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Obstructive sleep apnea is associated with severity and long-term prognosis of acute coronary syndrome

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Journal of Geriatric Cardiology 2018年第2期15卷 146-152页

作者： Shuo JIA Yu-Jie zhou yi YU Si-Jing WU Yan SUN zhi-Jian WANG Xiao-Li LIU Bright Eric King ying-Xin ZHAO Dong-Mei SHI Yu-Yang LIU zhi-Ming zhou Bejing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing China

Background Obstructive sleep apnea （OSA） is a common disease in patients with acute coronary syndrome （ACS） and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography. We divided the patients into two groups： moderate to severe OSA group [apnea-hypopnea index （AHI）〉 15 events/h] and control group （AHI ≤ 15 events/h）. They were followed up for up 32 months. Then, we compared the ACS severity and long-term major adverse cardiovascular events （MACE） in patients with different severity of OSA. Results Five hundred and twenty nine patients were included in the final analysis, with 76% of them being men and an average age of 59 ＋ 10 years. The overall mean AHI is 29 ± 19 events/h, 70.5% of them （373/529） being with moderate to severe OSA and 29.5% （156/529） assign into control group. Compared with controls, patients with moderate or severe OSA exhibited a higher prevalence of hypertension as well as higher body mass index, SYNTAX score, Epworth score and length of hospitalization. With a median follow-up duration of 30 months, accumulative rate of MACE was also higher in patients with moderate or severe OSA than that in the control group （8.6% vs. 3.2%, P = 0.028）. After adjusting for baseline confounders by cox regression model, moderate to severe OSA was an independent risk factor of long-term MACE （P = 0.047, HR = 1.618, 95% CI： 1.069-3.869）. Conclusions The results of this study demonstrate that moderate or severe OSA is correlated with disease severity and associated with worse long-term prognosis in ACS patients. The results rai

关键词： Coronary angiogram Coronary artery disease Obstructive sleep apnea Outcomes

Characterizations of Weighted BMO Space and Its Application

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Acta Mathematica Sinica,English Series 2021年第8期37卷 1278-1292页

作者： Ding Huai WANG Jiang zhou zhi Dong TENG School of Mathematics and Statistics Anhui Normal UniversityWuhu 241002P.R.China College of Mathematics and System Sciences Xinjiang UniversityUrumqi 830046P.R.China

In this paper,we prove that the weighted BMO space BMO^(p)(ω)={f∈L^(1)_(loc):sup||χQ||^(-1)Lp(ω)||(F-Fq)ω^(-1)χQ||LP(ω)<∞Q}is independent of the scale p∈(0,∞)in sense of norm whenω∈A_(1).Moreover,we can replace L^(p)(ω)by L^(p,∞)(ω).As an application,we characterize this space by the boundedness of the bilinear commutators[b,T]_(j)(j=1,2),generated by the bilinear convolution type Calderdn-Zygmund operators and the symbol b,from L^(p1)(ω)×L^(p2)(ω)to L^(p)(ω^(1-p))with 1

关键词： Boundedness Calderon-Zygmund operators characterization commutators weighted BMO space

基于Midas GTS分析的深基坑降水开挖变形特性研究

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工程建设与设计 2024年第6期 16-19页

作者：温世聪周汇智广东省建筑科学研究院集团股份有限公司广州510500 广东省建设工程质量安全检测总站有限公司广州510500

基于Midas GTS软件对广州某深基坑开挖过程进行数值模拟,考虑渗流作用的影响,对比分析了两种情况下基坑开挖过程中周边地表沉降变形、围护结构水平位移的变化规律,并与现场地面沉降调查结果进行比较。结果表明,地下水渗流作用在基坑降... 详细信息

基于Midas GTS软件对广州某深基坑开挖过程进行数值模拟,考虑渗流作用的影响,对比分析了两种情况下基坑开挖过程中周边地表沉降变形、围护结构水平位移的变化规律,并与现场地面沉降调查结果进行比较。结果表明,地下水渗流作用在基坑降水开挖过程中有显著影响。

关键词：基坑降水数值模拟 Midas GTS 变形特性

基于熵权TOPSIS的区域公路物流综合评价研究——以宁波市为例

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物流工程与管理 2024年第4期46卷 1-4,9页

作者：张灵源胡振崑徐樨沈艺周志丹浙江万里学院物流与电子商务学院浙江宁波315100 浙江万里学院商学院浙江宁波315100

我国物流业发展迅速,公路物流作为基础承载了大量社会物流量。宁波为港口城市,公路运输对港口物流的发展至关重要。文中通过构建经济基础、基础设施、物流数字化能力等5个二级指标,采用熵权TOPSIS法评价了宁波近几年的公路物流综合能力... 详细信息

我国物流业发展迅速,公路物流作为基础承载了大量社会物流量。宁波为港口城市,公路运输对港口物流的发展至关重要。文中通过构建经济基础、基础设施、物流数字化能力等5个二级指标,采用熵权TOPSIS法评价了宁波近几年的公路物流综合能力,发现其呈稳步上升趋势,展现出较好的经济韧性,基础设施成熟度较高。为助推宁波公路物流向更高层次、更高效的方向发展,进一步提升公路物流综合能力,文中提出加快数字化转型,加强产业链协同,培养人才队伍,推进绿色物流发展,优化基础设施运营建设等建议。

关键词：区域公路物流熵权TOPSIS 综合评价宁波市

Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

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Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin zhou Tianming Zhao Hanlong Zhu Tingting Luo Kang Jiang Xiaoxiao Shi Chunyan Chen Han Zhang Si Zhao Xiaoping Zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo Jiang Bing Xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

Linkage of mineral inclusions and zoning of magnetite with fluid evolution of hydrothermal systems: A case study of the Fenghuangshan Cu-Fe-Au skarn deposit， Eastern China

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Journal of Earth Science 2024年

作者： Xiao-Wen Huang yiping Yang Mei-Fu zhou Yu-Miao Meng Jian-Feng Gao Liang Qi State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials， Guangzhou Institute of Geochemistry， Chinese Academy of Sciences

Magnetite from hydrothermal deposits may show compositional zoning with various mineral inclusions in response to the evolution of hydrothermal fluids. Magnetite from the Fenghuangshan Cu-Fe-Au skarn deposit (Eastern China) is a common mineral formed in the earlier stage of skarnization. Magnetite grains have dark gray and light gray zones and contain diverse mineral inclusions. Dark gray zones have higher Si， Ca， Al， and Mg contents than light gray zones. The magnetite matrix from dark gray zones shows superstructure along the [0-11] zone axis in fast Fourier transform patterns， different from magnetite from light gray zones with normal structure. Three types of mineral inclusions are identified within magnetite: nano-， micron- and submicron-nanometer inclusions. Nanoinclusions hosted in dark gray zones are actinolite， diopside， and trace element-rich magnetite， and these are likely formed by growth entrapment during magnetite crystallization at the skarn stage. The chain-width order-disorder intergrowths of diopside nanoinclusion likely indicate fluctuating fluid compositions in a lattice scale. Submicron to nanometer inclusions at the boundary between dark gray and light gray zones are quartz， titanite， and Ti-rich magnetite， which were formed via a dissolution and reprecipitation process at the quartz-sulfide stage. Micron-inclusions randomly distributed in both dark and light gray zones include calcite， ankerite， quartz， and chlorite， and these were formed via penetration of fluids at the carbonate stage. Zoned magnetite was formed by fluid replacement， overgrowth， and fluid infilling. Our study highlights the importance of mineral inclusion assemblages， and textural and chemical zonation of magnetite in constraining fluid evolution.

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跨既有铁路线T型刚构桥转体施工关键技术

价值工程 2024年第6期43卷 86-89页

作者：周逸瑜石朋杰中铁十二局集团第三工程有限公司太原030024

在进行上跨既有铁路线的桥梁转体施工过程中,由于受铁路运营影响,不能长时间阻碍交通运行,因此增加了上跨桥梁的施工难度。本文以某高速公路跨铁路段T型刚构桥转体施工为依托,研究了转体结构施工中转体牵引力、安全系数等转体参数的计算... 详细信息

在进行上跨既有铁路线的桥梁转体施工过程中,由于受铁路运营影响,不能长时间阻碍交通运行,因此增加了上跨桥梁的施工难度。本文以某高速公路跨铁路段T型刚构桥转体施工为依托,研究了转体结构施工中转体牵引力、安全系数等转体参数的计算,为转体设备的布置及选型提供依据。通过研究转体施工中的关键技术问题,把控桥跨转体过程中的重要节点,确保了施工过程中的结构安全及稳定。

关键词：转体施工铁路上跨关键技术

Cr5Si3B and Hf5Si3B:New MAB phases with anisotropic electrical,mechanical properties and damage tolerance

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Journal of Materials Science & Technology 2018年第8期34卷 1441-1448页

作者： Yanchun zhou Huimin Xiang Fu-zhi Dai zhihai Feng Science and Technology on Advanced Functional Composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyNo.1 South Dahongmen RoadBeijing 100076China

Through a combination of electronic structure, chemical bonding and mechanical property investigations, anisotropic electrical and mechanical properties, and damage tolerant ability of MAB phases CrsSi3 B and HfsSi3B are predicted. The anisotropic electrical conductivity is due to the anisotropic distribution of Cr in CrsSiaB and Hf in HfsSi3B, which mainly contribute to the electrical conductivity. The anisotropic mechanical properties are underpinned by the anisotropic chemical bonding within the crystal structures of CrsSi3B and HfsSi3B. The high stiffness is determined by the strong covalent-ionic Crl--B--Crl and Crl--Si bonds in CrsSi3B and the ionic-covalent Hfl--B--Hfl and Si--B bonds in HfsSi3B; while the low shear deformation resistance is attributed to the presence of metallic Cr--Cr, Hf--Hf and Si--Si bond. Based on the low Pugh＇s ratio, CrsSi3B and Hfs Si3B are predicted tolerant to damage. The possible cleavage plane is （0001） and the possible slip systems are 〈1 100〉1{11 20} and 〈11 20〉1{0001} for both CrsSi3B and HfsSi3B.

关键词： MAB phases CrsSi3B and HfsSi3 BFirst-principles calculations Mechanical properties Chemical bonding

Decoding Retinoblastoma: Differential Gene Expression

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International Journal of Clinical Medicine 2024年第4期15卷 177-196页

作者： Ahmed Jasim Mahmood Al-Mashhadani Franko Shehaj Lianhong zhou Department of Ophthalmology Renmin Hospital of Wuhan University Wuhan China

Background: Retinoblastoma, the most common intraocular pediatric cancer, presents complexities in its genetic landscape that necessitate a deeper understanding for improved therapeutic interventions. This study leverages computational tools to dissect the differential gene expression profiles in retinoblastoma. Methods: Employing an in silico approach, we analyzed gene expression data from public repositories by applying rigorous statistical models, including limma and de seq 2, for identifying differentially expressed genes DEGs. Our findings were validated through cross-referencing with independent datasets and existing literature. We further employed functional annotation and pathway analysis to elucidate the biological significance of these DEGs. Results: Our computational analysis confirmed the dysregulation of key retinoblastoma-associated genes. In comparison to normal retinal tissue, RB1 exhibited a 2.5-fold increase in expression (adjusted p Conclusions: Our analysis reinforces the critical genetic alterations known in retinoblastoma and unveils new avenues for research into the disease’s molecular basis. The discovery of chemoresistance markers and immune-related genes opens potential pathways for personalized treatment strategies. The study’s outcomes emphasize the power of in silico analyses in unraveling complex cancer genomics.

关键词： Retinoblastoma Gene Expression In Silico Study Differentially Expressed Genes Chemoresistance Immune Response Computational Biology