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Impact of minimally invasive surgery on immune function and stress response in gastric cancer patients

World Journal of Gastrointestinal Surgery 2024年第8期16卷 2484-2493页

作者： Rong-hua zhu Peng-Cheng Li Jie Zhang hua-hua Song Department of General Surgery Chongming Hospital Affiliated to Shanghai University of Medicine and Health SciencesShanghai 202150China Department of Respiratory Medicine Chongming Hospital Affiliated to Shanghai University of Medicine and Health ScienceShanghai 202150China

BACKGROUND Gastric cancer remains a leading cause of cancer-related mortality *** open surgery for gastric cancer is often associated with significant morbidity and prolonged *** To evaluate the effectiveness of laparoscopic minimally invasive surgery as an alternative to traditional open surgery for gastric cancer,focusing on its potential to reduce trauma,accelerate recovery,and achieve comparable oncological *** This study retrospectively analyzed 203 patients with gastric cancer who underwent surgery at the Shanghai Health Medical College Affiliated Chongming Hospital from January 2020 to December *** patients were divided into two groups:Minimally invasive surgery group(n=102),who underwent laparoscopic gastrectomy,and open surgery group(n=101),who underwent traditional open *** compared surgical indicators(surgical incision size,intraop-erative blood loss,surgical duration,and number of lymph nodes dissected),recovery parameters(time to first flatus,time to start eating,time to ambulation,and length of hospital stay),immune function(levels of IgA,IgG,and IgM),intestinal barrier function(levels of D-lactic acid and diamine oxidase),and stress response(levels of C-reactive protein,interleukin-6,and procalcitonin).RESULTS The minimally invasive surgery group demonstrated significantly better outcomes in terms of surgical indicators,including smaller incisions,less blood loss,shorter surgery time,and more lymph nodes dissected(P<0.05 for all).Recovery was also faster in the minimally invasive surgery group,with earlier return of bowel function,earlier initiation of diet,quicker mobilization,and shorter hospital stays(P<0.05 for all).Furthermore,patients in the minimally invasive surgery group had better preserved immune function,superior intestinal barrier function,and a less pronounced stress response postoperatively(P<0.05 for all).CONCLUSION Laparoscopic minimally invasive surgery for gastric cancer not on

关键词： Gastric cancer Laparoscopic surgery Minimally invasive surgery Immune function Intestinal barrier Stress response

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NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis

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Journal of Integrative Plant Biology 2024年第1期66卷 54-65页

作者： Qiao‐Yun zhu Lin‐Lin Zhang jian‐Xiang Liu State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China

Plants are highly susceptible to abiotic stresses,particularly heat stress during the reproductive ***,the specific molecular mechanisms underlying this sensitivity remain largely *** the current study,we demonstrate that the Nuclear Transcription Factor,X-box Binding Protein 1-Like 1(NFXL1),directly regulates the expression of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A(DREB2A),which is crucial for reproductive thermotolerance in ***1 is upregulated by heat stress,and its mutation leads to a reduction in silique length(seed number)under heat stress ***-Seq analysis reveals that NFXL1 has a global impact on the expression of heat stress responsive genes,including DREB2A,Heat Shock Factor A3(HSFA3)and Heat Shock Protein 17.6(HSP17.6)in flower ***,NFXL1 is enriched in the promoter region of DREB2A,but not of either HSFA3 or *** experiments using electrophoretic mobility shift assay have confirmed that NFXL1 directly binds to the DNA fragment derived from the DREB2A ***,effector-reporter assays have shown that NFXL1 activates the DREB2A *** DREB2A mutants are also heat stress sensitive at the reproductive stage,and DEREB2A is epistatic to NFXL1 in regulating thermotolerance in flower *** is known that HSFA3,a direct target of DREB2A,regulates the expression of heat shock proteins genes under heat stress ***,our findings establish NFXL1 as a critical upstream regulator of DREB2A in the transcriptional cassette responsible for heat stress responses required for reproductive thermotolerance in Arabidopsis.

关键词： Arabidopsis DREB2A heat stress NFXL1 reproductive thermotolerance

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TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

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Current Medical Science 2024年第3期44卷 589-602页

作者： An-bang SUN Fang-hua LI Lin zhu Xi-xi ZENG Min zhu Qing-hua LEI Yan-hong LIAO Department of Anatomy School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Transfusion Medicine Wuhan Hospital of Traditional Chinese and Western MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Nephrology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Basic Medical Teaching Demonstration Center Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Neurological Diseases of Ministry of Education Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Renal fibrosis is the ultimate pathway of various forms of acute and chronic kidney ***,the knockout of transient receptor potential channel 6(TRPC6)has shown promise in alleviating renal ***,the regulatory impact of TRPC6 on renal fibrosis remains *** In vivo,TRPC6 knockout(TRPC6−/−)mice and age-matched 129 SvEv(WT)mice underwent unilateral renal ischemia-reperfusion(uIR)injury surgery on the left renal pedicle or sham *** and serum were collected on days 7,14,21,and 28 after *** vitro,primary tubular epithelial cells(PTECs)were isolated from TRPC6−/−and WT mice,followed by treatment with transforming growth factorβ1(TGFβ1)for 72 *** anti-fibrotic effect of TRPC6−/−and the underlying mechanisms were assessed through hematoxylin-eosin staining,Masson staining,immunostaining,qRT-PCR,and Western *** Increased TRPC6 expression was observed in uIR mice and PTECs treated with TGFβ***6−/−alleviated renal fibrosis by reducing the expression of fibrotic markers(Col-1,α-SMA,and vimentin),as well as decreasing the apoptosis and inflammation of PTECs during fibrotic progression both in vivo and in ***,we found that the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/glycogen synthase kinase 3 beta(GSK3β)signaling pathway,a pivotal player in renal fibrosis,was down-regulated following TRPC6 *** These results suggest that the ablation of TRPC6 may mitigate renal fibrosis by inhibiting the apoptosis and inflammation of PTECs through down-regulation of the PI3K/AKT/GSK3β*** TRPC6 could be a novel therapeutic strategy for preventing chronic kidney disease.

关键词： transient receptor potential channel 6 ischemia-reperfusion injury renal fibrosis renal tubular epithelial cells

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On the Quantum Cohomology of Blow-ups of Four-dimensional Quadrics

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Acta Mathematica Sinica,English Series 2024年第1期40卷 313-328页

作者： jian Xun HU hua Zhong KE Chang Zheng LI Lei SONG School of Mathematics Sun Yat-sen UniversityGuangzhou 510275P.R.China

We propose a conjecture relevant to Galkin’s lower bound conjecture,and verify it for the blow-ups of a four-dimensional quadric at a point or along a projective *** also show that Conjecture O holds in these two cases.

关键词： Quantum cohomology blow-up quadric hypersurface

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Atomic force microscopy-based nanoscale infrared techniques for liquid environments

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Science Bulletin 2024年第2期69卷 151-153页

作者： jian Li Jing Liang Mu-Hao Lan Xing-hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Infrared(IR)light energy matches well with the vibration and rotation of chemical bonds in molecules,hence IR spectroscopy is commonly used for accurate molecular identification[1].Conventional IR analysis involves bulk samples,providing averaged information of the entire *** spatially-resolved investigation of heterogeneous sample properties is constrained by the micrometer-level spatial resolution of optical IR microscopy.

关键词： spatially hence rotation

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Experimental investigation on using CO_(2)/H_(2)O emulsion with high water cut in enhanced oil recovery

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Petroleum Science 2024年第2期21卷 974-986页

作者： Xi-Dao Wu Peng Xiao Bei Liu Guang-Jin Chen jian-hua Pang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Ocean Intelligence Technology Center Shenzhen Institute of Guangdong Ocean UniversityShenzhen518120GuangdongChina

CO_(2) emulsions used for EOR have received a lot of interest because of its good performance on CO_(2)mobility ***,most of them have been focusing on the high quality CO_(2) emulsion(high CO_(2) fraction),while CO_(2) emulsion with high water cut has been rarely *** this paper,we carried out a comprehensive experimental study of using high water cut CO_(2)/H_(2)O emulsion for enhancing oil ***,a nonionic surfactant,alkyl glycosides(APG),was selected to stabilize CO_(2)/H_(2)O emulsion,and the corresponding morphology and stability were evaluated with a transparent PVT ***,plugging capacity and apparent viscosity of CO_(2)/H_(2)O emulsion were measured systematically by a sand pack displacement apparatus connected with a 1.95-m long capillary ***,a high water cut(40 vol%) CO_(2)/H_(2)O emulsion was selected for flooding experiments in a long sand pack and a core sample,and the oil recovery,the rate of oil recovery,and the pressure gradients were *** results indicated that APG had a good performance on emulsifying and stabilizing CO_(2) *** inversion from H_(2)O/CO_(2) emulsion to CO_(2)/H_(2)O emulsion with the increase in water cut was ***_(2)/H_(2)O emulsions with lower water cuts presented higher apparent viscosity,while the optimal plugging capacity of CO_(2)/H_(2)O emulsion occurred at a certain water ***,the displacement using CO_(2)/H_(2)O emulsion provided 18.98% and 13.36% additional oil recovery than that using pure CO_(2) in long sand pack and core tests,*** work may provide guidelines for EOR using CO_(2) emulsions with high water cut.

关键词： CO_(2)/H_(2)O emulsion High water cut CO_(2) mobility control Enhanced oil recovery

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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng jian Yang Xue-Mei zhu Feng-Ling Xiang Jing Tu Ming-Xue huang Yun Wang Jin-hua Gan Wei-hua Yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of Southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis

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基于神经网络的岩土工程结构随机有限元分析

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同济大学学报（自然科学版） 2002年第3期30卷 269-272页

作者：邓建朱合华同济大学地下建筑与工程系上海200092

针对有限元蒙特卡罗法计算量大的弊端和岩土工程结构功能函数不能用显式表达的可靠性分析问题 ,提出并论证了基于神经网络的随机有限元 (有限元蒙特卡罗 )分析法 .神经网络具有高度非线性的映射能力 ,可用来逼近结构响应量与随机变量的... 详细信息

针对有限元蒙特卡罗法计算量大的弊端和岩土工程结构功能函数不能用显式表达的可靠性分析问题 ,提出并论证了基于神经网络的随机有限元 (有限元蒙特卡罗 )分析法 .神经网络具有高度非线性的映射能力 ,可用来逼近结构响应量与随机变量的映射关系 .通过典型岩土工程结构的应用实例分析。

关键词：神经网络有限元蒙特卡罗法可靠性分行结构分析岩土工程非线性映射能力

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游离^(125)I与血浆蛋白的结合及其对血药浓度测定的影响

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高等学校化学学报 2008年第10期29卷 1959-1962页

作者：吴雅卿钱隽朱建华复旦大学药学院上海200032

通过体内、外实验,研究了游离125I与血浆蛋白的结合及其在三氯乙酸(TCA)沉淀后的沉淀百分率,并与125I-RGD-Sak在SD大鼠中不同时间血药浓度的结果进行了比较.结果表明,游离125I能与血浆蛋白结合,并为TCA所沉淀,且在一定范围内,游离125I... 详细信息

通过体内、外实验,研究了游离125I与血浆蛋白的结合及其在三氯乙酸(TCA)沉淀后的沉淀百分率,并与125I-RGD-Sak在SD大鼠中不同时间血药浓度的结果进行了比较.结果表明,游离125I能与血浆蛋白结合,并为TCA所沉淀,且在一定范围内,游离125I与血浆蛋白结合后的沉淀百分率与温育时间及游离125I的活度无关.体内、外实验中,游离125I与血浆蛋白结合后的沉淀百分率分别为(1.26±0.14)%及(1.38±0.33)%.沉淀物中含有吸附在沉淀物表面的游离125I,该吸附需要用TCA沉淀2~3次才能去除.采用125I核素示踪法进行生物类制品的药代动力学研究时,应对游离125I的影响进行校正.

关键词：游离125I 药代动力学血浆蛋白结合血药浓度

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Experimental Study on the Sinking and Leveling of A Large-Capacity Offshore Wind Turbine Five-Bucket Foundation in Sand

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China Ocean Engineering 2024年第4期38卷 586-601页

作者： LIAN Ji-jian zhu Hang GUO Yao-hua WANG Hai-jun YU Tong-shun State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Tianjin University of Technology Tianjin 300384China College of Engineering Ocean University of ChinaQingdao 266100China

As offshore wind farms expand into deeper and farther ocean regions and the unit capacity of offshore wind turbines(OWTs)increases,there is a pressing need for a new foundation structure that can accommodate deep-sea conditions and support large capacities while maintaining economical and *** meet this goal of integrated transportation and one-step installation,a novel five-bucket jacket foundation(FBJF),with its suction installation and leveling methods in sand,has been proposed,analyzed and experimentally ***,seepage failure experiments of the FBJF at various depths were conducted,and a formula for calculating the critical suction of seepage failure suitable for the FBJF in sand was chosen and recommended for use with a range of values for the permeability coefficient ***,through leveling experiments of the FBJF at different depths,the maximum adjustable leveling angle during the sinking process was defined using seepage failure and the adjustable leveling angle of the foundation as control *** leveling control strategies were proposed and ***,an automatic sinking and leveling control system for the FBJF was developed and experimentally verified for feasibility.

关键词： offshore wind turbine(OWT) bucket foundation seepage failure suction installation

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