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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-ying Zhang Ai-Ai Gao Cheng zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

The roles and mechanisms of SREBP1 in cancer development and drug response

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Genes & Diseases 2024年第4期11卷 258-269页

作者： ying He Shasha Qi Lu Chen Jinyu zhu Linda Liang Xudong Chen Hao Zhang Lvjia zhuo Shujuan Zhao Shuiping Liu Tian Xie School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer Centre SingaporeSingapore 169610Singapore

Cancer occurrence and development are closely related to increased lipid produc-tion and glucose *** are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and *** regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid *** addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly ***,no review of sREBP1 in cancer biology has yet been ***,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ***-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.

关键词： Cancer Drug Lipid metabolism reprogramming Resistance SREBP1

Predictive model for non-malignant portal vein thrombosis associated with cirrhosis based on inflammatory biomarkers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1213-1226页

作者： Guo-Le Nie Jun Yan ying Li Hong-Long Zhang Dan-Na Xie Xing-Wang zhu Xun Li The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT),a complication of liver cirrhosis,is a major public health *** prediction is the most effective method for PVT diagnosis and *** To develop and validate a nomogram and network calculator based on clinical indicators to predict PVT in patients with *** Patients with cirrhosis hospitalized between January 2016 and December 2021 at the First Hospital of Lanzhou University were screened and 643 patients with cirrhosis who met the eligibility criteria were *** a 1:1 propensity score matching 572 patients with cirrhosis were screened,and relevant clinical data were *** risk factors were identified using the least absolute shrinkage and selection operator(LASSO)and multivariate logistic regression *** inflation factors and correlation matrix plots were used to analyze multicollinearity among the variables.A nomogram was constructed to predict the probability of PVT based on independent risk factors for PVT,and its predictive performance was verified using a receiver operating characteristic curve(ROC),calibration curves,and decision curve analysis(DCA).Finally,a network calculator was constructed based on the *** This study enrolled 286 cirrhosis patients with PVT and 286 without *** analysis revealed 13 variables as strongly associated with PVT *** logistic regression analysis revealed nine indicators as independent PVT risk factors,including etiology,ascites,gastroesophageal varices,platelet count,D-dimer,portal vein diameter,portal vein velocity,aspartate transaminase to neutrophil ratio index,and platelet-to-lymphocyte *** and correlation matrix plot results revealed no significant multicollinearity or correlation among the variables.A nomogram was constructed based on the screened independent risk *** nomogram had excellent predictive performance,with an area under the ROC curve of 0.821 and 0.829 in the

关键词： Portal vein thrombosis Liver cirrhosis Nomogram Inflammatory markers Aspartate aminotransferase to neutrophil ratio index Platelet-to-lymphocyte ratio

Linking Perceived Risk of Public Health Emergency to Psychological Distress among Chinese College Students: The Chain Mediation Role of Balanced Time Perspective and Negative Coping Styles

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International Journal of Mental Health Promotion 2024年第8期26卷 599-610页

作者： chang B. zhu S. Xie Q. Dai Y. School of Education Science Nanjing Normal University Nanjing 210024 China Center of Clinical Psychology The Third People’s Hospital of Heze City Heze 274031 China School of Education Science Northwest Normal University Lanzhou 730070 China Mental Health Center Hubei Polytechnic University Huangshi 435003 China College of Teacher Education Zhejiang Normal University Jinhua 321004 China

Background: With public health emergencies (PHE) worldwide increasing, the perceived risk of PHE has been one of the critical factors influencing college students’ psychological distress. However, the mechanisms by which the perceived risk of PHE affects college students’ psychological distress are not clear. The study’s purpose was to investigate the mediation roles of deviation from a balanced time perspective (DBTP) and negative coping styles between the perceived risk of PHE and psychological distress. Methods: A convenience sampling method was used to survey 1054 Chinese college students with self-reporting. Data was collected using the Public Risk Perception Scale (PRPS), the Zimbardo Time Perspective Inventory (ZTPI), the Simplified Coping Style Questionnaire (SCSQ), the PHE Anxiety Scale, and the Chinese version of the Patient Health Questionnaire (PHQ). The associations between the perceived risk of PHE, DBTP, negative coping styles, and psychological distress were clarified using the correlation analysis. Additionally, the mediating roles of DBTP and negative coping styles between the perceived risk of PHE and psychological distress were investigated using a structural equation model. Results: The findings revealed low to moderate correlations between the variables studied. Students’ perceived risk of PHE was a positive predictor of their psychological distress (b = 0.219, p < 0.01). DBTP and negative coping styles played chain mediation roles between them with the effect being 0.009 and a 95% Boot CI of [0.003, 0.023]. This chain mediation model had an excellent fit index (χ2/df = 4.732, CFI = 0.973, TLI = 0.930, RMSEA = 0.048, SRMR = 0.047). Conclusion: These findings showed how the perceived risk of PHE affected college students’ psychological distress. Specifically, these results suggested that improving students’ mental ability to switch effectively among different time perspectives depending on task features and situational considerations and reducin

关键词： balanced time perspective China college students negative coping styles Perceived risk of public health emergency psychological distress

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基于神经网络的雷达抗干扰效果评估

火力与指挥控制 2006年第1期31卷 77-80页

作者：卢盈齐王颖龙祝长英空军工程大学导弹学院陕西三原713800

分析了常用的雷达抗干扰效果评估方法的特点,建立了雷达抗干扰效果评价指标集,对指标数据的采集和处理方法进行了分析,提出了一种基于神经网络的雷达抗干扰效果评估模型,论述了网络结构和样本获取方法,最后通过算例验证了模型的正确性... 详细信息

分析了常用的雷达抗干扰效果评估方法的特点,建立了雷达抗干扰效果评价指标集,对指标数据的采集和处理方法进行了分析,提出了一种基于神经网络的雷达抗干扰效果评估模型,论述了网络结构和样本获取方法,最后通过算例验证了模型的正确性和实用性。

关键词：抗干扰评估神经网络 BP算法

TOPSIS法用于区域防空重点保卫目标排序计算

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火力与指挥控制 2006年第2期31卷 20-21,28页

作者：卢盈齐王颖龙祝长英空军工程大学导弹学院陕西三原713800

区域防空作战中优化选择重点保卫目标,集中部署优势防空兵力,才能确保重点目标不受或少受损失。分析了影响保卫目标重要性的主要因素,采取德尔菲法获得指标值,采用层次分析法得到指标权重,利用逼近理想解的排序法对保卫目标的重要性进... 详细信息

区域防空作战中优化选择重点保卫目标,集中部署优势防空兵力,才能确保重点目标不受或少受损失。分析了影响保卫目标重要性的主要因素,采取德尔菲法获得指标值,采用层次分析法得到指标权重,利用逼近理想解的排序法对保卫目标的重要性进行了定量分析。最后通过算例对算法的正确性和实用性进行了验证。

关键词：区域防空保卫目标德尔菲法层次分析法逼近理想解的排序法

高校国际邮轮乘务专业跨文化适应能力培养的现状和途径

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广州航海学院学报 2015年第3期23卷 39-41页

作者：朱常英广州航海学院外语系广东广州510725

随世界和我国邮轮旅游的快速发展,我国高等院校应抓住契机,加强国际邮轮乘务专业教育,要认清当前我国国际邮轮乘务专业教育现状和任务,帮助在校邮轮乘务专业学生明确国际邮轮乘务的国际属性,努力加强其语言和跨文化课程的教学和心理的自... 详细信息

随世界和我国邮轮旅游的快速发展,我国高等院校应抓住契机,加强国际邮轮乘务专业教育,要认清当前我国国际邮轮乘务专业教育现状和任务,帮助在校邮轮乘务专业学生明确国际邮轮乘务的国际属性,努力加强其语言和跨文化课程的教学和心理的自律,增强该专业学生跨文化适应和服务能力的培养.

关键词：国际邮轮乘务专业国际化属性跨文化适应能力邮轮旅游人才

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我国国际邮轮乘务员跨文化适应问题探讨

广州航海高等专科学校学报 2014年第4期22卷 31-33页

作者：朱常英广州航海学院外语系广东广州510725

我国邮轮旅游业快速发展,越来越多的中国籍邮轮乘务员出现在各大国际邮轮.国际邮轮是一个国际化的社区,邮轮乘务员的工作和生活呈现国际化特色,这些对我国国际乘务员跨文化适应能力提出了很大挑战.本文结合在丽星和歌诗达邮轮上工作的1... 详细信息

我国邮轮旅游业快速发展,越来越多的中国籍邮轮乘务员出现在各大国际邮轮.国际邮轮是一个国际化的社区,邮轮乘务员的工作和生活呈现国际化特色,这些对我国国际乘务员跨文化适应能力提出了很大挑战.本文结合在丽星和歌诗达邮轮上工作的11名中国籍邮轮乘务的工作和生活经历,阐述了我国国际邮轮乘务员跨文化适应能力的主要影响因素和跨文化适应的后续问题.

关键词：国际邮轮乘务员跨文化适应邮轮文化

Rapidly growing primordial black holes as seeds of the massive high-redshift JWST Galaxies

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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 143-150页

作者： Guan-Wen Yuan Lei Lei Yuan-zhu Wang Bo Wang Yi-ying Wang Chao Chen Zhao-Qiang Shen Yi-Fu Cai Yi-Zhong Fan Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences School of Astronomy and Space Science University of Science and Technology of China Institute of High Energy Physics Chinese Academy of Sciences Deep Space Exploration Laboratory/Department of Astronomy School of Physical SciencesUniversity of Science and Technology of China Jockey Club Institute for Advanced Study The Hong Kong University of Science and Technology

A group of massive galaxies at redshifts of z■7 have been recently detected by the James Webb Space Telescope（JWST）, which were unexpected to form at such an early time within the standard Big Bang cosmology. In this work, we propose that this puzzle can be explained by the presence of some primordial black holes（PBHs） with a mass of ～1000M⊙. These PBHs act as seeds for early galaxy formation with masses of ～10～8-1010M⊙at high redshift, hence accounting for the JWST observations. We use a hierarchical Bayesian inference framework to constrain the PBH mass distribution models, and find that the Lognormal model with the Mc～750M⊙is preferred over other hypotheses. These rapidly growing BHs are expected to have strong radiation and may appear as high-redshift compact objects, similar to those recently discovered by JWST. Although we focused on PBHs in this work, the bound on the initial mass of the seed black holes remains robust even if they were formed through astrophysical channels.

关键词： primordial black hole dark matter halo black hole accretion primordial galaxies

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