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Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease:Current Progresses and Challenges

Journal of Clinical and Translational Hepatology 2022年第5期10卷 955-964页

作者： Yu-Xian Teng Si Xie Ping-Ping Guo zhu-jian deng Zi-Yi Zhang Wei Gao Wan-Guang Zhang jian-Hong Zhong Hepatobiliary Surgery Department Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research CenterGuangxi Medical University Cancer HospitalNanningGuangxiChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationGuangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorNanningGuangxiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

The rising global prevalence of metabolic diseases has increased the prevalence of non-alcoholic fatty liver disease(NAFLD),leading to an increase in cases of NAFLD-related hepatocellular carcinoma(HCC).To provide an updated literature review detailing epidemiology,risk factors,pathogenic pathways,and treatment strategies linked to NAFLD-related HCC,we conducted a literature search on PubMed from its inception to December 31,*** 25%of the global population suffers from *** annual incidence of HCC among NAFLD patients is approximately 1.8 per 1,000 *** age,male sex,metabolic comorbidities,unhealthy lifestyle habits(such as smoking and alcohol consumption),physical inactivity,genetic susceptibility,liver fibrosis,and degree of cirrhosis in NAFLD patients are important risk factors for NAFLD-related ***,low-calorie diet,moderate-intensity exercise,treatment of metabolic comorbidities,and cessation of smoking and alcohol are the main measures to prevent NAFLD-related *** addition,all patients with advanced NAFLD-related fibrosis or cirrhosis should be screened for *** suppression disorders and changes in the liver microenvironment may be the main pathogenesis of NAFLD-related *** resection,liver transplantation,ablation,transarterial chemoembolization,radiotherapy,targeted drugs,and immune checkpoint inhibitors are used to treat NAFLD-related *** treatment may lead to better overall survival,while immune checkpoint inhibitors may lead to worse overall *** the specific risk factors for NAFLD-related HCC,primary prevention is ***,the same treatment may differ substantially in efficacy against NAFLD-related HCC than against HCC of other etiologies.

关键词： Epidemiology Hepatocellular carcinoma Non-alcoholic fatty liver disease Risk factor Treatment strategy

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Treatments of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus:Current Status and Controversy

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 147-158页

作者： zhu-jian deng Le Li Yu-Xian Teng Yu-Qi Zhang Yu-Xin Zhang Hao-Tian Liu jian-Li Huang Zhen-Xiu Liu Liang Ma jian-Hong Zhong Hepatobiliary Surgery Department Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research CenterGuangxi Medical University Cancer HospitalNanningGuangxiChina

The proportions of patients with hepatocellular carcinoma(HCC)involving portal vein tumor thrombus(PVTT)varies greatly in different countries or regions,ranging from 13%to 45%.The treatment regimens for PVTT recommended by HCC guidelines in different countries or regions also vary *** recent years,with the progress and development of surgical concepts,radiotherapy techniques,systematic therapies(for example,VEGF inhibitors,tyrosine kinase inhibitors and immune checkpoint inhibitors),patients with HCC involving PVTT have more treatment options and their prognoses have been significantly *** achieve the maximum benefit,both clinicians and patients need to think rationally about the indications of treatment modalities,the occurrence of severe adverse events,and the optimal fit for the *** this review,we provide an update on the treatment modalities available for patients with HCC involving *** with large sample size for patients with advanced or unresectable HCC are also reviewed.

关键词： Hepatocellular carcinoma Portal vein tumor thrombus Treatment modality

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Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin XU Chenchen deng jianfeng zhu Yao WANG Shaojun WEI Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG jian NIE Wei HUANG Jin zhu Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin zhu Teng jiang Junshan Zhou Fuling Yan Qiwen deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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细胞自噬在植物应答盐胁迫中的作用研究

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四川大学学报（自然科学版） 2016年第6期53卷 1403-1408页

作者：朱峰简伟邓星光林宏辉四川大学生命科学学院成都610064 扬州大学园艺与植物保护学院扬州225009

本研究以模式植物拟南芥为材料,利用生理学和遗传学手段分析了盐胁迫下细胞自噬基因和活性氧(ROS)变化的相关性.结果表明野生型拟南芥Col-0在遭受盐胁迫处理3d表现了叶片漂白的症状并且会诱导ROS的产生和积累了大量的细胞死亡.荧光定量... 详细信息

本研究以模式植物拟南芥为材料,利用生理学和遗传学手段分析了盐胁迫下细胞自噬基因和活性氧(ROS)变化的相关性.结果表明野生型拟南芥Col-0在遭受盐胁迫处理3d表现了叶片漂白的症状并且会诱导ROS的产生和积累了大量的细胞死亡.荧光定量PCR实验表明盐胁迫会诱导细胞自噬相关基因的表达,细胞自噬参与了调控植物的防御机制来响应盐胁迫.进一步的实验表明拟南芥细胞自噬突变体atg2和atg5在遭受盐胁迫处理3d表现了更加严重的叶片漂白症状并且积累大量的细胞死亡和ROS.初步表明细胞自噬主要是通过调控ROS的产生来应答盐胁迫.

关键词：细胞自噬活性氧盐胁迫拟南芥

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BEBA对丁羟推进剂界面粘接作用的研究

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固体火箭技术 2016年第5期39卷 667-671页

作者：张习龙刘苗娥王祝愿邓剑如湖南大学化学化工学院长沙410082

合成了聚醚类和聚酯类互联单体,并用互联单体合成了硼酸酯键合剂(BEBA)。采用反相气相色谱法,测算了AP、RDX、丁羟聚氨酯(HTPB-PU)基体和BEBA间的界面酸碱作用焓。结果显示,5种BEBA与AP、RDX的界面作用焓,均远大于HTPB-PU基体与AP、RDX... 详细信息

合成了聚醚类和聚酯类互联单体,并用互联单体合成了硼酸酯键合剂(BEBA)。采用反相气相色谱法,测算了AP、RDX、丁羟聚氨酯(HTPB-PU)基体和BEBA间的界面酸碱作用焓。结果显示,5种BEBA与AP、RDX的界面作用焓,均远大于HTPB-PU基体与AP、RDX、BEBA的界面作用焓,表明5种BEBA均优先吸附在AP、RDX上,以聚酯链段合成的BEBA-4更有利于吸附,并采用EDS证实了BEBA-4吸附在AP、RDX表面。通过接触角法,测算了AP、RDX吸附BEBA-4后的AP、RDX与HTPB-PU基体间的界面张力和界面粘附功。结果表明,吸附BEBA-4的AP、RDX与HTPB-PU基体间的界面张力降低,界面粘附功增加,界面粘接强度增强。BEBA用于推进剂力学性能测试和SEM观察的结果与界面粘接作用结果基本吻合,即以聚己二酸丁二醇酯为互联链段合成的BEBA-4对推进剂力学性能改善的效果最为显著。

关键词：丁羟推进剂硼酸酯键合剂互联链段反相气相色谱接触角

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三相不平衡低压微网的多目标优化调度

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电力建设 2017年第2期38卷 106-113页

作者：朱健罗辉邓武军汪洪春吴志云国网四川省电力公司建设管理中心成都市610021

提出了一种含多种分布式电源的三相不平衡微网综合优化调度策略。首先,确定了三相不平衡微网安全、经济、高效运行的评价指标;建立了多目标优化调度模型,并通过对多目标调度模型的求解得到微网的运行策略。其次,对各目标函数从不同的运... 详细信息

提出了一种含多种分布式电源的三相不平衡微网综合优化调度策略。首先,确定了三相不平衡微网安全、经济、高效运行的评价指标;建立了多目标优化调度模型,并通过对多目标调度模型的求解得到微网的运行策略。其次,对各目标函数从不同的运行角度进行了分析,以充分利用多目标方法的有效性。算例仿真验证了所提出的优化调度策略在充分发挥各种分布式电源作用方面的优势。

关键词：不平衡微网分布式电源储能调度策略多目标优化

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Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry and π-bridge effect design philosophy

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Science China Chemistry 2025年

作者： Qiong Liu Qiyun deng Changxu zhu Kongqi Chen Lidan Chen Zhaohui Sun Ben Zhong Tang Zhiming Wang AIE Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province South China University of Technology Department of Laboratory Medicine General Hospital of Southern Theater Command School of Life Sciences The Chinese University of Hong Kong Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong HKUST-Shenzhen Research Institute

The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging *** this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge *** a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these ***,the probe TPhIQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission (AIE) effect,and the ability to distinguish tumor cells from normal ***,it efficiently generated reactive oxygen species (ROS) and specifically labeled lipid droplets,enabling the precise staining and killing of cancer *** study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy (PDT) by harnessing the unique properties of AIE materials.

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融合BiLSTM与CNN的推特黑灰产分类模型

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计算机工程与应用 2025年第1期61卷 186-195页

作者：朱恩德王威高见中国人民公安大学信息网络安全学院北京100038

当前推特等国外社交平台,已成为从事网络黑灰产犯罪不可或缺的工具,对推特上黑灰产账号进行发现、检测和分类对于打击网络犯罪、维护社会稳定具有重大意义。现有的推文分类模型双向长短时记忆网络(bi-directional long short-term memor... 详细信息

当前推特等国外社交平台,已成为从事网络黑灰产犯罪不可或缺的工具,对推特上黑灰产账号进行发现、检测和分类对于打击网络犯罪、维护社会稳定具有重大意义。现有的推文分类模型双向长短时记忆网络(bi-directional long short-term memory,BiLSTM)可以学习推文的上下文信息,却无法学习局部关键信息,卷积神经网络(convolution neural network,CNN)模型可以学习推文的局部关键信息,却无法学习推文的上下文信息。结合BiLSTM与CNN两种模型的优势,提出了BiLSTM-CNN推文分类模型,该模型将推文进行向量化后,输入BiLSTM模型学习推文的上下文信息,再在BiLSTM模型后引入CNN层,进行局部特征的提取,最后使用全连接层将经过池化的特征连接在一起,并应用softmax函数进行四分类。模型在自主构建的中文推特黑灰产推文数据集上进行实验,并使用TextCNN、TextRNN、TextRCNN三种分类模型作为对比实验,实验结果显示,所提的BiLSTM-CNN推文分类模型在对四类推文进行分类的宏准确率为98.32%,明显高于TextCNN、TextRNN和TextRCNN三种模型的准确率。

关键词：文本分类双向长短期记忆网络(BiLSTM) 卷积神经网络(CNN) 黑灰产推特

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