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一种天线阵列定位法及其仿真研究

电子与信息学报 2005年第6期27卷 841-844页

作者：邓平朱中梁西南交通大学移动通信研究所成都610031 西南电子电信技术研究所成都610041

为了克服CDMA移动台(MS)定位估计中面临的远近效应问题,该文提出了一种在服务基站(BS)附近布置一种天线阵列,采用TSOA/AOA混合定位技术对MS进行定位估计的方法,分析了采用不同定位法的GDOP分布, 并给出了相应的TSOA/AOA混合定位算法。... 详细信息

为了克服CDMA移动台(MS)定位估计中面临的远近效应问题,该文提出了一种在服务基站(BS)附近布置一种天线阵列,采用TSOA/AOA混合定位技术对MS进行定位估计的方法,分析了采用不同定位法的GDOP分布, 并给出了相应的TSOA/AOA混合定位算法。不同条件下的仿真结果表明,只要AOA测量值达到一定精度,采用这种方法就能对MS进行准确定位。

关键词：天线阵列到达时间和到达时间差到达角几何精度衰减因子

Unusual bendable soft molecule-based ferroelectric crystals enabling the flexible photo-pyroelectric detection

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InfoMat 2024年第10期6卷 44-52页

作者： Liwei Tang Xinxu zhu yu Ma Haojie Xu Shiguo Han Yi Liu Yaoyao Chen Daohua Wang Junhua Luo Zhihua Sun State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujianthe People's Republic of China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijingthe People's Republic of China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujianthe People's Republic of China

Soft molecule-based ferroelectrics with unique structural flexibility hold apromise for versatile applications of non-volatile memory, imaging and photovoltaicdevices. Except for few polymers (e.g., polyvinylidene fluoride, PVDF),it is challenging to exploit soft ferroelectric crystals toward free-standing flexiblephotoactive devices. We here report a multiaxial soft molecule-based ferroelectric,(n-PA)_(2)PbCl_(4) (1, where n-PA^(+)is n-pentylammonium), of whichspontaneous polarization can be reversibly switched in both crystal and powderforms. Strikingly, single crystals of 1 have unusual structural flexibility andbendability, achieving the self-standing bending with a bending radius of0.22 mm. Besides, the pyroelectric activities are also preserved for these singlecrystals after several bending cycles. Further, the bendable crystal-basedphotodetector of 1 allows broadband photoactivities via the photo-pyroelectriceffect, covering a wide range from 405 to 940 nm spectral region, breakingthrough the limit of optical absorption bandgap. As the first study of bendablefree-standing photo-pyroelectric detectors in ferroelectric crystals, our worksheds light on the assembly of flexible smart photoelectric devices.

关键词： broadband photoresponse photo-pyroelectric effect self-standing bendable crystals soft molecular-based ferroelectric

Vector Fields with Stable Shadowable Property on Closed Surfaces

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1449-1456页

作者： Sheng Zhi zhu School of Science Beijing Jiaotong University Beijing 100044 P. R. China

We prove that the set of vector fields satisfying the C1 stable shadowable property on closed surfaces is characterized as the set of Morse-Smale vector fields. Hence, the vector fields satisfying shadowing property o... 详细信息

关键词： Pseudo orbit shadowing stable shadowable

Activation of autophagy in photoreceptor necroptosis after experimental retinal detachment

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 745-752页

作者： Kai Dong Zi-Cheng zhu Feng-Hua Wang Gen-Jie Ke Zhang yu Xun Xu Department of Ophthalmology Anhui Provincial HospitalAnhui Medical University Department of Ophthalmology Shanghai First People's HospitalSchool of MedicineShanghai Jiaotong University Eye Research Institute of Shanghai Jiaotong University Department of Morphology Fudan University Shanghai Medical College Department of Ophthalmology Shanghai First People's HospitalSchool of Medicine Shanghai Jiaotong University Shanghai Key Laboratory of Fundus Disease

AIM:To investigate whether photoreceptor necroptosis induced by z-VAD-FMK(pan caspase inhibitor) was involved the activation of autophagy and whether Necrostatin-1, a specific necroptosis inhibitor, could inhibit this induction of autophagy after experimental retinal ***:Experimental retinal detachment models were created in Sprague-Dawley rats by subretinal injection of sodium hyaluronate and subretinal injections of z-VAD-FMK, vehicle or z-VAD-FMK plus *** days after retinal detachment, morphologic changes were observed by transmission electron microscopy. In other animals, retinas were subjected to immunoprecipitation and Western Blotting, then probed with anti-RIP1, phosphoserine, LC-3II or caspase ***:It was proved by immunoprecipitation and western blotting, that photoreceptor necroptosis was mediated by caspase-8 inhibition and receptor interacting protein kinase(RIP1) phosphorylation activation. Transmission electron microscope and western blotting results indicated that photoreceptornecroptosis was involved the LC-3II and autophagosomes induction. We also discovered Necrostatin-1 could inhibit RIP1 phosphorylation and LC-3II ***:These data firstly indicate photoreceptor necroptosis is associated with the activation of autophagy. Necrostatin-1 protects photoreceptors from necroptosis and autophagy by down-regulation of RIP1 phosphorylation and LC-3II.

关键词： retinal detachment autophagy necroptosis

Floristics and Plant Biogeography in China

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Journal of Integrative Plant Biology 2008年第7期50卷 771-777页

作者： De-zhu Li Key Laboratory of Biodiversity and Biogeography Kunming Institute of Botany the Chinese Academy of Sciences and Plant Germplasm and Genomics Center Germplasm Bank of Wild Species Kunming 650204 China

In 1998, a revolutionary system of angiosperm classification, the Angiosperm Phylogeny Group system was published. Meanwhile, another new system of classification of angiosperms, the eight-class system was proposed by C.Y. Wu and colleagues based on long term work on the flora of China. The Flora Reipublicae Popularis Sinicae project was initiated in 1959 and completed by 2004. It is the largest Flora so far completed in the world, including 31 228 species of vascular plants, or one-eighth of the global plant diversity. The English-language and updated Flora of China （FOC） is an international joint effort initiated in 1988 and accelerated in 1998. Up to now, 15 of the 24 volumes of the FOC have been published. Based on the floristic data, the composition, characteristics, floristic divisions and affinities of the flora of China have been studied by Wu and colleagues since 1965. In the past 10 years, analyses of the available floristic data have been very productive. The East Asiatic Floristic Kingdom was proposed in 1998. All 346 families of angiosperms in China, according to the eight-class system of classification, were comprehensively discussed by using knowledge of current and historical distribution of seed plants in the world, together with some morphological and molecular data. A scheme of distribution patterns or areal-types of families and genera of seed plants in China was modified and elucidated, together with a proposed scheme of areal-types of the world. Molecular phylogenetic and biogeographical studies of angiosperms in China in the past 10 years also witnessed a progressive development. Integration of morphological and molecular data and fossil evidence revealed some significant results. Eastern Asia, which used to be regarded as an important center of survival during the ice age, is likely an important center of diversification of angiosperms.

关键词： biogeography center of diversification eastern Asia floristics phylogenetics.

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高龄女性卵子颗粒细胞转录组的数据分析

中国组织工程研究 2025年第19期29卷 4069-4075页

作者：秦立峰王加强朱伶东北农业大学生命科学学院黑龙江省哈尔滨市150030 重庆市妇幼保健院人类胚胎工程重庆市重点实验室重庆市400013

背景:颗粒细胞的状态很大程度上影响卵母细胞的质量。随着高龄女性在辅助生殖中占比不断增多,为了能更好地评估卵母细胞的质量,此研究在转录水平对不同年龄段患者来源的颗粒细胞进行了检测。目的:探究低龄和高龄患者颗粒细胞mRNA及长链... 详细信息

背景:颗粒细胞的状态很大程度上影响卵母细胞的质量。随着高龄女性在辅助生殖中占比不断增多,为了能更好地评估卵母细胞的质量,此研究在转录水平对不同年龄段患者来源的颗粒细胞进行了检测。目的:探究低龄和高龄患者颗粒细胞mRNA及长链非编码RNA表达变化。方法:在辅助生殖治疗周期中收集患者取卵时获得的废弃卵丘颗粒细胞,其中低龄组患者年龄为25-35周岁,高龄组患者年龄为38-45周岁。对低龄和高龄女性颗粒细胞进行RNA-seq分析,每组3个重复。结果与结论:①RNA-seq分析结果显示,样本平均测序量超过14 G,质控后的数据质量Q30超过93%,数据平均比对率为98.4%,表明数据质量较好;②主成分分析及相关性分析结果显示高龄组和低龄组样本间基因表达水平具有明显差异;③差异分析结果显示,相对于低龄组,高龄组颗粒细胞中共有410个差异表达的mRNA,其中上调基因167个,下调基因243个,GO分析结果显示下调基因主要富集到胞吐作用调节、激素代谢过程等,GSEA分析结果显示高龄组颗粒细胞中与分泌相关的通路表达下调;④相对于低龄组,高龄组共检测到662个差异表达的长链非编码RNA,这部分长链非编码RNA直接调控的蛋白质编码基因为1772个,其中与差异表达基因交集59个。结果表明:高龄组颗粒细胞中与分泌相关的基因及通路表达下调,从而影响卵母细胞质量,同时这些表达下调的基因受到长链非编码RNA调控,因此长链非编码RNA的表达可能与年龄有关。

关键词：年龄颗粒细胞卵母细胞全转录组差异基因长链非编码基因

EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

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Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang yuanyuan Guo Lijuan zhu Xinyuan zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

Cu(II)-baicalein enhance paracrine effect and regenerative function of stem cells in patients with diabetes

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Bioactive Materials 2024年第6期36卷 455-473页

作者： Kaijing Liu Ruihao Li Shusen Wang Xue Fu Ni zhu Xiaoyu liang Huiyang Li Xiaoli Wang Le Wang Yongjun Li Jianwu Dai Jing Yang Key Laboratory of Advanced Medical Materials and Devices Institute of Biomedical EngineeringTianjin Institutes of Health ScienceChinese Academy of Medical Science&Peking Union Medical CollegeTianjin300192China Tianjin Medical Health Research Institute Tianjin300192China Organ Transplant Center Tianjin First Central HospitalNankai UniversityTianjinChina Tianjin Clinical Research Center for Organ Transplantation TianjinChina Department of Vascular Surgery Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China Graduate School of Peking Union Medical College Beijing100730China

The development of engineered or modified autologous stem cells is an effective strategy to improve the efficacy of stem cell *** this study,the stemness and functionality of adipose stem cells derived from type 1 diabetic donors(T1DM-ASC)were enhanced by treatment with Cu(II)-baicalein microflowers(Cu-MON).After treatment with Cu-MON,T1DM-ASC showed enhanced expression of the genes involved in the cytokine-cytokine receptor interaction pathway and increased cytokine *** the top 13 differentially expressed genes between T1DM-ASC and Cu-MON-treated T1DM-ASC(CMTA),some genes were also expressed in HUVEC,Myoblast,Myofibroblast,and Vascular Smooth Muscle cells,inferring the common role of these cell *** vivo experiments showed that CMTA had the same therapeutic effect as adipose-derived stem cells from non-diabetic donors(ND-ASC)at a 15%cell dose,greatly reducing the treatment *** together,these findings suggest that Cu-MON promoted angiogenesis by promoting the stemness and functionality of T1DM-ASC and influencing multiple overall repair processes,including paracrine effects.

关键词： Angiogenesis Adipose stem cells Type 1 diabetes mellitus Paracrine effect Regenerative function

Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei HUANG Xue Zan DING yu zhu Feng Ren WANG Jia ZOU yuan Jie DU yuan Zhen ZHANG Ya Jun HUI Zi Wen zhu Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of Occupational Safety and Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of Occupational Medicine and Health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing