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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 25-36页

作者： Jue zhu Longyuan LI Ningtao zhu Zhejiang Provincial Engineering Research Center for the Safety of Pressure Vessel and Pipeline Key Laboratory of Impact and Safety Engineering (Ningbo University) Ministry of Education School of Engineering Computing and Mathematics University of Plymouth Xi'an Zhanshi Testing & Engineering Co.Ltd.

Carbon nanotubes(CNTs) have garnered great attention in recent years due to their outstanding electrical, thermal, and mechanical properties. The incorporation of small amounts of CNTs in polymers can substantially improve the sensitivity of the polymer's electrical conductivity. This paper presents a modified Maxwell model to evaluate the electrical conductivity of CNTs-filled polymer composites by introducing a transition zone to account for the tunneling effect. In this modified Maxwell model, the CNTs-filled polymer composite is modeled as a three-phase composite, consisting of a matrix(polymer), inclusions(CNTs), and a transition zone(tunneling zone). The effective electrical conductivity(EEC) of the composite is calculated based on the volume fractions and electrical conductivities of the matrix, inclusions, and transition zone. The model's validity is confirmed through the use of available test data, which demonstrates its capability to accurately capture the nonlinear conductivity behavior observed in CNTs-polymer composites. This study offers valuable insights into the design of high-performance conductive polymer nanocomposites, and enhances the understanding of electrical conduction mechanisms in CNT-dispersed polymer composites.

关键词： Nanoclay

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肺癌脑转移的药物治疗进展

中国肿瘤临床与康复 2024年第7期31卷 397-406页

作者：朱以香王洁国家癌症中心、国家肿瘤临床医学研究中心、中国医学科学院北京协和医学院肿瘤医院肺癌转化实验室、分子肿瘤学国家重点实验室北京100021

脑转移是肺癌预后较差的一种疾病类型,既往传统化疗时代,缺乏特异性的治疗手段。但随着靶向治疗药物、免疫治疗药物、抗体偶联药物等诸多药物的发展,肺癌的治疗手段更为丰富。上述治疗方式使肺癌脑转移的治疗效果也有了显著提升。基于此... 详细信息

脑转移是肺癌预后较差的一种疾病类型,既往传统化疗时代,缺乏特异性的治疗手段。但随着靶向治疗药物、免疫治疗药物、抗体偶联药物等诸多药物的发展,肺癌的治疗手段更为丰富。上述治疗方式使肺癌脑转移的治疗效果也有了显著提升。基于此,文章从靶向治疗药物、抗体偶联药物及免疫检查点抑制剂等方面对当前治疗肺癌脑转移的药物进展进行概述,梳理并总结目前可用的手段及未来发展方向,希望对肺癌脑转移的治疗有一定参考意义。

关键词：肺癌肿瘤转移脑靶向治疗抗体偶联药物免疫检查点抑制剂

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基于生涯规划的中职名师PDCA成长研究

江苏教育研究 2020年第12期 34-38页

作者：朱益湘景小文江苏省丹阳中等专业学校教务处江苏丹阳212300 江苏省丹阳中等专业学校江苏丹阳212300

中职名师的成长不是一蹴而就,也不是偶然的,大多数中职名师的成长都有明确的职业生涯规划。在生涯规划指导下,分修炼期、磨练期、提炼期、教练期四个成长阶段。针对不同阶段的成长需求,通过PDCA管理,循环递进,促进名师快速成长。

关键词：职业生涯规划中职名师 PDCA成长 SWOT分析

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PS塑料合金热性能的研究

高分子材料科学与工程 1989年第6期5卷 80-86页

作者：钱义祥朱支蔷毛韵琦上海石油化工研究所高桥石化公司化工二厂塑研所

本文用热分析技术(DSC,TG,TMA)全面系统地表征了SBS/HIPS-PS增韧性高分子合金的热特性。测定研究该塑料合金的玻璃化转变,比热,热形变,热降解,热氧化降解及其动力学参数。并将其与材料的性能,结构和加工塑化进行关联,为研究SBS/HIPS-PS... 详细信息

本文用热分析技术(DSC,TG,TMA)全面系统地表征了SBS/HIPS-PS增韧性高分子合金的热特性。测定研究该塑料合金的玻璃化转变,比热,热形变,热降解,热氧化降解及其动力学参数。并将其与材料的性能,结构和加工塑化进行关联,为研究SBS/HIPS-PS塑料合金加工过程-结构-性能相互关系提供了基础数据。

关键词： PS塑料合金热性能

高管持股、内部控制与企业社会责任非效率投入

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山东财经大学学报 2018年第6期30卷 55-65页

作者：刘建秋朱益祥湖南商学院会计学院湖南长沙410205

企业如何履行企业社会责任一直是研究的热点,但是,以往研究重点强调企业承担社会责任,忽视了企业社会责任的效率问题,现实中企业社会责任非效率投入普遍存在,对于这些非效率社会责任投入的成因和治理,目前理论研究鲜有关注。文章借鉴公... 详细信息

企业如何履行企业社会责任一直是研究的热点,但是,以往研究重点强调企业承担社会责任,忽视了企业社会责任的效率问题,现实中企业社会责任非效率投入普遍存在,对于这些非效率社会责任投入的成因和治理,目前理论研究鲜有关注。文章借鉴公司治理的核心手段—激励和约束制度,分析高管持股与内部控制对企业社会责任非效率投入的影响,利用2012—2015年中国全部A股上市公司数据进行了实证分析。研究发现,内部控制对企业社会责任非效率投入具有显著的治理作用;较低水平高管持股加剧了企业社会责任非效率投入,较高水平高管持股表现出对企业社会责任非效率投入的治理作用;较高水平高管持股与内部控制的共同实施对企业社会责任非效率投入具有显著的综合治理效应。研究结果表明,企业社会责任的有效履行在目前阶段主要依靠约束机制,股权激励需要进一步的改进才能发挥预期的治理作用。

关键词：高管持股内部控制企业社会责任非效率投入

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO Jin-Hui YANG Guang zhu State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

可切除Ⅲa/N2期非小细胞肺癌治疗模式探讨

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中国肺癌杂志 2019年第2期22卷 111-117页

作者：许子宜邢镨元马迪朱以香应建明李峻岭国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院北京100021 贵州医科大学附属肿瘤医院(贵州省肿瘤医院) 贵阳550004

临床可切除Ⅲa/N2期非小细胞肺癌(non-small cell lung cancer, NSCLC)的治疗模式一直存在争议,化疗、放疗、手术等治疗手段都有可改善其生存的报道,靶向治疗和免疫治疗的研究也有较多新进展,联合治疗的选择更是很多临床试验研究的重点... 详细信息

临床可切除Ⅲa/N2期非小细胞肺癌(non-small cell lung cancer, NSCLC)的治疗模式一直存在争议,化疗、放疗、手术等治疗手段都有可改善其生存的报道,靶向治疗和免疫治疗的研究也有较多新进展,联合治疗的选择更是很多临床试验研究的重点。联合治疗包括化疗联合手术或放疗,以及化疗、放疗和手术三种治疗的联合。对于NSCLC最佳治疗模式目前尚无定论。本文通过对多项II期、Ⅲ期临床试验及meta分析、个案报道的综述回顾,比较不同治疗方式对临床可切除Ⅲa/N2期NSCLC的生存影响,结果显示多学科治疗中手术对于延长患者生存是必要的选择,而新辅助化疗后联合手术并不优于联合放疗。依据肿瘤大小、淋巴结累及情况等进行个体化治疗是未来值得进一步探索的方向。

关键词：可切除Ⅲa/N2期非小细胞肺癌化疗放疗手术

断陷湖盆浅水三角洲的形成过程与发育模式——以苏丹Muglad盆地Fula凹陷Jake地区AG组为例

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石油学报 2016年第12期37卷 1508-1517页

作者：陈诚朱怡翔石军辉李顺明张佳佳吴穹螈中国石油勘探开发研究院北京100083 中国石油天然气集团公司尼罗河公司北京100034 中国石油大学地球科学学院北京102249 中海石油(中国)有限公司天津分公司天津300452

以苏丹Muglad盆地Fula凹陷Jake地区为例,利用岩心、测井和三维地震资料,结合水槽模拟实验展开湖盆浅水三角洲沉积学特征的研究,总结浅水三角洲形成过程和发育模式。Jake地区白垩系Abu Gabra组上部发育浅水三角洲,随着水体变浅,其单一朵... 详细信息

以苏丹Muglad盆地Fula凹陷Jake地区为例,利用岩心、测井和三维地震资料,结合水槽模拟实验展开湖盆浅水三角洲沉积学特征的研究,总结浅水三角洲形成过程和发育模式。Jake地区白垩系Abu Gabra组上部发育浅水三角洲,随着水体变浅,其单一朵叶规模和沉积物厚度逐渐减小。在垂向上分别出现小型叠瓦状、波状、薄片状和发散状4种前积反射样式,单一同相轴长宽比依次增大。而在平面上,朵叶中水道的频繁分叉和改道使分流河道呈鳞片状展布。浅水三角洲的发育期受季节性水位升降和物源供给影响较大,一个沉积周期中可分为洪水期、间洪期和枯水期。洪水期物源供给充足,其前中期水位高,水道在水下被破坏,朵叶快速向前呈席状沉积,后期水位下降,朵叶露出水面,新水道出现;间洪期水位较高,物源供给较充足,主流线频繁变化,水道宽而浅,朵体扩大明显;枯水期物源供给匮乏,水位低,水道窄而深并下切朵体,朵叶建设作用弱。

关键词：浅水三角洲前积作用地震沉积学水槽模拟 Fula凹陷 Muglad盆地

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu Chen Jie Li Chen zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan Li Wei-Hong zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide