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Predictive values of plasma TNFαand IL-8 for intracranial hemorrhage in patients with acute promyelocytic leukemia

Frontiers of Medicine 2022年第6期16卷 909-918页

作者： Fangyi Dong Li Chen Chaoxian Zhao Xiaoyang Li Yun Tan huan Song Wen jin Hongming zhu Yunxiang Zhang Kai Xue Junmin Li Kankan Wang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China CNRS-LIA Hematology and Cancer Sino-French Research Center for Life Sciences and GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

In patients with acute promyelocytic leukemia(APL),intracranial hemorrhage(ICH),if not identified promptly,could be *** is the leading cause of failure of induction and early ***,biomarkers that could promptly predict severe complications are ***,cytokine differences between patients with APL with and without ICH were investigated to develop predictive models for this *** initial cytokine profiling using plasma samples from 39 patients and 18 healthy donors found a series of cytokines that were remarkedly different between patients with APL and healthy *** APL patients were subsequently divided into high and low white blood cell count *** showed that tumor necrosis factor a and interleukin 8(IL-8)were vital in distinguishing patients with APL who did or did not develop *** addition,verification in 81 patients with APL demonstrated that the two cytokines were positively correlated with the cumulative incidence of ***,in-vitro and in-vivo experimental evidence were provided to show that IL-8 influenced the migration of APL-derived NB4 cells and impaired the blood-brain barrier in PML/RARαpositive blast-transplanted FVB/NJ *** assessments may facilitate the early warning of ICH and reduce future mortality levels in APL.

关键词： acute promyelocytic leukemia intracranial hemorrhage cytokines biomarker

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GdNi2合金选择性合成Gd金属包合物和单壁碳纳米管

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材料工程 2008年第10期36卷 321-323,327页

作者：俞海军彭汝芳王金刚朱根华金波楚士晋西南科技大学材料科学与工程学院四川绵阳621010 中国工程物理研究院四川绵阳621000

以GdNi2合金为金属源,采用电弧放电法,控制不同的He压选择性地合成了Gd金属富勒烯包合物和单壁碳纳米管。当He压为16kPa时,主要得到Gd金属富勒烯包合物,当He压为80kPa时,选择性获得单壁碳纳米管。

关键词：富勒烯包合物单壁碳纳米管 GdNi2合金电弧放电合成

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Genome-wide identification,molecular evolution, and expression divergence of the hexokinase gene family in apple

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Journal of Integrative Agriculture 2021年第8期20卷 2112-2125页

作者： zhu Ling-cheng SU jing jin Yu-ru ZHAO Hai-yan TIAN Xiao-cheng ZHANG Chen MA Fengwang LI Ming-jun MA Bai-quan State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China Department of Plant Biology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Hexokinase(HXK)is the first irreversible catalytic enzyme in the glycolytic pathway,which not only provides energy for plant growth and development but also serves as a signaling molecule in response to environmental ***,the evolutionary pattern of the HXK gene family in apple remains *** this study,a total of nine HXK genes were identified in the Malus×domestica genome GDDH13 *** physiological and biochemical properties,exonintron structures,conserved motifs,and cis-elements of the MdHXK genes were *** subcellular localization indicated that the MdHXK genes were mainly distributed in the mitochondria,cytoplasm,and *** duplication revealed that whole-genome duplication(WGD)and segmental duplication played vital roles in MdHXK gene family ***ωvalues of pairwise MdHXK genes indicated that this family was subjected to strong purifying selection during apple ***,five subfamilies were classified,and recent/old duplication events were identified based on phylogenetic tree *** evolutionary rates were estimated among the various HXK ***,divergent expression patterns of the MdHXK genes in four source-sink tissues and at five different apple fruit developmental stages indicated that they play vital roles in apple fruit development and sugar *** study provides a theoretical basis for future elucidation of the biological functions of the MdHXK genes during apple fruit development.

关键词： apple hexokinase cis-element screening evolutionary pattern sugar accumulation

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Genomic Characterization of a New Coronavirus from Migratory Birds in Jiangxi Province of China

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Virologica Sinica 2021年第6期36卷 1656-1659页

作者： Wentao zhu Wentao Song Guoyin Fan jing Yang Shan Lu Dong jin Xue-lian Luo Ji Pu Haiying Chen Jianguo Xu State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control Jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne DiseasesNanchang Center for Disease Control and PreventionNanchang 330038China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Dear Editor,The emergence of COVID-19 since December 2019 has attracted great attention around the world and reminds the powerful pathogenic potential of viruses(Zhou et al.2020).The subfamily Orthocoronavirinae of the family Coronaviridae contains four genera Alphacoronavirus,Betacoronavirus,Gammacoronavirus,and Deltacoronavirus,which are the largest group of positive-sense,non-segmented,single-stranded,enveloped RNA viruses(Woo et al.2012;Shi et al.2016).The genus Gammacoronavirus currently has five species(https://***/taxonomy/),which are primarily spread through birds(Woo et al.2012).

关键词： taxonomy Corona Jiangxi

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Network pharmacology-based analysis of heat clearing and detoxifying drug JC724 on the treatment of colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 90-101页

作者： hua-Zhen Tang Zhen-Peng Yang Shuai Lu Bing Wang Yu-Ying Wang Xi-Bo Sun jin-Xiu Qu Ben-Qiang Rao Department of Gastrointestinal Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastrointestinal Surgery Key Laboratory of Cancer FSMP for State Market RegulationBeijing 100038China Department of Breast Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina

BACKGROUND Heat-clearing and detoxifying drugs has protective effect on colorectal cancer(CRC).Given the complicated features of Traditional Chinese medicine formulas,network pharmacology is an effective approach for studying the multiple interactions between drugs and *** To systematically explore the anticancer mechanism of heat-clearing and detoxifying drug *** This study obtained the active compounds and their targets in JC724 from Traditional Chinese Medicine System Pharmacology *** addition,the CRC targets were obtained from Drugbank,TTD,DisGeNET and GeneCards *** performed transcriptome analysis of differentially expressed genes in CRC treated with *** diagram was used to screen the JC724-CRC intersection targets as candidate *** targets were selected by proteinprotein interaction network and herb ingredient-target-disease network *** functional and pathway of core targets were analysed by enrichment *** We found 174 active ingredients and 283 compound targets from JC724.940 CRC-related targets were reserved from the four databases and 304 CRC differentially expressed genes were obtained by transcriptome *** constructed the network and found that the five core ingredients were quercetin,βBeta sitosterol,wogonin,kaempferol and *** core JC724-CRC targets were CYP1A1,HMOX1,CXCL8,NQO1 and ***724 acts on multiple signaling pathways associated with CRC,including the Nrf2 signaling pathway,oxidative stress,and the IL-17 signaling *** In this study,we systematically analyzed the active ingredients,core targets and main mechanisms of JC724 in the treatment of *** study could bring a new perspective to the heat-clearing and detoxifying therapy of CRC.

关键词： Heat-clearing and detoxifying therapy Colorectal cancer Network pharmacology Transcriptomics

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Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2020年第4期10卷 646-666页

作者： Xiaokang Li Jian Lu Yixiang Xu Jiaying Wang Xiaoxia Qiu Lei Fan Baoli Li Wenwen Liu Fei Mao jin zhu Xu Shen Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Medicine and Life Sciences Nanjing University of Chinese MedicineNanjing 210023China Center for Drug Safety Evaluation and Research State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Drug repurposing is an efficient strategy for new drug *** latest study found that nitazoxanide(NTZ),an approved anti-parasite drug,was an autophagy activator and could alleviate the symptom of Alzheimer’s disease(AD).In order to further improve the efficacy and discover new chemical entities,a series of NTZ-based derivatives were designed,synthesized,and evaluated as autophagy activator against *** compounds were screened by the inhibition of phosphorylation of p70S6K,which was the direct substrate of mammalian target of rapamycin(mTOR)and its phosphorylation level could reflect the mTOR-dependent autophagy *** these analogs,compound 22 exhibited excellent potency in promotingβ-amyloid(Aβ)clearance,inhibiting tau phosphorylation,as well as stimulating autophagy both in vitro and in ***’s more,22 could effectively improve the memory and cognitive impairments in APP/PS1 transgenic AD model *** results demonstrated that 22 was a potential candidate for the treatment of AD.

关键词： Alzheimer’s disease Autophagy Nitazoxanide β-amyloid Tau protein

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Asymptotic Behavior for Random Walks in Time-Random Environment on Z^1

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Journal of Mathematical Research and Exposition 2008年第1期28卷 199-206页

作者： HU Xue-ping zhu Dong-jin Department of Mathematics Anqing Normal College Anhui 246011 China College of Math. ＆ Comput. Sci. Anhui Normal University Anhui 241000 China

In this paper, we give a general model of random walks in time-random environment in any countable space. Moreover, when the environment is independently identically distributed, a recurrence-transience criterion and the law of large numbers are derived in the nearest-neighbor case on Z^1. At last, under regularity conditions, we prove that the RWIRE {Xn} on Z^1 satisfies a central limit theorem, which is similar to the corresponding results in the case of classical random walks.

关键词： Keywords Random walks in time-random environment recurrence-transience criteria stronglaw of large numbers central limit theorem.

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Sources and degradation of organic matter in the surface sediments of the Chukchi Sea:insights from amino acids

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Acta Oceanologica Sinica 2023年第11期42卷 9-18页

作者： Weiwei Li Zhongqiao Li zhuoyi zhu Alexander Polukhin Youcheng Bai Yang Zhang Futao Fang Haiyan jin Anatolii S.Astakhov Xuefa Shi Jianfang Chen Key Laboratory of Marine Ecosystem and Biogechemistry Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Shanghai Key Laboratory of Polar Life and Environment Sciences School of OceanographyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Polar Science of Ministry of Natural Resources Polar Research Institute of ChinaShanghai 201209China Laboratory of Biohydrochemistry Shirshov Institute of OceanologyRussian Academy of SciencesMoscow 117997Russia State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China V.I.Il’ichev Pacific Oceanological Institute Far Eastern BranchRussian Academy of SciencesVladivostok 690012Russia Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China

In the context of global warming and rapid environment change in the Arctic,the supply of organic matter(OM)has increased significantly and a large amount of OM are buried on the Arctic *** the fate of OM in Arctic shelf sediments is crucial to understanding the global carbon *** a marginal sea of the Arctic Ocean,the Chukchi Sea is one of the most critical areas where OM is *** on the surface sediment samples collected during the sixth Chinese National Arctic Research Expedition in the summer of 2014 and the SinoRussian joint Arctic Research Expedition in the summer of 2016,this study takes amino acids(AAs)as the primary tool to explore the source and degradation of OM in the surface sediments of the Chukchi *** study shows that total hydrolyzable amino acid(THAA)concentrations(dry weight)are high,with a mean value of(32.7±15.8)μmol/*** spatial distribution is related to primary productivity,hydrodynamic conditions,sediment properties and other *** source of OM in the surface sediments of the Chukchi Sea is dominated by diatom-dominated marine productivity,with some input from terrestrial ***,as the main source of the D-enantiomer of AA(D-AA),not only have transforming effect on OM,but their cell walls and remnants likewise supply the OM *** on a series of diagenetic indicators,we conclude that the OM in the surface sediments of the Chukchi Sea has undergone extensive degradation[DI(degradation index)=-0.59±0.44],and the degradation degree in the slope is higher than that in the *** study uses AA to explore the sources and degradation of OM in the sediments of the Chukchi Sea,which facilitates our understanding of OM transport and transformation on the Arctic shelf.

关键词： Chukchi Sea amino acids degradation indicator organic matter

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Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

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Precision Clinical Medicine 2023年第4期6卷 213-225页

作者： Fengqin zhu Dehuai jing Huihui Zhou Zongjing Hu Yan Wang Guiyuan jin Yonghong Yang Guangxi Zhou Department of Gastroenterology Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China Medical Research Center Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Background:Ulcerative colitis(UC)is a progressive chronic inflammatory *** play a critical role in regulating in-testinal mucosal homeostasis in *** tyrosine kinase(Syk)is involved in several inflammatory ***,we evaluated the effects and underlying mechanisms of Syk on neutrophil immune-responses in ***:Syk expression in the colonic tissues of patients with UC was determined using quantitative reverse transcription-polymerase chain reaction(qRT-PCR),western blotting,and *** biopsies from patients with UC were obtained for single-cell *** isolated from peripheral blood were pre-treated with R788(a Syk inhibitor)and gene differences were determined using RNA *** functions were analyzed using qRT-PCR,flow cytometry,and Transwell assay.R788 was administered daily to mice with dextran sulfate sodium(DSS)-induced colitis to verify the effects of Syk on intestinal ***:Syk expression was increased in inflamed mucosa and neutrophils of patients with UC and positively correlated with dis-ease *** inhibition of Syk in neutrophils decreased the production of pro-inflammatory cytokines,chemokines,neutrophil extracellular traps,reactive oxygen species,and *** and migration of neutrophils were sup-pressed by Syk *** blockade ameliorated mucosal inflammation in DSS-induced murine colitis by inhibiting neutrophil-associated immune ***,Syk regulated neutrophil immune-responses via the mammalian target of rapamycin kinase/rubicon-like autophagy enhancer-dependent autophagy ***:Our findings indicate that Syk facilitates specific neutrophil functional responses to mucosal inflammation in UC,and its inhibition ameliorates mucosal inflammation in DSS-induced murine colitis,suggesting its potential as a novel therapeutic target for UC treatment.

关键词： Syk UC neutrophils autophagy

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多层螺旋CT无创冠状动脉成像的临床应用和进展

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中国医学科学院学报 2006年第1期28卷 110-114页

作者：宋兰张竹花金征宇中国医学科学院中国协和医科大学北京协和医院放射科北京100730

多层螺旋CT(MSCT)的出现对心血管成像有重大影响,作为一种无创检查技术,MSCT不仅可用于评价冠状动脉狭窄和定性、定量检测冠状动脉斑块,还可用于分析心功能和心肌灌注,评价支架和桥血管的通畅性。近年来的研究显示,MSCT无创冠状动脉成... 详细信息

多层螺旋CT(MSCT)的出现对心血管成像有重大影响,作为一种无创检查技术,MSCT不仅可用于评价冠状动脉狭窄和定性、定量检测冠状动脉斑块,还可用于分析心功能和心肌灌注,评价支架和桥血管的通畅性。近年来的研究显示,MSCT无创冠状动脉成像可作为一种有效的冠心病筛查手段,同时用于介入和手术治疗后的随访观察。

关键词：体层摄影术 X线计算机冠状动脉成像血管造影术

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