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Circulating microRNAs as potential biomarkers for diagnosis of congenital heart defects

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World Journal of Emergency Medicine 2016年第2期7卷 85-89页

作者： Wan-qin Xie lin zhou Yong Chen Bin Ni Family Planning Research Institute of Hunan Province Changsha 410126 China

BACKGROUND: Micro RNAs are small non-coding RNAs of approximately 22 nucleotides in length, and play important regulatory roles in normal heart development and the pathogenesis of heart diseases. Recently, a few prospective studies have implicated the diagnostic role of micro RNAs in congenital heart defects(CHD).DATA RESOURCES: This review retrieved the research articles in Pub Med focusing on the altered microR NAs in cardiac tissue or serum of patients with CHD versus healthy normal controls, as well as the studies exploring circulating microR NAs as potential biomarkers for(fetal) ***: Most of the studies of interest were conducted in recent years, implicating that the topic in this review is a newly emerging field and is drawing much attention. Moreover, a number of differentially expressed microR NAs between CHD specimens and normal controls have been ***: Circulating micro RNAs may serve as potential biomarkers for diagnosis of CHD in the future, with more efforts paving the road to the aim.

关键词： Congenital heart defects Biomarkers MicroRNA

Clinically significant endoscopic findings in patients of dyspepsia with no warning symptoms:A cross-sectional study

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World Journal of Clinical Cases 2021年第15期9卷 3597-3606页

作者： Li-Qi Mao Shuang-Shuang Wang Yan-lin zhou lin Chen Lei-Min Yu Meng Li Bin Lv Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou 317000Zhejiang ProvinceChina Department of Gastroenterology Guangxing Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dyspepsia is one of the commonest clinical ***,controversy remains over the role of endoscopy in patients with *** studies have evaluated the diagnostic value of endoscopy in patients with no warning symptoms according to the Rome IV *** To study the diagnostic value of endoscopy in dyspeptic patients with no warning *** This cross-sectional study included dyspeptic patients with no warning symptoms who met the inclusion and exclusion criteria at The First Affiliated Hospital,Zhejiang Chinese Medical University from April 2018 to February *** clinical data were collected using questionnaires,including dyspeptic information,warning symptoms,other diseases,family history and basic demographic *** on dyspeptic symptoms,patients can be divided into epigastric pain syndrome,postprandial distress syndrome or overlapping *** A total of 1016 cases were enrolled,304(29.9%)had clinically significant findings that were detectable by *** endoscopy findings included esophageal lesions in 180(17.7%)cases,peptic ulcers in 115(11.3%)cases and malignancy in 9(0.89%)*** logistic regression analysis showed that males[odds ratio(OR)=1.758,P25(OR=1.660;P=0.005),epigastric pain(OR=1.423;P=0.019)and Helicobacter pylori infection(OR=1.949;Plinically significant findings on *** Chinese patients with dyspepsia with no warning symptoms should undergo endoscopy,particularly males,patients with body mass index>25,epigastric pain or Helicobacter pylori infection.

关键词： Rome IV Dyspepsia Questionnaire Endoscopy Warning symptoms Diagnosis

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极早产儿合并早产后呼吸疾病的危险因素分析

中华儿科杂志 2025年第1期63卷 50-54页

作者：尤优吕静雯周琳王丽平张菊风王利张拥军夏红萍上海交通大学医学院附属新华医院新生儿科上海

目的探讨极早产儿合并早产后呼吸疾病(PPRD)的危险因素。方法前瞻性队列研究。纳入2019年1月至2023年6月生后1周内于上海交通大学医学院附属新华医院新生儿重症监护病房住院的369例极早产儿, 分析极早产儿校正年龄1岁内的呼吸系统疾病情... 详细信息

目的探讨极早产儿合并早产后呼吸疾病(PPRD)的危险因素。方法前瞻性队列研究。纳入2019年1月至2023年6月生后1周内于上海交通大学医学院附属新华医院新生儿重症监护病房住院的369例极早产儿, 分析极早产儿校正年龄1岁内的呼吸系统疾病情况, 并收集极早产儿和母亲的临床特征、早产儿并发症及相关治疗情况。根据是否合并PPRD将极早产儿分为PPRD组和无PPRD组。采用Mann WhitneyU检验、χ2检验或连续校正χ2检验进行组间比较, 应用多因素Logistic回归分析探讨PPRD的危险因素。结果 369例极早产儿中男217例(58.8%), 出生胎龄为30(28, 31)周, 出生体重为1 320(1 085, 1 590)g, 116例(31.4%)合并PPRD, 253例(68.6%)未合并PPRD。PPRD组极早产儿的出生胎龄和出生体重均低于无PPRD组(均P<0.001)。与无PPRD组相比, PPRD组男性更多, 第1、5分钟Apgar评分均更低, 剖宫产出生、支气管肺发育不良、应用肺表面活性物质治疗的极早产儿均更多, 有创机械通气天数和总氧疗天数均更长, 出院时年龄的体重Z评分更低, 差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示, 出生胎龄(OR=0.85, 95%CI 0.73～0.99, P=0.037)、剖宫产出生(OR=2.23, 95%CI 1.21～4.10, P=0.010)、有创机械通气天数≥7 d(OR=2.51, 95%CI 1.43～4.39, P=0.001)和出院时年龄的体重Z评分(OR=0.82, 95%CI 0.67～0.99, P=0.040)均是PPRD的独立危险因素。结论对于出生胎龄小、剖宫产出生、有创机械通气天数≥7 d及出院时年龄的体重Z评分低的极早产儿, 出院后应密切观察是否合并PPRD, 并给予规范的呼吸管理。

关键词：支气管肺发育不良危险因素婴儿, 极早产早产后呼吸疾病

A high mobility C_(60) field-effect transistor with an ultrathin pentacene passivation layer and bathophenanthroline/metal bilayer electrodes

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Chinese Physics B 2012年第2期21卷 498-503页

作者： zhou Jian-lin Yu Jun-Sheng Yu Xin-Ge Cai Xin-Yang State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic InformationUniversity of Electronic Science and Technology of ChinaChengdu 610054China Department of Electronic Engineering College of Communication and ElectronicsChongqing UniversityChongqing 400044China

C60 field-effect transistor （OFET） with a mobility as high as 5.17 cm2/V.s is fabricated. In our experiment, an ultrathin pentacene passivation layer on poly-（methyl methacrylate）（PMMA） insulator and a bathophenanthroline （Bphen）/Ag bilayer electrode are prepared. The OFET shows a significant enhancement of electron mobility compared with the corresponding device with a single PMMA insultor and an Ag electrode. By analysing the C60 film with atomic force microscopy and X-ray diffraction techniques, it is shown that the pentacene passivation layer can contribute to C60 film growth with the large grain size and significantly improve crystallinity. Moreover, the Bphen buffer layer can reduce the electron contact barrier from Ag electrodes to C60 film efficiently.

关键词： organic field-effect transistors C60 Bphen passivation layer

Kinetics of Evaporation of Zn and Pb from Carbon-bearing Pellets Made of Dust Containing Zn-Pb-Fe Oxides

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International Journal of Minerals,Metallurgy and Materials 2000年第3期14卷 178-183页

作者： Weiqing Chen, Dongyan Wang, Rongzhang zhou, Zongcai lin (Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China) Metallurgy School University of Science and Technology Beijing Beijing 100083 China

The influence of reduction temperature, size of coal powder and the carbon content on the evaporation rates of Zn and Pb in pellets made of ZnO-PbO-FeO bearing dust has been investigated between 1100-1300℃. The evaporation rate of Zn and Pb obtained from the experiments has been analyzed with kinetic models. The results show that the control step for evaporation of Zn is reduction reaction of ZnO by CO at the interface，and that the evaporation rate of Pb is controlled by the volatilization of reduction products, i.e. liquid lead. The overall apparent activation energies of Zn and Pb evaporation from the pellet are 79.42kJ/mol and 88.74kJ/mol respectively.

关键词： Zn-Pb-bearing dust carbon-containing pellet evaporation kinetics

Stability of NiCrAlY coating/titanium alloy system under pure thermal exposure

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Rare Metals 2017年第8期36卷 659-665页

作者： Xiao-Min Peng An-Ru Wu Li-Jun Dong You-Rui Tao Wei-Guo Gao Xiang-lin zhou State Key Laboratory of Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Hunan Institute of EngineeringXiangtan 411101China

In this paper,NiCrAlY coating was deposited on TC4 titanium alloy using arc ion plating,and the stability of NiCrAlY coating/TC4 substrate system under pure thermal exposure was analyzed in a wide temperature *** the thermal exposure,β→γ′→γphase transformation takes place in the NiCrAlY *** NiCrAlY coating phases totally decompose above the allotropic transformation temperature of *** allotropic transformation ofα-Ti to β-Ti of the substrate significantly influences the stability of NiCrAlY coating/TC4 substrate *** coating elements are mainly consumed by interfacial reactions below the allotropic transformation temperature of *** the allotropic transformation temperature of TC4,NiCrAlY coating elements are mainly consumed by element dissolution in β-*** NiCrAlY coating totally degrades for the dissolution of coating elements in the substrate to form thickβ-Ti stabilized layer.

关键词： NiCrAlY coating Titanium alloy Stability Pure thermal exposure Degradation

Copper-catalyzed asymmetric dearomatizing amination of 2-naphthols:Csp^(2)–N coupling via 1,3-reductive elimination

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Science China Chemistry 2024年第8期67卷 2694-2700页

作者： Aying Yihuo Maoping Pu Zheng Tan Jibang Liao Jiuqi Tan Qi-lin zhou Xiaohua Liu Xiaoming Feng Key Laboratory of Green Chemistry&Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Frontiers Science Centerfor New Organic MatterNankai UniversityTianjin300071China

An efficient catalytic asymmetric dearomatizing amination of 2-naphthols and phenols catalyzed by N,N′-dioxide-copper(I)complex as a chiral catalyst was presented.A variety of optically activeβ-naphthalenone compounds with a nitrogen-containing quaternary carbon stereocenter were obtained with high yield and enantioselectivity under mild reaction *** studies indicated that this Csp^(2)–N dearomatizing coupling proceeds via 1,3-reductive elimination of phenolate-Cu~Ⅲ-amino intermediate in five-membered ring transition *** origin of enantioselectivity has also been elucidated based on density functional theory calculations.

关键词： asymmetric catalysis amination dearomatization copper catalysis coupling reaction

Chiral effect on Aβ fibrillation from molecular-scale to nanoscale

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Nano Research 2022年第7期15卷 6721-6729页

作者： Guanbin Gao Guowei Zhu Liangchong Yu Zijun Zhang Ting Zhang Xinglin Liu Cheng Zhang lin zhou Taolei Sun State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China

β-Amyloid(Aβ)peptide fibrillation,one of the characteristic hallmarks of Alzheimer’s disease,is determined by many interfacial physical-chemical factors,e.g.,charge,hydrophobicity,*** extensive research,chiral effect in different-scales on the fibrillation process of Aβremains ***,molecular-scale,sub-nanoscale,and nanoscale chiral-structures were constructed to investigate their chiral effect on the fibrillation of Aβ_(40) *** structures from molecular-scale to nanoscale were obtained from the different periods of the chemosynthesis process of chiral ZnS quantum-dots(QDs),confirmed by real-time monitoring of circular dichroism *** molecular-scale,both L-penicillamine(L-P)and D-P ligands accelerated the fibrillation of Aβ_(40),and the speed-up effect of D-P was slightly stronger than *** sub-nanoscale,both two chiral Zncomplexes(L-Zn and D-Zn)induced the agglomeration of Aβ_(40) without chirality *** nanoscale,both L-ZnS and DZnS QDs inhibited the fibrillation of Aβ_(40),and the inhibition effect of L-ZnS was notably better than that of ***-situ kinetics experiments of Aβ_(40) co-incubated with two chiral QDs demonstrated that L-ZnS completely prevents the misfolding of Aβ_(40) from unfolded toβ-sheet,while D-ZnS cannot achieve *** site-replacement experiments and simulation results revealed the underlying molecular mechanisms of the different inhibition efficiency of chiral ZnS QDs on Aβ_(40) fibrillation,which mainly attribute to the stereoselectivity interaction between the chiral ligands of ZnS QDs and electro-positive amino acid residues(R5,K16,and K28)of Aβ_(40).This work offers a microscopic insight of chiral effect on Aβfibrillation exerted by structures in different-scales,and provides a guidance in precise regulation of protein fibrillation via manipulating chiral structures in different-scales.

关键词： chirality molecular-scale sub-nanoscale nanoscale Aβ_(40) fibrillation

Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

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Insect Science 2024年第4期31卷 1090-1106页

作者： Yi Wei Xiao-lin zhou Peng Chen Tai-Hang Liu Cheng Lu Min-Hui Pan State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest UniversityChongqingChina Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang ProvinceChina

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole *** the same time,the hormones produced by insects significantly change during ***,the regulatory mechanism for ovarian development and hormones is not fully understood in ***,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx *** process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in *** proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in *** results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP *** study provides new insights into the regulatory mechanism of MMP2 and ovarian development in ***.

关键词： Bombyx mori collagen I insulin-like peptide matrix metalloproteinase ovarian development