检索结果-南通市图书馆

Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2025年第02期23卷 203-213页

作者： Ben Niu Xiaohong An Yongmei Chen Ting He Xiao Zhan Xiuqi Zhu Fengfeng Ping Wei Zhang jia zhou School of Traditional Chinese Pharmacy China Pharmaceutical University Wuxi People's Hospital Nanjing Medical University Yunnan Characteristic Plant Extraction Laboratory Yunnan Yunke Characteristic Plant Extraction Laboratory Co. Ltd. Drug Discovery and Development Laboratories Ningxia Hui Medicine Research Institute Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences & Peking Union Medical College

Nigella sativa L. seeds have been traditionally utilized in Chinese folk medicine for centuries to treat vitiligo. This study revealed that the ethanolic extract of Nigella sativa L.(HZC) enhances melanogenesis and mitigates oxidative stress-induced cellular senescence and dysfunction in melanocytes. In accordance with established protocols, the ethanol fraction from Nigella sativa L. seeds was extracted, concentrated, and lyophilized to evaluate its herbal effects via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays, tyrosinase activity evaluation, measurement of cellular melanin contents, scratch assays, senescence-associated β-galactosidase(SA-β-gal) staining, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis for expression profiling of experimentally relevant proteins. The results indicated that HZC significantly enhanced tyrosinase activity and melanin content while notably increasing the protein expression levels of Tyr, Mitf, and gp100 in B16F10 cells. Furthermore, HZC effectively mitigated oxidative stress-induced cellular senescence, improved melanocyte condition, and rectified various functional impairments associated with melanocyte dysfunction. These findings suggest that HZC increases melanin synthesis in melanocytes through the activation of the MAPK, PKA, and Wnt signaling *** addition, HZC attenuates oxidative damage induced by H2O2 therapy by activating the nuclear factor E2-related factor 2-antioxidant response element(Nrf2-ARE) pathway and enhancing the activity of downstream antioxidant enzymes, thus preventing premature senescence and dysfunction in melanocytes.

关键词： Cellular senescence Melanin Nigella sativa L. seed extract (HZC) ROS Vitiligo

Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Critical Care Medicine 2025年第1期14卷 111-117页

作者： Guan-Xing Yuan Zhi-Ping Zhang jia zhou Department of Emergency Wuhan Asia General HospitalWuhan 430056Hubei ProvinceChina Department of Neurosurgery Central Theater Command General HospitalWuhan 430000Hubei ProvinceChina

BACKGROUND Cardiac arrest caused by acute pulmonary embolism(PE)is the most serious clinical circumstance,necessitating rapid identification,immediate cardiopulmonary resuscitation(CPR),and systemic thrombolytic *** CPR(ECPR)is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be *** SUMMARY We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical *** arrival at the emergency department with ongoing manual chest compressions,bedside pointof-care ultrasound revealed an enlarged right ventricle without *** PE was suspected as the cause of cardiac arrest,and intravenous thrombolytic therapy with 50 mg tissue plasminogen activator was administered during mechanical chest *** 31 minutes of CPR,return of spontaneous circulation was not achieved until 8 minutes after initiation of Veno-arterial extracorporeal membrane oxygenation(ECMO)*** ECMO support,the hemodynamic status and myocardial contractility significantly ***,the patient ultimately did not survive due to intracerebral hemorrhagic complications,leading to death a few days later in the *** This case illustrates the potential of combining systemic thrombolysis with ECPR for refractory cardiac arrest caused by acute PE,but it also highlights the increased risk of significant bleeding complications,including fatal intracranial hemorrhage.

关键词： Pulmonary embolism Cardiac arrest Thrombolytic therapy Cardiopulmonary resuscitation Extracorporeal membrane oxygenation Intracranial hemorrhage Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美丽中国建设的制度体系研究

生态经济 2025年第1期41卷 13-18页

作者：董战峰周佳生态环境部环境规划院北京100041

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中... 详细信息

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中国建设的制度体系思路,提出了健全生态环境空间管控、责任体系、市场体系等十大重点任务,为全面推进美丽中国建设提供坚实支撑。

关键词：美丽中国生态文明制度环境治理现代化重点任务

在线全文

学校读者我要写书评

暂无评论

合作原则视角下《初来乍到》的言语幽默研究

语言与文化研究

语言与文化研究 2025年第1期33卷 20-23页

作者：周佳江苏师范大学徐州221116

幽默作为一种特殊的言语交际,是语用学研究的重要课题。美国情景喜剧《初来乍到》因其简短、幽默和跨文化等特点,深受广大观众喜爱。选取《初来乍到》第一季为研究语料,以格赖斯的合作原则为理论框架,通过对剧中人物对话进行定性分析,... 详细信息

幽默作为一种特殊的言语交际,是语用学研究的重要课题。美国情景喜剧《初来乍到》因其简短、幽默和跨文化等特点,深受广大观众喜爱。选取《初来乍到》第一季为研究语料,以格赖斯的合作原则为理论框架,通过对剧中人物对话进行定性分析,探究情景喜剧中违反合作原则如何实现言语幽默的效果,其对剧中人物塑造的作用,并揭示违反合作原则的根本原因,以期丰富合作原则指导下的幽默研究,同时为提高语言交际能力,实现和谐的跨文化交际做出一定贡献。

关键词：合作原则言语幽默《初来乍到》跨文化交际

在线全文

学校读者我要写书评

暂无评论

基于收益共享契约的供应商入侵策略分析

管理科学学报 2025年第1期28卷 29-41页

作者：黄佳舟吴瑶斌陈祥锋南京审计大学金融学院上海大学管理学院复旦大学管理学院

在由单一供应商和单一零售商组成的供应链中，本研究分析了收益共享契约对供应商入侵策略的影响，并研究了供应链企业对供应商入侵的偏好条件.结果表明对零售商而言，较高的收益共享比例会提高自身的服务努力水平，从而扩大产品的市场... 详细信息

在由单一供应商和单一零售商组成的供应链中，本研究分析了收益共享契约对供应商入侵策略的影响，并研究了供应链企业对供应商入侵的偏好条件.结果表明对零售商而言，较高的收益共享比例会提高自身的服务努力水平，从而扩大产品的市场供给量，增加消费者剩余，并使得供应商入侵有利于自身利润提升；对供应商而言，只有当零售商服务努力的成本系数较高时，供应商入侵能使自身受益，此时零售商和供应商均存在最优的收益共享比例，且最优的收益共享比例随零售商服务努力的成本系数增大而减小.本研究还从产品竞争、直销运营成本、数量决策顺序三个方面验证了主要结论的稳定性.研究结论丰富了现有渠道管理的理论成果，为供应链企业多渠道销售提供参考和借鉴.

关键词：供应商入侵收益共享渠道竞争直销

“疆理虽重海,车书本一家”——山东运河区域方志所见民族交往交流交融研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

德州学院学报 2025年第1期41卷 79-84页

作者：周嘉赵传聊城大学运河学研究院山东聊城252059

地方志是研究区域社会史不可或缺的史料。明清时期大运河的贯通进一步推动了方志业的发展。运河区域各级市镇都纂修了大量志书,保存了民族交往交流交融的许多史料,揭示了民族交往交流交融的特点与途径。对山东运河区域方志中民族交往交... 详细信息

地方志是研究区域社会史不可或缺的史料。明清时期大运河的贯通进一步推动了方志业的发展。运河区域各级市镇都纂修了大量志书,保存了民族交往交流交融的许多史料,揭示了民族交往交流交融的特点与途径。对山东运河区域方志中民族交往交流交融的研究,有助于了解山东运河区域多民族的形成与发展,对当代铸牢中华民族共同体意识的实践有一定借鉴意义。

关键词：山东运河地方志民族交往交流交融中华民族共同体意识

Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma:Is it reliable?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第5期31卷 105-116页

作者： Liu-Jun Li Chao-Qun Wu Fei-Le Ye zhou Xuan Xiao-Li Zhang jian-Ping Li jia zhou Zhong-Zhen Su Department of Ultrasound The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Microvascular invasion(MVI)is a critical prognostic factor for postoperative hepatocellular carcinoma recurrence,but the reliability of its current pathological diagnosis remains *** To evaluate the accuracy of current 7-point sampling methods and propose an optimal pathological protocol using whole-mount slide imaging(WSI)for better MVI *** We utilized 40 New Zealand white rabbits to establish VX2 liver tumor *** entire tumor-containing liver lobe was subsequently obtained,following which five different sampling protocols(A-E)were employed to evaluate the detection rate,accuracy,quantity,and distribution of MVI,with the aim of identifying the optimal sampling *** VX2 liver tumor models were successfully established in 37 rabbits,with an incidence of MVI of 81.1%(30/37).The detection rates[27%(10/37),43%(16/37),62%(23/37),68%(25/37),and 93%(14/15)]and quantity(15,36,107,125,and 395)of MVI increased significantly from protocols A to *** distribution of MVI showed fewer MVIs farther away from the tumor,but the percentage of MVI detected quantity gradually increased from 6.7%to 48.3%in the distant nonneoplastic liver tissue from protocols A to *** C was identified as the optimal sampling method by comparing them in *** sampling protocol of three consecutive interval WSIs at the tumor center(WSI3)was further screened to determine the optimal number of *** A(7-point sampling method)exhibited only 46%accuracy and a high false-negative rate of 67%.Notably,the WSI3 protocol improved the accuracy to 78%and decreased the false-negative rate to 27%.CONCLUSION The current 7-point sampling method has a high false-negative rate in MVI *** contrast,the WSI3 protocol provides a practical and effective approach to improve MVI diagnostic accuracy,which is crucial for hepatocellular carcinoma diagnosis and treatment planning.

关键词： Hepatocellular carcinoma Microvascular invasion Histopathological diagnosis Whole-mount slide imaging Sampling protocol

活动理论视域下的跨学科主题学习教研活动研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

教育理论与实践 2025年第5期45卷 3-8页

作者：周嘉腾朱莉萍刁仪菲北京师范大学教育学部北京邮编100875 华中师范大学教育学院湖北武汉邮编430079

跨学科主题学习是新课标背景下实现课程综合性与实践性的重要举措,而教研模式的转型是其落地的关键。活动理论秉承系统思维,为构建跨学科主题学习教研模式及分析教师学习机制奠定了理论基础。基于活动理论,遵循“提炼主题—关联学科—... 详细信息

跨学科主题学习是新课标背景下实现课程综合性与实践性的重要举措,而教研模式的转型是其落地的关键。活动理论秉承系统思维,为构建跨学科主题学习教研模式及分析教师学习机制奠定了理论基础。基于活动理论,遵循“提炼主题—关联学科—协同设计—迭代方案—反思提升”的过程逻辑,构建了跨学科主题学习教研的模型。跨学科主题学习教研中的教师学习活动具有跨界性、协作性和创造性。教师具体的学习机制包括:推动跨界对话,协商中实现知识共享;缔结信任关系,重构教研组学习情境;联通学科脉络,实现跨学科视域融合;解决系统矛盾,集体跨越最近发展区。

关键词：跨学科主题学习活动理论教研活动教师学习

Mechanical Properties of Interlocked-ring Polymers: A Molecular Dynamics Simulation Study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2019年第12期37卷 1298-1304,I0008页

作者： Zheng-Tao Wu jia-jia zhou College of Engineering Zhejiang Normal UniversityJinhua 321004China School of Chemistry Beihang UniversityBeijing 100191China

Interlocked-ring polymers,also known as polycatenanes,possess an interesting molecular *** polymers are composed of many interlocked rings in a linear *** topological constrain between neighboring rings distinguishes the interlockedring polymer from its linear *** we present extensive molecular dynamic simulations on the interlocked-ring polymers and analyze the static properties of the *** applying external forces to the polymer,we also study the force-extension curves of the polymer,which provides rich information about the mechanical properties of the interlockedring polymers.

关键词： Poly catenanes Molecular dynamics simulation Force-extension Entanglement