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Plant Diversity 2024年第4期46卷 547-550页

作者： Hui zhu Weixiao Lei qing Lai Yongshuai Sun Dafu Ru State Key Laboratory of Grassland Agro-ecosystems College of EcologyLanzhou UniversityLanzhou 730000China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Xi'an Center for Disease Control and Prevention Xi'an 710068China

Genome-scale data,while promising for illuminating phylogenetic relationships,frequently pose a conundrum by yielding conflicting topologies and highly variable gene tree distributions(Pease et al.,2016).This complexity likely arises from the reticulate evolution observed in many taxa,where genetic information exchange occurs through diverse biological processes.

关键词： sorting processes yielding

Real-time arrival picking of rock microfracture signals based on convolutional-recurrent neural network and its engineering application

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 761-777页

作者： Bing-Rui Chen Xu Wang Xinhao zhu qing Wang Houlin Xie State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Accurately picking P-and S-wave arrivals of microseismic(MS)signals in real-time directly influences the early warning of rock mass failure.A common contradiction between accuracy and computation exists in the current arrival picking ***,a real-time arrival picking method of MS signals is constructed based on a convolutional-recurrent neural network(CRNN).This method fully utilizes the advantages of convolutional layers and gated recurrent units(GRU)in extracting short-and long-term features,in order to create a precise and lightweight arrival picking ***,the synthetic signals with field noises are used to evaluate the hyperparameters of the CRNN model and obtain an optimal CRNN *** actual operation on various devices indicates that compared with the U-Net method,the CRNN method achieves faster arrival picking with less performance *** application of large underground caverns in the Yebatan hydropower station(YBT)project shows that compared with the short-term average/long-term average(STA/LTA),Akaike information criterion(AIC)and U-Net methods,the CRNN method has the highest accuracy within four sampling points,which is 87.44%for P-wave and 91.29%for S-wave,*** sum of mean absolute errors(MAESUM)of the CRNN method is 4.22 sampling points,which is lower than that of the other *** the four methods,the MS sources location calculated based on the CRNN method shows the best consistency with the actual failure,which occurs at the junction of the shaft and the second ***,the proposed method can pick up P-and S-arrival accurately and rapidly,providing a reference for rock failure analysis and evaluation in engineering applications.

关键词： Rock mass failure Microseismic event P-wave arrival S-wave arrival Deep learning

Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme

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Nuclear Science and Techniques 2024年第4期35卷 15-28页

作者： Xue-Chao Zhao Rui Yan Gui-feng zhu Ya-fen Liu Jian Guo Xiang-Zhou Cai Yang Zou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A molten salt reactor(MSR)has outstanding features considering the application of thorium fuel,inherent safety,sustainability,and resistance to ***,fissile material^(233)U is significantly rare at the current stage,thus it is difficult for MSR to achieve a pure thorium-uranium fuel ***,using plutonium or enriched uranium as the initial fuel for MSR is more *** this study,we aim to verify the feasibility of a small modular MSR that utilizes plutonium as the starting fuel(SM-MSR-Pu),and highlight its advantages and ***,the structural design and fuel management scheme of the SM-MSR-Pu were ***,the neutronic characteristics,such as the graphite-irradiation lifetime,burn-up performance,and coefficient of temperature reactivity were calculated to analyze the physical characteristics of the *** results indicate that plutonium is a feasible and advantageous starting fuel for a SM-MSR;however,there are certain shortcomings that need to be *** a 250 MWth SM-MSR-Pu,approximately 288.64 kg^(233)U of plutonium with a purity of greater than 90% is produced while 978.00 kg is burned every ten *** temperature reactivity coefficient decreases from -4.0 to -6.5 pcm K^(-1) over the 50-year operating time,which ensures a long-term safe ***,the amount of plutonium and accumulation of minor actinides(MAs)would increase as the burn-up time increases,and the annual production and purity of^(233)U will *** achieve an optimal burn-up performance,setting the entire operation time to 30 years is ***,more than 3600 kg of plutonium eventually accumulate in the *** research is required to effectively utilize this accumulated plutonium.

关键词： Molten salt fuel Plutonium utilization ^(233)U TRUs mole fraction Temperature feedback coefficient

In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin,an impurity in levofloxacin

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In silico and in vitro genotoxicity evaluation of descarboxy...

In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin,an impurity in levofloxacin

作者： zhu qing-fen WEI Xia QU Jian-song LI Jun WANG Wei-jian Shandong Institute for Food and Drug Control

OBJECTIVE To evaluate the genotoxicity of Descarboxyl Levofloxacin by In silico and In vitro methods. METHODS Assessment of genotoxicity using Derek for Windows We used DEREK for Windows(DfW,Lhasa Ltd.,Leeds,UK) version 11.0 for toxicity *** structures are entered into the program in *** format. The program applies structure-activity relationships〔(Q)SARs〕and other expert knowledge rules to derive a reasoned prediction about the potential toxicity of the query *** reverse mutation assay(Ames test) The Salmonella histidine point mutation assay proposed by Maron and Ameswas *** *** histidine autotrophic strains(TA97,TA98,TA100 and TA102) used in this test were obtained from Shandong center for disease control. Normal saline(NS) was used as a vehicle control.2-Aminofluorene(2-AF,10μg/plate),1,8-dihydroxyanthraquinone (50 ug/plate),Sodium azide(NaN_3,1.5μg/plate),and Dexon(50μg/plate) were used as positive *** levofloxacin was assayed at concentrations of 31.25,62.5,125,250,and 500μg/***,0.1 ml of test substance(or control solution),0.1 ml of bacterial culture〔(1 -2)×10~(12) L~(-1)〕and 0.5 ml of S9 mix(NS for treatment without activation) were mixed and poured onto the agar plates after addition of 1.8 ml of top agar(0.6%agar Difco, 0.5%NaCI,50μmol·L~(-1) L-histidine,50μmol·L~(-1) biotin,45℃) at 45℃.Plates were inverted and incubated for 48h at 37℃in the *** colonies were counted and the background lawn was inspected for signs of toxicity or compound *** assay was performed two times in triple and included negative and positive *** aberrations in Chinese hamster lung cells Chinese Hamster Lung(CHL) cells were obtained from Shandong center for disease *** cells were grown in DMEM medium supplemented with 10%heat-inactivated calf serum at 37℃in an atmosphere containing 5%of CO_*** test for Chromosomal aberrations in CHL cells was conducte

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In silico and in vitro genotoxicity evaluation of descarboxy...

Seasonal response of nitrogen exchange fluxes to crab disturbance at sediment-water interface in coastal tidal wetlands

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： zhu qing-fen WEI Xia QU Jian-song LI Jun WANG Wei-jian Shandong Institute for Food and Drug Control

OBJECTIVE To evaluate the genotoxicity of Descarboxyl Levofloxacin by In silico and In vitro methods. METHODS Assessment of genotoxicity using Derek for Windows We used DEREK for Windows(DfW,Lhasa Ltd.,Leeds,UK) version 11.0 for toxicity *** structures are entered into the program in *** format. The program applies structure-activity relationships[(Q)SARs]and other expert knowledge rules to derive a reasoned prediction about the potential toxicity of the query *** reverse mutation assay(Ames test) The Salmonella histidine point mutation assay proposed by Maron and Ameswas *** *** histidine autotrophic strains(TA97,TA98,TA100 and TA102) used in this test were obtained from Shandong center for disease control. Normal saline(NS) was used as a vehicle control.2-Aminofluorene(2-AF,10μg/plate),1,8-dihydroxyanthraquinone (50μg/plate),Sodium azide(NaN,1.5μg/plate),and Dexon(50μg/plate) were used as positive *** levofloxacin was assayed at concentrations of 31.25,62.5,125,250,and 500 ug/***,0.1 ml of test substance(or control solution),0.1 ml of bacterial culture[(1 -2)×10L]and 0.5 ml of S9 mix(NS for treatment without activation) were mixed and poured onto the agar plates after addition of 1.8 ml of top agar(0.6%agar Difco, 0.5%NaCI,50μmol·L L-histidine,50μmol·L biotin,45℃at 45℃.Plates were inverted and incubated for 48h at 37℃in the *** colonies were counted and the background lawn was inspected for signs of toxicity or compound *** assay was performed two times in triple and included negative and positive *** aberrations in Chinese hamster lung cells Chinese Hamster Lung(CHL) cells were obtained from Shandong center for disease *** cells were grown in DMEM medium supplemented with 10%heat-inactivated calf serum at 37℃in an atmosphere containing 5%of *** test for Chromosomal aberrations in CHL cells was conducted according to published pr

关键词： genotoxicity impurity descarboxyl levofloxacin SARs CHL chromosomal aberration

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Water Science and Engineering 2024年第2期17卷 129-138页

作者： Guo-fen Hua Shang-qing Liu Xiang-dong Liu Jin-li Li Yue Fang Wen-ting Xie Xiang Xu College of Water Conservancy and Hydroelectric Power Hohai UniversityNanjing 210098China College of Renewable Energy Hohai UniversityNanjing 210098China

Coastal wetlands are hotspots for nitrogen(N)cycling,and crab burrowing is known to transform N in intertidal marsh ***,the underlying mechanisms remain *** study conducted field experiments and used indoor control test devices to investigate the seasonal response of nitrogen to crab disturbance at the sediment-water interface in coastal tidal flat *** results showed that crab disturbance exhibited significant seasonality with large seasonal differences in cave density and *** to crab disturbance,nitrogen fuxes at the sediment-water interface were much greater in the box with crabs than in the box without *** summer,NH-N showed a positive flux from the sediment to the overlying water,but NO2-N and NOg-N showed positive fluxes from the sediment to the overlying water only in early *** winter,NH-N showed a positive flux from the sediment to the overlying water,but NO-N and NO,-N both exhibited positive and negative *** results indicated that the presence of crab burrows can cause the aerobic layer to move downward by approximately 8-15 cm in summer and directly promote nitrification at the sediment surface.

关键词： Coastal tidal flat wetland Crab disturbance Nitrogen flux Nitrification Denitrification Sediment-water interface

猪十二指肠类肝素对动脉平滑肌细胞增殖的影响

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药学学报 2000年第11期35卷 814-817页

作者：祝清芬丁华周序斌山东医科大学基础医学院药理学教研室山东济南250012 山东省药品检验所药理科济南250012

目的　研究类肝素对平滑肌细胞增殖的影响及其机制。方法　分别以结晶紫和MTT染色、透射电镜及流式细胞仪等方法 ,观察类肝素对平滑肌细胞增殖 ,细胞形态 ,细胞内α 肌动蛋白含量及原癌基因c myc,c fos表达的影响。结果　类肝素 0 2 ,0... 详细信息

目的　研究类肝素对平滑肌细胞增殖的影响及其机制。方法　分别以结晶紫和MTT染色、透射电镜及流式细胞仪等方法 ,观察类肝素对平滑肌细胞增殖 ,细胞形态 ,细胞内α 肌动蛋白含量及原癌基因c myc,c fos表达的影响。结果　类肝素 0 2 ,0 4及 0 8mg·mL-1可以抑制 10 %小牛血清所致平滑肌细胞增殖 ,类肝素 0 8mg·mL-1可以使细胞维持类似收缩型的形态学表现 ,使细胞内α actin含量增加 ,c myc,c fos原癌基因表达减少。结论　类肝素可以抑制平滑肌细胞增殖 ,其机制可能与抑制细胞表型转化。

关键词：动脉粥样硬化血管平滑肌细胞类肝素结晶紫

Testing the first law of black hole mechanics with gravitational waves

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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 80-86页

作者： Chao-Wan-Zhen Wang Jin-Bao zhu Guo-qing Huang Fu-Wen Shu Department of Physics Nanchang University Center for Relativistic Astrophysics and High Energy Physics Nanchang University GCAP-CASPER Physics DepartmentBaylor University

The successful observation of gravitational waves has provided humanity with an additional method to explore the universe, particularly black holes. In this study, we utilize data from LIGO and Virgo gravitational wave observations to test the first law of black hole mechanics, employing two different approaches. We consider the secondary compact object as a perturbation to the primary black hole before the merger, and the remnant black hole as a stationary black hole after the merger. In the pre-merger and post-merger analysis, our results demonstrate consistency with the first law, with an error level of approximate 25% at a68% credibility level for GW190403 051519. In the full inspiral-merger-ringdown analysis, our results show consistency with the first law of black hole mechanics, with an error level of about 6% at a 68% credibility level and 10% at a 95% credibility level for GW191219 163120. Additionally, we observe that the higher the mass ratio of the gravitational wave source, the more consistent our results are with the first law of black hole mechanics. Overall, our study sheds light on the nature of compact binary coalescence and their implications for black hole mechanics.

关键词： gravitational waves black hole mechanics data analysis ringdown

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Effect of biochar application on rice,wheat,and corn seedlings in hydroponic culture

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Journal of Environmental Sciences 2024年第1期135卷 379-390页

作者： Yingjie Yin Jikai Li Sihang zhu qing Chen Chong Chen Yukui Rui Jianying Shang College of Land Science and Technology China Agricultural UniversityKey Laboratory of Plant-Soil InteractionsMinistry of Educationand Key Laboratory of Arable Land Conservation in North ChinaMinistry of Agriculture and Rural AffairsBeijing 100193China Agricultural Management Institute Ministry of Agriculture and Rural AffairsBeijing 102208China College of Resources and Environmental Sciences China Agricultural UniversityBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationBeijing 100193China

In recent years,biochar has attracted considerable attention for soil quality improvement and carbon sequestration due to its unique physicochemical ***,the mechanism by which biochar application negatively affects the growth of crop seedlings has not been fully *** this study,a hydroponic experiment was conducted to evaluate the response of rice,wheat,and corn seedlings to biochar application(CK,0 g/L;BC1,0.5 g/L;and BC2,1.0 g/L).Compared with the CK treatment,the BC1 and BC2 treatments decreased the fresh shoot and root weights of rice and corn seedlings(P0.05).For the contents of nutrient elements in seedlings,both BC1 and BC2 treatments hindered the roots from absorbing Fe and Cu and increased the uptake of Ca and *** with the CK treatment,the translocation factor(TF)values of Ca,Mn,and Zn were significantly decreased especially in rice seedlings(35.3%-36.8%,68.7%-76.5%,and 29.8%-22.0%,respectively)under the BC1 and BC2 treatments,while only Mn was significantly decreased in wheat and corn seedlings(P<0.05).Transmission electron microscope(TEM)analysis of root cross-sections showed that nano-sized biochar particles(10~23 nm)were found in the root cells under BC2 treatment *** findings reveal that a large amount of biochar application can reduce nutrient absorption and translocation,and hinder rice,wheat,and corn seedlings,particularly rice seedling,in hydroponic system.

关键词： Biochar Toxicity Seedling growth Hydroponic cultivation

Improved observation of colonized roots reveals the regulation of arbuscule development and senescence by drought stress in the arbuscular mycorrhizae of citrus

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Horticultural Plant Journal 2024年第2期10卷 425-436页

作者： Xilong Yin Wei Zhang Zengwei feng Guangda feng Honghui zhu qing Yao College of Horticulture South China Agricultural UniversityKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China)Ministry of Agriculture and Rural AffairsGuangdong Province Key Laboratory of Microbial Signals and Disease ControlGuangzhouGuangdong 510642China Key Laboratory of Agricultural Microbiomics and Precision Application Ministry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationKey Laboratory of Agricultural MicrobiomicsState Key Laboratory of Applied Microbiology Southern ChinaGuangdong Microbial Culture Collection Center(GDMCC)Institute of MicrobiologyGuangdong Academy of SciencesGuangzhouGuangdong 510070China

Citrus is the typical mycorrhizal fruit tree species establishing symbiosis with arbuscular mycorrhizal (AM) fungi. However, arbuscule development and senescence in colonized citrus roots, especially in response to drought stress, remain unclear, which is mainly due to the difficulty in clearing and staining lignified roots with the conventional method. Here, we improved the observation of colonized roots of citrus plants with the sectioning method, which enabled the clear observation of AM fungal structures. Furthermore, we investigated the effects of one week of drought stress on arbuscule development and senescence with the sectioning method. Microscopy observations indicated that drought stress significantly decreased mycorrhizal colonization (F%and M%) although it did not affect plant growth performance. Fluorescence probes (WGA 488 and/or Nile red) revealed that drought stress inhibited arbuscule development by increasing the percentage of arbuscules at the early stage and decreasing the percentages of arbuscules at the midterm and mature stages. Meanwhile, drought stress accelerated arbuscule senescence, which was characterized by the increased accumulation of neutral lipids. Overall, the sectioning method developed in this study enables the in-depth investigation of arbuscule status, and drought stress can inhibit arbuscule development but accelerate arbuscule senescence in the colonized roots of citrus plants. This study paves the way to elaborately dissecting the arbuscule dynamics in the roots of fruit tree species in response to diverse abiotic stresses.

关键词： Arbuscular mycorrhizae Citrus Drought stress Arbuscule development Arbuscule senescence Fruit tree species