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三尖瓣反流动物模型研究进展

复旦学报（医学版） 2024年第2期51卷 257-261页

作者：林大卫张晓春张峰潘文志周达新复旦大学附属中山医院心内科上海200032 上海市心血管病研究所上海200032

我国三尖瓣反流(tricuspid regurgitation,TR)患者分布广,合并症多。中重度TR患者临床药物疗效不佳,且外科手术风险较高,发展为右心衰后预后差。近年来随着瓣膜器械创新与技术发展,经导管三尖瓣手术有望为外科手术中高风险的TR患者提供... 详细信息

我国三尖瓣反流(tricuspid regurgitation,TR)患者分布广,合并症多。中重度TR患者临床药物疗效不佳,且外科手术风险较高,发展为右心衰后预后差。近年来随着瓣膜器械创新与技术发展,经导管三尖瓣手术有望为外科手术中高风险的TR患者提供新的选择。国内外的经导管三尖瓣手术治疗正处于早期探索和临床验证阶段,涌现出许多模拟临床TR的动物模型,用来进行三尖瓣器械的研发及机制探究。因此,本综述聚焦于如何建立TR动物模型,并比较不同方法的优缺点。

关键词：三尖瓣三尖瓣反流(TR) 动物模型

用于女性偏头痛患者分流和临床决策的偏头痛患者卵圆孔未闭风险预测模型

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复旦学报（医学版） 2024年第4期51卷 505-514页

作者：张晓春范家宁朱丽张峰林大卫王婉凌潘文志周达新葛均波复旦大学附属中山医院心内科上海200032 复旦大学附属金山医院心内科上海201508 美国东北大学数据分析系波士顿02115

目的探究合并卵圆孔未闭(patent foramen ovale,PFO)女性偏头痛患者的临床特征并设计女性偏头痛患者PFO风险预测模型(migraineur PFO risk prediction model,MPRPM)。方法选取2019年6月1日至2022年12月31日期间于复旦大学附属中山医院... 详细信息

目的探究合并卵圆孔未闭(patent foramen ovale,PFO)女性偏头痛患者的临床特征并设计女性偏头痛患者PFO风险预测模型(migraineur PFO risk prediction model,MPRPM)。方法选取2019年6月1日至2022年12月31日期间于复旦大学附属中山医院就诊的女性偏头痛患者。收集患者术前信息以及停药后的随访结果,并根据食管超声结果,将患者分为PFO阳性组和PFO阴性组。构建多因素Logistic回归模型和随机森林模型并对其多维度验证。根据准确率下降系数(mean decrease accuracy,Mda)筛选关键特征并构建MPRRM。结果共纳入305名女性患者,其中PFO阳性组204人,PFO阴性组101人,多因素Logistic回归分析显示,偏头痛发病年龄、发作频率、发作时严重影响生活、运动相关性头痛、月经引起的头痛、先兆性偏头痛和隐源性脑卒中病史是PFO阳性患者的预测因素。随机森林模型可以预测女性偏头痛患者PFO发病率,其AUC为0.895(95%CI:0.847~0.943)。MPRPM的灵敏度为71.6%,特异度为91.1%(AUC:0.862,95%CI:0.818~0.906,P<0.001)。最佳临界值为2.5分。模型分类正确的患者症状改善率高于分类不正确的患者(94.3%vs.82.0%,P=0.023)。结论确定了女性偏头痛患者合并PFO的预测因素。MPRPM可为女性偏头痛患者的诊断过程和治疗决策提供指导,辅助偏头痛患者就诊分流,减轻医疗负担。

关键词：卵圆孔未闭(PFO) 偏头痛机器学习预测因子预测模型

Simulation of Light Intensification Induced by Defects of Polished Fused Silica

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Chinese Physics Letters 2011年第1期28卷 109-111页

作者： WANG Feng-Rui LIU Hong-Jie HUANG Jin zhou xin-da JIANG Xiao-Dong WU Wei-Dong ZHENG Wan-Guo JU xin Research Center of Laser Fusion China Academy of Engineering Physics Mianyang 621900 Department of Physics University of Science and Technology Beijing Beijing 100083

Light intensity distribution in the vicinity of inclusions and etched cracks in polished fused silica at wavelength scale are simulated by using the finite-difference time-domain algorithm. Light intensity enhancement factor as functions of diameter and refractive index of inclusions are investigated, more than 10 times that of incident beam is obtained in the simulation. We model the etched crack in close proximity to a real structure, which is characterized by AFM. We find that the peak light intensity of the crack is a function of its cross sectional breadth depth ratio, providing good hints for the effective processing of fused silica samples to improve the damage threshold.

关键词： Computational physics Condensed matter: electrical magnetic and optical Condensed matter: structural mechanical & thermal

Expression of intercellular adhesive molecule-1 in liver cancer tissues and liver cancer metastasis

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World Journal of Gastroenterology 1998年第3期4卷 22-25页

作者： SUN Jing Jing, zhou xin da, zhou Ge and LIU Yin Kun

AIM To study the relationship between intercellular adhesive molecule 1 (ICAM 1) and liver cancer metastasis and to search for factors to predict metastasis of liver cancer. METHODS ICAM 1 expression in fresh tissues of normal liver and hepatocellular cancer (HCC) was examined by immunoperoxidase staining. The expression of ICAM 1 in human hepatoma, tumor surrounding tissues and normal livers were semiquantitatively analyzed by Dot immuno blot. Tissue ICAM 1 expression at mRNA level was detected by Northern blot. RESULTS All 6 cases of normal liver samples were negative in anti ICAM 1 immunohistochemical staining, 80 0% (36/45) of HCC presented various ICAM 1 expression. The number of positive cells was a little higher in large tumors, tumors with intact capsule and metastasis, but there was no significant difference. Two cases with cancer embolus also had high ICAM 1 expression. ICAM 1 concentration in HCC (13 43±0 09) was higher than that in tumor surrounding tissues (5 89±0 17, P <0 01) and normal livers (4 27±0 21, P <0 01). It was also higher in metastasis group (20 24±0 30) than in nonmetastasis group (10 23±0 12, P <0 05). Northern blot analysis revealed that ICAM 1 expression at mRNA level was also higher in HCC and cancer embolus than that in tumor surrounding tissues and normal livers. CONCLUSION Tissue ICAM 1 could indicate the growth and metastasis of HCC, and may be an index that can predict liver cancer metastasis.

关键词： liver cancer tumor metastasis intercellular adhesion molecule 1

支撑鞘与圈套导丝平行锚定技术在经导管三尖瓣置换术中的应用1例

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中国介入心脏病学杂志 2024年第8期32卷 478-480页

作者：方雁行潘文志周达新葛均波复旦大学附属中山医院心内科、上海市心血管病研究所、国家放射与治疗临床医学研究中心上海200032

经导管三尖瓣置换术(TTVR)创伤小,恢复快,围术期死亡率远低于外科手术,是三尖瓣外科置换术后生物瓣膜衰败患者的首选治疗方式。但是当输送系统体积较大时,由于外科换瓣后瓣口面积减小,瓣架限制操作,可能会出现输送系统推进困难,并且由... 详细信息

经导管三尖瓣置换术(TTVR)创伤小,恢复快,围术期死亡率远低于外科手术,是三尖瓣外科置换术后生物瓣膜衰败患者的首选治疗方式。但是当输送系统体积较大时,由于外科换瓣后瓣口面积减小,瓣架限制操作,可能会出现输送系统推进困难,并且由于右心路径曲折,导丝提供的支撑力有限,操作难度也会有所增加。本病例报道中的患者即为外科三尖瓣置换后生物瓣衰败,在进行TTVR时出现输送系统跨瓣困难,笔者团队及时运用本中心提出的支撑鞘与圈套导丝平行锚定(PASS)技术,使用大尺寸支撑鞘联合圈套器套住主路加硬导丝头端,将曲折路径拉直,为加硬导丝提供额外支撑力,最终成功推进输送系统跨过三尖瓣,为破解TTVR术中跨瓣困难提供了切实有效的借鉴。

关键词：经导管三尖瓣置换术输送系统圈套器支撑鞘推进技术

Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-xin zhou Xian Kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1791-1802页

作者： Yin-Jie zhou Zhi-E Tan Wei-da Zhuang xin-Hua Xu Department of Oncology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Nuclear Medicine The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Athe and Intestinal Surgery Cancer Hospital of The Chinese Academy of Medical SciencesBeijing 100021China

BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical ***-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment ***,there is still li-mited research on the factors affecting CSS in mCRC patients and their *** To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with *** data were extracted from the United States Surveillance,Epidemiology,and End Results database from 2018 to *** eligible patients were randomly divided into a training cohort and a validation *** Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external *** A multivariate Cox proportional risk model was used to identify independent risk factors for ***,new CSS columns were developed based on these *** consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:*** calibration map and clinical decision curve showed good agreement and good potential clinical *** risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different *** median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),*** Our study developed a new nomogram model to predict CSS in patients with synchronous *** addition,the risk-grading system helps to accurately ass

关键词： Colorectal tumor Surveillance epidemiology and end results database Nomogram analysis Survival prognosis Retrospective study

Activation of leukotriene B_(4)receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils

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Cellular & Molecular Immunology 2024年第3期21卷 245-259页

作者： Yan xin Sihan Xiong Linghong zhou xin Lin Institute for Immunology and School of Medicine Tsinghua University100084BeijingChina Tsinghua University-Peking University Center for Life Sciences 100084BeijingChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghai200040China

Invasive fungal infections are life-threatening,and neutrophils are vital cells of the innate immune system that defend against *** role of LTA4H-LTB_(4)-BLT1 axis in regulation of neutrophil responses to fungal infection remains poorly ***,we demonstrated that the LTA4H-LTB_(4)-BLT1 axis protects the host against Candida albicans and Aspergillus fumigatus,but not Cryptococcus neoformans infection,by regulating the antifungal activity of *** results show that deleting Lta4h or Blt1 substantially impairs the fungal-specific phagocytic capacity of ***,defective activation of the spleen tyrosine kinase(Syk)and extracellular signal-related kinase(ERK1/2)pathways in neutrophils accompanies this ***,BLT1 regulates CR3-mediated,β-1,3-glucan-induced neutrophil phagocytosis,while a physical interaction with CR3 with slight influence on its dynamics is *** findings thus demonstrate that the LTA4H-LTB_(4)-BLT1 axis is essential for the phagocytic function of neutrophils in host antifungal immune response against Candida albicans and Aspergillus fumigatus.

关键词： LTA4H BLT1 Phagocytosis Complement receptor 3 Fungi

Experimental and numerical investigation of two blended blade and endwall configurations

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Chinese Journal of Aeronautics 2024年第9期37卷 150-163页

作者： Tongtong MENG xin LI Ling zhou Lucheng JI Institute for Aero Engine Tsinghua UniversityBeijing 100084China Schoolof Aerospace Engineering Bejing Institute of TechnologyBeijing 0081China

The Blended Blade and Endwall(BBEW)technique has proven to be effective in control-ling the intersection of boundary layer in corner region of the compressor *** this study,the experiment and analysis of two different BBEW designs are ***,based on a linear cas-cade with 0.7 Mach number inflow,two different configurations,BBEW 1 and BBEW 2,are well ***,according to the experimental result,control effects of these two BBEW configu-rations are validated and compared subsequently under various working *** results demonstrate a reduction in total pressure loss of 12.8%and 29%at the design point for BBEW 1 and BBEW 2,***,the BBEW technique proves effective in suppressing the development of the boundary layer and preventing corner *** by detailed numerical analysis,improvements around the corner region,especially for the boundary layer,are extracted to show the mechanisms and distinctions between the two *** results indicate that BBEW 1 significantly restrains the development of boundary layer before separation occurs,while BBEW 2 directly controls the strength and scale of the corner separation.

关键词： Aerodynamic Computational fluid dynamic Experiment Corner separation Blended Blade and Endwall(BBEW)