *** 5 patients with chronic pancreatitis,4 men suffered from alcoholic chronic *** juice samples were obtained from patients by endoscopic retrograde *** resonance spectroscopyn was performed on an 11.7-T scanner (Bruker DRX-500) using Call-Purcell-Meiboom-Gill pulse *** parameters were as follows:spectral width,15 KHz;time domain,64 K;number of scans,512;and acquisition time,2.128 ***:The main component of pancreatic juice included leucine,iso-leucine,valine,lactate,alanine,acetate,aspartate,lysine,glycine,threonine,tyrosine,histidine,tryptophan,and *** performing 1D 1H and 2D total correlation spectroscopy,we found a triplet peak at the chemical shift of 1.19 ppm,which only appeared in the spectra of pancreatic juice obtained from patients with alcoholic chronic *** triplet peak was considered the resonance of the methyl of ethoxy group,which may be associated with the metabolism of alcohol in the ***:The triplet peak,at the chemical shift of 1.19 ppm is likely to be the characteristic metabolite of alcoholic chronic pancreatitis.

关键词： Pancreatic juice Pancreatic cancer Chronic pancreatitis Magnetic resonance spectroscopy Magnetic resonance imaging

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导管通路在慢性胰腺炎致病机制中的作用进展

生物医学转化 2024年第1期5卷 66-71页

作者：杜甑衎王元辰邹文斌廖专海军军医大学附属长海医院上海200433 上海市胰腺疾病研究所上海200433

慢性胰腺炎(CP)是一种遗传和环境等多因素作用下的进行性纤维性胰腺炎性疾病。目前,CP遗传致病机制主要分为胰蛋白酶依赖性通路、蛋白错误折叠通路和导管通路。胰腺导管上皮细胞作为胰腺外分泌部的一种重要细胞类型,可以产生H2O和HCO_(3... 详细信息

慢性胰腺炎(CP)是一种遗传和环境等多因素作用下的进行性纤维性胰腺炎性疾病。目前,CP遗传致病机制主要分为胰蛋白酶依赖性通路、蛋白错误折叠通路和导管通路。胰腺导管上皮细胞作为胰腺外分泌部的一种重要细胞类型,可以产生H2O和HCO_(3)^(-),负责碱化、稀释和输送消化酶。当导管通路相关的易感基因发生功能障碍时,将会导致导管内离子浓度失衡与消化酶转运障碍,促进CP的发生与发展。既往导管通路相关致病基因较少,近年来对其认知逐步加深,新型易感基因陆续被发现。本文主要针对导管通路相关基因及其主要致病机制展开论述,以加深对CP发生机制的认识。

关键词：慢性胰腺炎易感基因导管通路致病机制