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The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

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Cellular & Molecular Immunology 2022年第2期19卷 276-289页

作者： Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu xuemei zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing100850China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Savaid Medical School University of Chinese Academy of SciencesBeijing101408China International Institute of Infection and Immunity Institutes of Biology and Medical SciencesSoochow UniversitySuzhouJiangsuChina

The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic *** tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious ***,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains ***,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory *** addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against ***,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy ***,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal *** together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD.

关键词： OTUD1 RIPK1 NF-κB IBD

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城乡公交服务质量评价方法

同济大学学报（自然科学版） 2015年第7期43卷 1031-1038页

作者：周雪梅石云林刘梅杜虎同济大学交通运输工程学院上海201804 同济大学建筑设计研究院(集团)有限公司桥梁工程分院上海200092

在解析城乡公交特性,建立城乡公交服务质量评价指标体系,以及对指标体系进行量化与分级的基础上,分别应用面向乘客需求的城乡公交服务质量差距模型和基于集对分析法(SPA)的城乡公交服务质量综合评价模型,研究城乡公交服务质量.以慈溪市... 详细信息

在解析城乡公交特性,建立城乡公交服务质量评价指标体系,以及对指标体系进行量化与分级的基础上,分别应用面向乘客需求的城乡公交服务质量差距模型和基于集对分析法(SPA)的城乡公交服务质量综合评价模型,研究城乡公交服务质量.以慈溪市城乡公交为案例进行实证分析,通过两种方法的对比得到了较为一致的结果,表明集对分析法在评价城乡公交服务质量上是可行的.

关键词：城乡公交服务质量乘客需求集对分析法(SPA)

Optical Space Time Pulse Position Modulation over Exponential Weibull Turbulence Channel

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Chinese Journal of Electronics 2024年第2期33卷 527-535页

作者： Yue ZHANG Huiqin WANG xuemei MA Minghua CAO Qingbin PENG School of Computer and Communication Lanzhou University of Technology School of Foreign Languages Lanzhou University of Technology

An optical space time pulse position modulation(OSTPPM) scheme is proposed to satisfy the communication requirement of high transmission rate and better reliability. For the OSTPPM scheme, an improved threshold judgment-based orthogonal matching pursuit(IT-OMP) algorithm with low-complexity and near optimal performance is proposed. The average bit error rate of OSTPPM-IT-OMP scheme is investigated over the exponential Weibull channel, and its analytical expression is verified via Monte Carlo simulation. With the same simulation parameters, the signal to noise ratio of(4,4,2)-OSTPPM-IT-OMP is respectively 3.75 d B and 8.5 d B better than that of spatial pulse position modulation(SPPM) scheme and generalized spatial pulse position modulation(GSPPM)scheme at a bit error rate of 1 × 10-3. With the same transmission bits per symbol, the computational complexity of(3,4,2)-OSTPPM-IT-OMP scheme is reduced by 90.47% and 75.4% compared with(16,4,2)-SPPM and(5,4,2)-GSPPM schemes, respectively.

关键词： Wireless communication Wireless sensor networks Monte Carlo methods Bit error rate Matching pursuit algorithms Adaptive optics Optical modulation

Comprehensive applicability evaluation of four precipitation products at multiple spatiotemporal scales in Northwest China

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Journal of Arid Land 2024年第9期16卷 1232-1254页

作者： WANG Xiangyu XU Min KANG Shichang LI xuemei HAN Haidong LI Xingdong School of Mathematics Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Faculty of Geomatics Lanzhou Jiaotong UniversityLanzhou 730070China

Precipitation plays a crucial role in the water cycle of Northwest *** accurate precipitation data is crucial for regional water resource management,hydrological forecasting,flood control and drought ***,the applicability of multi-source precipitation products for long time series in Northwest China has not been thoroughly *** this study,precipitation data from 183 meteorological stations in Northwest China from 1979 to 2020 were selected to assess the regional applicability of four precipitation products(the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5),Global Precipitation Climatology Centre(GPCC),Climatic Research Unit gridded Time Series Version 4.07(CRU TS v4.07,hereafter CRU),and Tropical Rainfall Measuring Mission(TRMM))based on the following statistical indicators:correlation coefficient,root mean square error(RMSE),relative bias(RB),mean absolute error(MAE),probability of detection(POD),false alarm ratio(FAR),and equitable threat score(ETS).The results showed that precipitation in Northwest China was generally high in the east and low in the west,and exhibited an increasing trend from 1979 to *** with the station observations,ERA5 showed a larger spatial distribution difference than the other *** overall overestimation of multi-year average precipitation was approximately 200.00 mm and the degree of overestimation increased with increasing precipitation *** multi-year average precipitation of GPCC and CRU was relatively close to that of station *** trend of annual precipitation of TRMM was overestimated in high-altitude regions and the eastern part of Lanzhou with more *** the monthly scale,GPCC performed well but underestimated precipitation in the Tarim Basin(RB=-4.11%),while ERA5 and TRMM exhibited poor accuracy in high-altitude ***5 had a large bias(RB≥120.00%)in winter months

关键词： precipitation products the fifth generation of European Centre for Medium-Range Weather Forecasts(ECMWF)atmospheric reanalysis of the global climate(ERA5) Global Precipitation Climatology Centre(GPCC) Climatic Research Unit gridded Time Series(CRU TS) Tropical Rainfall Measuring Mission(TRMM) applicability evaluation Northwest China

Eco-physiological characteristics of Tetracentron sinense *** in response to different light intensities

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Journal of Forestry Research 2024年第3期35卷 29-44页

作者： Rong Wang Xueheng Lu Hongyan Han xuemei Zhang Yonghong Ma Qinsong Liu Xiaohong Gan Key Laboratoryof Southwest Wildlife Resources Conservation Ministry of EducationChina West Normal UniversityNanchong 637009People's Republic of China Institute of Plant Adaptation and Utilization in Southwest Mountain China West Normal UniversityNanchong 637009People's Republic of China Office of the People's Government of Yuexi County Yuexi County 616650Liangshan Yi Autonomous PrefecturePeople's Republic of China

The regeneration of Tetracentron sinense *** poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in *** is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural *** this study,the light intensity in *** habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling *** differences were observed in morphology(including leaf area,and specific leaf area)under different light *** to L1 and L3,chloroplast structure in L2 was *** increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was *** decreased osmoregulation substance contents of leaves but increased *** results suggest that light intensities significantly affect the eco-physiological characteristics of *** saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological ***,50%natural sunlight should be created to promote saplings establishment and population recovery of *** during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open.

关键词： Chloroplast ultrastructure Eco-physiological characteristics Light intensities Sapling establishment Tetracentron sinense Oliv

LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： Juan zhou Yiran Xu Luyao Wang Yu Cong Ke Huang Xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei Xu xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child Health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

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TMSR-SF高温下多群核数据库的研究

核技术 2014年第12期37卷 47-51页

作者：周雪梅王小鹤中国科学院上海应用物理研究所嘉定园区上海201800 中国科学院核辐射与核能技术重点实验室上海201800 中国科学院大学北京100049

基于最新发布的评价核数据库ENDF/B-VII.1,简要介绍了利用标准程序NJOY加工固态燃料钍基熔盐堆(Thorium Molten Salt Reactor-Solid Fuel,TMSR-SF)中子能谱测量所需温度下多群截面库的过程。详细分析了两个典型的核素加工所得核反应道... 详细信息

基于最新发布的评价核数据库ENDF/B-VII.1,简要介绍了利用标准程序NJOY加工固态燃料钍基熔盐堆(Thorium Molten Salt Reactor-Solid Fuel,TMSR-SF)中子能谱测量所需温度下多群截面库的过程。详细分析了两个典型的核素加工所得核反应道的多群截面与温度的关系,并将不同温度下的截面库用于中子能谱测量,分析了中子能谱测量结果的误差与温度所引起截面库变化的关系。结果表明,不同类型核反应道的截面所受温度影响不同,特别是核素对超热中子的截面存在共振峰问题受温度影响最大,这是由于多普勒效应影响,所以中子能谱测量结果受核反应道选择的影响符合物理规律,加工所得873 K下的核截面库可用于TMSR-SF相关中子能谱测量。

关键词： ENDF/B-VII.1 中子能谱多群核截面加工 TMSR—SF反应堆

Efficiency-first spraying mission arrangement optimization with multiple UAVs in heterogeneous farmland with varying pesticide requirements

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Information Processing in Agriculture 2024年第2期11卷 237-248页

作者： Yang Li Yanqiang Wu Xinyu Xue xuemei Liu Yang Xu Xinghua Liu Nanjing Institute of Agricultural Mechanization Ministry of Agriculture and Rural AffairsNanjing 210014PR China College of Mechanical&Electronic Engineering Shandong Agricultural UniversityTai'an 271018PR China Key Laboratory of Modern Agricultural Equipment Ministry of Agriculture and Rural AffairsNanjing 210014PR China Shandong Provincial Key Laboratory of Horticultural Machinery and Equipment Tai’an 271018PR China Shandong Provincial Engineering Laboratory of Agricultural Equipment Intellectualization Tai’an 271018PR China

Combining multiple crop protection Unmanned Aerial Vehicles(UAVs)as a team for a scheduled spraying mission over farmland now is a common way to significantly increase ***,given some issues such as different configurations,irregular borders,and especially varying pesticide requirements,it is more important and more complex than other multi-Agent Systems(MASs)in common *** this work,we focus on the mission arrangement of UAVs,which is the foundation of other high-level cooperations,systematically propose Efficiency-first Spraying Mission Arrangement Problem(ESMAP),and try to construct a united problem framework for the mission arrangement of crop protection ***,to characterise the differences in sub-areas,the varying pesticide requirement per unit is well considered based on Normalized Difference Vegetation Index(NDVI).Firstly,the mathematical model of multiple crop-protection UAVs is established and ESMAP is ***,an acquisition method of a farmland’s NDVI map is proposed,and the calculation method of pesticide volume based on NDVI is ***,an improved Genetic Algorithm(GA)is proposed to solve ESMAP,and a comparable combination algorithm is *** simulations for algorithm analysis are carried out within MATLAB,and it is determined that the proposed GA is more efficient and accurate than the ***,a mission arrangement tested with three UAVs was carried out to validate the effectiveness of the proposed GA in spraying *** results illustrated that it performed well,which took only 90.6%of the operation time taken by the combination algorithm.

关键词： Efficiency-first optimization Mission arrangement Multi-UAVs Heterogeneous farmland

Investigation of improving the thermophysical properties and corrosion resistance of RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates by component design with RE doping

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Journal of Advanced Ceramics 2024年第6期13卷 842-860页

作者： Zeyu Chen Yiling Huang Zhaoxuan Zhang Wei Zheng xuemei Song Yaran Niu Yi Zeng The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

In this research,a novel method for regulating components in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates was developed,combining the benefits of a suitable thermal expansion coefficient(CTE)and outstanding corrosion resistance against calcium–magnesium–alumino–silicate(CMAS).This approach enhanced the overall thermophysical ***,the results from the CMAS corrosion resistance test indicated that(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)SiO_(5)/(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)Si_(2)O_(7)and(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)SiO_(5)/(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)Si_(2)O_(7)exhibited exceptional resistance to CMAS penetration,even at temperatures up to 1500℃.To comprehend the corrosion mechanism of CMAS on these silicates,we introduced a reaction–diffusion model,which involved observing the changes in the interface between the corrosion product layer and the silicate *** was achieved using electron backscatter diffraction(EBSD).These findings lay a theoretical basis for selecting rare earth elements in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates based on the radii of different rare earth cations.

关键词： thermal conductivity environmental barrier coatings(EBCs) thermal expansion coefficient(CTE) multiphase silicates calcium-magnesium-alumino-silicate(CMAS)corrosion resistance reaction-diffusion