检索结果-南通市图书馆

Biomedical and Environmental Sciences 2024年第4期37卷 423-427页

作者： ZHANG Sai CHEN Zhi Xian ZHANG Mo DU Yan zhou jia yi WU Jing YU yin Hua CAO Qi ZHAO Hong Bo Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

Placental site trophoblastic tumor(PSTT),a rare gestational trophoblastic neoplasm(GTN),exhibits slow growth,late-onset metastasis,and chemotherapy insensitivity[1,2].The invasive capacity of trophoblasts induces angiogenesis in PSTT,yet the specific mechanism remains unclear[3].PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75%-80%[4,5].Therefore,investigating the precise emergence and progression of PSTT is crucial,aiming to identify novel targets for diagnosis and therapy.

关键词： chemotherapy diagnosis metastasis

在线全文

学校读者我要写书评

暂无评论

基于混合策略的机坪车辆主动式实时调度方法

交通运输工程学报 2024年第3期24卷 251-265页

作者：包丹文陈卓姚馨宇周佳怡南京航空航天大学民航学院江苏南京211106

为解决不确定性事件造成的机坪车辆调度扰动问题,提出了一种基于混合策略的机坪车辆主动式实时调度方法;设计了一种考虑机坪分区的灵活运行机制,以允许车辆自适应调整停放区域;建立了一个混合整数规划模型,旨在最小化航班保障请求总响... 详细信息

为解决不确定性事件造成的机坪车辆调度扰动问题,提出了一种基于混合策略的机坪车辆主动式实时调度方法;设计了一种考虑机坪分区的灵活运行机制,以允许车辆自适应调整停放区域;建立了一个混合整数规划模型,旨在最小化航班保障请求总响应时间与机坪车辆总行驶距离;从时空双重维度考虑服务代价,引入车辆时空服务半径指标,设计了基于未来请求信息的灵活等待策略与动态搬迁策略;通过主动式调度策略提高航班保障服务质量,降低服务车辆运行成本,并以北京首都国际机场为实例进行了实证研究。研究结果表明:与传统调度模式相比,灵活运行机制可有效提高车辆运行效率,并缩短空闲车辆折返距离,请求总响应时间与车辆总行驶距离分别下降了37.0%和36.8%;灵活等待策略适用于航班起降密集的高峰时段,车辆总行驶距离缩短了11.6%;动态搬迁策略适用于覆盖范围较广的机坪区域,在请求总响应时间降低17.8%的同时会产生较高的搬迁成本,车辆总行驶距离将增加12.5%。由此可见,针对繁忙的大型枢纽机场,采用混合策略能够在航班保障服务质量与服务车辆运行成本间取得有效平衡。

关键词：航空运输动态车辆路径问题主动式实时调度等待策略搬迁策略机坪车辆

人源胎盘部位滋养细胞肿瘤类器官模型的构建与鉴定

在线全文

学校读者我要写书评

暂无评论

复旦学报（医学版） 2024年第5期51卷 800-806页

作者：张赛周佳宜吴静于焕镝丁雨潇杜琰鹿欣赵洪波复旦大学附属妇产科医院生物样本库上海200011 复旦大学附属妇产科医院临床研究中心上海200011 复旦大学附属妇产科医院妇科上海200011

目的构建并鉴定人源胎盘部位滋养细胞肿瘤(placental site trophoblastic tumor,PSTT)的类器官模型。方法选取PSTT组织进行消化和分离,得到肿瘤细胞后进行基质胶包埋,利用特定的类器官培养基进行培养。HE染色观察类器官模型的组织学形态... 详细信息

目的构建并鉴定人源胎盘部位滋养细胞肿瘤(placental site trophoblastic tumor,PSTT)的类器官模型。方法选取PSTT组织进行消化和分离,得到肿瘤细胞后进行基质胶包埋,利用特定的类器官培养基进行培养。HE染色观察类器官模型的组织学形态,通过免疫组化和免疫荧光染色分析中间型滋养细胞标志物人胎盘催乳素(human placental prolactin,HPL)、人类白细胞抗原-G(human leukocyte antigen-G,HLA-G)和胎盘碱性磷酸酶(placental alkaline phosphatase,PLAP)的表达,鉴定构建的PSTT类器官模型与PSTT组织之间的一致性。同时对构建的模型进行传代及冻存、复苏,显微镜下分析其生长形态与速度,探讨其作为类器官模型在PSTT基础及临床转化研究应用的可能性。结果构建的类器官模型可稳定增殖并传代,可见其从小微球状态长成紧致实性球体或带有滤泡样结构的球体,约7~10天可长满并传代,冻存及复苏后细胞状态稳定;经HE染色发现类器官中细胞形态与PSTT原代肿瘤细胞相似;免疫组化与免疫荧光染色鉴定结果显示,PSTT类器官组织高表达中间型滋养细胞的标志分子HPL、HLA-G和PALP,提示构建的类器官模型主要包含中间型滋养细胞。结论成功建立了人源PSTT类器官(adult-derived PSTT organoid,ADPO)模型并进行鉴定。

关键词：类器官胎盘部位滋养细胞肿瘤(PSTT) 细胞培养

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

大孔树脂纯化秦皮香豆素工艺研究

中成药 2024年第9期46卷 2885-2891页

作者：张冬旭张永许陈思菡周佳怡余乐洋王申澍张彤丁越上海中医药大学中药学院上海201203

目的考察大孔树脂纯化秦皮中秦皮甲素、秦皮苷、秦皮乙素、秦皮素工艺。方法静态吸附实验筛选树脂型号,单因素试验优化纯化工艺,UPLC-QTOF-MS/MS法鉴定主要成分,绘制热图。结果最佳树脂型号为ADS-5。最佳纯化工艺为上样量1.1 BV,上样液... 详细信息

目的考察大孔树脂纯化秦皮中秦皮甲素、秦皮苷、秦皮乙素、秦皮素工艺。方法静态吸附实验筛选树脂型号,单因素试验优化纯化工艺,UPLC-QTOF-MS/MS法鉴定主要成分,绘制热图。结果最佳树脂型号为ADS-5。最佳纯化工艺为上样量1.1 BV,上样液质量浓度0.75 g/mL,2 BV纯水清洗杂质,4 BV 25%乙醇洗脱有效成分,香豆素总转移率为84.42%,纯度为53.28%,得率为4.79%。共鉴定出37种成分,其中香豆素类、苯乙醇苷类主要富集在25%乙醇洗脱液中,有机酸类、环烯醚萜类、黄酮类主要富集在95%乙醇洗脱液中。结论该方法稳定、可行、准确,可表征大孔树脂不同洗脱液中秦皮香豆素分布规律,为后续相关药学研究提供指导。

关键词：秦皮香豆素纯化工艺大孔树脂 UPLC-QTOF-MS/MS

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao Yue Gong ying-jia Qi Zhi-Ming Shao yi-zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

Machine Learning Security Defense Algorithms Based on Metadata Correlation Features

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第2期78卷 2391-2418页

作者： Ruchun jia jianwei Zhang yi Lin College of Computer Science Sichuan UniversityChengdu610065China

With the popularization of the Internet and the development of technology,cyber threats are increasing day by *** such as malware,hacking,and data breaches have had a serious impact on *** network security environment in the era of big data presents the characteristics of large amounts of data,high diversity,and high real-time *** security defense methods and tools have been unable to cope with the complex and changing network security *** paper proposes a machine-learning security defense algorithm based on metadata association *** control over unauthorized users through privacy,integrity,and *** user model is established and the mapping between the user model and the metadata of the data source is *** analyzing the user model and its corresponding mapping relationship,the query of the user model can be decomposed into the query of various heterogeneous data sources,and the integration of heterogeneous data sources based on the metadata association characteristics can be *** and classify customer information,automatically identify and perceive sensitive data,build a behavior audit and analysis platform,analyze user behavior trajectories,and complete the construction of a machine learning customer information security defense *** experimental results show that when the data volume is 5×103 bit,the data storage integrity of the proposed method is 92%.The data accuracy is 98%,and the success rate of data intrusion is only 2.6%.It can be concluded that the data storage method in this paper is safe,the data accuracy is always at a high level,and the data disaster recovery performance is *** method can effectively resist data intrusion and has high air traffic control *** can not only detect all viruses in user data storage,but also realize integrated virus processing,and further optimize the security defense effect of user big data.

关键词： Data-oriented architecture metadata correlation features machine learning security defense data source integration

Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 2968-2993页

作者： jian-Bin Zhang Nan zhou Li-Hui Zhang Cong-Hui Shang jia-Xuan Li yi Zhao Guo-Hui jia Ru-Sen Yang Hua Xu Xiao-Bo Li Shaanxi Joint Key Laboratory of Graphene Shaanxi Key Laboratory of High-Orbits-Electron Materials and Protection Technology for AerospaceShaanxi Joint Key Laboratory of GrapheneSchool of Advanced Materials and NanotechnologyXidian UniversityXi'an710126China Guangzhou Institute of Technology Xidian UniversityGuangzhou 710068China Xi'an Thermal Power Research Institute Co. LtdXi'an 710054China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an Xi'an 710119China

Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial,spectral and polarized ***,low-dimensional anisotropic materials with inherent anisotropic properties,ultrathin thickness,tunable bandgap and feasible integration with complementary metal oxide semiconductor(CMOS)fabrication processes have attracted great interest for their facilitation of polarized photodetector devices *** the polarized detection performance of low-dimensional materials to satisfy realistic needs stimulates the exploration of modulation of anisotropic *** this review,we comprehensively introduce the latest research progress in modulating the optical and optoelectronic anisotropy characteristics of low-dimensional *** strategy of anisotropy regulation through crystal structure engineering and coupling system is discussed ***,the latest progress in image recognition applications using anisotropic low-dimensional materials is reviewed in ***,we summarize the challenge and propose future opportunities in the practical application of polarized-sensitive imaging photodetectors based on low-dimensional anisotropic materials.

关键词： Anisotropy Polarized detection Image recognition Low-dimensional materials

Interplay between Microscopic Structures and Macroscopic Viscoelastic Properties of Polyampholyte Gels

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1360-1367,I0008页

作者： You-Cai Xue yi-Ming Yang Di jia Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Polyampholyte gels,which have hierarchical structures,exhibit excellent self-healing properties and have great promise for biomaterials and *** investigated the relationship between microscopic structures and macroscopic viscoelastic properties of polyampholyte gels and found three factors influencing their viscoelastic properties,including the chemical crosslinking bonds,topological entanglements controlled by monomer concentration,and the ionic *** strength plays a major role on the strength of ionic bonds.A crossover point of elastic modulus and loss modulus was observed in the dynamic frequency sweeps at low monomer concentration or low chemical crosslinking density for gels with intermediate strength of ionic *** solid-liquid transition signaled by the crossover point is a typical feature of dynamic associated gels,representing the dynamical association-dissociation of the ionic bonds and full relaxation of the topological entanglements in the gel *** the crossover point disappears when the ionic bonds are too weak or too strong to form“permanent”***,in the non-linear yielding measurement,gels with intermediate strength of the ionic bonds are ductile and yield at very large shear strain due to the self-healing properties and the dynamic association-dissociation of the ionic *** the self-healing properties disappear when the ionic bond strength is too weak or too *** work reveals the mechanism of how the dynamic association-dissociation of ionic bonds influences both the linear and non-linear viscoelastic properties of the polyampholyte gels.

关键词： Polyampholyte gel Ionic bond Topological entanglement Self-healing Hierarchical structure

Woven fabric triboelectric nanogenerators for human-computer interaction and physical health monitoring

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5540-5548页

作者： Yu Miao Mengjuan zhou jia yi Yanyan Wang Guangjin Tian Hongxia Zhang Wenlong Huang Wenhao Wang Ronghui Wu Liyun Ma College of Textile and Clothing Xinjiang UniversityUrumqi 830046China College of Textiles Donghua UniversityShanghai 201620China College of Physics Xiamen UniversityXiamen 201620China Department of Bioengineering Imperial College LondonLondon SW72AZUK

Triboelectric nanogenerator(TENG)converts mechanical energy into valuable electrical energy,offering a solution for future energy *** an indispensable part of TENG,textile TENG(T-TENG)has incredible advantages in harvesting biomechanical energy and physiological signal ***,the application of T-TENG is restricted,partly because the fabric structure parameter and structure on T-TENG performance have not been fully *** study comprehensively investigates the effect of weaving structure on fabric TENGs(F-TENGs)for direct-weaving yarn TENGs and post-coating fabric *** direct-weaving F-TENGs,a single-yarn TENG(Y-TENG)with a core-sheath structure is fabricated using conductive yarn as the core layer yarn and polytetrafluoroethylene(PTFE)filaments as the sheath *** fabrics with five different sets of parameters were designed and *** post-coating F-TENGs,fabrics with weaving structures of plain,twill,satin,and reinforced twill were fabricated and coated with conductive silver ***,the twill F-TENGs have the best electrical outputs,followed by the satin F-TENGs and plain weave ***,the increase of the Y-TENG gap spacing was demonstrated to improve the electrical output ***,T-TENGs are demonstrated for human-computer interaction and self-powered real-time *** systematic work provides guidance for the future T-TENG’s design.

关键词： single-yarn triboelectric nanogenerators woven fabric triboelectric nanogenerators fabric weaving structures and parameters human-computer interaction physical health monitoring

电泳辅助制备伪1-3陶瓷/聚合物压电复合材料

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理学报 2014年第2期63卷 294-299页

作者：武峥周嘉仪曹艺马柯贾艳敏张以河浙江师范大学物理系及地理与环境科学学院金华321004 中国地质大学材料科学与工程学院北京100083

1-3压电复合材料的压电、介电及铁电性能要远远优于0-3压电复合材料.在制备传统的0-3复合材料过程中引入电泳技术,使得压电颗粒在聚合物基体中取向排列,制备得到伪1-3复合材料.实验结果表明:在制备PZT/环氧树脂0-3复合压电材料固化过程... 详细信息

1-3压电复合材料的压电、介电及铁电性能要远远优于0-3压电复合材料.在制备传统的0-3复合材料过程中引入电泳技术,使得压电颗粒在聚合物基体中取向排列,制备得到伪1-3复合材料.实验结果表明:在制备PZT/环氧树脂0-3复合压电材料固化过程中,采用500 V/mm,4 kHz的电场对其进行电泳辅助取向,可使得颗粒呈现珍珠串状排列,得到伪1-3复合材料;其压电、介电、铁电性能均比原来的0-3复合材料有显著的提高.电泳辅助制备技术用于制备伪1-3复合压电材料具有操作简单、成本低廉、压电、介电、铁电性能显著提高等优点,在智能传感领域具有很好的实际应用前景.

关键词：压电 0-3复合伪1-3复合电泳