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重症超声监测指导创伤性休克患者液体复苏的效果

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中国实用医刊 2024年第7期51卷 54-57页

作者：廖磊周贺民杨迪李佳璐驻马店市中心医院急诊科驻马店463000

目的分析创伤性休克患者重症超声监测下行液体复苏的效果。方法分析性研究。抽取2021年4月至2023年4月驻马店中心医院收治的96例创伤性休克患者,按随机数表法分为对照组与观察组,每组48例。对照组行常规液体复苏,观察组于重症超声监测... 详细信息

目的分析创伤性休克患者重症超声监测下行液体复苏的效果。方法分析性研究。抽取2021年4月至2023年4月驻马店中心医院收治的96例创伤性休克患者,按随机数表法分为对照组与观察组,每组48例。对照组行常规液体复苏,观察组于重症超声监测下行液体复苏。对比两组血流动力学、氧代谢水平、复苏24 h后各项指标情况、穿刺情况。结果复苏1 h,两组平均动脉压(MAP)、心率(HR)、乳酸、氧合指数比较,差异未见统计学意义(P>0.05);复苏24 h后,观察组MAP高于对照组,HR、乳酸、氧合指数低于对照组,差异有统计学意义(P<0.05)。观察组乳酸清除率为(25.69±3.21)%,一次穿刺成功率为75.00%(36/48),总体成功率为93.75%(45/48),高于对照组的(14.89±2.20)%、54.17%(26/48)、79.17%(38/48),P<0.05。观察组补液量少于对照组,血管活性药物应用时间、操作时间短于对照组,差异有统计学意义(P<0.05)。结论重症超声监测应用于创伤性休克液体复苏治疗患者中效果显著,可更有效的稳定患者血流动力学,改善氧代谢,提高液体复苏效果与穿刺成功率。

关键词：创伤性休克液体复苏重症超声监测血流动力学氧代谢

Mixed-Alkali Effect on Thermal Property and Elastic Behavior in Borosilicate Glasses

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1017-1024页

作者： XIE Xianmao zhou hemin KE Xuefei WANG Xiaowei WANG Yadan ZHANG Jiayan QIAO Ang TAO Haizheng State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China AVIC Jonhon Optronic Technology Co.Ltd. Luoyang 471003China Wuhan University of Technology Advanced Engineering Technology Research Institute of Zhongshan City Zhongshan 528437China

We investigated the mixed alkali effect on the thermal properties and elastic response to temperature in the borosilicate glasses system with the composition of 70.65Si O_(2)·21.09B_(2)O_(3)·1.88Al_(2)O_(3)·(6.38-x)Li_(2)O·x Na_(2)O glasses,where x=0.00,1.595,3.19,4.785,and *** for the expected positive and negative deviations from linearity for the coefficients of thermal expansion,room temperature E and G,we observed a new mixed alkali efiect on the response of elastic moduli to *** transform infrared spectra were obtained to elucidate the possible structural origin of the mixed alkali *** work provides a valuable insight into the structural and mechanical properties of mixed-alkali borosilicate glasses.

关键词： mixed-alkali effect borosilicate glass elastic response to temperature structural origin

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综合等负荷函数法的逆向算法

钢铁 2001年第1期36卷 38-41页

作者：白埃民周和敏钢铁研究总院

讨论了“综合等负荷函数法”的改进 ,将原有正向迭代 ,改为温度—厚度的正反向交叉迭代 ,并通过在迭代中过程中人为增加负荷余量和采用新的迭代参数 ,极大地改善了目标函数性态和算法的稳定性 ,为该方法的实时在线应用奠定了坚实的基础。

关键词：综合等负荷函数法交叉迭代算法稳定性单调函数板带轧制

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基于流程的钢铁生产过程环境负荷分析与优化

中国材料进展 2016年第3期35卷 187-196,204页

作者：周和敏周子衿钢铁研究总院先进钢铁流程与材料国家重点实验室北京100081 四川大学经济学院四川成都610065

叙述了生命周期评价方法在钢铁工业中应用现状和发展前景,并对钢铁生产传统工艺流程和钢铁生产新工艺流程和新技术的环境负荷进行分析和评价。基于钢铁生产新工艺流程和新技术的不断应用,对熔融还原炼铁和薄板坯连铸连轧生产工艺和流程... 详细信息

叙述了生命周期评价方法在钢铁工业中应用现状和发展前景,并对钢铁生产传统工艺流程和钢铁生产新工艺流程和新技术的环境负荷进行分析和评价。基于钢铁生产新工艺流程和新技术的不断应用,对熔融还原炼铁和薄板坯连铸连轧生产工艺和流程的环境负荷进行了评价,与传统高炉流程相比,熔融还原炼铁废气污染物和废水污染物减排效果十分明显;与传统热连轧工艺相比,薄板坯连铸连轧工艺吨材煤气消耗降低2/3,吨材烟粉尘排放降低约27%。此外,针对我国钢铁生产矿物资源和能源消耗过大、环境污染问题十分突出的现状,指出通过改进原料和能源结构,加强环境排放控制和管理,有利于较大幅度地减少污染物的发生量和排放量。最后结合钢铁企业发展循环经济的实例,提出用生命周期评价方法对实施循环经济前后的环境负荷和循环经济发展程度进行分析研究。结果表明,钢铁企业采用新工艺流程和新技术,尤其是建设循环经济型企业,有利于从根本上降低钢铁生产过程环境负荷。

关键词：生命周期评价环境负荷钢铁生产流程循环经济

4-Hydroxy-2-Oxoglutaric Acid,A KeyMetabolite Involved in Trypsin-Regulation of Arginine Metabolism in Hylocereus undatus during Storage

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 885-900页

作者： Bairu Li Jingyu Jia hemin Wang Jiaju Sun Enyan Chen Xin Li College of Food and Bioengineering Henan University of Science and TechnologyLuoyang471023China Henan Engineering Research Center of Food Microbiology Luoyang471023China National Demonstration Center for Experimental Food Processing and Safety Education Luoyang471000China

Trypsin,a novel superoxide scavenger,significantly enhances the storage quality of Hylocereus undatus(***).To elucidate the preservation mechanism of trypsin on ***,a widely targeted metabolomic analysis,and transcriptomics analysis were ***,a total of 453 metabolites were identified,with organic acids and their derivatives constituting the largest proportion(25%).Amino acids and their metabolites,prominent among organic acids,were further *** them,73 metabolites were associated with amino acids,and 37 exhibited significant *** most enriched Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway was arginine biosynthesis(map00220),with polyamine metabolites showing the most pronounced differences,particularly spermine(FC=1.7594).Compared with the control group,4-hydroxy-2-oxoglutaric acid was significantly upregulated(FC=2.117)in the process of spermine ***,the results of Gene Ontology(GO)and KEGG enrichment analysis of the *** transcriptome profile revealed that trypsin treatment led to 187 differentially expressed genes associated with *** GO and KEGG analyses exhibited significant enrichment in the spermine biosynthetic process(GO:0006597)(map:00220)within the arginine biosynthesis ***,most enzymes and metabolites within the spermine biosynthesis pathway in *** were *** results of the PPI network highlighted that ADC,SPDS,and SAMDC,among others,were pivotal proteins involved in trypsin-regulated arginine metabolism and spermine *** study revealed that trypsin could significantly delay postharvest senescence of *** at room *** effect might be attributed to trypsin triggering the synthesis of 4-hydroxy-2-oxoglutaric acid in the fruit peel,thereby promoting the biosynthesis of spermine and other polyamines.

关键词： Trypsin arginine transcriptomics widely targeted metabolomics

Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

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Science China(Life Sciences) 2024年第3期67卷 504-517页

作者： Qi Fu Yu Qian hemin Jiang Yunqiang He Hao Dai Yang Chen Zhiqing Xia Yucheng Liang Yuncai zhou Rui Gao Shuai Zheng Hui Lv Min Sun Kuanfeng Xu Tao Yang Department of Endocrinology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

During the pathogenesis of type 1 diabetes(T1D) and type 2 diabetes(T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy to compensate for the shortage of insulin, but the exact mechanism needs to be defined. High-fat diet(HFD) and streptozotocin(STZ) treatment are well-established models to study islet damage in T2D and T1D respectively. Therefore, we applied these two diabetic mouse models, triggered at different ages, to pursue the cell fate transition of isletβ cells. Cre-LoxP systems were used to generate islet cell type-specific(α, β, or δ) green fluorescent protein(GFP)-labeled mice for genetic lineage tracing, thereinto β-cell GFP-labeled mice were tamoxifen induced. Single-cell RNA sequencing(scRNA-seq) was used to investigate the evolutionary trajectories and molecular mechanisms of the GFP-labeled β cells in STZ-treated mice. STZ-induced diabetes caused extensive dedifferentiation of β cells and some of which transdifferentiated into α or δ cells in both youth-and adulthood-initiated mice while this phenomenon was barely observed in HFD models. β cells in HFD mice were expanded via self-replication rather than via transdifferentiation from α or δ cells, in contrast, α or δ cells were induced to transdifferentiate into β cells in STZ-treated mice(both youthand adulthood-initiated). In addition to the re-dedifferentiation of β cells, it is also highly likely that these “α or δ” cells transdifferentiated from pre-existing β cells could also re-trans-differentiate into insulin-producing β cells and be beneficial to islet recovery. The analysis of ScRNA-seq revealed that several pathways including mitochondrial function, chromatin modification, and remodeling are crucial in the dynamic transition of β cells. Our findings shed light on how islet β cells overcome the deficit of insulin and the molecular mechanism of islet recovery in T1D and T2D pathogenesis.

关键词： islet regeneration lineage tracing high fat diet(HFD) streptozotocin(STZ)

Optimal Initialization and Starting Approach of Synchronous Condenser Integrated Power Grid

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 248-260页

作者： Puyu Wang Xing Liu Qingwen Mou Tao Yuan Tianming Gu hemin Yang Xiao-Ping Zhang Zhengrong Xiang Chunyi Guo School of Automation Nanjing University of Science and TechnologyNanjing 210094China NARI Group Corporation/State Grid EPRI and also with NARI Technology Co.Ltd. Nanjing 211106China School of Engineering University of BirminghamBirminghamB152TTUnited Kingdom State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China

Synchronous condensers(SCs)are generally used at the receiving-end stations of ultra-high-voltage direct current(UHVDC)transmission systems due to their strong reactive power support and flexible regulation of reactive power according to the interconnected grids operating *** this paper,different starting control schemes of a SC integrated power grid are investigated providing four main contributions:1)The principle of reactive power support of the SC on the interconnected power grid is analytically studied,providing the establishment of mathematical models.2)Four different starting control schemes are developed for the initialization and SC integration,*** Scheme 1,a preset initial falling speed is directly utilized without initialization;in Scheme 2,a black start sequential control approach with a static frequency converter(SFC)is proposed;in Scheme 3,PI/PD/PID controllers are respectively applied for the excitation device at the speed-falling stage;in Scheme 4,a pre-insertion approach of an energy absorption component with R/L/RL is utilized to suppress the surges at the SC integration instant.3)The dynamic behaviors of four different starting schemes at specific operating stages are evaluated.4)The success rate of SC integration is analyzed to evaluate starting control *** of the SC interconnected system with four different starting control schemes is evaluated in the timedomain simulation environment PSCAD/EMTDC^(TM).The results prove the superiority of the proposed starting control approach in Scheme 4.

关键词： Black start dynamic behaviors excitation system pre-insertion of energy absorption components starting control schemes static frequency converter(SFC) success rate of integration synchronous condenser(SC)

EuSHT Acts as a Hub Gene Involved in the Biosynthesis of 6-Hydroxyluteolin and Quercetin Induced by Salt Stress in Eucommia ulmoides

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2095-2113页

作者： Fuxin Li Enyan Chen Xinxin Chen Jingyu Jia hemin Wang Jie Zhang Jianrui Sun Xin Li College of Food and Bioengineering Henan University of Science and TechnologyLuoyang471023China Henan Engineering Research Center of Food Microbiology Luoyang471023China National Demonstration Center for Experimental Food Processing and Safety Education Luoyang471000China

Salt stress inhibits plant growth and affects the biosynthesis of its secondary *** are natural compounds that possess many important biological activities,playing a significant role in the medicinal activity of Eucommia ulmoides(***).To investigate the mechanism by which salt stress affects the biosynthesis of flavonoids in ***,a comprehensive analysis of metabolomics and transcriptomics was *** results indicated that salt stress led to the wilting and darkening of *** leaves,accompanied by a decrease in chlorophyll levels,and significantly induced malondialdehyde(MDA)and relative electrical *** salt stress,most metabolites in the flavonoid biosynthesis pathway of *** were upregulated,indicating that flavonoid biosynthesis is likely the main induced pathway under salt *** them,secondary metabolites such as 6-Hydroxyluteolin and Quercetin are likely key metabolites induced by salt *** correlation analysis of transcriptomics and metabolomics revealed that EuSHT is a hub gene induced by salt stress,promoting the production of flavonoids such as *** co-expression network showed a strong positive correlation between EuSHT and the biosynthesis of 6-Hydroxyluteolin and Quercetin,while it exhibited a negative correlation with Catechin *** branches leading to Luteolin and Dihydroquercetin are likely the main pathways for flavonoid compound biosynthesis in the plant stress response during salt *** results of this study provided a preliminary mechanism of secondary metabolites such as flavonoids in the medicinal plant *** induced by salt stress and provided new theoretical support for discussing the mechanism of plant stress *** also provided useful information for subsequent exploration of resistance genes in ***.

关键词： Eucommia ulmoides ﬂavonoid salt stress transcriptomics widely targeted metabolomics

Giant panda(Ailuropoda melanoleuca)neonates use broadband calls to communicate with their mothers

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Integrative Zoology 2024年第2期19卷 277-287页

作者： Lin ZHAO Jianbin CHENG Wen ZENG Bo YANG Guiquan ZHANG Desheng LI hemin ZHANG Christina DBUESCHING Dingzhen LIU Ministry of Education Key Laboratory of Biodiversity Science and Ecological EngineeringCollege of Life SciencesBeijing Normal UniversityBeijingChina Key Laboratory of State Forestry and Grassland Administration on Conservation Biology of Rare Animals in The Giant Panda National Park China Conservation and Research Center for the Giant PandaDujiangyanSichuan611830China Department of Biology Irving K.Barber Faculty of ScienceUniversity of British ColumbiaOkanaganKelownaBritish ColumbiaCanada

Infant call structure should have evolved to elicit maximum maternal attention and *** of giant pandas produce three types of vocalizations reported to be vitally important in the context of mother–infant ***,how cubs,0–15 days old,communicate with their mothers to elicit maternal care remains *** analyzed 12 different call parameters of 3475 squawks,1355 squalls,and 491 croaks from 11 captive giant panda(Ailuropoda melanoleuca)neonates from age 0 to 15 *** playback experiments,we also tested whether mothers could detect *** results show that neonates use broadband calls with ultrasonic frequencies up to 65 kHz to convey information about their physiological needs and to attract maternal *** playback experiments,we tested if mothers reacted differently to broadband calls(BBC)than to artificially altered calls that included only frequencies20 kHz(USC).Playback confirmed that,although adult females responded significantly less often to USC,BBC than to or AUDC,they could detect USC,BBC and generally made appropriate behavioral responses,indicating a potential benefit for neonates to utilize ultrasonic and broadband *** findings provide a new insight into mother–infant communication in giant pandas and will be helpful for reducing the mortality of cubs,younger than 1 month old,in captivity.

关键词： acoustic communication broadband calls maternal care neonates ultrasonic frequencies