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A mini review： Shape memory polymers for biomedica applications

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Frontiers of Chemical Science and Engineering 2017年第2期11卷 143-153页

作者： Kaojin Wang Satu Strandman x. x. zhu Departement de Chimie Universite de Montreal Montreal QC H3C 3J7 Canada

Shape memory polymers （SMPs） are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applica- tions are highlighted.

关键词： shape memory polymer biodegradability biocompatibility biomedical application bile acids

使用基于临床和影像学特征的机器学习模型预测接受新辅助化疗的食管鳞状细胞癌病人的病理完全缓解

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国际医学放射学杂志 2024年第1期 128-129页

作者： J.Wang x.zhu J.Zeng C.Liu W.Shen x.J.Sun 刘莹莹

摘要目的建立基于影像学特征的机器学习模型，以预测食管鳞状细胞癌（ESCC）病人新辅助化放疗（nCRT）的病理临床缓解（pCR）。方法招募2008年1月—2018年12月期

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Regulation of lysosomal ion homeostasis by channels and transporters

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Science China(Life Sciences) 2016年第8期59卷 777-791页

作者： Jian xiong Michael x.zhu Department of Integrative Biology and Pharmacology Mc Govern Medical School Program of Cell and Regulatory Biology Graduate School of Biomedical Sciences The University of Texas Health Science Center at Houston

Lysosomes are the major organelles that carry out degradation functions. They integrate and digest materials compartmental- ized by endocytosis, phagocytosis or autophagy. In addition to more than 60 hydrolases residing in the lysosomes, there are also ion channels and transporters that mediate the flux or transport of H＋, Ca2＋, Na＋, K＋, and C1- across the lysosomal mem- branes. Defects in ionic exchange can lead to abnormal lysosome morphology, defective vesicle trafficking, impaired autoph- agy, and diseases such as neurodegeneration and lysosomal storage disorders. The latter are characterized by incomplete lyso- somal digestion and accumulation of toxic materials inside enlarged intracellular vacuoles. In addition to degradation, recent studies have revealed the roles of lysosomes in metabolic pathways through kinases such as mechanistic target of rapamycin （mTOR） and transcriptional regulation through calcium signaling molecules such as transcription factor EB （TFEB） and cal- cineurin. Owing to the development of new approaches including genetically encoded fluorescence probes and whole endoly- sosomal patch clamp recording techniques, studies on lysosomal ion channels have made remarkable progress in recent years. In this review, we will focus on the current knowledge of lysosome-resident ion channels and transporters, discuss their roles in maintaining lysosomal function, and evaluate how their dysfunction can result in disease.

关键词： lysosomal storage disease(LSD) ion homeostasis calcium lysosome acidification

Assembly of Highly Ordered 2D Arrays of Silver-PNIPAM Hybrid Microgels

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Chinese Journal of Polymer Science 2017年第10期35卷 1212-1221页

作者： Jun-ying Weng zhuo Tang 关英 x.x.zhu 张拥军 Key Laboratory of Functional Polymer Materials and State Key Laboratory of Medicinal Chemical Biology The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of Chemistry Universite de Montreal C. P. 6128 Succursale Centre-ville Montreal QC H3C 3J7 Canada

A strategy was developed for the synthesis of highly ordered 2D arrays of Ag-PNIPAM hybrid microgel. The highly ordered 2D arrays of PNIPAM microgel were prepared by dispersing PNIPAM microgel on a charge-reversible substrate. The microgel spheres self-assembled into a 3D colloidal crystal, and the first 111 plane was fixed in situ onto the substrate as a result of spontaneous charge reversal of the substrate, leaving a high-quality 2D array of PNIPAM microgel. Ag nanoparticles were then synthesized in situ inside the microgel spheres by introduction of Ag＋ ions into the microgel spheres and reduction with sodium borohydride. The resulting 2D arrays are highly ordered. The inter-particle distance in the array can be tuned. In addition, the method allows the synthesis of large size arrays and the use of nonplanar substrate.

关键词： bonding conductive triazine intermolecular Hydrogen PEDOT responsive glycol polyethylene compressive

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis x.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai x.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen x.R.Chen x.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi x.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.x.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding x.x.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong x.Dong M.C.Du S.x.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.x.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han x.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou x.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.x.Huang L.Q.Huang x.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji x.B.Ji x.L.Ji Y.Y.Ji x.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang x.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing x.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki x.L.Kang x.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner x.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.x.Li R.Li S.x.Li T.Li W.D.Li W.G.Li x.Li x.H.Li x.L.Li x.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

A novel TRPC6-dependent mechanism of TGF-β-induced migration and invasion of human hepatocellular carcinoma cells

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Science China(Life Sciences) 2018年第9期61卷 1120-1122页

作者： Yun Tian Michael x.zhu College of Bioscience and Biotechnology Hunan Agricultural University Department of Integrative Biology and Pharmacology McGovern Medical School The University of Texas Health Science Center at Houston

Mechanisms on cancer cell migration and invasion have been major topics of cancer research and anti-cancer therapy development. Among the multiple cell signaling pathways involved in cell migration, those elicited by transforming growth factorβ（TGF-β） have attracted tremendous attention. The TGF-βpolypeptide cytokines include four isoforms：TGF-β1, TGF-β2, TGF-β3, and TGF-β4, which are secreted mainly from cells of white blood cell lineage, such as macrophages, T cells and platelets.

关键词： A novel TRPC6-dependent mechanism of TGF NCx Ca HCC induced migration and invasion of human hepatocellular carcinoma cells

Canonical transient receptor potential 4 and its small molecule modulators

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Science China(Life Sciences) 2015年第1期58卷 39-47页

作者： FU Jie GAO ZhaoBing SHEN Bing zhu Michael x. Department of Physiology Anhui Medical University International Scientist Workstation of Neuropharmacology Shanghai Institute of Materia MedicaChinese Academy of Sciences Department of Integrative Biology and Pharmacology the University of Texas Health Science Center at Houston

Canonical transient receptor potential 4(TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca2+ entry into cells following stimulation of G protein coupled receptors and receptor tyrosine ***,the channels are regulated by pertussis toxin-sensitive Gi/o proteins,lipids,and various other signaling ***4-containing channels participate in the regulation of a variety of physiological functions,including excitability of both gastrointestinal smooth muscles and brain *** review is to present recent advances in the understanding of physiology and development of small molecular modulators of TRPC4 channels.

关键词： TRPC4 channel non-selective cation channel G protein coupled receptors small molecular modulators G proteins excitation contraction Ca2+ signaling

Glucose-sensitivity of core-shell microspheres and their crystalline colloidal arrays

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Science China Chemistry 2013年第1期56卷 65-70页

作者： BAZIN Gwénaёlle zhu Julian x. x. Département de Chimie Université de MontréalC.P.6128Succursale Centre-villeMontréalQuébec H3C 3J7Canada

Thermoresponsive core-shell microspheres are prepared and functionalized with 3-aminophenylboronic acid to make them responsive to *** volume phase transition of the resulting particles is shifted to a lower temperature and a clear swelling is caused by the presence of *** particles after the functionalization preserved their capability to form crystalline colloidal *** changes of their properties may be used in the design of glucose sensors.

关键词： core-shellmicrospheres thermo-sensitivity crystalline colloidal arrays glucose sensors

Paleogene-Neogene stratigraphic realm and tectonic-sedimentary evolution of the Qilian Mountains and their surrounding areas

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Science China Earth Sciences 2017年第5期60卷 992-1009页

作者： YANG LiRong LI Jianxing YUE LePing WANG HongLiang GUO HuaiJun zhu xiaoHui zhu Tao DU Kai ZHANG Rui ZHANG Yunxiang GONG HuJun State Key Laboratory of Continental Dynamics Department of Geology Northwest University Ministry of Land and Resources Key Laboratory of Magmatism Mineralization and Prospecting Xi'an Geological Survey CenterChina Geological Survey

The Cenozoic uplift of Qilian Mountains is critical to comprehend the uplift and extension of the Tibet Plateau as well as the formation of the first and second steps in China's topography. This study summarized dynamic stratigraphic realm comprehensively on the basis of stratigraphic correlation of different Cenozoic sedimentary basin regions of the Qilian Mountains and adjacent mountains. This facilitated the re-creation of the tectonic-sedimentary evolutionary process of the Qilian Mountains and their surrounding areas. The results indicate that during the Early Paleogene(Paleocene-Eocene), the Qilian Mountains were part of an uplift realm. During the Oligocene, Guide-xining-Lanzhou-Linxia sag basin at the northern margin of the West Qinling Mountains came into being and was subjected to sedimentation. The Suli Basin located between the North and South Qilian paleo-uplifts began to form and undergo sedimentation. Intracontinental orogenic extrusion and basin detachment occurred at the Qilian Mountains during the Miocene, which caused successive uplifts of various mountains, including the Laji, South Qinghai,Jishi, Liupan, and South Shule Mountains. Until Pliocene, Qilian Mountains uplifted continuously and resulted in the shrink,extinction and being eroded of the basins, and aeolian red clay started to accumulate.

关键词： Paleogene-Neogene Stratigraphic realm Tectonic-sedimentary evolution Qilian Mountain Tibet Plateau

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