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Effects of Total Saponins from Dioscorea Nipponica Makino on Monosodium Urate-Induced M1-Polarized Macrophages through Arachidonic Acid Signaling Pathway:An in vitro Study

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Chinese Journal of Integrative Medicine 2023年第1期29卷 44-51页

作者： zhou Qi SUN Hui-juan LIU Shu-min Research Institute of Chinese Medicine Heilongjiang University of Chinese MedicineHarbin150040China Graduate School Heilongjiang University of Chinese MedicineHarbin150040China Technological Innovation Team of Basic Theory Study Research of Institution of Higher Education in Heilongjiang Province Heilongjiang University of Chinese MedicineHarbin150040China

Objective To investigate and reveal the underlying mechanism of the effect of total saponins from Dioscoreae nipponica Makino(TSDN)on the arachidonic acid pathway in monosodium urate(MSU)crystal-induced M1-polarized macrophages.Methods M1 polarization of RAW264.7 cells were induced by 1µg/mL lipopolysaccharide(LPS).The methylthiazolyldiphenyl-tetrazolium bromide method was then used to screen the concentration of TSDN.MSU(500µg/mL)was used to induce the gouty arthritis model.Afterwards,10µg/L TSDN and 8µmol/L celecoxib,which was used as a positive control,were added to the above LPS and MSU-induced cells for 24 h.The mRNA and protein expressions of cyclooxygenase(COX)2,5-lipoxygenase(5-LOX),microsomal prostaglandin E synthase derived eicosanoids(mPGES)-1,leukotriene B(LTB)4,cytochrome P450(CYP)4A,and prostaglandin E_(2)(PGE_(2))were tested by real-time polymerase chain reaction and Western blotting,respectively.The enzyme-linked immunosorbent assay was used to test the contents of M1 markers,including inducible nitric oxid synthase(NOS)2,CD80,and CD86.Results TSDN inhibited the proliferation of M1 macrophages and decreased both the mRNA and protein expressions of COX2,5-LOX,CYP4A,LTB4,and PGE_(2)(P<0.01)while increased the mRNA and protein expression of mPGES-1(P<0.05 or P<0.01).TSDN could also significantly decrease the contents of NOS2,CD80,and CD86(P<0.01).Conclusion TSDN has an anti-inflammation effect on gouty arthritis in an in vitro model by regulating arachidonic acid signaling pathway.

关键词： gouty arthritis Dioscorea nipponica Makino arachidonic acid signaling pathway M1/M2 polarization

Total Saponin Fraction of Dioscorea Nipponica Makino Improves Gouty Arthritis Symptoms in Rats via M1/M2 Polarization of Monocytes and Macrophages Mediated by Arachidonic Acid Signaling

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Chinese Journal of Integrative Medicine 2023年第11期29卷 1007-1017页

作者： zhou Qi SUN Hui-juan ZHANG Xi-wu Research Institute of Chinese Medicine Heilongjiang University of Chinese MedicineHarbin(150040)China Graduate School Heilongjiang University of Chinese MedicineHarbin(150040)China

Objective:To explore the mechanism of effects of total saponin fraction from Dioscorea Nipponica Makino(TSDN)on M1/M2 polarization of monocytes/macrophages and arachidonic acid(AA)pathway in rats with gouty arthritis(GA).Methods:Seventy-two Sprague Dawley rats were randomly divided into 4 groups(n=18 in each):normal,model,TSDN at 160 mg/kg,and celecoxib at 43.3 mg/kg.Monosodium urate crystal(MSU)was injected into the rats’ankle joints to induce an experimental GA model.Blood and tissue samples were collected on the 3rd,5th,and 8th days of drug administration.Histopathological changes in the synovium of joints were observed via hematoxylin and eosin(HE)staining.The expression levels of arachidonic acid(AA)signaling pathway were assessed via real-time polymerase chain reaction(q PCR)and Western blot.Flow cytometry was used to determine the proportion of M1 and M2 macrophages in the peripheral blood.An enzyme-linked immunosorbent assay(ELISA)was used to detect interleukine(IL)-1β,tumor necrosis factoralpha(TNF-α),IL-4,IL-10,prostaglandin E_(2)(PGE_(2)),and leukotriene B4(LTB4).Results:HE staining showed that TSDN improved the synovial tissue.q PCR and Western blot showed that on the 3rd,5th and 8th days of drug administration,TSDN reduced the m RNA and protein expressions of cyclooxygenase(COX)2,microsomal prostaglandin E synthase-1 derived eicosanoids(m PGES-1),5-lipoxygenase(5-LOX),recombinant human mothers against decapentaplegic homolog 3(Smad3),nucleotide-binding oligomerization domain-like receptor protein 3(NALP3),and inducible nitric oxide synthase(i NOS)in rats’ankle synovial tissues(P<0.01).TSDN decreased COX1 m RNA and protein expression on 3rd and 5th day of drug administration and raised it on the 8th day(both P<0.01).It lowered CD68 protein expression on days 3(P<0.01),as well as m RNA and protein expression on days 5 and 8(P<0.01).On the 3rd,5th,and 8th days of drug administration,TSDN elevated the m RNA and protein expression of Arg1 and CD163(P<0.01).Flow cytometry results showed that TSDN decreased

关键词： Smad3 Blood mother

Phosphorus-doped NiS_(2)electrocatalyst with a hybrid structure for hydrogen evolution

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Science China(Technological Sciences) 2022年第7期65卷 1506-1512页

作者： zhou Qi LIU HaoRui JIAO SunZhi FENG ChenChen State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of TechnologyLanzhou 730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China College of Mechanical Engineering Longdong UniversityQingyang 745000China

In this article,P-NiS_(2)/Ni_(x)P electrocatalysts were synthesized by dealloying the Ni-Al precursor followed by phosphosulfide treatment.We found that the hybrid structure of P-NiS_(2)/Ni_(x)P provides rich active sites for the surface hydrogen evolution reaction (HER),and the doping of P enhances the electronic conductivity of electrodes.In particular,the obtained electrode shows a low overpotential of 196 mV at 10 mA cm^(-2)and a small Tafel slope of only 110 mV dec^(-1)in the HER.Meanwhile,longterm constant current electrolysis test experiments indicate that P-NiS_(2)/Ni_(x)P has good service stability.This research will help to open a new window on the design and fabrication of HER electrocatalysts.

关键词： nickle phosphosulfides hybrid structure hydrogen evolution reaction dealloying

Hydrothermal preparation of Nb-doped NaTaO_(3) with enhanced photocatalytic activity for removal of organic dye

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Chinese Journal of Chemical Engineering 2022年第6期35卷 142-149页

作者： Hao zhou qi Yin State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China

The construction of efficient photocatalysts has received much attention in wastewater treatment.In this study,Nb-doped NaTaO_(3) was prepared with different doping ratio by a facile hydrothermal method.The prepared catalysts were analyzed by X-ray diffraction,scanning electron microscopy,Brunauer-EmmettTeller(BET)theory,ultraviolet–visible diffuse reflectance spectroscopy.Then the synthesized catalysts were employed to degrade a model pollutant,methylene blue(MB),under a 250 W mercury lamp.The characterization tests confirm that Nb was successfully doped into the crystal structure of NaTaO_(3) and the modified NaNb_(x)Ta_(1)·xO_(3)(x is the doping ratio;x=0.25,0.5,0.75)samples were formed,which were in regular cubic shapes just like pure NaTaO_(3).The synthesized NaNb_(x)Ta_(1)·xO_(3)(x=0.25,0.5,0.75)had improved specific surface area and narrowed band gaps compared with pure NaTaO_(3).In photocatalytic degradation experiments,NaNb0.75Ta0.25O_(3) presented the best photocatalytic activity ascribed to the narrow band gap and the high surface area,degradating 95.7%of MB after 180 min of reaction,which was even twice the ability of pure NaTaO_(3).Besides,the effects of possible inorganic anions and cations in wastewater on photocatalytic degradation were investigated.Electron spin resonance(ESR)tests and capture experiments were also conducted and a possible photocatalytic mechanism was proposed.This work provides a direction for constructing superior NaTaO_(3)-based photocatalysts to be widely utilized in environmental protection.

关键词： Photocatalytic degradation Methylene blue NaTaO_(3)

Defensible citadel:History and architectural character of the Lahore Railway Station

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Frontiers of Architectural Research 2020年第4期9卷 805-819页

作者： Naubada Ali zhou Qi Department of Architecture Southeast UniversityNanjing210096China

This study aims to investigate the defensible character of the Lahore railway station built in response to"the war of independenee in 1857,"which greatly impacted the location and design of the building.This study demonstrates the in tegral role played by the railway station in the development of the new colonial city,which the British wants to be defensive in every aspect.Railways were introduced in Pakistan(India)soon after their inauguration in Britain.Beginning from the mode of transportation,the multifaced contribution of railways toward the urban growth,new architectural style,mode of construction,and technology cannot be recanted.The research is based on the documentation and analysis of the history of Lahore railway station design.First,this study uses primary and secondary data to offer a history of the Lahore railway station from its inception to final execution.Second,it explores the criteria adopted by the British for its site selection to make the station a defensible post.The research finding in eludes the visual features that enhanced the architectural character of the building.Qualitative methods are used including several other approaches,namely,literature review,archival data collection,analysis of photographs,and study of architectural drawings and old maps,to achieve the objectives.

关键词： History Lahore Railway station Defensible character Architectural character

US Technological Decoupling from China:Strategic Motives and Policy Measures

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China International Studies 2023年第1期 101-126页

作者： zhou Qi the Institute of American Studies Chinese Academy of Social Sciences(CASS)

In just a few years,decoupling has become a hotly debated topic around the world.Most common scenarios relate to trade and investment,especially during the COVID-19 pandemic.The decoupling of science and technology,du... 详细信息

关键词： investment linkage Strategic

Distributed Event-Triggered Formation Control of USVs with Prescribed Performance

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Journal of Systems Science & Complexity 2022年第3期35卷 820-838页

作者： CHEN Guangdeng YAO Deyin zhou Qi LI Hongyi LU Renquan School of Automation and Guangdong Province Key Laboratory of Intelligent Decision and Cooperative Control Guangdong University of TechnologyGuangzhou 510006China

In this paper,the formation control problem is investigated for a team of uncertain underactuated surface vessels(USVs)based on a directed graph.Considering the risk of collision and the limited communication range of USVs,the prescribed performance control(PPC)methodology is employed to ensure collision avoidance and connectivity maintenance.An event-triggered mechanism is designed to reasonably use the limited communication resources.Moreover,neural networks(NNs)and an auxiliary variable are constructed to deal with the problems of uncertain nonlinearities and underactuation,respectively.Then,an event-triggered formation control scheme is proposed to ensure that all signals of the closed-loop system are uniformly ultimately bounded(UUB).Finally,simulation results are presented to demonstrate the effectiveness of the proposed control scheme.

关键词： Event-triggered control formation control prescribed performance underactuated surface vessels(USVs)

Application of phase‑conjugate beams in beam correction and underwater optical wireless communication subject to surface wave turbulence

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Frontiers of Optoelectronics 2022年第3期15卷 87-96页

作者： qi Li Xiuhua Yuan Feng zhou Zeyu zhou Wujie Liu School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Hunan Province On Information Photonics and Freespace Optical Communications School of Information Science and EngineeringHunan Institute of Science and TechnologyYueyang 414006China

Water surface wave turbulence is one of the factors afecting the performances of underwater optical wireless communication(UOWC)systems.In our research,a phase-conjugate beam was used to correct the beam distortion and enhance the communication performances when a system is subject to surface wave turbulence.The phase-conjugate beam was generated by a phase-conjugate mirror(PCM),and a turbulence generator was used to generate surface wave turbulence in the experiment.We calculated the beam centroid distribution and the results showed that the phase-conjugate beam had a better propagation performance than the distorted beam at the diferent water depths.The root mean square(RMS)of the beam centroid for the phase-conjugate beam was 11 times less than that for the distorted beam,which meant that the phase-conjugate beam could efectively correct the beam drift.We further investigated the scintillation index and the signal-to-noise ratio(SNR);the results showed that the phase-conjugate beam was able to reduce the scintillation and an obvious improvement in SNR could be obtained.This research has the potential to be applied in UWC.

关键词： Phase-conjugate beam Underwater optical wireless communication(UOWC) Degenerate four-wave mixing(DFWM) Surface wave turbulence

U.S.Technological Decoupling from China:Process and Impact

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Contemporary World 2022年第5期 31-36页

作者： zhou Qi the Institute of Global Governance and Development at Tongji University

Decoupling is becoming a new phenomenon in international relations and the world economy.Of all the areas of decoupling,the most striking is that of technology,given the special feature of high-tech and its close connections with trade.The United States is implementing a policy of decoupling itself from China in the entire range of high-tech.IMF experts predict that technological decoupling will not only define the strategic competition between China and the U.S.,but also in turn have a strong impact on Europe.

关键词： U.S. Impact striking