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Quality of life and survival analyses of breast cancer cases treated with integrated traditional Chinese and Western medicine

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World Journal of Clinical Cases 2024年第20期12卷 4074-4081页

作者： Yu-Kun Wang Rong-wei zhu Zhi-Peng Gao Yi Tao Thyroid and Breast Surgery Department the First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530000Guangxi Zhuang Autonomous RegionChina Clinical Integration of Traditional Chinese and Western Medicine Guangxi University of Chinese MedicineNanning 530000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Breast cancer(BC)is the second leading cause of tumor-related mortality after lung *** resistance remains a major challenge to progress in BC treatment,warranting further exploration of feasible and effective alternative *** To analyzed the quality of life(QoL)and survival of patients with BC treated with integrated traditional Chinese and Western medicine(TCM-WM).METHODS This study included 226 patients with BC admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine between February 2018 and February 2023,including 100 who received conventional Western medicine treatment(control group)and 126 who received TCM-WM treatment(research group).The total effective rate,side effects(alopecia,nausea and vomiting,hepatorenal toxicity,and myelosuppression),QoL assessed using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire(EORTC QLQ-C30),1-year overall survival(OS),recurrence and metastasis rates,and serum inflammatory factors[interleukin(IL)-6,IL-10,and tumor necrosis factor alpha]were comparatively *** The research group showed statistically better overall efficacy,EORTC QoL-C30 scores,and 1-year OS than the control group,with markedly lower side effects and 1-year recurrence and metastasis ***,the posttreatment levels of serum inflammatory in the research group were significantly lower than the baseline and those in the control *** Overall,TCM-WM demonstrated significantly improved therapeutic efficacy while ensuring drug safety in BC,which not only improved patients’QoL and prolonged survival,but also significantly inhibited the inflammatory response.

关键词： Integrated traditional Chinese and Western medicine Breast cancer Quality of life Survival Chemotherapy regimen

Study on the Efficacy Claim and Evaluation Method of Lip Cosmetics

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China Detergent & Cosmetics 2024年第1期9卷 54-62页

作者： Wu Fan Pan Yao Zhao Hua zhu wei Lin Lin Fan Yangyi Department of Cosmetics College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityChina Beijing Key Laboratory of Plant Resources Research and Development China Shanghai Corday Biotechnology Co. Ltd.China

To study the efficacy of lip moisturizing cosmetics and explore the methods for evaluating their *** claimed efficacy and number of claimed efficacy of 44 lip moisturizing cosmetics were investigated,and a combination of in vitro and human testing was used to evaluate the efficacy of the lip moisturizing *** efficacy claims of lip cosmetics mainly included 4 categories of moisturizing,repairing,soothing and anti-wrinkle,with 79.55%of the products claiming 3~4 categories of *** the in vitro test,the cell morphology of the skin damage model improved and the secretion of pro-inflammatory factors decreased *** the human trial,the water content,skin softness and brightness L value of the cuticle of the lips increased significantly in 31 subjects,and the transepidermal water loss,redness a value,and the area and volume of lip wrinkles decreased significantly;the dryness of the lip skin and the uniformity of the skin texture improved *** dryness of lip skin and the uniformity of skin texture were significantly *** results show that the moisture content of the stratum corneum can be used to evaluate the moisturizing efficacy of lip *** transepidermal water loss,skin color,skin softness and expert assessment can be used to evaluate the repairing *** observation of cell morphology of skin damage models and the detection of pro-inflammatory factor content can be used to evaluate the soothing *** area and volume of lip wrinkles can be used to evaluate the anti-wrinkle efficacy of products.

关键词： lip cosmetic efficacy claim clinical trial in vitro test

电网的分散负荷安全域及其应用(二):线路静态失稳的边界-本质-形态及负荷安全域的稳定裕度

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中国电机工程学报 2024年第5期44卷 1737-1749,I0006页

作者：竺炜肖魏罗贤超于瀚翔郑超长沙理工大学电气与信息工程学院湖南省长沙市410114 中国电力科学研究院有限公司北京市海淀区100192

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、... 详细信息

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、机理,而全网静态稳定的充要条件是每条支路都满足静态稳定。基于线路的复变量状态方程,得到末端的复功率-电压(即P_(j)-Q_(j)-U_(j))、复功率-功角(即P_(j)-Q_(j)-θ_(ij))的独立方程;通过可解条件分析、偏导证明,得到唯一的P_(j)-Q_(j)稳定边界及其特征,证明两种失稳的同质性;通过解析几何分析,推导U_(j)和θ_(ij)的稳定边界及其特征,得到符合实际情况的失稳形态解释。基于P_(j)-Q_(j)稳定边界,提出线路负荷安全域的稳定裕度指标以及电压安全水平的修正方法。理论验证基于首端参考系线路模型分析的可行性,提出电网上下级拓扑的稳定域匹配方法。最后,基于状态可观性判据、方程独立性以及平衡点生成原理,分析线路功-角特性的局限性。算例表明,所提的稳定边界、稳定域匹配方法都与PSASP程序收敛性结果吻合。在新能源大量接入导致线路潮流波动性大的背景下,该研究更具理论价值及现实意义。

关键词：线路静态稳定稳定边界失稳形态线路负荷安全域稳定裕度

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长三角城乡融合发展推动共同富裕的协同治理与范式创新

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苏州大学学报（哲学社会科学版） 2024年第1期45卷 33-43页

作者：朱志伟苏州大学、中国特色城镇化研究中心/社会学院江苏苏州215123

长三角城乡融合发展是城市与乡村内部结构、组织功能与相互关系发生质的变化,是推动共同富裕的客观要求,需要多主体、跨区域的协同治理。基于SFIC协同治理模型对长三角城乡融合发展的协同治理基础与过程展开研究后发现,现阶段长三角城... 详细信息

长三角城乡融合发展是城市与乡村内部结构、组织功能与相互关系发生质的变化,是推动共同富裕的客观要求,需要多主体、跨区域的协同治理。基于SFIC协同治理模型对长三角城乡融合发展的协同治理基础与过程展开研究后发现,现阶段长三角城乡融合发展推动共同富裕的协同治理需要从分级领导协商、社会力量动员、信息融合共享、快速响应协作与成本责任共担方面做好机制构建。未来,长三角城乡融合发展推动共同富裕的协同治理范式创新要迈向“统合型包容”,但统合型包容协同治理作为一种持续性过程,仍要立足于长三角城乡融合协同治理全过程与共同富裕发展新需要,从主体统合、任务统合、资源统合与技术统合等四个层面以应对不确定性风险发生。

关键词：长三角城乡融合共同富裕协同治理统合型包容范式创新

Effect analysis of applying high-quality service model to surgical nursing

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World Journal of Clinical Cases 2024年第19期12卷 3744-3751页

作者： Li Chen Qiu-Mei Tu Zhao-Di Guo Xiao-wei zhu wei Wang Hui-Fang Xie Yuan Ye Hand Surgery The First People’s Hospital of Jiangxia DistrictWuhan 430200Hubei ProvinceChina

BACKGROUND Surgical care of the hand plays a crucial role in the medical field,as problems with the hand can profoundly affect a patient's quality of life and *** order to meet the needs of patients,improve patient satisfaction and improve treatment outcomes,high-quality service models have been introduced in the field of *** To explore the effect analysis of applying high-quality service model to surgical *** We conducted a retrospective study of patients who underwent hand surgery at our hospital between 2019 and 2022,using a quality service model that included improved patient education,pain management,care team collaboration,and effective *** group of patients received traditional care as a control *** compared postoperative recovery,satisfaction,complication rate,and length of hospital stay between the two *** statistics were used to compare the difference between the two groups by independent sample t test,Chi-square test and other methods to evaluate the effect of intervention *** Postoperative recovery time decreased from 17.8±2.3 d to 14.5±2.1 d,pain score decreased from 4.7±1.9 to 3.2±1.4,and hand function score increased from 78.4±7.1 to 88.5±*** terms of patient satisfaction,the quality service model group scored 87.3±5.6 points,which was significantly higher than that of the traditional care group(74.6±6.3 points).At the same time,patients'understanding of medical information also improved from 6.9±1.4 to 8.6±*** terms of postoperative complications,the application of the quality service model reduced the incidence of postoperative complications from 26%to 10%,the incidence of infection from 12%to 5%,and the incidence of bleeding from 10%to 3%.The reduction in these data indicates that the quality service model plays a positive role in reducing the risk of *** addition,the average hospital stay of patients in the quality service model group was shortened fr

关键词： Hand surgery nursing Quality service model Clinical outcomes Patient satisfaction Collaboration Pain management

A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression

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Science China(Life Sciences) 2024年第4期67卷 765-777页

作者： Hui Zhao Lin-Lin Liu Jian Sun Lian Jin Hai-Bing Xie Jian-Bo Li Hui Xu Dong-Dong Wu Xiao-Lin zhuang Min-Sheng Peng Ya-Jun Guo wei-zhu Qian Newton OOtecko wei-Jie Sun Liang-Hu Qu Jie He Zhao-Li Chen Rong Liu Ce-Shi Chen Ya-Ping Zhang State Key Laboratory for Conservation and Utilization of Bio-resource School of Life SciencesSchool of Ecology and Environmental ScienceYunnan UniversityKunming 650091China School of Forensic Medicine Kunming Medical UniversityKunming 650500China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China The Third Affiliated Hospital Kunming Medical UniversityKunming 650118China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650201China State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China The Key Laboratory of Gene Engineering of the Ministry of Education State Key Laboratory for BiocontrolSun Yat-sen UniversityGuangzhou 510275China National Engineering Research Center for Antibody Medicine and Shanghai Key Laboratory of Cell Engineering and Antibody Shanghai 201203China Department of Thoracic Surgery Cancer Institute and HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Human-specific insertions play important roles in human phenotypes and *** we reported a 446-bp insertion(Insert-446)in intron 11 of the TBC1D8B gene,located on chromosome X,and traced its origin to a portion of intron 6 of the EBF1 gene on chromosome ***,Insert-446 was present in the human Neanderthal and Denisovans genomes,and was fixed in humans after human-chimpanzee *** have demonstrated that Insert-446 acts as an enhancer through binding transcript factors that promotes a higher expression of human TBC1D8B gene as compared with orthologs in *** addition,over-expression TBC1D8B promoted cell proliferation and migration through“a dual finger”catalytic mechanism(Arg538 and Gln573)in the TBC domain in vitro and knockdown of TBC1D8B attenuated tumorigenesis in *** of Insert-446 prevented cell proliferation and migration in cancer and normal *** results reveal that the human-specific Insert-446 promotes cell proliferation and migration by upregulating the expression of TBC1D8B *** findings provide a significant insight into the effects of human-specific insertions on evolution.

关键词： human-specific insertion enhancer gene expression cell proliferation and migration

江苏如东沿海经济开发区夏季O_(3)污染特征及来源分析

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中国环境监测 2024年第3期40卷 115-124页

作者：陈刚胡伟郑飞阳朱伟诸露露聚光科技(杭州)股份有限公司浙江杭州310052 江苏省如东洋口化工园管委会江苏南通226407

为探究如东沿海经济开发区夏季大气中的O_(3)污染成因,基于2022年6月园区大气超级站的监测数据,较为全面地分析了O_(3)污染来源、水平及二次生成潜势等。结果表明:2022年6月园区O_(3)超标天数占比为34.5%,共计10 d,污染严重程度为2018—... 详细信息

为探究如东沿海经济开发区夏季大气中的O_(3)污染成因,基于2022年6月园区大气超级站的监测数据,较为全面地分析了O_(3)污染来源、水平及二次生成潜势等。结果表明:2022年6月园区O_(3)超标天数占比为34.5%,共计10 d,污染严重程度为2018—2022年同期最高水平(151μg/m3);分析4个污染过程发现,高温低湿、静稳天气易诱发O_(3)污染事件,结合污染天气象条件发现,当温度>25℃且相对湿度<75%时极易发生O_(3)污染;污染天VOCs组分贡献率主要受芳香烃、烯烃及烷烃影响,其中邻二甲苯、甲苯、间-对二甲苯是O_(3)管控的关键活性物种;后向轨迹聚类分析显示,园区O_(3)污染主要受到上海、江西和苏南本地气团输送的影响,主导轨迹出现概率分别为30%、27%和24%,其余小部分时段可能受到来自中国北部和东部的下沉气流影响。为科学管控园区夏季O_(3)污染,应加强监测并协同管控本地关键VOCs物种。

关键词：如东沿海经济开发区 O_(3)污染气象特征后向轨迹分析

孤独症人群的公共设施需求——初步实证与规划思考

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城市规划 2024年第2期48卷 84-93页

作者：朱玮王嘉欣同济大学建筑与城市规划学院城市规划系上海同济城市规划设计研究院有限公司数字规划技术研究中心

包容性城市理念下,城乡规划须兼顾孤独症人群的公共设施需求。基于文献研究、问卷调查、孤独症家庭及专家机构访谈,总结孤独症人群使用公共设施的行为和需求特征,重点分析其“痛点”需求,讨论规划应对原则和措施。研究发现:公园绿地的... 详细信息

包容性城市理念下,城乡规划须兼顾孤独症人群的公共设施需求。基于文献研究、问卷调查、孤独症家庭及专家机构访谈,总结孤独症人群使用公共设施的行为和需求特征,重点分析其“痛点”需求,讨论规划应对原则和措施。研究发现:公园绿地的使用强度最高、障碍最小;体育设施虽常用,但配套功能缺乏、存在潜在危险,社区运动场地是其主要替代;其他设施的使用都存在较大困境,硬件、公众认识和服务支持的包容性缺失是主要障碍;重点需求设施功能包括干预训练、家庭咨询、日间照料、庇护就业、全日养护。当前规划主要任务是制定面向孤独症人群的公共设施配置标准,同时在专用型、共用型设施(服务)上分别制定配置指标或包容性设计导则。

关键词：孤独症公共设施需求规划标准

清淤泥浆脱水-固化一体化工艺效果和机制研究

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岩土力学 2024年第2期45卷 443-453页

作者：林小蔚侯豪刘环季浪谈正伟朱伟河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210098 河海大学土木与交通学院江苏南京210098 河海大学环境学院江苏南京210098

疏浚工程中清淤泥浆的含水率通常非常高,常采用先脱水为泥饼再进行固化的方法,处理效率相对较低。为此选择普通硅酸盐水泥和硫铝酸盐水泥作为固化材料,结合絮凝材料和板框压滤技术,对太湖清淤泥浆进行脱水-固化一体化工艺研究。通过比... 详细信息

疏浚工程中清淤泥浆的含水率通常非常高,常采用先脱水为泥饼再进行固化的方法,处理效率相对较低。为此选择普通硅酸盐水泥和硫铝酸盐水泥作为固化材料,结合絮凝材料和板框压滤技术,对太湖清淤泥浆进行脱水-固化一体化工艺研究。通过比阻试验和固化试验等手段,分析了该工艺中泥浆的脱水性能、固化效果的变化规律以及固化材料的损失情况。此外,还基于一体化工艺试验中泥浆的基本性质变化,讨论了固化材料流失的途径以及对泥浆脱水性能的影响机制。研究结果表明,采用脱水-固化一体化工艺能够改善清淤泥浆的粒径、压缩性,从而提高脱水特性,并且在工艺过程中固化材料的流失在9%以内,由于脱水泥饼性质更好,后续同样能够实现良好的固化效果。实际工程应用中,采用脱水固化一体化工艺可以提升泥浆处理的效率。

关键词：清淤泥浆脱水固化泥处理泥利用