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Photonics Research 2024年第6期12卷 1303-1312页

作者： YANXIAN guo YE LIU CHAOCAI LUO YUE ZHANG YANG LI FEI ZHOU zhouyi guo ZHENGFEI ZHUANG ZHIMING LIU School of Electronic Engineering and Intelligentization Dongguan University of TechnologyDongguan 523808China Department of Physics University of Science and Technology of ChinaHefei 230026China MOE Key Laboratory of Laser Life Science&Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Rapid detection of pathogens present on contaminated surfaces is crucial for food safety and public health due to the high morbidity and mortality of bacterial ***,a sensitive and efficient method for on-site identification of foodborne pathogens on anisotropic surfaces was developed by using an in situ instantaneously prepared surface-enhanced Raman scattering(SERS)*** achieve this,molybdenum-doped gallic acidderived carbon dots(MCDs)are utilized as the reductant for synthesizing Au@MCDs nanohybrids within just 3 s at ambient *** synergistic effect of the electromagnetic enhancement and charge transfer of Au@MCDs enables excellent SERS performance 10 times stronger than bare Au *** bioassay platform requires less than 5 min to complete the quantitative detection of foodborne pathogens on various microbial-contaminated interfaces with a sensitivity of 10 CFU/m *** innovative strategy breaks the long-standing limitations of SERS substrates in practical use,such as the time-consuming process,interference of residual surfactants,poor surface stability,and few application scenarios,providing a promising tool for widespread applications in biomedical research and clinical diagnostics.

关键词： temperature molybdenum consuming

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Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics

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Chinese Chemical Letters 2024年第9期35卷 232-237页

作者： Yiqiao Chen Ao Liu Biwen Yang Zhenzhen Li Binggang Ye zhouyi guo Zhiming Liu Haolin Chen Department of Anesthesiology General Hospital of Southern Theater Command of People’s Liberation ArmyGuangzhou 510010China MOE Key Laboratory of Laser Life Science&Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Healthy Medical Engineering Technology Research Center Guangdong Food and Drug Vocational CollegeGuangzhou 510520China

Theranostic carbon dots(CDs)have attracted widespread attention recently due to their tunable optical properties and diverse *** fluorescent imaging application,the photothermal property endows CDs with the potential for microbial ***,realization of the effective conversion between fluorescence and heat in one CD system has rarely been ***,we provide a simple strategy for targeted microbial theranostics based on 4-carboxyphenylboronic acid-derived CDs(PCBA-CDs)which possess concentration-dependent photoluminescence/photothermal *** lower concentrations,PCBA-CDs show bright and stable fluorescent signals ranging from blue to *** fluorescence intensity gradually decreases with increasing concentration,while on the contrary,the photothermal effect of PCBA-CDs ascends progressively due to the rearrangement of electronic transitions in aggregated ***-CDs also demonstrate high affinity to the polysaccharide structures on the surface of microbe which allows rapid microbial fluorescence imaging as well as specific photothermal ablation of pathogens in skin wounds using PCBA-CDs at lower and higher concentrations,*** study supplies a facile nanotheranostic strategy for just-in-time microbial management using bioactive CDs.

关键词： Theranostic carbon dots Fluorescence imaging Phenylboronic acid Photothermal therapy Nanotheranostic

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Monitoring the penetration and accumulation of gold nanoparticles in rat skin ex vivo using surface-enhanced Raman scattering spectroscopy

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 71-81页

作者： Honglian Xiong zhouyi guo Huiqing Zhong Yanhong Ji Sun-Yat sen University Cancer Center Guangzhou 510060 P.R.China Institute of Laser Life Science College of Biophotonics South China Normal UniversityGuangzhou 510631P.R.China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510006 P.R.China

Contamination by accidental cutaneous contact with the commercial products and the air pol-hutants raised a considerable health and safety *** study aimed to trace the dynamics of the 20 nm gold nanopartide(GNP)penetration and accumulation in rat skin tissues using a surface-enhanced Raman scattering(SERS)*** the topical application of GNPs on rat skin surface,the SERS spectra were recorded for every 15 pum to an overall depth of 75 pum from skin surface for 150 *** processes of GNP penetration in rat skin were accompanied by aggregation of GNPs,which affected SERS *** results revealed that 20 nm GNPs can penetrate through stratum corneum layer,viable epidermis layer,and then into dermis *** study demonstrated for the first time the potential of SERS spectroscopy to monitor the penetration and accumulation of GNPs in rat skin.

关键词： Surface enhanced Raman scattering spectroscopy rat skin gold nanopartide pene-tration aggregation.

Study on cerebral microcirculation by Optical Doppler Tomography

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Science China(Physics,Mechanics & Astronomy) 2008年第12期51卷 1883-1891页

作者： MENG Jie DING ZhiHua YANG Yong guo zhouyi State Key Laboratory of Modern Optical Instrumentation Zhejiang UniversityHangzhou 310027China Key Laboratory of Laser Life Science Ministry of EducationSouth China Normal UniversityGuangzhou 510631China Institute of Biomedical Engineering Hangzhou Dianzi UniversityHangzhou 310018China

Optical Doppler Tomography (ODT) provides a novel method to measure the blood flow velocity in vessels with the diameter at micrometer scale. Rats with cranial window are used as a model, and the changes in the blood flow velocity of cerebral arterioles in sensory cortex are measured in real time with an established ODT system, under electrical stimulation and drug administration. The results show significant differences in the blood flow velocity between experimental groups and control groups, demonstrating the feasibility of ODT in the cerebral microcircula- tion study. Compared with the conventional Doppler ultrasound, ODT provides much higher spatial resolution, and thus holds a promising future in the application of the cerebral microcirculation study, especially in the observation of the blood flow velocity in micrometer scale vessels.

关键词： Optical Doppler Tomography cerebral microcirculation blood flow velocity electrical stimulation drug administration

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Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway

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Regenerative Biomaterials 2020年第3期7卷 303-311页

作者： Deqiu Huang Fujian Zhao Wendong Gao Xiaofeng Chen zhouyi guo Wen Zhang MOE Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou 510631GuangdongChina Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641GuangdongChina Department of Medical Biotechnology School of Basic Medical SciencesGuangzhou University of Chinese MedicineGuangzhouGuangdongChina

Strontium-substituted bioactive glass(Sr-BG)has shown superior performance in bone ***-BG-induced osteogenesis has been extensively studied;however,Sr-BG-mediated osteoclastogenesis and the underlying molecular mechanism remain *** is recognized that the balance of osteogenesis and osteoclastogenesis is closely related to bone repair,and the receptor activators of nuclear factor kappaB ligand(RANKL)signaling pathway plays a key role of in the regulation of ***,we studied the potential impact and underling mechanism of strontium-substituted sub-micron bioactive glass(Sr-SBG)on RANKL-induced osteoclast activation and differentiation in *** expected,Sr-SBG inhibited RANKL-mediated osteoclastogenesis significantly with the experimental performance of decreased mature osteoclasts formation and downregulation of osteoclastogenesis-related gene ***,it was found that Sr-SBG might suppress osteoclastogenesis by the combined effect of strontium and silicon released through inhibition of RANKL-induced activation of p38 and NF-κB *** results elaborated the effect of Sr-SBG-based materials on osteoclastogenesis through RANKLinduced downstream pathway and might represent a significant guidance for designing better bone repair materials.

关键词： strontium-substituted sub-micron bioactive glass osteoclastogenesis RANKL signaling pathway RAW264.7

A saccharides sensor developed by symmetrical optical waveguide-based surface plasmon resonance

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 19-25页

作者： Ang Li zhouyi guo Qing Peng Chan Du Xida Han Le Liu Jun guo Yonghong He Yanhong Ji MOE Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of Biophotonics South China Normal University Guangzhou 510631P.R.China Department of Ophthalmology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092P.R.China Shenzhen Key Laboratory for Minimal Invasive Medical Technologies Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China MOE Key Laboratory of Laser Life Science College of Biophotonics South China Normal University Guangzhou 510631P.R.China

We proposed a new saccharides sensor developed by symmetrical optical waveguide(SOW)-based surface plasmon resonance(SPR).This unique MgF_(2)/Au/MgF_(2)/Analyte film structure results in longer suface plasmon wave(SPW)propagation lengths and depths,leading to an increment of *** this paper,we managed to decorate the dielectric interface(MgF_(2) layer)by depositing a thin polydopamine film as surface adherent that provides a platform for secondary reactions with the probe molecule.3-Aminophenylboronic acid(3-PBA)is chosen to be the saccharides sense probe molecule in the present *** aqueous huumnor of Diabetes and Cataract patient whose blood glucose level is normal are analyzed and the results dermonstrated that this sensor shows great potential in monitoring the blood siugar and can be adapted in the field of biological monitoring in the future.

关键词： Saccharides sensor surface plasmon resonance symmetrical optical waveguide 3-Aminophenylboronic acid dopamine

Rapid label-free SERS detection of foodborne pathogenic bacteria based on hafnium ditelluride-Au nanocomposites

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Journal of Innovative Optical Health Sciences 2020年第5期3卷 105-115页

作者： Yang Li Yanxian guo Binggang Ye Zhengfei Zhuang Peilin Lan Yue Zhang Huiqing Zhong Hao Liu zhouyi guo Zhiming Liu SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science College of Biophotonics South China Normal University GuangzhouGuangdong 510631P.R.China Healthy Medical Engineering Technology Research Center Guangdong Food and Drug Vocational College Guangzhou 510520 P.R.China

Two-dimensional(2D)nanomaterials have captured an increasing attention in biophotonics owing to their excellent optical ***,2D hafnium ditelluride(HfTe_(2)),a new member of transition metal tellurides,is exploited to support gold nanoparticles fabricating HfTe_(2)-Au *** nanohybrids can serve as novel 2D surface-enhanced Raman scattering(SERS)substrate for the label-free detection of analyte with high sensitivity and *** mechanism originated from HfTe_(2) nanosheets and the electromagnetic enhancement induced by the hot spots on the nano-hybrids may largely contribute to the superior SERS effect of HfTe_(2)-Au ***,HfTe_(2)-Au nanocomposites are utilized for the label-free SERS analysis of foodborne pathogenic bac-teria,which realize the rapid and ultrasensitive Raman test of Escherichia coli,Listeria mono-cytogenes,Staphylococcus aureus and Salmonella with the limit of detection of 10 CFU/mL and the maximum Raman enhancement factor up to 1.7×10^(8).Combined with principal component analysis,HfTe_(2)-Au-based SERS analysis also completes the bacterial classification without extra treatment.

关键词： Two-dimensional nanomaterials hafnium ditelluride surface-enhanced Raman scattering foodborne pathogenic bacteria

In vivo experimental study of optical characteristics of human acupuncture points

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Frontiers of Optoelectronics 2011年第2期4卷 223-227页

作者： Yimei HUANG Hongqin YANG Yuhua WANG Shusen XIE zhouyi guo Songhao LIU Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education Fujian Provincial Key Laboratory of Photonic Technology Institute of Laser and Optoelectronics Technology Fujian Normal University Laboratory of Photonic Traditional Chinese Medicine and Key Laboratory of Laser Life Science of Ministry of Education South China Normal University

Effective attenuation coefficients and diffuse reflectance spectra of acupuncture point and non-acupuncture point were measured in vivo before and after the brachial artery was constricted with a *** results showed that the effective attenuation coefficient of acupuncture point was smaller than that of non-acupuncture point. When the brachial artery was constricted, the effective attenuation coefficients of acupuncture point and non-acupuncture point ***, the increasing amplitude of effective attenuation coefficient of acupuncture point was smaller than that of the non-acupuncture point. Diffuse reflectance of acupuncture point was lower than that of non-acupuncture point within the wavelength range of 470 to 600 nm. Both the diffuse reflectance of acupuncture point and nonacupuncture point decreased after the brachial artery was constricted. These experimental results indicated that the optical characteristics of acupuncture point tissues were correlated with the physiologic changes. Therefore, these optical characteristics of acupuncture points would be helpful to study the mechanism of acupuncture meridian.

关键词： effective attenuation coefficient diffuse reflectance spectrum acupuncture point oxy-hemoglobin brachial artery

Redox responsive nanoparticle encapsulating black phosphorus quantum dots for cancer theranostics

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Bioactive Materials 2021年第3期6卷 655-665页

作者： Haolin Chen Zhiming Liu Bo Wei Jun Huang Xinru You Jingyang Zhang Zhiling Yuan Zhilie Tang zhouyi guo Jun Wu Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province School of Biomedical EngineeringSun Yat-sen UniversityGuangzhou510006China MOE Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou510631China School of Physics and Telecommunication Engineering South China Normal UniversityGuangzhou510006China

Effective cancer treatment puts high demands for cancer *** cancer diagnostics,optical coherence tomography(OCT)technology(including photothermal optical coherence tomography(PT-OCT))has been widely investigated since it induces changes in optical phase transitions in tissue through environmental changes(such as temperature change for PT-OCT).In this report,redox responsive nanoparticle encapsulating black phosphorus quantum dots was developed as a robust PT-OCT ***,black phosphorus quantum dots(BPQDs)are incorporated into cysteine-based poly-(disulfide amide)(Cys-PDSA)to form stable and biodegradable *** excellent photothermal feature allows BPQD/Cys-PDSA nanoparticles(NPs)as a novel contrast agent for high-resolution PT-OCT *** Cys-PDSA can rapidly respond to glutathione and effectively release BPQDs and drugs in vitro and in *** the obtained NPs exhibit excellent near-infrared(NIR)photothermal transduction efficiency and drug delivery capacity that can serve as novel therapeutic platform,with very low chemo drug dosage and side *** of the polymer and BPQD are degradable,indicating this platform is a rare PT-OCT agent that is completely ***,our research highlights a biodegradable and biocompatible black phosphorus-based nanoagent for both cancer diagnosis and therapy.

关键词： Optical coherence tomography Black phosphorus Theranostic Photothermal Cancer therapy

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering

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Journal of Innovative Optical Health Sciences 2023年第2期16卷 3-15页

作者： Xiao Ma Honglian Xiong Jinhao guo Zhiming Liu Yaru Han Mingdi Liu Yanxian guo Mingyi Wang Huiqing Zhong zhouyi guo MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University Guangzhou 510631 P.R.China Department of Physics and Optoelectronic Engineering Foshan University Guangdong 528011P.R.China

Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good *** are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental *** with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early ***,it has been proposed as promising biomarkers for diagnosis of early-stage ***,distinguishing different exosomes remain is a major biomedical *** this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%*** with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior *** results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future.

关键词： Exosomes surface-enhanced Raman scattering(SERS) breast cancer convolutional neural model label-free