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Artificial intelligence software for assessing brain ischemic penumbra/core infarction on computed tomography perfusion:A real-world accuracy study

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World Journal of Radiology 2024年第8期16卷 329-336页

作者： zhu-Qin Li Wu Liu Wei-Liang Luo Su-Qin Chen Yu-Ping deng Department of Neurology Huizhou Central People’s HospitalHuizhou 516001Guangdong ProvinceChina

BACKGROUND With the increasingly extensive application of artificial intelligence(AI)in medical systems,the accuracy of AI in medical diagnosis in the real world deserves attention and objective *** To investigate the accuracy of AI diagnostic software(Shukun)in assessing ischemic penumbra/core infarction in acute ischemic stroke patients due to large vessel *** From November 2021 to March 2022,consecutive acute stroke patients with large vessel occlusion who underwent mechanical thrombectomy(MT)post-Shukun AI penumbra assessment were *** tomography angiography(CTA)and perfusion exams were analyzed by AI,reviewed by senior neurointerventional *** the case of divergences among the three experts,discussions were held to reach a final *** the results of AI were inconsistent with the neurointerventional experts’diagnosis,the diagnosis by AI was considered *** A total of 22 patients were included in the *** vascular recanalization rate was 90.9%,and 63.6%of patients had modified Rankin scale scores of 0-2 at the 3-month *** computed tomography(CT)perfusion diagnosis by Shukun(AI)was confirmed to be invalid in 3 patients(inaccuracy rate:13.6%).CONCLUSION AI(Shukun)has limits in assessing ischemic *** clinical and imaging data(CT,CTA,and even magnetic resonance imaging)is crucial for MT decision-making.

关键词： Artificial intelligence Acute ischemic stroke Penumbra Core infarction Computed tomography perfusion

The Synthesis of adenosine analogues and their sedative and hypnotic activity

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The Synthesis of adenosine analogues and their sedative and ...

特征光谱吸收法测量人血清前列腺特异性抗原浓度的研究

中国化学会第十届全国天然有机化学学术会议

作者： Cheng-Gen zhu Zheng-Gang Yue jian-Jun Zhang jian-Gong Shi State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

＜正＞Adenosine derivatives have significant sedative and hypnotic activity1,*** 2’-deoxyadenosine derivatives（4a-4e）and five adenosine derivatives（5a-5e）were synthesized,and accessed for their sedative and hypnotic *** result showed that 3a-3e and 4a-4e were less active than 5a-5e（Table 1）.This indicates that the ribose unit is important for the sedative and

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光谱学与光谱分析 2012年第1期32卷 196-199页

作者：朱健铭陈真诚中南大学地球科学与信息物理学院湖南长沙410083 桂林电子科技大学生命与环境科学学院广西桂林541004

采用免疫层析金标试纸配合特征光谱吸收法检测前列腺特异性抗原(PSA,prostate-specific anti-gen)浓度,采用合适发射光波长(520～535nm)的LED照射已用PSA标准液处理过的胶体金标记试纸,用合适接收波长(520～540nm)的光电二极管测试试纸... 详细信息

采用免疫层析金标试纸配合特征光谱吸收法检测前列腺特异性抗原(PSA,prostate-specific anti-gen)浓度,采用合适发射光波长(520～535nm)的LED照射已用PSA标准液处理过的胶体金标记试纸,用合适接收波长(520～540nm)的光电二极管测试试纸特定区域的反射光强度,据此得出表征试纸吸光的量,再用线性拟合方法确定PSA浓度与试纸吸光度的关系。研究中采用不同浓度的PSA标准液标定了实验检测系统,发现在浓度范围为5～***-1时,PSA的浓度与试纸的吸光度成线性关系。在该浓度范围内对不同于标定浓度的21种PSA标准液做了检测实验,检测值与真实值的相关系数为0.910。实验证明,采用特征光谱吸收法测量PSA浓度的方法是可行的。

关键词：前列腺特异性抗原光谱吸收金标试纸免疫层析法

Numerical simulation of three-dimensional wake transition

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Numerical simulation of three-dimensional wake transition

V/SBA-15的水热合成法制备及其催化氧化性能研究

第十届全国分离流、旋涡和流动控制会议

作者： deng jian~(1)), REN An-lu, ZOU jian-feng (Department of Mechanics, Zhejiang University, Hangzhou 310027, China)

The studies concerning the wake transition regime of the flow around a circular cylinder become hot these years. Many experiments have been made for this problem but no accurate three-dimensional numerical simulations have hitherto been made. In this paper, a parallel procedure was developed to simulate the three-dimensional Navier-Stokes equations on an SGI Origin3900 machine. Two different parallel strategies on this application were analyzed about their efficiency. The critical Reynolds number of 195 is found. and the wake flow below this Reynolds number is pure two-dimensional. When the Reynolds number go beyond this critical point, the wake flow becomes instable to three-dimensional small disturb. The transition regime involves two modes of small-scale three-dimensional instability (modes A an B), depending on the regime of Reynolds number (Re). It is found that the two different modes A and B scales on different physical features of the flow, and many other important questions are addressed in this paper.

关键词： : three-dimensional Navier-Stokes equations, three-dimensional instability, wake transition. parallel computing

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化学工程 2014年第11期42卷 66-69页

作者：朱玉镇沈健辽宁石油化工大学化学学部辽宁抚顺113001

为了制备负载型介孔分子筛V/SBA-15并研究其在乙苯制苯乙酮反应中的催化性能,以P123(三嵌段共聚物)为模板剂,正硅酸乙酯为硅源,柠檬酸氧钒配合物为前驱体,在酸性条件下采用水热法一步合成了V/SBA-15有序介孔材料,利用XRD,BET,FT-IR等手... 详细信息

为了制备负载型介孔分子筛V/SBA-15并研究其在乙苯制苯乙酮反应中的催化性能,以P123(三嵌段共聚物)为模板剂,正硅酸乙酯为硅源,柠檬酸氧钒配合物为前驱体,在酸性条件下采用水热法一步合成了V/SBA-15有序介孔材料,利用XRD,BET,FT-IR等手段对所合成的V/SBA-15材料进行了结构表征,并在乙苯制苯乙酮反应中以苯乙酮选择性和收率来验证催化剂的催化性能。实验结果表明:此合成材料具有类似于SBA-15的高度有序的六方介孔结构,活性组分钒均匀分散在介孔氧化硅基体中;在催化氧化乙苯制苯乙酮反应的优化条件下,苯乙酮选择性和收率分别为80.87%,35.26%。

关键词： V/SBA-15 介孔结构水热合成乙苯苯乙酮

Epidemiology of methicillin-resistant Staphylococcus aureus infection and empirical antibiotic therapy for MRSA infection： multicenter investigation

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Chinese Medical Journal 2013年第19期126卷 3745-3749页

作者： deng Li-jing WU Xiao-dong KANG Yan XU Yuan ZHOU jian-xin WANG Di-fen CHEN De-chang Department of Critical Care Medicine West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Critical Care Medicine Beijing Tongren Hospital Beijing 100730 China Department of Critical Care Medicine Beijing Tiantan Hospital Beijing 10050 China Department of Critical Care Medicine Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Department of Critical Care Medicine Shanghai Changzhen Hospital Shanghai 200003 China

Background The epidemiology of methicillin-resistant Staphylococcus aureus （MRSA） maybe changed by strict infection control measures,and the impact of empirical antibiotic therapy on the outcomes of MRSA infection was not *** aimed to investigate the present epidemiological status of MRSA infection and empirical antibiotic therapy for MRSA infection in university teaching hospitals in China's *** The present study was a multicenter prospective observational study conducted in five university teaching *** who were consecutively admitted to the intensive care unit and signed a consent form from March 3,2011 to May 31,2011 were *** with age 〈18 years or with a length of hospital stay 〈48 hours were excluded from this *** following variables were collected or recorded：demographic data,general status,APACHE Ⅱ score of the patient at the time of admission,infections,and the use of antibiotics during a *** outcomes and prognostic indicators included length of hospital stay and 28-day and 90-day *** differences between the patients with appropriate empirical therapy and patients with inappropriate therapy were analyzed to detect the influences of antibiotic therapy on the prognosis of MRSA *** A total of 682 cases were *** （66.2%） of 88 MRSA cases were treated with effective antibiotics for MRSA infection; only 20% received appropriate empirical antibiotic *** empirical therapy group compared with the target therapy group had a shorter length of stay,but there were no significant differences in mortality *** were no significant differences in the length of hospital stay,length of stay,and 28-day and 90-day mortality between MRSA-infected patients who received or not received effective *** hundred and eighteen cases received sensitive antibiotics for *** The MRSA infection rates are at relatively low levels in university teaching hospit

关键词： methicillin-resistant Staphylococcus aureus empirical antibiotic therapy epidemiology mortality

美托洛尔分子烙印聚合物应用于固相萃取的研究

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中国药学杂志 2008年第12期43卷 943-946页

作者：何建峰邓芹英广州中医药大学中药学院广州510006 中山大学化学与化学工程学院广州510275

目的将分子烙印聚合物(MIP)作为固相萃取的吸附剂,研究其分子识别性能。方法采用分子烙印技术制备了美托洛尔分子烙印固相萃取柱,并与空白聚合物柱对照,探讨了其在非平衡吸附条件下的最大负载量,确定了上样、淋洗和洗脱的最佳萃取模型... 详细信息

目的将分子烙印聚合物(MIP)作为固相萃取的吸附剂,研究其分子识别性能。方法采用分子烙印技术制备了美托洛尔分子烙印固相萃取柱,并与空白聚合物柱对照,探讨了其在非平衡吸附条件下的最大负载量,确定了上样、淋洗和洗脱的最佳萃取模型。结果美托洛尔的分子烙印固相萃取柱对原模板具有较高的选择性和识别能力,而空白聚合物却不具有这样的特性。在优化的萃取条件上,美托洛尔与其结构相似的卡维地洛和普萘洛尔在柱上得到了很好的分离。结论MIP作为固相萃取吸附剂为解决药物的纯化提供了一条可行的有效途径。

关键词：美托洛尔分子烙印技术固相萃取条件优化

Nationwide survey on the usage of ovulation-induction agents among obstetricians and gynecologists in China

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Chinese Medical Journal 2019年第20期132卷 2489-2491页

作者： Yan deng Yan-Fang Wang Shi-Yang zhu Wei Xue Xiao Ma Rui-Lin Ma Ai-Jun Sun Department of Obstetrics and Gynecology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Ovulation-induction refers to the type of ovarian stimulation for anovulatory women aimed at restoring normal fertility by generating normal ovulatory cycles and inducing single dominant follicle selection and ovulation. In China, a great number of women with ovulatory disorders are treated by obstetricians and gynecologists (ob-gyns) who are not specialized in infertility. The aim of this study was to investigate the self-reported ob-gyns proficiency of ovulation induction and the most commonly used drug for this procedure.

关键词： specialized generating women

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应用于干涉显微镜的直线压电作动器

光学精密工程 2013年第6期21卷 1524-1530页

作者：朱华曹如意菅磊南京航空航天大学机械结构力学与控制国家重点实验室江苏南京210016

提出了应用于干涉显微镜焦距调节的直线压电叠堆作动器和微动台。介绍了基于三角位移放大原理的压电作动器结构设计,利用ANSYS的APDL语言实现了对作动器钢架结构的建模,并采用Optimus中自带的差分进化算法(DE)对其结构尺寸进行了优化。... 详细信息

提出了应用于干涉显微镜焦距调节的直线压电叠堆作动器和微动台。介绍了基于三角位移放大原理的压电作动器结构设计,利用ANSYS的APDL语言实现了对作动器钢架结构的建模,并采用Optimus中自带的差分进化算法(DE)对其结构尺寸进行了优化。制作了实验样机,激光干涉实验表明:当驱动电压信号幅值为40～100V时,作动器位移放大倍数可以达到7。最后,将设计的直线作动器作为驱动核心安装在自行设计的微动台上,然后将组成的系统用于光学干涉显微镜。实验显示,整个系统在电压为24～40V,阶梯增量电压为0.8V时,步进分辨率可达23nm,满足干涉显微镜细分干涉条纹所需要的直线位移分辨率的要求。

关键词：干涉显微镜三角放大原理步进式压电作动器结构优化干涉条纹