检索结果-南通市图书馆

Drug-peptide supramolecular hydrogel boosting transcorneal permeability and pharmacological activity via ligand-receptor interaction

引用

Bioactive Materials 2022年第4期7卷 420-429页

作者： Lin Chen Jie Deng Ailing Yu Yuhan Hu Bo Jin Pengyuan Du jianhong zhou Lei Lei Yuan Wang Serhii Vakal Xingyi Li Institute of Biomedical Engineering School of Ophthalmology&OptometryEye HospitalWenzhou Medical University270 Xueyuan RoadWenzhou325027PR China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated HospitalWenzhou Medical UniversityWenzhou325027PR China Structural Bioinformatics Laboratory BiochemistryÅbo Akademi UniversityTurku20541Finland

Boosting transcorneal permeability and pharmacological activity of drug poses a great challenge in the field of ocular drug *** the present study,we propose a drug-peptide supramolecular hydrogel based on anti-inflammatory drug,dexamethasone(Dex),and Arg-Gly-Asp(RGD)motif for boosting transcorneal permeability and pharmacological activity via the ligand-receptor *** drug-peptide(Dex-SA-RGD/RGE)supramolecular hydrogel comprised of uniform nanotube architecture formed spontaneously in phosphate buffered saline(PBS,pH=7.4)without external *** storage at 4℃,25℃,and 37℃ for 70 days,Dex-SA-RGD in hydrogel did not undergo significant hydrolysis,suggesting great long-term *** comparison to Dex-SA-RGE,Dex-SA-RGD exhibited a more potent in vitro anti-inflammatory efficacy in lipopolysaccharide(LPS)-activated RAW 264.7 macrophages via the inhibition of nuclear factorкB(NF-κB)signal *** importantly,using drug-peptide supramolecular hydrogel labeled with 7-nitro-2,1,3-benzoxadiazole(NBD),the Dex-SA-K(NBD)RGD showed increased performance in terms of integrin targeting and cellular uptake compared to Dex-SA-K(NBD)RGE,as revealed by cellular uptake *** topical instillation in rabbit’s eye,the proposed Dex-SA-K(NBD)RGD could effectively enhance the transcorneal distribution and permeability with respect to the Dex-SA-K(NBD)***,our findings demonstrate the performance of the ligand-receptor interaction for boosting transcorneal permeability and pharmacological activity of drug.

关键词： Active transport Integrin Supramolecular hydrogel Ocular retention Corneal permeability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

引用

Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi Xu jianhong Yang Yao Xu Xiaofeng Wang Xiang Gao Jie Sun Chenhui zhou Yi Huang Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province NingboZhejiang ProvinceChina

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier *** microvascular endothelial cells are a major component of the blood-brain *** mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial *** this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial *** found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial ***,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial *** established an in vitro brain microvascular endothelial cell model of the blood-brain *** found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain *** a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic *** found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic *** findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

浙江省40~69岁女性的生活方式与绝经相关症状的相关性研究

引用

中华全科医学 2024年第1期22卷 77-81页

作者：胡凯灵许凌丁悦虹马麟娟应倩周坚红宁玉梅慈溪市第三人民医院医疗健康集团妇产科浙江宁波315324 杭州师范大学医学院临床医学系浙江杭州311121 浙江省妇幼和生殖保健中心临床医务部浙江杭州310012 浙江大学医学院附属妇产科医院妇三科浙江杭州310006 浙江省肿瘤医院肿瘤研究所浙江杭州310022

目的探讨女性生活方式与绝经相关症状的相关性。方法采用多阶段分层整群抽样方法抽取浙江省40~69岁女性7 856名进行问卷调查,有序变量采用Mantel-Haenszel检验,无序变量采用Kruskal-Wallis H检验,联合多因素logistic回归分析对生活方... 详细信息

目的探讨女性生活方式与绝经相关症状的相关性。方法采用多阶段分层整群抽样方法抽取浙江省40~69岁女性7 856名进行问卷调查,有序变量采用Mantel-Haenszel检验,无序变量采用Kruskal-Wallis H检验,联合多因素logistic回归分析对生活方式与绝经相关症状的相关性进行分析,绘制ROC曲线。结果年龄与绝经及绝经相关症状均具有相关性(P<0.05)。生活方式中被动吸烟、饮酒、饮茶、体育锻炼强度、烫染发频率(P<0.05)均与绝经相关症状具有相关性。年龄大(OR=1.103,95%CI:1.094~1.112)、绝经(OR=4.011,95%CI:3.573~4.503)、家属吸烟(OR=1.346,95%CI:1.206~1.501)和工作环境被动吸烟(OR=1.432,95%CI:1.175~1.745)均是绝经相关症状的危险因素(P<0.05)。低强度体育锻炼(OR=0.881,95%CI:0.822~0.944)、低频率烫发(OR=0.823,95%CI:0.774~0.876)均是绝经相关症状的保护因素(P<0.05)。生活方式相关因素预测绝经相关症状的ROC曲线下面积为0.731。结论浙江省40~69岁女性生活方式与绝经相关症状具有相关性,可以对女性进行生活方式指导以减少或缓解绝经相关症状。

关键词：绝经相关症状绝经生活方式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results

引用

Science China Earth Sciences 2023年第5期66卷 1015-1030页

作者： Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu zhou Yaozhi JIANG Xiangnan YAO Hui LU Xiaogang MA Lin OUYANG Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO jianhong zhou Mijun ZOU Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing100084China National Tibetan Plateau Data Center State Key Laboratory of Tibetan Plateau Earth System and Resource EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China Research Center for Ecology College of ScienceTibet UniversityLhasa850011China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Science and Natural Resources ResearchChinese Academy of SciencesBeijing100101China Chongqing Jinfo Mountain Karst Ecosystem National Observation and Research Station School of Geographical SciencesSouthwest UniversityChongqing400715China

The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four *** lack of precipitation observations is a bottleneck for the study of land surface processes in this *** the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 *** observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air *** observation dataset has been released in the National Tibetan Plateau Data Center.

关键词： Central and western Tibetan Plateau Rainfall observation transects Observation uncertainty Spatiotemporal characteristics of precipitation Precipitation data evaluation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent development in electrode design for wide-temperature supercapacitors

引用

Science China Chemistry 2024年

作者： jianhong Liu Qiang zhou Yuxiao Lin Xinsheng Zhao Guangmin zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal University Tsinghua-Berkeley Shenzhen Institute & Tsinghua Shenzhen International Graduate School Tsinghua University

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors (SCs). The active electrode is one of the most important parts of SC, which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature environment. Compared with the SC electrodes aimed for room-temperature application, the SC electrodes for operating at wide-temperature scene often face greater challenges. In this review, the main challenges of SC electrodes under various temperature conditions, including low, high and cross-fade temperatures, are summarized. The relevant performance decay and failure mechanisms of wide-temperature SC electrodes are analyzed. In addition, this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active materials. Finally, the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第2期23卷 158-163页

作者： Jie LUO Zhimin SONG Tao ZHANG Ketan CHU Jingyi LI jianhong zhou Jun LIN Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310006China Department of Obstetrics and Gynecology Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Department of Reproductive Endocrinology Women’s HospitalZhejiang University School of MedicineHangzhou 310006

At present,endometriosis remains a worldwide health burden,with the main symptoms of dysmenorrhea,chronic pelvic pain,and infertility,markedly reducing the quality of life(de Ziegler et al.,2010).Although there is no proof that the disease is associated with high mortality,this disorder can significantly contribute to the deterioration of women’s general well-being(McPeak et al.,2018).

关键词： markedly endometriosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bifunctional passivation by lewis-base molecules for efficient printable mesoscopic perovskite solar cells

引用

Journal of Energy Chemistry 2024年第9期96卷 177-184页

作者： Hang Yang jianhong Zhao Xiaodong Ren Tong zhou Henbing Zhang Weilong Zhang Jin Zhang Guangzhi Hu Yuming Zhang Wen-Hua Zhang Qingju Liu Yunnan Key Laboratory for Micro/Nano Materials & Technology National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan UniversityKunming 650091YunnanChina Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental Science Yunnan UniversityKunming 650091YunnanChina

Printable mesoscopic perovskite solar cells(PM-PSCs)possess notable merits in terms of cost-effectiveness,easy manufacturing,and large scale ***,the absence of a hole transport layer contributes to the exacerbation of carrier recombination,and the defects between the perovskite and electron transport layer(ETL)interfaces significantly decrease the efficiency of the *** this study,a bifunctional surface passivation approach is proposed by applying a thioacetamide(TAA)surfactant on the mesoporous TiO_(2)*** results demonstrate that TAA molecules could interact with TiO_(2),thereby diminishing the oxygen vacancy ***,the amino group and sulfur atoms in TAA molecules act as Lewis base to effectively passivate the uncoordinated Pb^(2+)in perovskite and improve the morphology of perovskite,and decrease the trap-state density of *** TAA passivation mechanism improves the alignment of energy levels between TiO_(2)and perovskite,facilitating electron transport and reducing carrier ***,the TAA-passivated device achieved a champion power conversion efficiency(PCE)of 17.86%with a high fill factor(FF)of 79.16%and an open-circuit voltage(V_(OC))of 0.971 *** investigation presents a feasible strategy for interfacial passivation of the ETL to further improve the efficiency of PM-PSCs.

关键词： Perovskite solarcells Carbon electrode Thioacetamide Interfacial passivation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

硅藻土/BiOBr光催化降解四环素废水研究

引用

广东化工 2024年第17期51卷 128-130页

作者：令玉林周建红冯玲玲陈亚丽王灿罗月雷敏悦黄紫芸黄来来遵义师范学院贵州遵义563006

利用简单的溶解热法成功制备了硅藻土(DT)/BiOBr复合光催化剂,对其形貌和成分进行了表征。对复合光催化剂降解废水中四环素的性能和催化剂的稳定性进行了试验。结果表明:BiOBr纳米片在硅藻土表面分散均匀,材料纯度高、结晶性好;DT/BiOB... 详细信息

利用简单的溶解热法成功制备了硅藻土(DT)/BiOBr复合光催化剂,对其形貌和成分进行了表征。对复合光催化剂降解废水中四环素的性能和催化剂的稳定性进行了试验。结果表明:BiOBr纳米片在硅藻土表面分散均匀,材料纯度高、结晶性好;DT/BiOBr-1的光催化性能最好,100 min内降解四环素的效率达到95.1%,重复使用4次后依旧保持较高的催化活性。光催化降解反应中的活性物种主要是羟基自由基和光生空穴,同时超氧自由基也起到了一定的作用。

关键词：光催化剂降解四环素废水硅藻土 BiOBr

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

含气泡油滴撞击油膜壁面时气泡的变形与破裂

引用

力学学报 2018年第2期50卷 427-437页

作者：周剑宏童宝宏王伟苏家磊安徽工业大学机械工程学院安徽马鞍山243032 合肥工业大学摩擦学研究所合肥230009

油-气润滑过程中润滑油液滴受高速气流扰动易形成含气泡油滴,微气泡将对油滴撞击壁面时的运动过程以及壁面油膜层的形成质量产生重要影响.基于耦合的水平集-体积分数方法,对含气泡油滴撞击油膜壁面行为进行数值模拟研究,考察含气泡油滴... 详细信息

油-气润滑过程中润滑油液滴受高速气流扰动易形成含气泡油滴,微气泡将对油滴撞击壁面时的运动过程以及壁面油膜层的形成质量产生重要影响.基于耦合的水平集-体积分数方法,对含气泡油滴撞击油膜壁面行为进行数值模拟研究,考察含气泡油滴撞击油膜壁面时气泡的变形运动过程,探讨气泡破裂的动力学机制,分析气泡大小、碰撞速度和液体黏度等因素对含气泡油滴撞壁过程中气泡变形特征参数的影响规律.研究表明:含气泡油滴撞击油膜壁面后气泡会发生变形,并破裂形成膜液滴;气泡随同液滴运动过程中,气泡内外压力和速度梯度变化是使气泡发生破裂的主要诱因.气泡大小对气泡破裂方式影响较大,气泡较小时发生单点破裂,而气泡较大时更容易发生多处破裂.不同大小气泡受力差异较大,气泡大小与破裂发生时刻没有明显相关性.碰撞速度和液体黏度对气泡的变形、破裂和破裂发生时刻都具有一定的影响.碰撞速度越大,油滴动能越大,更容易产生气泡变形和破裂现象.液体黏度增大,在油滴撞壁运动前期促进气泡变形,而在运动后期可以阻延气泡破裂行为发生.

关键词：油滴气泡油膜壁面气泡破裂数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

硫系玻璃Ge_(28)Sb_(12)Se_(60)薄膜光学非线性增强色散特性

引用

红外与激光工程 2022年第7期51卷 393-398页

作者：孙旭赵建行周姚曹英浩周见红长春理工大学光电工程学院吉林长春130022 光电测量和光信息传输技术教育部重点实验室吉林长春130022

采用真空热蒸发以及退火工艺制备了支持局域表面等离激元的微纳结构薄膜,在此薄膜上蒸镀了硫系玻璃Ge_(28)Sb_(12)Se_(60)薄膜。应用Z-扫描技术,在飞秒激光脉冲激发下研究其光学非线性增强的色散特性,在650 nm和850 nm波段观察到了非线... 详细信息

采用真空热蒸发以及退火工艺制备了支持局域表面等离激元的微纳结构薄膜,在此薄膜上蒸镀了硫系玻璃Ge_(28)Sb_(12)Se_(60)薄膜。应用Z-扫描技术,在飞秒激光脉冲激发下研究其光学非线性增强的色散特性,在650 nm和850 nm波段观察到了非线性吸收增强;非线性折射率随着波长的增加由负变正。通过扫描电子显微镜和透过光谱表征和分析了硫系玻璃Ge_(28)Sb_(12)Se_(60)薄膜非线性吸收增强的原理,非线性吸收随着波长的增加由单光子吸收为主逐渐转变为双光子吸收为主;银膜的微纳结构导致硫系玻璃薄膜的共振中心频率发生了偏移。实验制备的用于增强硫系玻璃非线性的微纳结构制作简单,无需复杂光刻工艺,为非线性光子学器件的设计提供了新的思路。

关键词：三阶光学非线性硫系玻璃局域表面等离激元 Z-扫描

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：