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Predicting dynamic compressive strength of frozen-thawed rocks by characteristic impedance and data-driven methods

Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2591-2606页

作者： shengtao zhou Zong-Xian Zhang Xuedong Luo Yifan Huang Zhi Yu Xiaowei Yang Faculty of Engineering China University of GeosciencesWuhan430074China Oulu Mining School University of OuluOulu90570Finland Zijin School of Geology and Mining Fuzhou UniversityFuzhou350116China Department of Earth Science&Engineering Imperial College LondonLondonSW72AZUK

In cold regions,the dynamic compressive strength(DCS)of rock damaged by freeze-thaw weathering significantly influences the stability of rock ***,testing the dynamic strength under freeze-thaw weathering conditions is often both time-consuming and ***,this study considers the effect of characteristic impedance on DCS and aims to quickly determine the DCS of frozen-thawed rocks through the application of machine-learning ***,a database of DCS for frozen-thawed rocks,comprising 216 rock specimens,was *** external load parameters(freeze-thaw cycle number,confining pressure,and impact pressure)and two rock parameters(characteristic impedance and porosity)were selected as input variables,with DCS as the predicted *** research optimized the kernel scale,penalty factor,and insensitive loss coefficient of the support vector regression(SVR)model using five swarm intelligent optimization algorithms,leading to the development of five hybrid *** addition,a statistical DCS prediction equation using multiple linear regression techniques was *** performance of the prediction models was comprehensively evaluated using two error indexes and two trend indexes.A sensitivity analysis based on the cosine amplitude method has also been *** results demonstrate that the proposed hybrid SVR-based models consistently provided accurate DCS *** these models,the SVR model optimized with the chameleon swarm algorithm exhibited the best performance,with metrics indicating its effectiveness,including root mean square error(RMSE)?3.9675,mean absolute error(MAE)?2.9673,coefficient of determination(R2)?0.98631,and variance accounted for(VAF)?*** suggests that the chameleon swarm algorithm yielded the most optimal results for enhancing SVR ***,impact pressure and characteristic impedance emerged as the two most influential parameters in DCS *** research is ant

关键词： Freeze-thaw cycle Characteristic impedance Dynamic compressive strength Machine learning Support vector regression

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Research on Blended Teaching Mode of Higher Vocational Computer Education under the Background of Information Technology

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Journal of Contemporary Educational Research 2024年第8期8卷 70-75页

作者： shengtao zhou Heilongjiang Ecological Engineering Vocational College Harbin 150025Heilongjiang ProvinceChina

With the rapid development of information technology,higher vocational computer education is facing an unprecedented *** the background of information technology,this paper discusses the construction and practice of blended teaching mode of higher vocational computer *** analyzing the theoretical basis of the blended teaching mode and combining the actual needs of higher vocational computer education,a blended teaching mode combining online and offline is proposed,aiming at enhancing students’independent learning ability,practical operation skills,and teamwork spirit,and providing new ideas and methods for the development of higher vocational computer education.

关键词： Information technology Computer education Blended teaching

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The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

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Science China(Life Sciences) 2024年第8期67卷 1549-1562页

作者： Peidong Zhang Peiwei Li Muya Tang Ryan CGimple Liang Huang Jing Yue Qiuhong Shen Yiwei Du Qian Zhang Zhengnan Yang Haihuai He Kailin Yang Linjie Zhao shengtao zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOEState Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Physician Scientist Training Program Department of MedicineWashington University School of MedicineSt.Louis 63110USA Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Department of Radiation Oncology Taussig Cancer CenterCleveland ClinicCleveland 44106USA

Mechanics shape cell and tissue plasticity and maintain their *** cancers,mechanical signals regulate cancer hallmarks via mechanotransduction pathways,such as proliferation,metastasis and metabolic ***,comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains ***,we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas(TCGA)*** the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway *** subtype has its own unique molecular expression pattern,mutation landscapes,immune infiltrates,and patient clinical *** further found that the responses of two subtypes of cancers,one with the optimal outcome and the other with the worst prognosis,to a classical mechanotherapeutic agent(Fasudil,RhoA/ROCK inhibitor)were totally different,indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic ***,our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.

关键词： pan-cancer cancer mechanics multi-omics immunology

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Shanghai Gynecologic Oncology Group’s consensus on the academic and industry’s clinical trial types

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中华医学杂志(英文版) 2024年第14期137卷 2024 Apr 24页

作者： Shi Tingyan Liu Jihong Zhu Jianqing Wang Xipeng Jiang Wei Lu Xin Feng Weiwei zhou shengtao Shen Yang Chen Gang Wu Zhenyu Zou Dongling Wu Peng Yang Huijuan Wu Sufang Zhu Tao Wang Huaying Zhang Yingli Qiu Lihua Guo Xiaoqing Xiang Libing Zhang Wei Ren Yulan Feng Yanling Liu Yanfei Chen Xiaojun Zang Rongyu Department of Gynecologic Oncology Fudan University Zhongshan Hospital Institute for Ovarian Cancer Fudan University Shanghai China Department of Gynecologic Oncology Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong China Department of Gynecologic Oncology Zhejiang Cancer Hospital Hangzhou Zhejiang China Department of Obstetrics and Gynecology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Gynecology Obstetrics and Gynecology Hospital Fudan University Shanghai China Department of Obstetrics and Gynecology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy West China Second Hospital Sichuan University and Collaborative Innovation Center Chengdu Sichuan China Department of Obstetrics and Gynecology Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu China National Clinical Research Center for Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China School of Public Health Key Laboratory of Public Health Safety and Collaborative Innovation Center of Social Risks Governance in Health Fudan University Shanghai China Gynecologic Oncology Center Chongqing University Cancer Hospital Chongqing China Department of Obstetrics and Gynecology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Gynecologic Oncology Fudan University Shanghai Cancer Center Shanghai China Department of Obstetrics and Gynecology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Obstetrics and Gynecology Renji Hospital School of Medicine

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m6A修饰对卵巢癌发生发展的作用及其作为潜在治疗靶点的价值探讨

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中国癌症防治杂志 2024年第2期16卷 238-242页

作者：龙宇浩郑博豪周圣涛四川大学华西第二医院妇产科成都610041 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 江南大学无锡医学院无锡214122

卵巢癌是全球妇科癌症相关死亡的第二大原因,严重威胁着妇女的生命健康。由于缺乏特定的早期症状,卵巢癌通常在诊断时已为晚期,患者5年总生存率较低。N6‐甲基腺苷(N6‐methyladenosine,m6A)修饰是哺乳动物RNA中最常见的表观遗传修饰。... 详细信息

卵巢癌是全球妇科癌症相关死亡的第二大原因,严重威胁着妇女的生命健康。由于缺乏特定的早期症状,卵巢癌通常在诊断时已为晚期,患者5年总生存率较低。N6‐甲基腺苷(N6‐methyladenosine,m6A)修饰是哺乳动物RNA中最常见的表观遗传修饰。近年来多项研究表明,m6A修饰及其相关修饰调控因子在卵巢癌患者中异常表达,可能在卵巢癌发生、进展、转移和化疗耐药方面起关键作用。m6A修饰及其相关调控因子可能成为卵巢癌早期预测和预后评估标志物,有望为卵巢癌的诊治提供新的方向。

关键词：卵巢癌 m6A 表观遗传学治疗策略

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Understanding endometriosis from an immunomicroenvironmental perspective

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Chinese Medical Journal 2023年第16期136卷 1897-1909页

作者： Dian Fan Xu Wang Zhixian Shi Yuting Jiang Bohao Zheng Lian Xu shengtao zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation CenterChengduSichuan 610041China Wuxi School of Medicine Jiangnan UniversityWuxiJiangsu 214122China Department of Pathology West China Second HospitalSichuan UniversityChengduSichuan 610041China 不详

Endometriosis,a heterogeneous,inflammatory,and estrogen-dependent gynecological disease defined by the presence and growth of endometrial tissues outside the lining of the uterus,affects approximately 5-10%of reproductive-age women,causing chronic pelvic pain and reduced *** the etiology of endometriosis is still elusive,emerging evidence supports the idea that immune dysregulation can promote the survival and growth of retrograde endometrial *** macrophages and natural killer(NK)cells exhibit deficient cytotoxicity in the endometriotic microenvironment,leading to inefficient eradication of refluxed endometrial *** addition,the imbalance of T-cell subtypes results in aberrant cytokine production and chronic inflammation,which contribute to endometriosis *** it remains uncertain whether immune dysregulation represents an initial cause or merely a secondary enhancer of endometriosis,therapies targeting altered immune pathways exhibit satisfactory effects in preventing disease onset and ***,we summarize the phenotypic and functional alterations of immune cells in the endometriotic microenvironment,focusing on their interactions with microbiota and endocrine and nervous systems,and how these interactions contribute to the etiology and symptomology of endometriosis.

关键词： Endometriosis Immune cells Microenvironment Inflammation

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直耦增强型CMOS相机技术研究

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红外技术 2024年第6期46卷 699-706,721页

作者：李亚情李晗艳张立昀陈旭华李晓露邱永生何俊高天礼杜培德周盛涛北方夜视技术股份有限公司云南昆明650217 山东省军民融合发展促进中心山东济南266406

直耦增强型CMOS(intensified complementary metal-oxide-semiconductor,ICMOS)相机通过将像增强器输出窗与CMOS直接耦合而成,具备灵敏度高、响应速度快、光谱范围可调等特点。本文根据ICMOS的组成结构,分析了阴极、微通道板、荧光屏、C... 详细信息

直耦增强型CMOS(intensified complementary metal-oxide-semiconductor,ICMOS)相机通过将像增强器输出窗与CMOS直接耦合而成,具备灵敏度高、响应速度快、光谱范围可调等特点。本文根据ICMOS的组成结构,分析了阴极、微通道板、荧光屏、CMOS等各组成部件对直耦ICMOS成像性能的影响,提出ICMOS用像增强器、CMOS成像器件的选型依据,并结合公司对像增强器的加工优势,基于18 mm NVT-7像增强器和1英寸CMOS开展了实际微光成像验证。结果表明,采用直耦方式的ICMOS相机能够在5×10^(-4)lx条件下清晰成像,分辨力达到16 lp/mm。此外,用于ICMOS耦合的像增强器增益不宜过高,4000 cd/(m^(2)·lx)比较适宜,另外,在增益适宜的条件下,荧光屏输出亮度对其性能影响不大。

关键词：像增强器光锥直耦分辨力

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Viral proteomics: The emerging cutting-edge of virus research

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Science China(Life Sciences) 2011年第6期54卷 502-512页

作者： zhou shengtao LIU Rui ZHAO Xia HUANG CanHua WEI YuQuan Department of Gynecology and Obstetrics West China Second HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China

Viruses replicate and proliferate in host cells while continuously adjusting to and modulating the host *** encode a wide spectrum of multifunctional proteins,which interplay with and modify proteins in host *** genomes were chronologically the first to be ***,the corresponding viral proteomes,the alterations of host proteomes upon viral infection,and the dynamic nature of proteins,such as post-translational modifications,enzymatic cleavage,and activation or destruction by proteolysis,remain largely *** high-throughput techniques,in particular quantitative or semi-quantitative mass spectrometry-based proteomics analysis of viral and cellular proteomes,have been applied to define viruses and their interactions with their ***,we review the major areas of viral proteomics,including virion proteomics,structural proteomics,viral protein interactomics,and changes to the host cell proteome upon viral infection.

关键词：结构蛋白质组学病毒复制宿主细胞细胞增殖相互作用病毒感染功能蛋白质翻译后修饰

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Chemical proteomics:terra incognita for novel drug target profiling

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Chinese Journal of Cancer 2012年第11期31卷 507-518页

作者： Fuqiang Huang Boya Zhang shengtao zhou Xia Zhao Ce Bian Yuquan Wei The State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041P.R.China Department of Gynecology and Obstetrics West China Second HospitalSichuan UniversityChengduSichuan 610041P.R.China.

The growing demand for new therapeutic strategies in the medical and pharmaceutic fields has resulted in a pressing need for novel druggable ***,however,the targets of certain drugs that are already widely used in clinical practice have largely not been *** the pharmacologic effects of a drug can only be appreciated when its interactions with cellular components are clearly delineated,an integrated deconvolution of drug-target interactions for each drug is *** emerging field of chemical proteomics represents a powerful mass spectrometry(MS)-based affinity chromatography approach for identifying proteome-wide small molecule-protein interactions and mapping these interactions to signaling and metabolic *** technique could comprehensively characterize drug targets,profile the toxicity of known drugs,and identify possible off-target *** the use of this technique,candidate drug molecules could be optimized,and predictable side effects might consequently be ***,we provide a holistic overview of the major chemical proteomic approaches and highlight recent advances in this area as well as its potential applications in drug discovery.

关键词：化学蛋白质组学药物靶标蛋白质相互作用临床实践药理作用细胞成分亲和层析代谢途径

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The metabolic switch and its regulation in cancer cells

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Science China(Life Sciences) 2010年第8期53卷 942-958页

作者： zhou shengtao, HUANG CanHua & WEI YuQuan State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China

The primary features of cancer are maintained via intrinsically modified metabolic activity, which is characterized by enhanced nutrient supply, energy production, and biosynthetic activity to synthesize a variety of macromolecular components during each passage through the cell cycle. This metabolic shift in transformed cells, as compared with non-proliferating cells, in-volves aberrant activation of aerobic glycolysis, de novo lipid biosynthesis and glutamine-dependent anaplerosis to fuel robust cell growth and proliferation. Here, we discuss the unique metabolic characteristics of cancer, the constitutive regulation of metabolism through a variety of signal transduction pathways and/or enzymes involved in metabolic reprogramming in cancer cells, and their implications in cancer diagnosis and therapy.

关键词： aerobic glycolysis cancer de novo fatty acid synthesis glutaminolysis metabolism

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