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LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1578-1591页

作者： Jie Zou xiaoyun zhu Dejuan Xiang Yanqiu Zhang Jie Li Zhigui Su Lingyi Kong Hao Zhang State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Advanced Pharmaceuticals and BiomaterialsChina Pharmaceutical UniversityNanjing 210009China

Limb and CNS expressed 1 like(LIX1L) is over-expressed in several types of ***,the function of LIX1L in glucose metabolism and hepatocellular carcinoma(HCC) progression remains *** we report that LIX1L is over-expressed in human HCC tissues,which predicts unfavorable ***1L deficiency in vivo significantly attenuated liver cancer initiation in *** studies indicated that LIX1L overexpression elevated proliferation,migratory,invasive capacities of HCC cells in vitro,and promoted liver cancer growth and metastasis in ***1L knockdown up-regulated fructose-1,6-bisphosphatase(FBP1) expression to reduce glucose consumption as well as lactate ***,LIX1L increased miR-21-3p expression,which targeted and suppressed FBP1,thereby promoting HCC growth and ***-21-3p inhibitor could abrogate LIX1L induced enhancement of cell migration,invasion,and glucose *** of miR-21-3p suppressed tumor growth in an orthotopic tumor *** results establish LIX1L as a critical driver of hepatocarcinogenesis and HCC progression,with implications for prognosis and treatment.

关键词： LIX1L FBP1 miR-21-3p Glucose metabolism Hepatocellular carcinoma Proliferation Metastasis Gluconeogenesis

Electrodeposition of Ni-W Amorphous Alloy and Ni-W-SiC Composite Deposits

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Journal of Materials Science & Technology 2000年第3期16卷 323-326页

作者： Zhongcheng GUO, xiaoyun zhu, Dacheng ZHAI and Xianwan YANG (Department of Metallurgy, Kunming University of Science and Technology, Kunming 650093, China) Department of Metallurgy Kunming University of Science and Technology Kunming 650093 China

Ni-W alloys and their composite deposits are electroplated on the metals when an appropriate complex agent is selected on the base of the theories of electrochemistry and complex chemistry, and the principle of induced codeposition. Effects of the bath composition, pH value, temperature and current density on the electrode position of Ni-W alloys and their composite deposits have been investigated, and the effect of heat treatment temperature on the hardness, structure and cohesive force of the amorphous Ni-W alloys and their composite deposits are also discussed. Results showed that the alloys containing more than 44 wt pct W content and the composite deposits containing 7.8 wt pct SiC content could be obtained by making use of the appropriate bath composition and plating conditions. Alloys and their composite deposits with over 44 wt pct W content show amorphous structure. The hardness of amorphous Ni-W alloys and their composite deposits increases obviously when heated, and can reach to 1350 HV and 1520 HV respectively for 46 wt pct W content. The cohesion on Cu, carbon steel and stainless steel is very good.

关键词： SiC Electrodeposition of Ni-W Amorphous Alloy and Ni-W-SiC Composite Deposits Ni

Design of a Student Recommendation Platform Based on Learning Behavior and Habit Training

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Journal of Electronic Research and Application 2024年第6期8卷 112-117页

作者： xiaoyun zhu Yunnan Open University Kunming 650500Yunnan ProvinceChina

This study innovatively built an intelligent analysis platform for learning behavior,which deeply integrated the cutting-edge technology of big data and Artificial Intelligence(AI),\mined and analyzed students’learning data,and realized the personalized customization of learning resources and the accurate matching of intelligent learning *** the help of advanced algorithms and multi-dimensional data fusion strategies,the platform not only promotes positive interaction and collaboration in the learning environment but also provides teachers with comprehensive and in-depth students’learning portraits,which provides solid support for the implementation of precision education and the personalized adjustment of teaching *** this study,a recommender system based on user similarity evaluation and a collaborative filtering mechanism is carefully designed,and its technical architecture and implementation process are described in detail.

关键词： Big data analysis Collaborative filtering Learning behavior analysis Personalized recommendation Intelligent matching

Geological Characteristics and Ore-forming Time of the Dexing Porphyry Copper Ore Mine in Jiangxi Province

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Acta Geologica Sinica(English Edition) 2012年第3期86卷 691-699页

作者： GUO Shuo ZHAO Yuany QU Huanchun WU Dexin XU Hong LI Chao LIU Yan zhu xiaoyun WANG Zengke China University of Geosciences Beijing 100083China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute Academy of Geological SciencesBeijing 100037China National Research Centre of Geoanalysis Beijing 100037China Jiangxi Copper Corporation Dexing Copper Dexing 334200China of Mineral ResourcesChinese

The Dexing porphyry copper ore mine is located in the Qin-Hang metallogenic belt between the Yangtze block and the Cathaysia block. It is a giant porphyry copper mine in China, including 3 ore districts： Tongchang, Fujiawu and zhushahong. Our analyses of Re in molybdenite indicate that the ore-forming material of the copper ore deposits in Dexing should be mainly mantle-derived. Our study fills in a gap in the study of formation time of the Dexing copper mine, and further proves that the copper ore deposits in the three ore districts should be formed simultaneously, about 170 Ma, belonging to the early Yanshan period, and that the formation time of the copper ore deposits should be consistent with the formation time of granodiorite porphyry in which the copper ore deposits are hosted. Promising areas for seeking porphyry copper ore deposits is predicated to be the west or southwest of Dexing.

关键词： Re-Os isotopic dating molybdenite porphyry copper deposit

LIX1-like protein drives hepatic stellate cell activation to promote liver fibrosis by regulation of chemokine mRNA stability

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Signal Transduction and Targeted Therapy 2021年第10期6卷 2950-2953页

作者： xiaoyun zhu Yanqiu Zhang Yucheng Zhao Dejuan Xiang Jie Zou Ourania Andrisani Hao Zhang Lingyi Kong Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjingChina Department of Basic Medical Sciences and Purdue Center for Cancer Research Purdue UniversityWest LafayetteINUSA

Dear Editor,Hepatic stellate cells(HSCs)play a key role in the fibrotic response,thus inactivating activated HSC could be a potential therapy for fibrosis.^(1,2) CCL20 expressed by HSCs and macrophages,may serve as a mediator of in flammation and fibrosis.^(3) LIX1L is a putative RNA-binding protein(RBP)that may play an important role in post-transcriptional gene regulation.^(4) However,the biological function of LIX1L in liver fibrosis remains unclear,we therefore aimed to characterize its functions in HSC activation and liver fibrosis.

关键词： CCL20 liver activation

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高银含量银包铜粉镀层结构及性能研究

稀有金属材料与工程 2012年第11期41卷 2017-2020页

作者：胡磊朱晓云昆明理工大学云南昆明650093

采用化学镀法制备具有高银含量、一定厚度、致密性好的银包铜粉,用SEM、XRD、粒度分布仪、数字欧姆表和差热分析仪表征了镀银铜粉和原始铜粉的表面形貌、表面结构及导电性能。结果表明:高银含量银包铜粉表面镀层致密性好、包覆完全,包... 详细信息

采用化学镀法制备具有高银含量、一定厚度、致密性好的银包铜粉,用SEM、XRD、粒度分布仪、数字欧姆表和差热分析仪表征了镀银铜粉和原始铜粉的表面形貌、表面结构及导电性能。结果表明:高银含量银包铜粉表面镀层致密性好、包覆完全,包覆层厚度达到336nm,同时具有较好的导电性和抗氧化性。

关键词：高银含量银包铜粉导电性抗氧化性

Application of Bayesian Analysis Based on Neural Network and Deep Learning in Data Visualization

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Journal of Electronic Research and Application 2024年第4期8卷 88-93页

作者： Jiying Yang Qi Long xiaoyun zhu Yuan Yang Yunnan Open University Kunming 650224Yunnan ProvinceChina

This study aims to explore the application of Bayesian analysis based on neural networks and deep learning in data *** research background is that with the increasing amount and complexity of data,traditional data analysis methods have been unable to meet the *** methods include building neural networks and deep learning models,optimizing and improving them through Bayesian analysis,and applying them to the visualization of large-scale data *** results show that the neural network combined with Bayesian analysis and deep learning method can effectively improve the accuracy and efficiency of data visualization,and enhance the intuitiveness and depth of data *** significance of the research is that it provides a new solution for data visualization in the big data environment and helps to further promote the development and application of data science.

关键词： Neural network Deep learning Bayesian analysis Data visualization Big data environment

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掺杂导电增强相对铝电极性能的影响

材料导报 2021年第8期35卷 82-87页

作者：汪冲朱晓云龙晋明昆明理工大学材料科学与工程学院昆明650093 昆明贵信凯科技有限公司昆明650039

掺杂不同含量的石墨烯、碳纳米管、纳米银、银包铝粉作为导电增强相制备铝浆,将其印刷在氧化锌基片上并在680℃烧结得到铝电极,研究不同导电增强相对铝电极的导电性和附着力等性能的影响。采用四探针法测定铝电极方阻,通过二次烧结银电... 详细信息

掺杂不同含量的石墨烯、碳纳米管、纳米银、银包铝粉作为导电增强相制备铝浆,将其印刷在氧化锌基片上并在680℃烧结得到铝电极,研究不同导电增强相对铝电极的导电性和附着力等性能的影响。采用四探针法测定铝电极方阻,通过二次烧结银电极,使用拉力试验机测定铝电极的附着力。采用扫描电镜(SEM)、X射线衍射仪(XRD)等手段对掺杂导电增强相铝电极的显微组织、形貌及成分等进行表征。结果表明:碳纳米管和石墨烯的掺杂量分别为1%、2%(质量分数,下同)时,铝电极导电性的提高效果较好,当掺杂量分别高于1.5%、3%时,铝电极表面形貌及组织会被破坏,导致铝电极导电能力差、附着力低;掺杂纳米银对铝电极导电性的提高效果最好,掺杂后铝电极表面平滑光整、组织致密均匀、金属光泽度高、附着力好。掺杂6%纳米银制备S3组铝电极,测定其平均方阻为0.22Ω/,该铝电极与氧化锌基体的附着力达到8.9 N/mm^(2)。同时,为了探究铝电极的稳定性,实验测定了掺杂不同导电增强相的铝电极在室温60 d内的电阻变化率。结果表明:各组铝电极电阻在室温环境下变化均较小,掺杂纳米银的铝电极电阻变化率最小,为0.98%;掺杂碳纳米管的铝电极电阻变化率最大,为1.52%。

关键词：掺杂铝电极导电增强相

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历史坐标中的法国“学院派”

中国国家博物馆馆刊 2018年第4期 114-119页

作者：朱晓云中国国家博物馆北京100006

学院派艺术始于16世纪末的意大利,后逐渐成为欧洲主流艺术流派。特别是法国学院派,因官方的格外重视与高度参与而成为18、19世纪法国艺术的代表形式,并奠定了法国作为欧洲艺术中心的地位。然而长期以来,学院派被视为印象派的敌人,为腐... 详细信息

学院派艺术始于16世纪末的意大利,后逐渐成为欧洲主流艺术流派。特别是法国学院派,因官方的格外重视与高度参与而成为18、19世纪法国艺术的代表形式,并奠定了法国作为欧洲艺术中心的地位。然而长期以来,学院派被视为印象派的敌人,为腐朽、僵化、保守的形象所笼罩。本文试从历史的维度,重温"学院"以及学院派在法国的发展,再现学院派在自由与权力的博弈中摸索前行,并逐渐形成现代法国美术教育与创作机制的特殊经历。

关键词：法兰西美术院巴黎国立高等美术学院沙龙