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Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice

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Chinese Journal of Natural Medicines 2020年第3期18卷 169-177页

作者： YI Hong-Wei zhu xiao-xiao HUANG xiao-Li LAI Yu-zhu TANG Yue Department of Pharmacology School of MedicineSoutheast UniversityNanjing 210009China

The objective of this study was to verify the protective effect of Bifidobacterium longum(BL) and the synergistical effect of Selenium and BL on alcohol plus high fat diet(HFD) induced hepatic injury in mice. We also want to explore the mechanism of Selenium-enriched Bifidobacterium longum(Se BL). C57 BL/6 mice were treated with alcohol plus HFD with or without different dosage of BL or Se BL for 4 weeks. Serum levels of ALT, AST, TC, TG, LDL-C, HDL-C, FFAs, TNF-α, IL-6 and IL-1β, hepatic MDA level, SOD activity, the m RNA levels of AMPK, PPAR-α and SREBP1 were invested. Se BL inhibited lipid accumulation in hepatocytes;reduced serum AST and ALT levels;improved dyslipidemia;decreased serum FFAs, TC, TG and LDL-C levels. Se BL also inhibited alcohol plus HFD-induced hepatocyte oxidative stress through decrease in hepatic MDA levels and increase in SOD activity. Se BL also regulated lipid metabolism related genes such as AMPK, PPAR-α and SREBP1. Although BL had similar effect as Se BL, Se BL is more effective than BL. Se BL protected mice from alcohol plus HFD-induced hepatic injury in mice because of its inhibitory effect on hepatocellular oxidative stress, lipogenesis and inflammation. Selenium enhanced the protective effect of BL.

关键词： Selenium-enriched Bifidobacterium longum Alcoholic liver disease Non-alcoholic fatty liver disease Oxidative stress Inflammation

Macular Perfusion Changes and Ganglion Cell Complex Loss in Patients with Silicone Oil-related Visual Loss

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Biomedical and Environmental Sciences 2020年第3期33卷 151-157页

作者： MA Ya zhu xiao Qing PENG xiao Yan Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective The aim of this study was to investigate macular perfusion changes and ganglion cell complex(GCC)loss in patients with unexplained visual loss following vitrectomy and silicone oil(SO)tamponade,and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT).Methods This retrospective study included seven eyes(seven patients)with unexpected visual loss after vitrectomy and SO *** was used to evaluate the alterations in retinal vessel density(VD)in the superficial capillary plexus(SCP),deep capillary plexus(DCP),and radial peripapillary capillary plexus(RPCP).OCT was used to measure the thickness of GCC and retinal nerve fiber layer(RNFL).Medical records of patients were *** Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls(all sections P<0.05).No difference was found in GCC thickness,but FLV(focal loss volume)and GLV(global loss volume)were significantly higher in the affected eyes(both P<0.001).SCP VD was inversely correlated with FLV and *** Silicone oil-related severe visual loss was associated with superficial retinal microvasculature damage and ganglion cell apoptosis.

关键词： Silicone oil Visual loss Optical coherence tomography angiography Ganglion cell complex

Effect of baffles on bubble behavior in a bubbling fluidized bed for chemical looping processes

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Particuology 2020年第6期18卷 154-167页

作者： xiao zhu Xuan Feng Yuanyuan Zou Laihong Shen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education Southeast UniversityNanjing 210096China

A bubbling fluidized bed is generally used as the fuel reactor in chemical looping ***,in sufficient gas-solid contact remains a steadfast *** such,we propose the use of in ternal baffles to split bubbles at a high gas velocity and to restrict the movement of large-scale solids in the fluidized *** investigated the effect of baffle arrangement on the bubble size and energy,pressure gradient,particle distribution,and particle velocity in a fluidized bed using a computational particle fluid dynamics simulation based on our experimental *** discuss the main influenci ng factors,which in elude presence of caps,number of baffles,and the baffle opening *** baffle structure with caps efficiently broke the large bubbles without creating jet *** baffles were deemed suitable in the bed owing to the small bubble size and uniform gas-solid distribution in each *** selected a baffle opening ratio of 20.5%,which improved the flow pattern without causing a significant increase in the pressure gradient and particle velocity through the *** also discussed the potential for sea ling up this baffled fluidized bed for industrial applications.

关键词： Baffle Bubble behavior Fluidized bed Chemical looping CPFD simulations

Fluidization of micro-interconnected fluidized beds for chemical looping

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Particuology 2021年第1期19卷 136-145页

作者： Tianxu Shen xiao zhu Tao Song Laihong Shen Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control School of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210042China

The micro-interconnected fluidized bed(MIFB)was designed to improve the evaluation condition of oxygen carrier,which is difficult to perform in a lab-scale interconnected fluidized bed because of the large demand for bed *** reduction of bed inventory in the MIFB was mainly achieved by the appropriate miniaturization of the reactor size,in which the wall effect and operating flexibility should be taken into *** hematite serving as the oxygen carrier,stable and flexible fluidization could be realized with 342.9 g of bed *** perforated plates were arranged in the middle of the reactor to improve gas-solid distribution,which also could restrain the slugging formation and increase the particle residence time by 28.9%.A different fluidization phenomenon was observed in this two-stage reactor in which the particle fluidization was reconstructed in the upper *** 48 h of cold operation,the hematite oxygen carrier attrition rate was evaluated as 0.151 wt.%/h corresponding to 660 h lifetime,where 12.5%of particle attrition was contributed by internal perforated *** excellent fitting performance was found between the pressure difference in the risers and the upward particle flow,but the correction factor should be adjusted according to the fluidization flow.

关键词： Micro chemical-looping reactor Bed inventory Internal perforated plate Hydrodynamics

Experimental research on the contact force of the bi-directional pig in oil and gas pipeline

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Petroleum Science 2023年第1期20卷 474-481页

作者： xiao-xiao zhu Chun-Ming Fu Yu-Tao Wang Shi-Ming Zhang College of Mechanical and Transportation Engineering China University of Petroleum-BeijingChangpingBeijing102249China

The migration process of the pig in oil and gas pipeline is a complex dynamic *** the pigging operation,the variation of friction force caused by the nonlinear contact between the sealing disc and the pipe wall is the key factor affecting the dynamic characteristics of the pig *** present,the existed pigging models for predicting pigging behavior regard friction as an invariant *** research indicates that the friction force of the pig varies with the contact force and the lubrication ***,the assumption that the friction force is constant cannot reflect the friction dynamic characteristics of the pig during pigging,and will also affect the accuracy of the pigging *** the variation of friction force of pig under different conditions is the basis of establishing the transient dynamic model of a *** a result,in this paper,a method of direct measurement of contact force between the pig and the pipeline is presented,the contact force,the friction force,as well as the friction coefficient of the pig are obtained from the *** results in this paper can help to establish a more accurate dynamic model of pig.

关键词： Pipeline pig Sealing disc Contact force Friction coefficient Experimental rig

Pressure observer based adaptive robust trajectory tracking control of a parallel manipulator driven by pneumatic muscles

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1928-1937页

作者： zhu xiao-cong TAO Guo-liang CAO Jian The State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

This paper presents a pressure observer based adaptive robust controller (POARC) for posture trajectory tracking of a parallel manipulator driven by three pneumatic muscles without pressure sensors. Due to model errors of the static forces and friction forces of pneumatic muscles, simplified average flow rate characteristics of valves, unknown disturbances of entire system, and unmeasured pressures, there exist rather severe parametric uncertainties, nonlinear uncertainties and dynamic uncertainties in modeling of the parallel manipulator. A nonlinear pressure observer is constructed to estimate unknown pressures on the basis of a single-input-single-output (SISO) decoupling model that is simplified from the actual multiple-input-multiple-output (MIMO) coupling model of the parallel manipulator. Then, an adaptive robust controller integrated with the pressure observer is developed to accomplish high precision posture trajectory tracking of the parallel manipulator. The experimental results indicate that the system with the proposed POARC not only achieves good control accuracy and smooth movement but also maintains robustness to disturbances.

关键词： Pneumatic muscle Parallel manipulator Pressure observer Adaptive robust control Trajectory tracking

Single link tracking scheme based on UWB localization

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Journal of Systems Engineering and Electronics 2009年第6期20卷 1207-1212页

作者： xiao zhu Xiong Hailiang Yu Quan Yi Kechu State Key Lab. of Integrated Service Networks Xidian Univ. Xi'an 710071 P. R. China School of Electronic Science and Engineering National Univ. of Defense Technology Changsha 410073 P. R. China Inst. of China Electronics Equipment System Engineering Corporation Beijing 100039 P. R. China

To investigate the low-complex and high-precise tracking method, a novel single link tracking scheme based on UWB localization is proposed. Two antenna arrays are settled at the fixed station （FS） to receive the UWB signal from mobile terminal （MT）, one FS is enough for the proposed scheme to track the MT. The UWB multipath detection algorithm for time difference of arrival （TDOA） estimation is presented and TDOA is thus adopted to estimate angle of arrival （AOA）, avoiding the synchronization and complicated beamforming for AOA. The impacts of localization errors, concluding multipath and non-line-of-sight （NLOS） errors are simulated for the proposed track scheme. It is demonstrated that the simulation curve can match the real target moving, and the feasibility of the proposed scheme is proved.

关键词： ultra-wide band localization single-link tracking angle of arrival estimation.

Sign-invariant and Explicit Solutions of Nonlinear Reaction-Diffusion Systems

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Communications in Theoretical Physics 2008年第6期49卷 1361-1364页

作者： zhu xiao-Ning ZHANG Shun-Li Center for Nonlinear Studies Department of Mathematics Northwest University Xi＇an 710069 China Center of Nonlinear Science Ningbo University Ningbo 315211 China

Using the sign-invariant theory, we study the nonlinear reaction-diffusion systems. We also obtain some new explicit solutions to the nonlinear resulting systems.

关键词： sign-invariant theory nonlinear reaction-diffusion system explicit solutions

Autumn intensification of the Ryukyu Current during 2003-2007

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Science China Earth Sciences 2010年第4期53卷 603-609页

作者： zhu xiao-Hua HUANG DaJi GUO XinYu State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China Center for Marine Environmental Study Ehime University2-5 Bunkyo-choMatsuyama 790-8577Japan

Inverse calculations using data from 16 repeat hydrographic transects collected from April 2003 to June 2007 have yielded velocity structures and volume transports(VTs) of the Ryukyu Current in the region east of the northern Ryukyu *** inverse calculation results show that the Ryukyu Current is dominated by a subsurface velocity core with maximum velocities from 15.1 to 80.0 cm/s,whose positions vary between 110 and 600 dbar and 27.2°-28.2°N along the *** mean velocity exhibits a subsurface velocity core with a maximum value of 24.6 cm/s at 326 dbar depth,a VT of 14.0 Sv(1 Sv≡106 m3/s),a vertical dimension of 800 m,and a horizontal dimension of 60 *** seasonal mean velocities show that the Ryukyu Current is stronger in autumn than in other *** is suggested that this seasonal variation is coincident with the intensification of the anticyclonic eddy south of Shikoku,Japan.

关键词： Ryukyu Current inverse technique subsurface maximum velocity core volume transports seasonal variation