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Time for a n.w Paradigm in.On.ology? Viewpoin. of the Radiobiologist

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Open.Journ.l of Biophysics 2024年第1期14卷 11-55页

作者： Aleksey n. Shoutko Departmen. of Tran.plan.ation.an. Cells Techn.logies Russian Research Center of Radiology and Surgical Technologies Named after A. M. Granov Saint-Petersburg Russia

The curren. immun.on.ology artificially ign.res the con.ection.with lymphopoiesis, though is on.y its derivative. Hematopoietic stem cells (HSC) provide physiological regen.ration.of biomass of the host, fetus, an. malign.n. tumors, as well, as the cells’ reparation.after sub-lethally in.urin. in.an. tissues an. their ren.wal. HSC, especially of lymphoid lin.age, are the most vuln.rable of those, which are respon.ible for viability of organ.sm. n.tural an. artificial deficits of HSC determin. agin., multi-organ. syn.romes an. death of the host, because their curren. proliferative resource (CPR) is in.ividually limited at birth, an. is spen.in. irreversibly durin. woun.s’ healin., pregn.n.y, tumor growth, an. on. CPR, bein. an.in.egral value of the n.mber of stem cells alon. the len.th of their telomeres, is a “shagreen.skin., for which the tumor competes with n.rmal tissues as a quasi-embryon.c favorite an. win.er, especially in.the fin.l period of a shorten.n. the life. The primary approach to can.er treatmen. must prioritize the preservation.of CPR remn.n.s, rather than.their destruction. in.order to temporarily halt the malign.n. process. The re-targetin. of HSC from tumors in.favor of n.rmal tissues is the immediate objective of competitive therapy, which allows for preservin. the rest of the CPR host’s resources, especially in.patien.s with advan.ed can.er. However, the con.radictory an. in.ign.fican. practically, the dogma of an.itumor cellular immun.ty con.in.es to domin.te an. hin.er progress in.on.ology.

关键词： Lymphopoiesis Proliferatin. Resource Morphogen.sis Can.er-Fetus Reparation.Regen.ration Competitive Therapy

The Effect of a Mon.tomic Layer on.a Surface on.the Tran.ition.Radiation

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Journ.l of High En.rgy Physics, Gravitation.an. Cosmology 2024年第2期10卷 710-723页

作者： Alexan.er n. Safron.v Obukhov In.titute of Atmospheric Physics Russian Academy of Sciences Moscow Russia

The tran.ition.radiation.of a charged particle crossin. the in.erface of two media havin. a mon.tomic impurity layer is in.estigated. It is shown.that at slidin. an.les of in.iden.e of a particle on.the boun.ary of the media, the tran.ition.radiation.is main.y determin.d by the properties of the surface layer. The possibility of usin. tran.ition.radiation.to study the surface of substan.es is discussed. In.addition. due to the hard radiation.presen. in.space, this research may be importan. for the use of light mon.atomic layers as a material for satellite an.en.as, “solar sails” an. cover layers in.a future space (in.erstellar) mission.

关键词： Relativistic Charged Particle Tran.ition.Radiation Mon.tomic Layer Spectral An.ular Distribution.of Radiation Slidin. An.le In.estigation.of Thin.Films In.erstellar Mission

Life Origin.in.the Milky Way Galaxy: III. Spatial Distribution.of Overheated Stars in.the Solar n.ighborhood

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Journ.l of High En.rgy Physics, Gravitation.an. Cosmology 2024年第2期10卷 693-709页

作者： Alexan.er n. Safron.v Obukhov In.titute of Atmospheric Physics Russian Academy of Sciences Moscow Russia

A con.ept of en.emble averaged stellar reactors is developed to study the dyn.mics of processes occurrin. in.stars, allocated in.the ~200 pc solar n.ighborhood. Accordin. to the effective temperature value, four stellar classes are iden.ified, for which the correlation.coefficien.s an. stan.ard deviation.are coun.ed. The theory of the buoyan.y terrestial elemen.s is gen.ralized to stellar systems. It was suggested that stars are over-heated due to the shift parameters of the n.clear processes occurrin. in.ide the stars, which leads to the syn.hesis of tran.uran.um elemen.s un.il the achievemen. of a critical n.clear mass an. star explosion. The heavy tran.uran.um elemen.s sin. down.ard an. are con.en.rated in.the stellar depth layers. The physical explan.tion.of the existen.e of the critical Chan.rasekhar star limit has been.offered. Based on.the spatial an.lysis of overheated stars, it was suggested that the withdrawal of the stellar reactor from the equilibrium state is a con.equen.e of extragalactic compression.in.ide the galaxy arm due to the arm spirality (n.t to be con.used with the spirality of the galaxy itself).

关键词： Stellar n.cleogen.sis En.emble-Averaged Stellar Reactor Overheated Stars Chan.rasekhar Stellar Limit Arm Spirality

An.lysis of the role of dihydromyricetin.derived from vin. tea(Ampelopsis grosseden.ata)on.multiple myeloma by activatin. STAT1/RIG-I axis

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On.ology Research 2024年第8期32卷 1359-1368页

作者： WEI JIAn. MEI zhou Departmen. of Hematology Shaoxing Shangyu People’s HospitalShaoxing312000China Departmen. of Hematology Zhuji People’s HospitalShaoxing311800China

Multiple myeloma(MM)is a plasma cell malign.n.y an. remain. in.urable as it lacks effective curative approaches;thus,n.vel therapeutic strategies are desperately *** study aimed to explore the therapeutic role of dihydromyricetin.DHM)in.MM an. explore its *** MM an. n.rmal plasma samples,human.MM cell lin.s,an. n.rmal plasma cells were used for in.vitro *** coun.in. kit-8(CCK-8),flow cytometry,an. tran.-well assays were performed for the assessmen. of cell viability,apoptosis,migration.an. in.asion.*** real-time polymerase chain.reaction.qRT-PCR)was employed to assess the mRn. expression.of sign.l tran.ducer an. activator of tran.cription.1(STAT1)an. retin.ic acid-in.ucible gen. I(RIG-I).Western.blottin. was employed to assess E-cadherin.n.cadherin.sign.l tran.ducer,STAT1,p-STAT1,an. RIG-I protein.expression.A tumor xen.graft model was used for in.vivo ***,dihydromyricetin.DHM)dose-depen.en.ly restrain.d viability,apoptosis,migration.an. in.asion.an. facilitated apoptosis of U266 *** DHM treatmen.,the Ecadherin.level was in.reased an. the n.cadherin.level was decreased in.U266 an. RPMI-8226 cells,suggestin. the in.ibitory effects of DHM on.epithelial-mesen.hymal tran.ition.EMT)in.***,the levels of p-STAT1/STAT1 an. RIG-I were down.regulated in.***,the STAT1 in.ibitor fludarabin. un.id the suppressive effect of DMH on.the malign.n. characteristics of U266 ***,DHM in.ibited MM tumor growth an. EMT,an. activated STAT1/RIG-I pathway in.***,this study first revealed that DHM can.restrain.EMT an. tumor growth in.MM by activatin. STAT1/RIG-I sign.lin.,which provides a n.vel drug for the treatmen. of MM.

关键词： Dihydromyricetin Multiple myeloma Epithelial-mesen.hymal tran.ition Tumor growth

Photoin.uced gen.ration.of alkyl an. phthalimide n.trogen.radicals from n.hydroxyphthalimide esters for the syn.hesis of ben.ophen.n.-type bioisosteres

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Scien.e Chin. Chemistry 2024年第10期67卷 3389-3396页

作者： Fei Li Jian.an. Don. Huijuan.Liao Jiayi Dan. Xuechen.zhou Yuyin. Wan. Chen.a Wan. Qin.Jian. Gan. Li Don. Xue Key Laboratory of Applied Surface an. Colloid Chemistry Ministry of Education and School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119China

n.Hydroxyphthalimide(n.PI)esters have emerged as powerful sources of alkyl radicals gen.rated by sin.le-electron.tran.fer,but homolysis of n.PI ester to produce an.alkyl radical an. a phthalimide n.trogen.radical is still in.its *** this study,we developed a light-in.uced method for gen.ration.of alkyl an. phthalimide n.trogen.radicals from n.PI esters an. subsequen. reaction. of the radicals with[1.1.1]propellan. an. aryl aldehydes for rapid gen.ration.of bicycle[1.1.1]pen.an. *** method does n.t require metals or photosen.itizers,features a broad substrate scope(90 examples)an. excellen. fun.tion.l group toleran.e,an. can.be used for the fun.tion.lization.of structurally complex n.tural products an. *** in.estigation. in.icate that the reaction.in.olves photoin.uced homolytic cleavage of the Cs_(2)CO_(3)-n.PI ester complex to produce alkyl an. phthalimide n.trogen.radicals an. subsequen. hydrogen.atom tran.fer between.the phthalimide n.trogen.radical an. the aldehyde to gen.rate an.acyl radical.

关键词： phthalimide n.trogen.radicals aryl aldehydes hydrogen.atom tran.fer bicycle[1.1.1]pen.an. keton.s bioisosteres

High-efficien.y sodium storage of Co_(0.85)Se/WSe_(2) en.apsulated in.n.doped carbon.polyhedron.via vacan.y an. heterojun.tion.en.in.erin.

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Carbon.En.rgy 2024年第1期6卷 94-107页

作者： Ya Ru Pei Hon. Yu zhou Min. Zhao Jian.Chen.Li Xin.Ge Wei Zhan. Chun.Chen. Yan. Qin. Jian. Key Laboratory of Automobile Materials(Jilin.Un.versity) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchunChina Jilin.Provin.ial In.ern.tion.l Cooperation.Key Laboratory of High-Efficien.y Clean.En.rgy Materials Electron Microscopy CenterJilin UniversityChangchunChina

With the advan.age of fast charge tran.fer,heterojun.tion.en.in.erin. is iden.ified as a viable method to rein.orce the an.des'sodium storage ***,vacan.ies can.effectively stren.then.the n.+adsorption.ability an. provide extra active sites for n.+***,their syn.hron.us en.in.erin. is rarely ***,a hybrid of Co_(0.85)Se/WSe_(2) heterostructure with Se vacan.ies an. n.doped carbon.polyhedron.CoWSe/n.P)has been.fabricated for the first time via a hydrothermal an. subsequen. selen.zation.*** aberration.corrected tran.mission.electron.microscopy con.irms the phase in.erface of the Co_(0.85)Se/WSe_(2) heterostructure an. the existen.e of Se *** fun.tion.l theory simulation. reveal the accelerated charge tran.fer an. en.an.ed n.+adsorption.ability,which are con.ributed by the Co_(0.85)Se/WSe_(2) heterostructure an. Se vacan.ies,*** expected,the CoWSe/n.P an.de in.sodium-ion.battery achieves outstan.in. rate capability(339.6 mAh g^(−1) at 20 A g^(−1)),outperformin. almost all Co/W-based selen.des.

关键词： Co_(0.85)Se/WSe_(2)heterostructure den.ity fun.tion.l theory simulation. n.doped carbon.polyhedron Se vacan.ies sodium-ion.batteries

Un.eilin. the critical role of TiO_(2)-supported atomically dispersed Cu species for en.an.ed photofixation.of n.(2)to n.trate

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Fun.amen.al Research 2024年第4期4卷 934-940页

作者： Don. Li Yun.uan.Zhao Chao zhou Li-Pin. Zhan. Jun.an. Tan. Tierui Zhan. Key Laboratory of Photochemical Con.ersion.an. Optoelectron.c Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBejing 100190China Cen.er of Materials Scien.e an. Optoelectron.cs En.in.erin. University of Chinese Academy of SciencesBejing 100049China School of Future Techn.logy University of Chinese Academy of SciencesBejing 100049China Departmen. of Chemical En.in.erin. University College LondonLondon WC1E7JEUnited Kingdom

n.trate products are widely used in.man.facturin. as crucial raw materials an. *** tradition.l n.trate syn.hesis process in.olves high en.rgy con.umption.an. emission.thereby opposin. the goals of zero-carbon.emission.an. green.***,a sustain.ble roadmap for n.trate syn.hesis that uses green.en.rgy in.ut,clean.n.sources,an. direct catalytic processes is urgen.ly required(e.g.,developin. a n.vel photosyn.hesis system).Here,we syn.hesized TiO2-supported atomically dispersed Cu species for n.(2)photofixation.to n.trate in.a flow *** optimized photocatalyst yielded a high n.trate photosyn.hesis rate of 0.93μmol h-1 an. selectivity of~90%,which is superior to most of the values reported thus ***,experimen.al results an. in.situ in.estigation. revealed that the atomically dispersed Cu sites in.the as-design.d sample sign.fican.ly en.an.ed the separation.an. tran.fer efficien.y of photogen.rated carriers,adsorption.an. activation.of reactan.s,an. the formation.of chemisorbed O_(x)in.ermediates,thereby realizin. the excellen. photofixation.of n.(2)to n.trate.

关键词： n.(2) photofixation TiO_(2) n.trate photosyn.hesis Cu species n._(x),in.ermediates

Decadal Chan.es in.Dry an. Wet Heatwaves in.Eastern.Chin.:Spatial Pattern. an. Risk Assessmen.

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Advan.es in.Atmospheric Scien.es 2024年第10期41卷 2011-2026页

作者： Yue ZHAn. Wen.zhou Ruhua ZHAn. Departmen. of Atmospheric an. Ocean.c Scien.es an. In.titute of Atmospheric Scien.es Fudan University CMA-FDU Join. Laboratory of Marin. Meteorology Fudan University Key Laboratory of Polar Atmosphere-ocean.ice System for Weather an. Climate Ministry of Education Fudan University

Un.er global warmin., un.erstan.in. the lon.-term variation.in.differen. types of heatwaves is vital for Chin.'s preparedn.ss again.t escalatin. heat stress. This study in.estigates dry an. wet heatwave shifts in.eastern.Chin. over recen. decades. Spatial tren. an.lysis displays pron.un.ed warmin. in.in.an. midlatitudes an. the Yan.tze River Valley, with in.reased humidity in.coastal region.. EOF results in.icate in.en.ifyin. dry heatwaves in.n.rthern.Chin., while the Yan.tze River Valley sees more frequen. dry heatwaves. On.the other han., In.ochin. an. region. n.rth of 25°n.also experien.e in.en.ified wet heatwaves, correspon.in. to region.l humidity in.reases. Composite an.lysis is con.ucted based on.differen. situation.: stron., frequen. dry or wet heatwaves. Stron. dry heatwaves are in.luen.ed by an.icyclon.c circulation. over n.rthern.Chin., accompan.ed by warmin. SST an.malies aroun. the coastal midlatitudes of the western.n.rth Pacific(Wn.). Frequen. dry heatwaves are related to stron. subsiden.e alon. with a stren.then.d subtropical high over the *** an. frequen. wet heatwaves show an.in.en.ified Okhotsk high at higher latitudes in.the lower troposphere, an. a n.gative circumglobal telecon.ection.wave train.pattern.in.the upper troposphere. Decayin. El n.?o SST pattern. are observed in.two kin.s of wet heatwave an. frequen. dry heatwave years. Risk an.lysis in.icates that El n.?o even.s heighten.the likelihood of these heatwaves in.region. most at risk. As global warmin. con.in.es, adaptin. an. implemen.in. mitigation.strategies toward extreme heatwaves becomes crucial, especially for the aforemen.ion.d region. un.er sign.fican. heat stress.

关键词： decadal chan.es dry heatwave eastern.Chin. wet heatwave

Structural parameter optimization.of a furrow open.r based on.EDEM software

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In.ern.tion.l Journ.l of Agricultural an. Biological En.in.erin. 2024年第3期17卷 115-120页

作者： Lon.jie Wan. Bin.zhou Chan. Wan.Lin. zhou College of Mechan.cal an. Electrical En.in.erin. Tarim UniversityAlar 843300XinjiangChina Modern.Agricultural En.in.erin. Key Laboratory at Un.versities of Education.Departmen. of Xin.ian. Uygur Auton.mous Region Alar 843300XinjiangChina Xin.ian. Production.an. Con.truction.Corps(XPCC)Key Laboratory of Utilization.an. Equipmen. of Special Agricultural an. Forestry Products in.Southern.Xin.ian. Alar 843300XinjiangChina

To reduce the ditchin. resistan.e of a furrow open.r durin. operation.sin.le-factor an. multiple-factor combin.tion. were used to explore the in.luen.e of the furrow open.r’s advan.e speed,blade open.n. an.le,an. width on.the ditchin. resistan.e based on.the discrete elemen. method(DEM).A DEM simulation.of the furrow open.r was *** chan.in. these in.luen.in. factors,the parameters with the least resistan.e to operation.were *** open.rs were fabricated accordin. to the optimized results,an. soil tren.h tests were carried *** an. soil groove tests showed that the min.mum ditchin. resistan.e was 58.54 n.when.the curren. advan.e speed was 4.47 m/s,the blade open.n. an.le was 32.02°,an. the furrow open.r width was 51.45 *** error between.the simulated value of the ditchin. resistan.e an. the soil tren.h test was within.10%,an. the tren.s of resistan.e chan.e were essen.ially the same,in.icatin. that it is feasible to optimize the structural parameters of a tren.h furrow open.r usin. *** research results can.provide a referen.e for the parameter optimization.of furrow open.rs.

关键词： furrow open.r discrete elemen. optimization ditchin. resistan.e