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广东省3～5岁儿童家长口腔健康知识状况

华南预防医学 2019年第4期45卷 354-356页

作者：肖冰莹杨晓霞周玥杉李剑波范卫华黄少宏潮州市中心医院广东潮州521000 南方医科大学口腔医院

目的了解广东省3~5岁儿童家长口腔健康知识和态度,为广东省口腔卫生保健工作提供科学依据。方法在广东省第4次全国口腔健康流行病学调查期间,采用多阶段分层等容量随机抽样方法,抽取广东省4个城区、4个乡镇的3~5岁儿童家长进行问卷调查... 详细信息

目的了解广东省3~5岁儿童家长口腔健康知识和态度,为广东省口腔卫生保健工作提供科学依据。方法在广东省第4次全国口腔健康流行病学调查期间,采用多阶段分层等容量随机抽样方法,抽取广东省4个城区、4个乡镇的3~5岁儿童家长进行问卷调查,问卷采用《第4次全国口腔健康调查问卷(儿童家长)》。结果本研究共调查广东省3~5岁儿童家长2 592人,男性占22.45%(582/2 592),女性占77.55%(2 010/2 562),以儿童母亲为主,占65.63%(1 701/2 562)。初中及以下文化程度占50.54%(1 310/2 592),初中以上占49.46%(1 282/2 562)。城市和农村各占50%。儿童家长对细菌可以引起牙龈发炎的知晓率最高,为83.18%,吃糖可以导致龋齿的知晓率为82.72%,氟化物牙膏能否保护牙齿和窝沟封闭能否预防儿童龋齿的知晓率较低,分别为32.91%、19.48%。城市儿童家长8道口腔知识的知晓率均高于农村儿童家长,差异均有统计学意义(P<0.05或P<0.01)。98.19%的家长同意口腔健康对自己的生活很重要,28.32%的家长同意母亲牙齿不好会影响孩子的牙齿的说法。城市家长在预防牙病首先靠自己、定期口腔检查是十分必要的、牙齿的好坏是天生的,与自己保护关系不大、母亲牙齿不好会影响孩子的牙齿的积极态度比例上均高于农村家长,差异均有统计学意义(P<0.05或P<0.01)。结论大部分儿童家长对口腔健康观念和口腔疾病有正确的认识,部分口腔知识较欠缺。口腔健康知识及态度城市儿童家长均好于农村。

关键词：口腔流行病学口腔健康知识问卷调查牙健康

Molecular basis for the selective recognition and ubiquitination of centromeric histone H3 by yeast E3 ligase Psh1

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Journal of Genetics and Genomics 2021年第6期48卷 463-472页

作者： Ning zhou Liuxin Shi shan shan Zheng zhou National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100089China

Centromeres are chromosomal loci marked by histone variant Cen H3(centromeric histone H3)and essential for genomic stability and cell *** budding yeast E3 ubiquitin ligase Psh1 selectively recognizes the yeast Cen H3(Cse4)for ubiquitination and controls the cellular level of Cse4 for proteolysis,but the underlying mechanism remains largely ***,we show that Psh1 uses a Cse4-binding domain(CBD,residues 1-211)to interact with Cse4-H4 instead of H3-H4,yielding a dissociation constant(Kd)of 27 ***1 recognizes Cse4-specific residues in the L1 loop and a2 helix to ensure Cse4 binding and *** map the Psh1-binding region of Cse4-H4 and identify a wide range of Cse4-specific residues required for the Psh1-mediated Cse4 recognition and *** analyses reveal that histone chaperone Scm3 can impair Cse4 ubiquitination by abrogating Psh1-Cse4 ***,our study reveals a novel Cse4-binding mode distinct from those of known Cen H3 chaperones and elucidates the mechanism by which Scm3 competes with Psh1 for Cse4 binding.

关键词： Cse4 CENP-A Psh1 Scm3 Selective recognition Ubiquitination

Engineering hollow core-shell hetero-structure box to induce interfacial charge modulation for promoting bidirectional sulfur conversion in lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第5期80卷 128-139,I0004页

作者： Weiliang zhou Xinying Wang Jiongwei shan Liguo yue Dongzhen Lu Li Chen Jiacheng Zhang Yunyong Li School of Materials and Energy Guangdong University of TechnologyNo.100 Waihuan Xi RoadGuangzhou Higher Education Mega CenterGuangzhou 510006GuangdongChina

Severe polysulfide shuttling and sluggish sulfur redox kinetics significantly decrease sulfur utilization and cycling stability in lithium-sulfur batteries(LSBs).Herein,we develop a hollow CoO/CoP-Box core-shell heterostructure as a model and multifunctional catalyst modified on separators to induce interfacial charge modulation and expose more active sites for promoting the adsorption and catalytic conversion ability of sulfur *** and experimental findings verify that the in-situ formed core-shell hetero-interface induces the formation of P-Co-O binding and charge redistribution to activate surface O active sites for binding lithium polysulfides(LiPSs)via strong Li-O bonding,thus strongly adsorbing with Li ***,the strong Li-O bonding weakens the competing Li-S bonding in LiPSs or Li2S adsorbed on CoO/CoP-Box surface,plus the hollow heterostructure provides abundant active sites and fast electron/Li+transfer,so reducing Li2S nucleation/dissolution activation *** expected,LSBs with CoO/CoP-Box modified separator and traditional sulfur/carbon black cathode display a large initial capacity of 1240 mA h g^(-1)and a long cycling stability with 300 cycles(~60.1%capacity retention)at ***,the thick sulfur cathode(sulfur loading:5.2 mg cm^(-2))displays a high initial areal capacity of 6.9 mA h cm^(-2).This work verifies a deep mechanism understanding and an effective strategy to induce interfacial charge modulation and enhance active sites for designing efficient dual-directional Li-S catalysts via engineering hollow core-shell hetero-structure.

关键词： CoO/CoP-Box Hollow core-shell hetero-structure Multifunctional catalysts Interfacial charge modulation Lithium sulfur batteries

Formation mechanism and preparation of YAl_(2) intermetallics by electro-deoxidation with different sintering conditions

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Rare Metals 2023年第3期42卷 1067-1074页

作者： yue-shan Wei Shi-Hong Yan Lin zhou De-Hong Chen Rui-Ying Miao Zhi-Qiang Wang National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous MetalsBeijing 100088China Grirem Advanced Materials Co. Beijing 100088China

A study was carried out on the preparation of YAl_(2) intermetallics from mixed oxide precursors using the method of electro-deoxidation.Y2O_(3) and Al_(2)O_(3) mixed in molar proportions of 1:2 were sintered at temperatures ranging from 800 to 12000C for different *** sintered pellet was then electrolyzed in a molten CaCl_(2) at850℃using a graphite anode at a potential of 3.1 *** this work,effects of sintering on the composition and the oxygen content in cathodic products were studied by X-ray diffraction(XRD)and oxygen-nitrogen *** mainly affects the porosity of the pellets,and it is found that porosity decreases gradually with the increase in sintering temperature and the extension of sintering *** sintered at 9000C for 4 h,the oxygen content in the cathodic product decreases to 1.85 wt%,and the efficiency of electro-deoxidation is 94.48%.At the same time,the mechanism of electrolysis was *** results suggest that the formation of YAl_(2) is a multi-step *** the reduction process from mixed oxides Y2O_(3)/Al_(2)O_(3) to YAl_(2) included many intermediate materials,such as YAlO_(3),Y3Al5O12 and YAl3,YAl_(2) intermediate alloy was prepared finally.

关键词： Yttrium aluminum oxide Molten salts YAl_(2)alloy Electro-deoxidation

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li shan-shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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铁路车站施工对行车影响的计算机分析方法研究

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铁道运输与经济 2002年第6期24卷 44-47页

作者：吴振帮乔文俊任秀明周磊山乐逸祥大同铁路分局山西大同037005 北方交通大学交通运输学院北京100044

为准确分析车站施工对行车的影响 ,根据图论原理 ,提出车站平面图和各联锁要素的信息化方法 ,以及道岔及交叉渡线的顶点阻塞方法 ;根据最短径路算法原理 ,设计了自动计算列车接发进路的算法 ;利用顶点状态标记方式自动检索施工对行车影... 详细信息

为准确分析车站施工对行车的影响 ,根据图论原理 ,提出车站平面图和各联锁要素的信息化方法 ,以及道岔及交叉渡线的顶点阻塞方法 ;根据最短径路算法原理 ,设计了自动计算列车接发进路的算法 ;利用顶点状态标记方式自动检索施工对行车影响的分析算法和以框架表示的可视化方法 ;设计了联锁元素的框架顶点计算公式。这些理论和算法已在大同铁路分局得到应用。

关键词：行车影响计算机分析铁路车站施工信息化自动化可视化

Suppressing irreversible phase transition and enhancing electrochemical performance of Ni-rich layered cathode LiNi_(0.9)Co_(0.05)Mn_(0.05)O_(2) by fluorine substitution

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Journal of Energy Chemistry 2021年第10期30卷 574-581,I0015页

作者： Qi-Qi Qiu shan-shan Yuan Jian Bao Qin-Chao Wang Xin-Yang yue Xun-Lu Li Xiao-Jing Wu Yong-Ning zhou Department of Materials Science Fudan UniversityShanghai 200433China

Ni-rich layered oxide LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(x≥0.8)is the most promising cathodes for future high energy automotive lithium-ion ***,its application is hindered by the undesirable cycle stability,mainly due to the irreversible structure change at high ***,we demonstrate that F substitution with the appropriate amount(1 at%)is capable for improve the electrochemical performance of LiNi_(0.9)Co_(0.05)Mn_(0.05)O_(2) cathode *** is revealed that F substitution can reduce cation mixing,stabilize the crystal structure and improve Li transport *** resulted LiNi_(0.9)Co_(0.05)Mn_(0.05)O_(1.99)F_(0.01)cathode can deliver a high capacity of 194.4 mAh g^(-1) with capacity retention of 95.5%after 100 cycles at 2 C and 165.2 mAh g^(-1) at 5 ***-situ synchrotron X-ray technique proves that F ions in the cathode materials can suppress the irreversible phase transition from H2 phase to H3 phase in high voltage region by preventing oxygen gliding in a-b planes,ensuring a long-term cycle stability.

关键词： Lithium batteries Cathode materials Nickel-rich Phase transition Fluorine substitution

Persistent greening against drying in northeast Asian semiarid grasslands:Asymmetrical responses of direct and legacy effects to intensified drought

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Advances in Climate Change Research 2024年第1期15卷 9-20页

作者： Yu-Tong MA Hai-shan CHEN Yao-Ming SONG Bo-Tao zhou shan-Lei SUN Xin-Guan DU yue SUN Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

Despite experiencing a decadal shift towards drought conditions at the end of the 2Oth century,semiarid grasslands in northeast Asia(NEA)exhibited an evident greening trend from 1982 to ***,the mechanism behind this phenomenon remains ***,we analysed the interdecadal changes in vegetation response to drought on the basis of the standardised precipitation evapotranspiration index(SPEI)and Global Inventory Modelling and Mapping Studies LAI4g datasets,with an emphasis on the differences between direct and legacy effects(as measured by resilience),to explore the mechanism of persistent grassland *** revealed that during the post-drought shift period(2000-2020),the sudden decrease in the water content of the intermediate soil layer triggered an intensified vegetation response to ***,although direct effects and resilience were amplified,they exhibited asymmetric *** was stronger than direct effects,and this difference increased with increasing drought(drought recovery)*** combined effects may account for persistent greening against intensified drying in the semiarid grasslands in *** the projected exacerbation of future droughts,this study holds notable importance for comprehending the long-term change dynamics of dryland ecosystems.

关键词： Semiarid grassland Drought decadal shift Direct effect Legacy effect(resilience) Northeast Asia

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药学专业有机化学考试改革初探

山西医科大学学报（基础医学教育版） 2005年第6期7卷 591-594页

作者：姜慧君周乐山张振琴何广武南京医科大学药学院南京210029 金陵职业教育中心

为适应现代药学教育的发展,分析了现行考试模式的不足及对教学的影响,结合教改实践,对药学专业有机化学考试方式、内容、形式、成绩及考试效果进行了改革实践,并对进一步开展考试考核改革提出思考.

关键词：有机化学教学方法考试改革