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The critical role of BTRC in hepatic steatosis as an ATGL E3 ligase

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Journal of Molecular Cell Biology 2023年第10期15卷 54-64页

作者： Weiwei Qi Zhenzhen Fang Chuanghua Luo Honghai Hong Yanlan Long Zhiyu Dai Junxi Liu Yongcheng Zeng ti zhou Yong Xia Xia Yang Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Department of Clinical Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510006China Department of Internal Medicine University of Arizona College of MedicinePhoenixAZ 85004USA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD),characterized by hepatic steatosis,is one of the commonest causes of liver *** triglyceride lipase(ATGL)is closely related to lipid turnover and hepatic steatosis as the speed-limited triacylglycerol lipase in liver ***,the expression and regulation of ATGL in NAFLD remain ***,our results showed that ATGL protein levels were decreased in the liver tissues of high-fat diet(HFD)-fed mice,naturally obese mice,and cholangioma/hepatic carcinoma patients with hepatic steatosis,as well as in the oleic acid-induced hepatic steatosis cell model,while ATGL mRNA levels were not *** protein was mainly degraded through the proteasome pathway in ***-transducin repeat containing(BTRC)was upregulated and negatively correlated with the decreased ATGL level in these hepatic steatosis ***,BTRC was identified as the E3 ligase for ATGL through predominant ubiquitination at the lysine 135 ***,adenovirus-mediated knockdown of BTRC ameliorated steatosis in HFD-fed mouse livers and oleic acid-treated liver cells via upregulating the ATGL *** together,BTRC plays a crucial role in hepatic steatosis as a new ATGL E3 ligase and may serve as a potential therapeutic target for treating NAFLD.

关键词： adipose triglyceride lipase(ATGL) beta-transducin repeat containing(BTRC) non-alcoholic fatty liver disease(NAFLD) obesity proteasomal degradation

Effect of Wave Nonlinearity on the Instantaneous Seabed Liquefaction

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China Ocean Engineering 2024年第1期38卷 93-103页

作者： WANG Zhao-jun SUI ti-ti ZHANG Chi PAN Jun-ning Key Laboratory of Port Waterway and Sedimentation Engineering of the Ministry of TransportNanjing Hydraulic Research InstituteNanjing 210024China Key Laboratory of Coastal Disaster and Protection(Hohai University) Ministry of EducationNanjing 210098China The National Key Laboratory of Water Disaster Prevention Nanjing 210098China

The nonlinear variation of wave is commonly seen in nearshore area,and the resulting seabed response and liquefaction are of high concern to coastal *** this study,an analytical formula considering the nonlinear wave skewness and asymmetry is adopted to provide wave pressure on the seabed *** liquefaction depth attenuation coefficient and width growth coefficient are defined to quantitatively characterize the nonlinear effect of wave on seabed *** on the 2D full dynamic model of wave-induced seabed response,a detailed parametric study is carried out in order to evaluate the influence of the nonlinear variation of wave loadings on seabed ***,new empirical prediction formulas are proposed to fast predict the maximum liquefaction under nonlinear *** indicate that(1)Due to the influence of wave nonlinearity,the vertical transmission of negative pore water pressure in the seabed is hindered,and therefore,the amplitude decreases significantly.(2)In general,with the increase of wave nonlinearity,the liquefaction depth of seabed decreases *** under asymmetric and skewed wave loading,the attenuation of maximum seabed liquefaction depth is the most significant among all the nonlinear wave ***,highly skewed wave can cause the liquefaction depth of seabed greater than that under linear wave.(3)The asymmetry of wave pressure leads to the increase of liquefaction width,whereas the influence of skewedness is not significant.(4)Compared with the nonlinear waveform,seabed liquefaction is more sensitive to the variation of nonlinear degree of wave loading.

关键词： nonlinear wave seabed response seabed liquefaction numerical simulation liquefaction prediction

Optoelectronic tuning of plasmon resonances via optically modulated hot electrons

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National Science Review 2024年第5期11卷 134-141页

作者： Jiacheng Yao Cheng Wang Chi Zhang Song Ma Li zhou ti Wang Ququan Wang Hongxing Xu Tao Ding Key Laboratory of Artificial Micro Nano Structure of Ministry of Education School of Physics and Technology Wuhan University Department of Physics Southern University of Science and Technology

Fast optical modulation of nanoplasmonics is fundamental for on-chip integration of all-optical *** various strategies have been proposed for dynamic modulation of surface plasmons, critical issues of device compatibility and extremely low efficiency in the visible spectrum hamper the application of optoplasmonic nanochips. Here we establish an optoplasmonic system based on Au@Cu2–xS hybrid core–shell nanoparticles. The optical excitation of hot electrons and their charge transfer to the semiconductor coating(Cu2–xS) lead to lowered electron density of Au, which results in the red shift of the localized surface plasmon resonance. The hot electrons can also transport through the Cu2–xS layer to the metal substrate, which increases the conductance of the nanogap. As such, the coupled gap plasmon blue-shifts with a magnitude of up to ～15 nm, depending on the excitation power and the thickness of the coatings, which agrees with numerical simulations. All of this optoelectronic tuning process is highly reversible, controllable and fast with a modulated laser beam, which is highly compatible and sufficiently useful for on-chip integration of nanophotonic devices.

关键词： hot carriers plasmon switching optoplasmonics circuit modelNPoM

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遥操作训练仿真系统的月球车虚拟样机设计

系统仿真学报 2016年第11期28卷 2701-2708页

作者：苗毅周倜北京航天飞行控制中心北京100094

为适应遥操作训练仿真的需要,研究了基于ADAMS的月球车虚拟样机仿真建模方法,提出了月球车仿真系统框架,建立了月球车本体三维模型,分析了各部件之间的相对运动关系,并对相对固定的部件进行了组合划分,为存在相对运动的部件采用运动副... 详细信息

为适应遥操作训练仿真的需要,研究了基于ADAMS的月球车虚拟样机仿真建模方法,提出了月球车仿真系统框架,建立了月球车本体三维模型,分析了各部件之间的相对运动关系,并对相对固定的部件进行了组合划分,为存在相对运动的部件采用运动副建立了约束关系模型,并采用驱动的方式为各部件的相对运动添加动力力矩。设计了一系列的实验验证太阳翼等活动机构对月球车运动过程中遥测参数仿真的影响。实验结果表明,提出的月球车虚拟样机模型实现了符合机械运动学特征的月面行走与探测仿真,为遥操作训练提供了逼真的训练数据。

关键词：月球车本体模型约束关系训练仿真 ADAMS

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基于计算树的航天遥测参数仿真

系统仿真学报 2017年第5期29卷 1064-1069页

作者：周倜苗毅北京航天飞行控制中心北京100094

航天测控仿真软件在每一次航天测控任务中都需要处理大量测控数据,不同参数的计算方法差别很大,在以往的应用中将计算方法以程序代码的形式固定在软件中,使得仿真系统难以进一步提高其可维护性和软件复用度。通过研究以配置文件的形式... 详细信息

航天测控仿真软件在每一次航天测控任务中都需要处理大量测控数据,不同参数的计算方法差别很大,在以往的应用中将计算方法以程序代码的形式固定在软件中,使得仿真系统难以进一步提高其可维护性和软件复用度。通过研究以配置文件的形式描述测控参数的计算方法,给出了参数计算灵活配置的设计方案,介绍了参数计算方法原理,软件模块、数据结构和处理算法。在该框架下,数据处理算法与软件代码相分离,使软件开发和具体航天型号任务之间的耦合度降低,增强了软件的可复用性,软件的稳定性也得到了有效保障。利用该方法对遥测参数进行了实验,验证了方法的有效性。

关键词：算法计算树配置文件耦合度可复用性

Canonical Wnt Pathway Dysregulation in Diabetic Nephropathy

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Canonical Wnt Pathway Dysregulation in Diabetic Nephropathy

IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

第七届全国医学生物化学与分子生物学和第四届全国临床应用生物化学与分子生物学联合学术研讨会暨医学生化分会会员代表大会

作者： ti zhou Jian-xing Ma Guoquan Gao Department of Biochemistry Zhongshan Medical SchoolSun Yat-sen University The University of Oklahoma Health Sciences Center

Aims/hypothesis The Wnt pathway mediates multiple physiological and pathological processes such as inflammation,angiogenesis and *** present study is to investigate whether the canonical Wnt signaling plays a role in ...

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Cellular & Molecular Immunology 2018年第5期15卷 493-505页

作者： Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi ti zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang Program of Molecular Medicine Affiliated Guangzhou Women and Children’s HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Institute of Pediatrics Affiliated Guangzhou Women and Children's Medical CenterSun Yat-sen UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhou 510063China PancreatoBiliary Surgery First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Engineering and Technology Research Center for Disease-Model Animals SUN Yat-sen UniversityGuangzhou 510006China Department of Radiation Oncology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially *** molecules,including some cytokines,have a close relationship with ***(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively *** serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in ***-25 was decreased in NAFLD patients and obese *** addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating ***-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated ***,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and *** conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes.

关键词： adipocyte immunometabolism IL-25 macrophage obesity

军队医院护理人员前沿外科手术队护理技术现况研究

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联勤军事医学 2024年第5期38卷 419-424页

作者：李景芳何晓庆雷璐敏邱晨何红艳周体陈巧灵曾登芬解放军医学院研究生院北京100853 解放军总医院第四医学中心眼科解放军总医院第四医学中心麻醉科解放军总医院第四医学中心骨科解放军总医院第四医学中心关节运动医学科解放军总医院第四医学中心护理部

目的探索军队护理人员前沿外科手术队(forward surgical team, FST)护理技术的掌握现况,为制定FST护理核心技术培训体系提供参考。方法 2023-02/2023-05月采用整群抽样法选取14所军队三甲医院718名护理人员作为调查对象,采用一般资料... 详细信息

目的探索军队护理人员前沿外科手术队(forward surgical team, FST)护理技术的掌握现况,为制定FST护理核心技术培训体系提供参考。方法 2023-02/2023-05月采用整群抽样法选取14所军队三甲医院718名护理人员作为调查对象,采用一般资料调查表与护理技术测评表对其进行调查。结果军队医院护理人员卫勤训练方式以线下理论培训最多(71.73%),卫勤任务类型以单位组织卫勤演练为主(72.14%),参加过的机动卫勤力量类型以野战医疗所(30.08%)、野战医疗队(29.53%)为主,卫勤任务中组室训练类型以其他组室(32.45%)、重伤救治组(26.46%)为主,94.57%的人员希望增加卫勤方面的培训。718名军队护理人员对FST护理技术中的通用技术模块掌握程度条目均分、培训需求条目均分最高,特殊技术模块掌握程度条目均分、培训需求条目均分最低。不同年龄、工作年限、职称的军队医院护理人员对通用技术和急救技术的掌握程度评分差异具有统计学意义(P均<0.05);不同工作年限、人员类别的军队医院护理人员对损伤控制技术和特殊技术的培训需求评分差异具有统计学意义(P均<0.05)。FST护理技术掌握程度与培训需求呈正相关关系。结论军队护理人员对FST护理技术整体掌握程度属于中等偏上水平,对技术条目的培训需求意愿强烈,应构建完善的FST护理技术培训体系,着重加强损伤控制技术和特殊技术模块知识的培训,为培训一专多能的FST护理队员提供重要参考。

关键词：外科手术队护理人员护理技术掌握程度培训需求

法律视角下对非物质文化遗产档案管理模式的思考

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档案与建设 2015年第3期 29-32页

作者：周倜南京大学信息管理学院江苏南京210093

目前学界对于非物质文化遗产的保护模式主要有私法保护和公法保护两种模式。我国现阶段的非物质文化遗产保护体系主要基于私法保护模式,即知识产权保护模式。本文基于实际案例,叙述并分析了这种保护模式的优势和缺点,旨在对包括非物质... 详细信息

目前学界对于非物质文化遗产的保护模式主要有私法保护和公法保护两种模式。我国现阶段的非物质文化遗产保护体系主要基于私法保护模式,即知识产权保护模式。本文基于实际案例,叙述并分析了这种保护模式的优势和缺点,旨在对包括非物质文化遗产在内的特殊形式档案的保护研究有所裨益。

关键词：非物质文化遗产保护模式知识产权