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中国青年研究 2009年第10期 52-55页

作者：文峰周聿峨暨南大学国际关系团委暨南大学华侨华人研究所

华裔新生代将在推动海外侨务工作开展、增强中国软实力方面扮演重要角色。本文以暨南大学华裔学生为个案,通过问卷调查和访谈,结合相关文化适应理论,探讨了华裔学生在华留学文化适应的特点,并对推动其文化适应提出了对策建议。

关键词：华裔中华文化认同对策

Cooling History of Mesozoic Magmatism and Implications for Large-Scale Gold Mineralization in the Jiaodong Peninsula, east China: Constraints from T-t Paths Determined by U-Pb Thermochronology of Zircon and Apatite

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Journal of earth Science 2024年第3期35卷 878-889页

作者： Guangyan zhou Mingchun Song Long Li Yan Luo DGraham Pearson Jianbo zhou Zhengjiang Ding Xuefeng Yu Yingxin Song Jie Li Shiyong Li Faculty of earth Sciences China University of GeosciencesWuhan 430074China Department of earth&Atmospheric Sciences University of AlbertaEdmontonAlberta T6G 2E3Canada Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China Shandong Provincial No.6 exploration Institute of Geology and Mineral Resources Weihai 264209China College of earth Sciences Jilin UniversityChangchun 130061China Ministry of Natural Resources Key Laboratory of Gold Mineralization Processes and Resources Utilization Key Laboratory of Metallogenic-Geologic Processes and Comprehensive Utilization of Minerals Resources in Shandong ProvinceShandong Institute of Geological SciencesJinan 250013China Shandong Nuclear Industry Geological Group 273 Yantai 264006China

The Mesozoic intrusions of the Jiaodong Peninsula,eastern China,host giant gold *** the genesis of these deposits requires the determination of the source of the parental auriferous fluid and the timing of gold mineralization,which are strongly influenced by the cooling/uplift histories of the hosting *** performed an integrated U-Pb geochronology study on both zircon and apatite from four major magmatic episodes of the Jiaodong *** zircon and apatite U-Pb ages are 156.9±1.2 and 137.2±2.4 Ma for the Linglong intrusion,129.9±1.0 and 125.0±3.8 Ma for the Qujia intrusion,119.5±0.7 and 117.2±1.8 Ma for the Liulinzhuang intrusion,118.6±1.0 and 111.6±1.6 Ma for the Nansu intrusion,*** coupled zircon and apatite data of these granitoids indicate a slow cooling rate(11.9°C/Ma)in the Late Jurassic,and rapid uplift and cooling(35.8-29.2°C/Ma)in the early *** dramatically increased uplift and cooling period in the early Cretaceous are contemporaneous with large-scale gold mineralization in the Jiaodong *** implies that thermal upwelling of asthenosphere and related tectonic extension played an important role in gold remobilization and precipitation.

关键词： magmatism geochronology zircon apatite gold deposits Jiaodong Peninsula

Sodium metals for single emitter strong coupling:Alternative plasmonic candidates beyond noble metals

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 106-117页

作者： Yi Zhang Shuying Chen Yuning Han Xiulai Xu Lin zhou National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210008China School of Information and electronic engineering(Sussex Artificial Intelligence Institute) Zhejiang Gongshang UniversityHangzhou 310018China Department of Physics&Astronomy University College LondonLondon WC1E 6BTUK State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

This work provides a theoretical investigation into the strong coupling between a single quantum emitter(Qe)and the surface plasmons of sodium metals in two representative plasmonic systems,i.e.,the semi-infinite metal-dielectric interface and the metal nanoparticles(NPs)of monomer/dimer *** both configurations,sodium metals exhibit distinctly stronger coupling strength and lower optical loss in the optical region than their noble metal counterparts,demonstrating the ideal candidate characteristics for single-molecule-level strong couplings with distinctly facile operation *** results provide new insights into extreme light-matter interactions with potential applications in quantum information,optical sensors,quantum chemistry,etc.

关键词： sodium metals plasmonics single quantum emitter strong coupling pseudomode

PABP-driven secondary condensed phase within RSV inclusion bodies activates viral mRNAs for ribosomal recruitment

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Virologica Sinica 2024年第2期39卷 235-250页

作者： Qiang Zhang Hanzhe Ye Cong Liu Haiwu zhou Mingbin He Xiaodong Liang Yu zhou Kun Wang Yali Qin Zhifei Li Mingzhou Chen State Key Laboratory of Virology and Modern Virology Research Center College of Life SciencesWuhan UniversityWuhan430072China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan430072China Hubei Jiangxia Laboratory Wuhan430200China

Inclusion bodies(IBs)of respiratory syncytial virus(RSV)are formed by liquid-liquid phase separation(LLPS)and contain internal structures termed“IB-associated granules”(IBAGs),where anti-termination factor M2-1 and viral mRNAs are ***,the mechanism of IBAG formation and the physiological function of IBAGs are ***,we found that the internal structures of RSV IBs are actual M2-1-free viral messenger ribonucleoprotein(mRNP)condensates formed by secondary ***,the RSV nucleoprotein(N)and M2-1 interact with and recruit PABP to IBs,promoting PABP to bind viral mRNAs transcribed in IBs by RNArecognition motif and drive secondary phase ***,PABP-eIF4G1 interaction regulates viral mRNP condensate composition,thereby recruiting specific translation initiation factors(eIF4G1,eIF4e,eIF4A,eIF4B and eIF4H)into the secondary condensed phase to activate viral mRNAs for ribosomal *** study proposes a novel LLPS-regulated translation mechanism during viral infection and a novel antiviral strategy via targeting on secondary condensed phase.

关键词： Respiratory syncytial virus(RSV) Inclusion bodies(IBs) Biomolecular condensates Liquid-liquid phase separation(LLPS) Secondary condensed phase mRNA activation

Saponin Ⅰ from Shuitianqi(Rhizoma Schizocapasae Plantagineae) inhibits metastasis by negatively regulating the transforming growth factor-β1/Smad7 network and epithelial-mesenchymal transition in the intrahepatic metastasis Bagg's Albino/c mouse model

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Journal of Traditional Chinese Medicine 2024年第4期44卷 642-651页

作者： LYU Meixian zhou Huan ZHI Limin zhou Jinling GAN Rizhi QIN Yanping He Nengting ZUO Qiqi LI Hao DONG Min LIANG Gang Pharmaceutical College Guangxi Medical UniversityNanning 530022China Department of Pharmacy Affiliated Tumor Hospital of Guangxi Medical UniversityNanning 530022China Drug clinical trial Facility office the People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530022China College of Pharmacy Guangxi University of Chinese MedicineNanning 530022China Department of Pharmacy the Second Affiliated Hospital of Guangxi Medical UniversityNanning 530005China Department of Pharmacy People's Hospital of Guangxi HezhouHezhou 542899China Department of Pharmacy Guangzhou Women and Children's Medical Center Liuzhou HospitalLiuzhou 545000China Department of Pharmacy First Affiliated Hospital of Gannan Medical UniversityGannan 341000China

OBJeCTIVe:To examine the influence of SaponinⅠfrom Shuitianqi(Rhizoma Schizocapasae Plantagineae)(SSPHⅠ)on hepatocellular carcinoma(HCC)metastasis,and to elucidate the underlying ***:The intrahepatic metastasis Bagg's Albino/c(BALB/c)mouse model was established with human hepatocellular carcinomas(HepG2)cells,then treated with normal saline(once per day),cisplatin(2 mg/kg,once every 2 d),and SSPHⅠ(25,50,and 75 mg/kg,once per day).Then,we assessed alterations in the hepatic pathology and target protein expressions in the intrahepatic metastasis BALB/c mouse model using a series of molecular biology ***:Based on our analysis,SSPHⅠsignificantly alleviated hepatocyte necrosis and tumor cells ***,SSPHⅠsuppressed extracellular matrix(eCM)degradation and angiogenesis via a decrease in matrix etalloproteinase-2(MMP-2),MMP-9,CD31,CD34,and vascular endothelial growth factor(VeGF)***,SSPHⅠrepressed invasion and metastasis by suppressing the transforming growth factor-β1(TGF-β1)/Smad7 axis and epithelial-mesenchymal transition(eMT),as evidenced by the scarce TGF-β1,Ncadherin,and Vimentin expressions,and elevated Smad7 and e-cadherin ***:The SSPHⅠ-mediated negative regulation of the TGF-β1/Smad7 axis and eMT are critical for the inhibition of HCC invasion and metastasis.

关键词： carcinoma,hepatocellular epithelial-mesenchymal transition transforming growth factor beta1 Smad7 protein Saponin I from Shuitianqi(Rhizoma Schizocapasae Plantagineae)

Protein lysine crotonylation in cellular processions and disease associations

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Genes & Diseases 2024年第5期11卷 219-235页

作者： Hongling Zhao Yang Han Pingkun zhou Hua Guan Shanshan Gao Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing 100850China

Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological *** e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these *** levels of Kcr modifications have been identified on both histone and non-histone *** present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological *** addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关键词： Cell biology Disease Lysine crotonylation Posttranslational modification Therapeutic target

Decoupled water electrolysis:Flexible strategy for pure hydrogen production with small voltage inputs

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Journal of energy Chemistry 2024年第7期94卷 340-356页

作者： Kexin zhou Jiahui Huang Daili Xiang Aijiao Deng Jialei Du Hong Liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongUniversity of JinanJinan 250022ShandongChina State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongChina Zhengzhou Vocational College of Industrial Safety Zhengzhou 451192HenanChina

Hydrogen gas is widely regarded as an ideal green energy carrier and a potential alternative to fossil fuels for coping with the aggravating energy crisis and environmental ***,the vast majority of the world's hydrogen is produced by reforming fossil fuels;however,this hydrogen-making technology is not sustainable or environmentally friendly because ofits high energy consumption and large carbon ***-driven water splitting(2H_(2)0-2H_(2)+0_(2))becomes an extensively studied scheme for sustain-able hydrogen *** water electrolysis requires an input voltage higher than 1.23 V and forms a gas mixture of H_(2)/O_(2),which results in high electricity consumption,potential safety hazards,and harmful reactive oxygen *** virtue of the auxiliary redox mediators(RMs)as the robust H^(+)/e^(-)reservoir,decoupled electrolysis splits water at a much lower potential and evolves O_(2)(H_(2)O+RMS_(ox)-O_(2)+H-RMS_(red))and H_(2)(H-RMS_(red)-H_(2)+RMS_(ox))at separate times,rates,and spaces,thus pro-ducing the puretarget hydrogen gas *** electrolysis has accelerated the development ofwater electrolysis technology for H_(2) ***,itis still lack of a comprehensive and in-depth review in this field based on different types of *** review highlights the basic principles and critical progress of this emerging water electrolysis mode over the past *** representative examples are then dis-played in detail according to the differences in the *** rational choice and design of RMs have also been ***,novel applications of decoupled water splitting are briefly discussed,including the manufacture of valuable chemicals,Cl_(2) production,pollutant degradation,and other half-reactions in artificial ***,thekey characteristics and disadvantages of each type of mediator are sum-marized in *** addition,we present an outlook for future directions in decoupled

关键词： Hydrogen production Conventional water splitting Decoupled water splitting Redox mediators Biomimetics

enhancing the activity and succinyl-CoA specificity of 3-ketoacyl-CoA thiolase Tfu_0875 through rational binding pocket engineering

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Synthetic and Systems Biotechnology 2024年第3期9卷 558-568页

作者： Lixia Liu Shuang Liu Xiangyang Hu Shenghu zhou Yu Deng National engineering Research Center of Cereal Fermentation and Food Biomanufacturing Jiangnan University1800 Lihu RoadWuxiJiangsu214122China Jiangsu Provincial Research Center for Bioactive Product Processing Technology Jiangnan University1800 Lihu RoadWuxiJiangsu214122China

The 3-ketoacyl-CoA thiolase is the rate-limiting enzyme for linear dicarboxylic acids ***,the promiscuous substrate specificity and suboptimal catalytic performance have restricted its *** we present both biochemical and structural analyses of a high-efficiency 3-ketoacyl-CoA thiolase Tfu_***,Tfu_0875 displayed heightened activity and substrate specificity for succinyl-CoA,a key precursor in adipic acid *** enhance its performance,a deep learning approach(DLKcat)was employed to identify effective mutants,and a computational strategy,known as the greedy accumulated strategy for protein engineering(GRAPe),was used to accumulate these effective *** the mutants,Tfu_0875N249W/L163H/e217L exhibited the highest specific activity(320%of wild-type Tfu_0875),the greatest catalytic efficiency(kcat/KM=1.00 min-1mM-1),the highest succinyl-CoA specificity(KM=0.59 mM,28.1%of Tfu_0875)and dramatically reduced substrate binding energy(-30.25 kcal mol^(-1)v.s.-15.94 kcal mol^(-1)).A structural comparison between Tfu_0875N249W/L163H/e217L and the wild type Tfu_0875 revealed that the increased interaction between the enzyme and succinyl-CoA was the primary reason for the enhanced enzyme *** interaction facilitated rapid substrate anchoring and ***,a reduced binding pocket volume improved substrate specificity by enhancing the complementarity between the binding pocket and the substrate in stereo ***,our rationally designed mutant,Tfu_0875N249W/L163H/e217L,increased the adipic acid titer by 1.35-fold compared to the wild type Tfu_0875 in shake *** demonstrated enzymatic methods provide a promising enzyme variant for the adipic acid *** above effective substrate binding pocket engineering strategy can be beneficial for the production of other industrially competitive biobased chemicals when be applied to other thiolases.

关键词： Adipic acid 3-Ketoacyl-CoA thiolase Claisen condensation Deep learning GRAPe strategy

Decoding the Puzzle of Late ediacaran Glaciation(s)

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Journal of earth Science 2024年第3期35卷 1049-1052页

作者： Bin Wen Yanting Lin Fuyun Shen Junyuan zhou School of earth Sciences China University of GeosciencesWuhan 430074China State Key Laboratory of Biogeology and environmental Geology China University of GeosciencesWuhan 430078China

INTRODUCTION In the earth’s history,the Late ediacaran to early Cambrian period witnessed a series of profound changes in both earth’s interior and surficial systems which may have made this planet more habitable for the first radiation of early animals(known as the global occurrence of ediacaran biota;Xiao and Narbonne,2020).Among those changes,the Late ediacaran glaciation,soon followed and accompanied by the early complex life of ediacaran biota,attracted much attention of scientists and may have provided a good opportunity to investigate the interactions between the earth’s surficial environment and the biosphere(e.g.,Xu et al.,2024;Zhang et al.,2023;Hoffman et al.,2017).To achieve this goal,the nature of the glaciation itself needs to be understood *** now,32 or more ediacaran glacial deposits have been documented on almost all the existing continents(Niu et al.,2024;Wang et al.,2023a,b,c),showing a similar distribution pattern to the two Cryogenian(Sturtian and Marinoan)Snowball earth glaciations if plotted in one single paleogeographic map(Figure 1;Niu et al.,2024;Li et al.,2013).But further compared to the Cryogenian Snowball earth glaciations,the Late ediacaran glaciation has some fundamentally different characteristics:(1)as shown in Figure 1,most glacial deposits are not stratigraphically overlain by the typical cap carbonate while it usually happened in the aftermath of a Snowball earth glaciation and represented an abrupt climatic switch from extreme icehouse(global freezing)to greenhouse(global warming)condition(Hoffman et al.,2017).

关键词： earth glacial Cambrian

论古典目录学的“小说”概念的非文体性质--兼论古今两种“小说”概念的本质区别

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复旦学报（社会科学版） 2008年第3期50卷 10-19页

作者：邵毅平周峨复旦大学中文系上海200433 上海中医药大学基础医学院上海201203

从《汉书.艺文志》到《四库全书总目》,古典目录学始终没有赋予"小说"以任何正面的具有质的规定性的定义,而其"小说家"也始终没有摆脱收容其他部类的"不入流之作"和无类可归的"驳杂之作"的"垃圾桶"性质。古典目录学的"小说"与今天文学性... 详细信息

从《汉书.艺文志》到《四库全书总目》,古典目录学始终没有赋予"小说"以任何正面的具有质的规定性的定义,而其"小说家"也始终没有摆脱收容其他部类的"不入流之作"和无类可归的"驳杂之作"的"垃圾桶"性质。古典目录学的"小说"与今天文学性的"小说"名同实异,所指非一。辨明这两个概念之间的本质区别,对推动古代小说、尤其是"文言小说"研究的顺利进展具有重要意义。

关键词：古典目录学小说家小说