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Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

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Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen Ling-Feng Wu Gao-Feng Shu Shi-Ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li zhou-guang wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu Lin Shen Hui-Fan Liu Xiang-Hui Zou Juan Zhao Yu Huang Yu-Fan Zhu Zhao-Yu Li Chao Xu Li-Hua Luo Zhi-Qiang Luo Min-Hao Wu Lin Cai Xiao-Kun Li zhou-guang wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 ***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

A Novel Method for Forecasting Freak Wave Occurrence in A Short Crested Coastal Sea

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China Ocean Engineering 2024年第1期38卷 104-116页

作者： wang Ying-guang State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China

In order to forecast the distribution of crest amplitudes and the occurrence of freak waves in a short crested coastal sea,a novel transformed linear simulation method is initially proposed in this paper.A Hermite transformation model expressed as a monotonic cubic polynomial serves as the foundation for the novel simulation *** wave crest amplitude exceedance probabilities of two sea states-one with a directional wave spectrum based on the measured wave elevation data at the Yura coast and the other with a typical directional JONSWAP wave spectrum-have been predicted using the novel simulation method that has been *** likelihood that a particular critical wave crest amplitude will be exceeded is directly correlated with the probability that freak waves will *** is shown that the novel simulation approach suggested can provide predictions that are more precise than those obtained from the Rayleigh crest amplitude distribution model,the Jahns and Wheeler crest amplitude distribution model,or the conventional linear simulation *** study also demonstrated that the nonlinear simulation method is less effective than the novel simulation method in terms of efficiency.

关键词： wave crest amplitude freak waves short crested sea transformed linear simulation

Numerical investigation on compressible flow around a cylinder in proximity to the heated wall

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Journal of Hydrodynamics 2024年第3期36卷 519-533页

作者： Yu-lu Liu Jun-wang Qu Yi-zhou Tao Yong-guang Lyu Xiang Qiu Shanghai Institute of Technology School of ScienceShanghai201418China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China

In this study,direct numerical simulations were conducted to investigate the compressible flow around a circular cylinder near a heated wall at a Reynolds number(Re)of 500 and a Mach number(Ma)of *** heating ratio T^(*)ranging from 1.0 to 1.6 represents the different situations of a heated wall,whereas the gap ratio ranges from 0.3 to *** study analyzed the impact of heating effect and wall proximity on flow characteristics and aerodynamic *** results indicated that the stability of the flow was enhanced as the gap ratio decreased or the heating ratio *** the calculation of enstrophy,it was found that the strength of shedding vortices weakens with a decrease in gap ratio or an increase in heating ***,the mean drag coefficient decreases as the heating ratio increases or the gap ratio *** contrast,the mean lift coefficient initially decreases and then increases as the gap ratio ***,the drag reduction mechanism was analyzed by examining the pressure distribution on the surface of the cylinder.

关键词： Compressible flow wall proximity heating effect stability enstrophy

Metasurface-assisted low-frequency performance enhancement of ultra-broadband honeycomb absorber based on carbon nanotubes

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Nano Research 2024年第9期17卷 8542-8551页

作者： Cai-Liang wang Shuang Bai Pei-Yan Zhao Tao zhou Hui-Ya wang Jun-Peng wang Luo-Xin wang guang-Sheng wang School of Chemistry Beihang UniversityBeijing 100191China Aerospace Science and Industry Corporation of Wuhan Magnetoelectricity Co. Ltd.Wuhan 430070China College of Materials Science and Engineering Key Laboratory for New Textile Materials and Applications of Hubei ProvinceWuhan Textile UniversityWuhan 430200China School of Chemistry and Chemical Engineering Lingnan Normal UniversityZhanjiang 524048China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Here,we present a unique method to enhance the low-frequency absorption performance of a honeycomb absorber by integrating a *** geometrical dimensions of the proposed metasurface have been numerically *** introduction of the metasurface allows exploitation of its robust resonance and superior impedance matching in low-frequency bands,thereby improving microwave absorption *** incorporation of the metasurface does not impact the wave transmission performance of the honeycomb core absorber at high-frequency band,thus preserving its high-frequency *** broadens the absorption range,leading to an expanded *** results reveal that the composite absorber(CA)exhibits strong absorption performance with an incident angle stability up to 45°for both transverse electric(TE)and transverse magnetic(TM)*** absorption mechanism of the CA has been investigated by using an equivalent circuit model and electromagnetic field analysis.A prototype was designed,fabricated,and tested to validate the proposed *** simulation and measurement results demonstrate that the prototype can achieve an average absorption rate exceeding 90%across a 1.0-18.0 GHz *** study introduces an innovative technique for creating microwave absorbers for low-frequency wideband applications.

关键词： low frequency metasurface radar absorption impedance matching

Synthesis-temperature-dependent phase composition manipulation toward high thermoelectric performance in tetrahedrites

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Journal of Materials Science & Technology 2024年第1期168卷 124-130页

作者： Yiqing Wei Jiaqi Liu Zien Cheng Pengfei Jiang Zizhen zhou Bin Zhang Guoyu wang guang Han Xu Lu Xiaoyuan zhou Center of Quantum Materials and Devices College of PhysicsChongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Tetrahedrite,an Earth-abundant natural mineral,has attracted extensive research interest because of its excellent thermoelectric ***,tetrahedrite samples comprising Cu-poor Cu_(12)Sb_(4)S_(13)and Cu-rich Cu_(14)Sb_(4)S_(13)phases have been synthesized using a colloidal method,in which the ratio of two phases is manipulated by controlling the synthesis temperature to improve the thermoelectric *** is found that an ultralow total thermal conductivity of∼0.3 W m^(−1)K^(−1)at 723 K is realized in the sample with a Cu-rich phase fraction of∼50%,which can be attributed to maximized phonon scattering by phase *** a result,combined with a decent power factor,this sample obtains an optimal zT of 1.15,which is about 85%higher than that of the sample with a Cu-rich phase fraction of∼64%and comparable to zT values of other eco-friendly,abundant Cu-based thermoelectric *** work demonstrates an effective synthesis-temperature-dependent phase composition manipulation strategy toward enhanced thermoelectric performance in tetrahedrites.

关键词： Tetrahedrite Thermoelectric Colloidal method Phase manipulation Thermal conductivity

Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

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Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi Meng Kaiwen wang Yang wang Jiangping Ma Chaogang Ban Yajie Feng Bin Zhang Kai zhou Liyong Gan guang Han Danmei Yu Xiaoyuan zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key Lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation

Killing effect of Chinese hamster V79 cells exposed to accelerated carbon ions and RBE determination

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Nuclear Science and Techniques 2002年第4期13卷 259-263页

作者： LI Qiang, zhou guang-Ming, wang Ju-Fang, LI Wen-Jian, WEI Zeng-Quan(Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) Institute of Modern Physics the Chinese Academy of Sciences Lanzhou 730000

Survival curves of Chinese hamster V79 cells exposed to accclerated carbon ions with linear energy transfers of 125.5, 200 and 700 keV/μm were measured, respectively. Inactivation cross sections corresponding to the irradiation above were deduced from the V79 cell survival curves. They are 7.86±0.17, 10.44±1.11 and 32.32±3.58 μm2 in turn. With the surviving response of V79 cells to 60Co γ-rays as a reference value, relative biological effectiveness at 10%, 20%, 50% and 80% survival levels were given for the accelerated carbon ions. The results showed that carbon ions with LET of 125.5 keV/μm had a higher value of RBE at all the four survival levels than the carbon ions with other LETs. It was prompted that the maximum value of RBE for the V79 cell surviving as the biological endpoint emerged at the LET below 200 keV/μm for carbon ions.

关键词：放射生物学碳离子 V79细胞

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

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Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU Wei Qiong zhou Wei guang zhou guang Wei LIAO Jia Xi SHI Jia Xing XIE FengYang LI Shou Heng wang Yong FENG Xian Hong GU Xiu Li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis