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基于ASP的工作流管理系统研究与实现

计算机应用研究 2006年第3期23卷 193-195页

作者：邵红伟张国军朱海平华中科技大学教育部智能制造技术重点实验室湖北武汉430074

分析了基于应用服务供应商(ASP)模式的工作流管理系统(W fMS)的现实意义及特点,在此基础上研究了其若干关键技术。在系统架构方面,给出了一个MVC模式的基于ASP的工作流管理系统参考模型及实现方法。讨论了基于EJB的W fMS应用服务器设计... 详细信息

分析了基于应用服务供应商(ASP)模式的工作流管理系统(W fMS)的现实意义及特点,在此基础上研究了其若干关键技术。在系统架构方面,给出了一个MVC模式的基于ASP的工作流管理系统参考模型及实现方法。讨论了基于EJB的W fMS应用服务器设计以及基于角色的访问控制技术。最后给出了应用实例。

关键词：应用服务供应商工作流管理系统基于角色的访问控制

EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment

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Nano Research 2024年第2期17卷 848-857页

作者： Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan zhu Xinyuan zhu Chuan Zhang School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Molecular MedicineSixth people’s HospitalSchool of MedicineShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200233China Institute of Molecular Medicine Shanghai Jiao Tong University Affiliated Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or *** chemo and gene therapy that integrates different therapeutic targets,may increase the chemosensitivity of pancreatic cancer and synergistically enhance the antitumor ***,conventional co-delivery of gene and chemo drugs is intensively dependent on complex nanoparticle delivery systems,thus would be limited by unstable drug packaging,nonspecific biodistribution,and biosafety ***,we rationally designed an epidermal growth factor-receptor(EGFR)-targeted and gemcitabine-incorporated oligonucleotide(termed as chemogene)with anti-Bcl-2 sequence,which achieves simple and precise integration of gemcitabine into a gene regulative agent,as well as the EGFR-targeted delivery for pancreatic cancer *** solid-phase synthesis,gemcitabine,as the first-line chemodrug for pancreatic cancer,is introduced to the antisense oligonucleotide to replace all cytosine nucleosides to obtain the gemcitabine-integrated chemogene(Ge-ASO^(Bcl-2)).Thereafter,Ge-ASO^(Bcl-2)is covalently coupled with EGFR nanobody to construct the final targeted chemogene without any exogenous ***,this nanobody-conjugated chemogene exhibits remarkable tumor targeting capability and antitumor effects both in vitro and in vivo,which initiates a first step toward the application of combinatorial chemo and gene therapy for future pancreatic cancer treatment.

关键词： antisense oligonucleotide chemogene nanobody drug delivery system pancreatic cancer

Theoretical Modeling and Surface Roughness Prediction of Microtextured Surfaces in Ultrasonic Vibration-Assisted Milling

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 163-183页

作者： Chenbing Ni Junjie zhu Youqiang Wang Dejian Liu Xuezhao Wang Lida zhu School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266525China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China

Textured surfaces with certain micro/nano structures have been proven to possess some advanced functions,such as reducing friction,improving wear and increasing *** prediction of micro/nano surface textures is of great significance for the design,fabrication and application of functional textured *** this paper,based on the kinematic analysis of cutter teeth,the discretization of ultrasonic machining process,transformation method of coordinate systems and the cubic spline data interpolation,an integrated theoretical model was established to characterize the distribution and geometric features of micro textures on the surfaces machined by different types of ultrasonic vibration-assisted milling(UVAM).Based on the theoretical model,the effect of key process parameters(vibration directions,vibration dimensions,cutting parameters and vibration parameters)on tool trajectories and microtextured surface morphology in UVAM is ***,the effect of phase difference on the elliptical shape in 2D/3D ultrasonic elliptical vibration-assisted milling(UEVAM)was *** to conventional numerical models,the method of the cubic spline data interpolation is applied to the simulation of microtextured surface morphology in UVAM,which is more suitable for characterizing the morphological features of microtextured surfaces than traditional methods due to the presence of numerous micro *** prediction of surface roughness indicates that the magnitude of ultrasonic amplitude in z-direction should be strictly limited in 1D rotary UVAM,2D and 3D UEVAM due to the unfavorable effect of axial ultrasonic vibration on the surface *** study can provide theoretical guidance for the design and fabrication of microtextured surfaces in UVAM.

关键词： Theoretical modeling Microtextured surface Ultrasonic vibration-assisted milling Cubic spline interpolation Surface roughness

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应该重视社会科学成果的转化和应用

东方论坛（青岛大学学报） 2015年第4期 109-117页

作者：朱妙宽朱海平中共江苏省兴化市委党校江苏兴化225700

社会科学成果只有得到转化应用,才能充分发挥其重要作用。在社会科学成果转化工作中,目前我国主要存在着转化率低,转化不及时、不充分、不到位等问题。无论是与自然科学相比,还是与发达国家社会科学相比,我国社会科学成果转化率都是很... 详细信息

社会科学成果只有得到转化应用,才能充分发挥其重要作用。在社会科学成果转化工作中,目前我国主要存在着转化率低,转化不及时、不充分、不到位等问题。无论是与自然科学相比,还是与发达国家社会科学相比,我国社会科学成果转化率都是很低的。这里有多方面原因。为了促进社会科学成果的转化,充分发挥社会科学成果的作用,特提出如下对策建议:必须高度重视社会科学研究成果的转化工作,必须明确社会科学研究的主攻方向,必须加强社会科学应用研究,必须提高哲学社会科学研究成果的质量,必须建立健全哲学社会科学成果的评价机制,必须建立健全哲学社会科学成果的转化机制。

关键词：哲学社会科学成果转化应用重要性存在问题原因对策建议

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从完善分配制度入手完善基本经济制度

海派经济学 2008年第4期6卷 151-163页

作者：朱妙宽朱海平江苏省兴化市委党校中共兴化市委党校

中共十七大报告指出,要坚持和完善公有制经济为主体、多种所有制经济共同发展的基本经济制度,毫不动摇地巩固和发展公有制经济,毫不动摇地鼓励、支持、引导非公有制经济发展;要深化收入分配制度改革,逐步扭转收入分配差距扩大趋势。目... 详细信息

中共十七大报告指出,要坚持和完善公有制经济为主体、多种所有制经济共同发展的基本经济制度,毫不动摇地巩固和发展公有制经济,毫不动摇地鼓励、支持、引导非公有制经济发展;要深化收入分配制度改革,逐步扭转收入分配差距扩大趋势。目前我国国有企业等公有制经济和私营企业等非公有制经济的分配制度都很不完善,导致不同群体之间收入差距持续扩大,既不利于公有制经济的巩固和发展,也不利于非公有制经济的健康发展。为了贯彻落实中共十七大精神,我们必须面对现实,正视问题,下定决心,从多方面采取措施,从完善分配制度入手完善基本经济制度,促进科学发展和社会和谐。

关键词：分配制度基本经济制度科学发展社会和谐

Efficient C-N coupling in electrocatalytic urea generation on copper carbonate hydroxide electrocatalysts

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Journal of Energy Chemistry 2024年第6期93卷 289-298,I0008页

作者： Yinuo Wang Yian Wang Qinglan Zhao Hongming Xu Shangqian zhu Fei Yang Ernest P.Delmo Xiaoyi Qiu Chi Song Juhee Jang Tiehuai Li ping Gao MDanny Gu Minhua Shao Advanced Materials Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400GuangdongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Materials Science and Engineering Southern University of Science and Technology of Chin11088 Xueyuan BoulevardShenzhen 518055GuangdongChina Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Chemistry City University of Hong KongTat Chee AvenueKowloonHong KongChina

Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of ***,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen *** thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~**** work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.

关键词： Copper carbonate hydroxide Co-reduction Urea generation C-N coupling DFT calculation

Preparation and Characterization of Cyano-Silicon-Containing Arylacetylene Resins and Their Composites:Dual Enhancement Strategy Involving Physical Interfacial Interactions and Chemical Crosslinking

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Chinese Journal of Polymer Science 2024年第11期 1719-1729页

作者： Chao-En Jin Hua-Mei zhu Lei Wang Fan Wang Ya-ping zhu Shi-Feng Deng Hui-Min Qi Lei Du Key Laboratory of Specially Functional Polymeric Materials and Related Technology of Ministry of Education School of Materials Science and Engineering East China University of Science & Technology

Silicon-containing arylacetylene (PSA) resins have broad application prospects because of their excellent heat ***,improving their mechanical properties and interfacial bonding with reinforcement fibers while maintaining heat resistance is a challenge in engineering ***,poly(diethynylbenzene-methylsilyl-3-benzonitrile)(DEB-CN) and poly(diethynylbenzene-methylsilyl-3,6-diethynylcarbazole-3-benzonitrile)(DEC-CN) were synthesized via an isopropylmagnesium chloride lithium-chloride complex (i-PrMgCl·LiCl),overcoming the compatibility problem between cyano groups and Grignard *** cyano and alkyne groups in the resin underwent cyclization to form pyridine,catalyzed by the-NH-moiety in DEC-CN,resulting in extremely high thermal stability (5%weight loss temperature:669.3°C,glass transition temperature>650°C).The combination of cyano dipole-dipole pairing and hydrogen bonding greatly enhanced the resin-fiber interface properties,while the generated pyridine promoted stress relief in the crosslinked network,substantially improving the mechanical properties of the cyano-silicon-containing arylacetylene resin *** flexural strength of quartz fiber cloth/DEC-CN composites was 298.2 MPa at room temperature and 145.9 MPa at 500°C,corresponding to 84.0%and 127.6%enhancements,respectively,over the cyano-free *** cyano-silicon-containing arylacetylene resins exhibited a dual reinforcement mechanism involving physical interfacial interactions and chemical crosslinking,achieving a good balance between thermal stability and mechanical properties.

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从国有经济入手加快调整国民收入分配结构

海派经济学 2010年第3期8卷 64-72页

作者：朱妙宽朱海平江苏省兴化市委党校江苏省社会科学院泰州分院海派经济学南京研究所江苏省兴化市委党校图书馆

目前我国国民收入分配结构,包括国有经济内部收入分配结构已很不公平、很不合理,已经到了必须下大力气解决的时候。鉴于目前社会分配不公、收入差距过大的状况,要转变经济发展方式,调整经济结构,首先要加快调整国民收入分配结构,其中又... 详细信息

目前我国国民收入分配结构,包括国有经济内部收入分配结构已很不公平、很不合理,已经到了必须下大力气解决的时候。鉴于目前社会分配不公、收入差距过大的状况,要转变经济发展方式,调整经济结构,首先要加快调整国民收入分配结构,其中又首先要加快调整国有经济收入分配结构。在这一方面,要学习和借鉴许多国家的成功经验,结合我国的现实情况,采取果断有力措施,深化分配制度改革,真正实行按劳分配,坚决消灭剥削,消除两极分化,逐步实现共同富裕。

关键词：国有经济收入分配存在问题政策建议按劳分配

A coupled thermo-mechanical peridynamic model for fracture behavior of granite subjected to heating and water-cooling processes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2006-2018页

作者： Luming Zhou Zhende zhu Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China Jiangsu Research Center for Geotechnical Engineering Technology Hohai UniversityNanjing210098China

Thermal damage and thermal fracture of rocks are two important indicators in geothermal mining *** paper investigates the effects of heating and water-cooling on granite specimens at various *** laboratory uniaxial compression experiments were also ***,a coupled thermo-mechanical ordinary state-based peridynamic(OSB-PD)model and corresponding numerical scheme were developed to simulate the damage of rocks after the heating and cooling processes,and the change of crack evolution process was *** results demonstrate that elevated heating temperatures exacerbate the thermal damage to the specimens,resulting in a decrease in peak strength and an increase in ductility of *** escalating occurrence of thermal-induced cracks significantly affects the crack evolution process during the loading *** numerical results accurately reproduce the damage and fracture characteristics of the granite under different final heating temperatures(FHTs),which are consistent with the test results in terms of strength,crack evolution process,and failure mode.

关键词： Peridynamics(PD) Granite Heating and cooling Damage and fracture Uniaxial compression