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协调多CT设备间肝脏影像组学特征的一致性

分子影像学杂志 2024年第9期47卷 928-935页

作者：周创辉周建伟麦迪娜·巴吐尔黄靖涵秦耿耿钟海舰赣南医科大学医学信息工程学院江西赣州341000 南方医科大学南方医院医学影像诊断科广东广州510515 南方医科大学生物医学工程学院广东广州510515

目的评估健康肝脏影像组学特征在多种CT扫描仪中的一致性,并探究基于图像和基于特征的协调方法对结果的影响。方法回顾性收集2015年1月1日~2023年1月1日赣州市人民医院4台CT设备的243例健康成年人的腹部CT检查结果(Optima CT660:n=83,Re... 详细信息

目的评估健康肝脏影像组学特征在多种CT扫描仪中的一致性,并探究基于图像和基于特征的协调方法对结果的影响。方法回顾性收集2015年1月1日~2023年1月1日赣州市人民医院4台CT设备的243例健康成年人的腹部CT检查结果(Optima CT660:n=83,Revolution 512 CT:n=56,Emotion 16:n=69,Definition AS+CT:n=35)。对每位患者在肝门层面选择肝实质勾画直径为30 mm的三维感兴趣区域,使用Pyradiomics提取93个影像组学特征。采用均值中心化、Z-Score、重采样、直方图匹配和ComBat方法协调设备间的差异。使用Mann-Whitney U检验比较两台扫描仪之间以及应用协调方法前后特征的一致性,并计算Cohen's d值,以评估不同方法的影响大小。结果肝脏影像组学特征总体一致性为55.38%,其中在相同制造商设备中为87.10%,在不同制造商设备为39.52%;经均值中心化、Z-Score、重采样、直方图匹配和ComBat方法协调后,总体保持一致的特征比例分别为:44.82%、68.82%、66.49%、76.52%和100%;d值分别为-0.57、0.62、0.57、0.78、1.59。结论肝脏CT影像组学特征在不同设备之间的一致性较差,仅在同一制造商的扫描仪中保持良好。基于图像和特征的协调方法能有效减少由不同CT制造商和设备型号引起的特征变异;其中,重采样和直方图匹配依赖于具体的参数设置和参考图像的选取;基于特征的ComBat协调表现最佳,使得所有特征在不同设备之间均能保持一致,对未来跨设备或跨中心的研究具有积极影响。

关键词： CT 批次效应影像组学特征一致性图像协调特征协调

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A comparison of average daily gain,apparent digestibilities,energy balance,rumen fermentation parameters,and serum metabolites between yaks(Bos grunniens)and Qaidam cattle(Bos taurus)consuming diets differing in energy level

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Animal Nutrition 2023年第1期12卷 77-86页

作者： Hu Liu jianwei zhou Allan Degen Hongshan Liu Xuliang Cao Lizhuang Hao Zhanhuan Shang Tao Ran Ruijun Long State Key Laboratory of Grassland Agro-Ecosystems Key Laboratory of Grassland Livestock Industry Innovation Ministry of Agriculture and Rural Affairs Engineering Research Center of Grassland IndustryMinistry of EducationCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730000China International Centre for Tibetan Plateau Ecosystem Management College of EcologyLanzhou UniversityLanzhou730000China Desert Animal Adaptations and Husbandry Wyler Department of Dryland AgricultureBlaustein Institutes for Desert ResearchBen-Gurion University of NegevBeer Sheva8410500Israel Key Laboratory of Plateau Grazing Animal Nutrition and Feed Science of Qinghai Province Qinghai Academy of Animal Science and Veterinary MedicineState Key Laboratory of Plateau Ecology and AgricultureQinghai UniversityXining810016China

Yaks(Bos grunniens),indigenous to the harsh Qinghai-Tibetan Plateau,are well adapted to the severe conditions,and graze natural pasture without supplements all year *** cattle(Bos taurus),introduced to the Qinghai-Tibetan Plateau 1,700 years ago,are raised at a lower altitude than yaks,provided with shelter at night and offered supplements in *** on their different backgrounds,we hypothesized that yaks have lower energy requirements for maintenance than *** test this hypothesis,we measured average daily gain(ADG),apparent digestibilities,energy balance,rumen fermentation parameters,and serum metabolites in growing yaks and cattle offered diets differing in metabolizable energy(ME)levels(6.62,8.02,9.42 and 10.80 MJ/kg),but with the same crude protein *** castrated yaks(155±5.8 kg)and 6 castrated Qaidam cattle(154±8.0 kg),all 2.5 years old,were used in 2 concurrent 4×4 Latin square *** and acid detergent fiber digestibilities were greater(P<0.05)in yaks than in cattle,and decreased linearly(P<0.05)with increasing dietary energy level;whereas,digestibilities of dry matter,organic matter,crude protein and ether extract increased(P<0.05)linearly with increasing energy *** ADG was greater(P<0.001)in yaks than in cattle,and increased(P<0.05)linearly with increasing energy *** the regressions of ADG on ME intake,the estimated ME requirement for maintenance was lower(P<0.05)in yaks than in cattle(0.43 vs.0.57 MJ/kg BW0.75).The ratios of digestible energy(DE):gross energy and ME:DE were higher(P<0.05)in yaks than in cattle,and increased(P<0.05)linearly with increasing dietary energy *** pH decreased(P<0.05),whereas concentrations of total volatile fatty acids(VFAs)and ammonia increased(P<0.01)with increasing dietary energy level,and all were greater(P<0.05)in yaks than in *** of ruminal acetate and iso-VFAs were greater(P<0.05),whereas propionate was lower(P<0.05)in yaks than in cattle

关键词： Yaks Dietary energy level Average daily gain Apparent digestibility Rumen fermentation Serum metabolite

Relationship between structure and function of JWA in the modulation of cell differentiation

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Chinese Science Bulletin 2001年第24期46卷 2063-2067页

作者： XIA Wei zhou jianwei CAO Haixia ZOU Changping WANG Chengya SHEN Qun LU Hua Department of Molecular Genetic Toxicology School of Public HealthNanjing Medical UniversityNanjing 210029China Department of OB/GYN.Gynecologic Oncology UT-Houston Medical SchoolHoustonTX 77225.USA Department of Hcmatology and Oncology the First Affiliate Hospital of Nanjing Medical UniversityNanjing 210029China Department of Hematology and Oncology the Second Affiliate Hospital of Nanjing Medical UniversityNanjing 210029China

To elucidate the structure characteristic, regulation of expression and the potential function of JWA——anovel rctinoic acid responsible and cytoskeleton associate gene, a rat JWA homologue gene and a 621-bp JWA promoter fragment were cloned and analyzed. Using reverse transcription-polymerase chain reaction (RT-PCR), JWA mRNA expression in NIH3T3, K562 and human primary acute promyelocytic leukaemia (APL) cells have been investigated after treatment with all trans retinoic acid (ATRA), N-4-hydroxyphenyl-retinamide (4HPR), arsenic trioxide (As2O3), Phorbol-12-myristate-13-acetate (TPA) and dimethyl sulfoxide (DMSO). The results showed that there is a complete TPA responsive element (TRE) existed in the promoter of JWA at -437 to -443 bp; rat JWA homologue gene showed that there are four nucleotides different from human JWA within coding region. After treatment with TPA, an uneven pattern of JWA transcription existed in different cell lines, suggesting that even TPA induces cell differentiation in

关键词： JWA cell differentiation ATRA TPA structure and function.

子宫颈细胞学PAX1/JAM3双基因甲基化检测用于子宫颈癌筛查的多中心研究

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中华医学杂志 2024年第20期104卷 1852-1859页

作者：商晓孔令华肖晓萍万茹王婧吴焕文陈小燕寿华锋费菁周建维郎景和李雷中国医学科学院北京协和医院妇产科北京中国医学科学院北京协和医院病理科北京浙江省人民医院妇科杭州浙江大学医学院附属第二医院妇科杭州

目的探讨宫颈细胞学PAX1/JAM3双基因甲基化检测在子宫颈癌筛查中的应用价值。方法本研究为一项多中心前瞻性研究。2022年5至10月, 在中国医学科学院北京协和医院、浙江大学医学院附属第二医院和浙江省人民医院妇科门诊行子宫颈癌机会性... 详细信息

目的探讨宫颈细胞学PAX1/JAM3双基因甲基化检测在子宫颈癌筛查中的应用价值。方法本研究为一项多中心前瞻性研究。2022年5至10月, 在中国医学科学院北京协和医院、浙江大学医学院附属第二医院和浙江省人民医院妇科门诊行子宫颈癌机会性筛查的女性中, 将接受液基薄层细胞学检测(TCT)、高危型人乳头瘤病毒(hrHPV)DNA检测与PAX1/JAM3双基因甲基化(PAX1m/JAM3m)检测者为研究对象, 共1 184例。基于hrHPV和细胞学结果, 根据现行指南对于需要转诊阴道镜的女性提供相关检查和活检。根据组织病理学结果, 研究比较各项检测方法及其组合用于子宫颈癌筛查的准确性。结果 1 184例研究对象的年龄[M(Q1, Q3)]为39(32, 51)岁, 其中子宫颈良性或慢性子宫颈炎(正常)、子宫颈上皮内瘤变(CIN)1、CIN2、CIN3和子宫颈癌分别为541例(45.7%)、273例(23.1%)、168例(14.2%)、140例(11.8%)和62例(5.2%)。根据病理学结果, PAX1m/JAM3m检测诊断CIN2或更严重病变(CIN2+)的灵敏度、特异度分别为74.1%和95.9%, 诊断CIN3+的灵敏度、特异度分别为87.6%和86.8%。受试者工作特征曲线显示, 对于诊断CIN3+, PAX1m/JAM3m优于TCT或hrHPV检测, 曲线下面积(AUC)(95%CI)分别为0.872(0.847～0.897)、0.580(0.551～0.610)和0.503(0.479～0.515)(均P<0.05)。结论子宫颈脱落细胞中PAX1m/JAM3m检测对于诊断CIN2+和CIN3+均具有优异的准确性, 优于传统的筛查方案和筛查策略。

关键词：宫颈肿瘤子宫颈上皮内瘤变 DNA甲基化高危HPV DNA检测细胞学前瞻性研究

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快照式显微光谱成像系统及水藻分类识别研究

激光与光电子学进展 2024年第6期61卷 331-337页

作者：李栋梁蔡红星任玉李霜花扬扬王婷婷周建伟曲冠男王朔曹洋铭张桁源长春理工大学物理学院吉林长春130022 长春理工大学吉林省光谱探测科学与技术重点实验室吉林长春130022 吉林求是光谱数据科技有限公司吉林长春130000

目前的显微光谱成像系统的探测模块主要以推扫型光谱成像仪为主,无法进行动态微观样本的观测。基于超材料宽谱调制型光谱成像技术体制,使用该原理研制的快照式光谱相机作为探测模块,其与显微镜模块形成新型的快照式显微光谱成像系统。... 详细信息

目前的显微光谱成像系统的探测模块主要以推扫型光谱成像仪为主,无法进行动态微观样本的观测。基于超材料宽谱调制型光谱成像技术体制,使用该原理研制的快照式光谱相机作为探测模块,其与显微镜模块形成新型的快照式显微光谱成像系统。该系统可实时获取样本的光谱曲线与光谱图像信息。同时利用该系统获取不同藻类的吸收光谱曲线,进一步使用基于支持向量机的图像分割识别算法,对水中的动态藻类样本进行识别。共测试样本80个,预测结果准确率为100%,召回率为65.52%,为快照式光谱成像技术在显微领域的应用奠定基础。

关键词：显微镜光谱成像快照式吸收光谱目标识别

Assessment of Geological Security and Integrated Assessment Geo-environmental Suitability in Worst-hit Areas in Wenchuan Quake

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Acta Geologica Sinica(English Edition) 2009年第4期83卷 816-825页

作者： LI Wenpeng WEN Dongguang zhou Aiguo SUN Xiaoming MENG Hui SHI Jusong CHEN Zongyu ZHANG Liqin FENG Xiaoming LIU Changli zhou jianwei China Institute of Geo-Environmental Monitoring Beijing 100081 China Geological Survey Beijing 100037 Institute of Geomechanics China Academy of Geological Science Beijing 100081 Tianjin Geological Survey Center of CGS Tianjin 300170 Geomechanics Institute of Chinese Geological Academy Beijing 100086 Nanjing Geological Survey Center of CGS Nanjing 210016 The Institute of Hydrogeology and Environmental Geology CAGS Shi Jiazhuang 050061

The Wenchuan earthquake in 2008 and geo-hazards triggered by the earthquake caused large injuries and deaths as well as destructive damage for infrastructures like construction, traffic and electricity. It is urgent to select relatively secure areas for townships and cities constructed in high mountainous regions with high magnitude earthquakes. This paper presents the basic thoughts, evaluation indices and evaluation methods of geological security evaluation, water and land resources security demonstration and integrated assessments of geo-environmental suitability for reconstruction in alp and ravine with high magnitude earthquakes, which are applied in the worst-hit areas （12 counties）. The integrated assessment shows that：（1） located in the Longmenshan fault zone, the evaluated area is of poor regional crust stability, in which the unstable and second unstable areas account for 79% of the total; （2） the geo-hazards susceptibility is high in the evaluation area. The spots of geo-hazards triggered by earthquake are mainly distributed along the active fault zone with higher distribution in the moderate and high mountains area, in which the areas of high and moderate susceptibility zoning accounts for 40.1% of the total; （3） geological security is poor in the evaluated area, in which the area of the unsuitable construction occupies 73.1%, whereas in the suitable construction area, the areas of geological security, second security and insecurity zoning account for 8.3 %, 9.3% and 9.3 % of the evaluated area respectively; （4） geo-environmentai suitability is poor in the evaluated area, in which the areas of suitability and basic suitability zoning account for 3.5% and 7.3% of the whole evaluation area.

关键词： Wenchuan earthquake geological security carrying capacity of water and land resources geo-environmental suitability

阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症的随机对照研究

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四川中医 2024年第5期42卷 177-181页

作者：周建伟李虹霖皮燕李春雨张继成四川省中医药科学院四川成都610041 成都中医药大学四川成都610075 四川省中西医结合医院四川成都610041 四川省第二中医医院四川成都610031

目的:探究阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症的临床疗效。方法:本研究纳入2021年6月至2023年12月于四川省中西医结合医院、四川省第二中医医院门诊就诊且符合纳入标准的神经根型颈椎病患者,共计370例。采用随机对照研究方法,... 详细信息

目的:探究阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症的临床疗效。方法:本研究纳入2021年6月至2023年12月于四川省中西医结合医院、四川省第二中医医院门诊就诊且符合纳入标准的神经根型颈椎病患者,共计370例。采用随机对照研究方法,将患者随机分为对照组和治疗组,每组185例。治疗组接受阿是穴四花刺法治疗,对照组接受常规针刺法治疗,分别在治疗前、治疗后第1、2、3、7、14天进行评定,并观察其疼痛强度、疼痛频度、疼痛持续时间、压痛、生活质量评分的变化,以判断疗效。结果:治疗后,两组患者在VAS评分、SF-MPQ评分、疼痛频度评分、疼痛持续时间评分、压痛评分、生活质量评分方面都有显著改善。与对照组相比,治疗组的疼痛频度更早得到改善,其余各项指标在相同时间节点改善程度更高(P<0.05)。结论:阿是穴四花刺法治疗神经根型颈椎病颈肩肢痛症具有肯定疗效,相比常规针刺法治疗其起效更快,疗效更好,在提高患者生活质量方面也表现出优势,是治疗神经根型颈椎病颈肩肢痛症的理想方法。

关键词：阿是穴阿是穴四花刺神经根型颈椎病临床疗效

Effect of dynamic loading orientation on fracture properties of surrounding rocks in twin tunnels

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 393-409页

作者： Ze Deng Zheming Zhu Lei zhou Leijun Ma jianwei Huang Yao Zhang Key Laboratory of Deep Earth and Engineering(Ministry of Education) College of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province College of Architecture and EnvironmentSichuan UniversityChengdu610065China Institute for Disaster Management and Reconstruction Sichuan UniversityChengdu610065China

For expedited transportation,vehicular tunnels are often designed as two adjacent tunnels,which frequently experience dynamic stress waves from various orientations during blasting *** analyze the impact of dynamic loading orientation on the stability of the twin-tunnel,a split Hopkinson pressure bar(SHPB)apparatus was used to conduct a dynamic test on the twin-tunnel *** two tunnels were rotated around the specimen’s center to consider the effect of dynamic loading ***-DYNA software was used for numerical simulation to reveal the failure properties and stress wave propagation law of the twin-tunnel *** findings indicate that,for a twin-tunnel exposed to a dynamic load from different orientations,the crack initiation position appears most often at the tunnel corner,tunnel spandrel,and tunnel *** the impact direction is created by a certain angle(30°,45°,60°,120°,135°,and 150°),the fractures are produced in the middle of the line between the left tunnel corner and the right tunnel *** the impact loading angle(a)is 90°,the tunnel sustains minimal damage,and only tensile fractures form in the surrounding *** orientation of the impact load could change the stress distribution in the twin-tunnel,and major fractures are more likely to form in areas where the tensile stress is concentrated.

关键词： Twin-tunnel Dynamic load Split Hopkinson pressure bar(SHPB) Fracture mode Stress distribution Displacement field distribution

Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide

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Chinese Science Bulletin 2002年第10期47卷 834-838页

作者： CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping zhou jianwei School of Public Health Nanjing Medical UniversityNanjing 210029China Department of Hematology and Oncology the Second Affiliate Hospital of Nanjing Medical University Deparcment of Hematology and Oncology the First Affiliate Hospital of Nanjing Medical UniversityNanjing 210029China Department of OB/GYN Gynecologic OncologyUT-Houston Medical SchoolHoustonTX 77030-4095USA

JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’

关键词： JWA cell differentiation apoptosis NB4 signal trans-duction.