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Relations between lymphangiogenesis and the size of pterygium

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 312-316页

作者： Lin Liu, xiu-Hua jia General Hospital of Guangzhou Military Command of Chinese PLA Guangzhou 510010 Guangdong Province China Department of Ophthalmology the Third Affiliated Hospital Sun Yat-sen University Guangzhou 510630 Guangdong Province China Department of Ophthalmology Guangzhou Children's Hospital Guangzhou 510120 Guangdong Province China

AIM: To examine the relations between lymphangiogenesis and the size of pterygium. METHODS: Tissues from 88 primary and 34 recurrent pterygia were evaluated, and those from 7 nasal epibulbar conjunctiva segments were used as controls. Pterygium slices from each patient were stained with LYVE-1 monodonal antibodies to identify lymphatic microvessel for calculating lymph-vascular area (LVA), lymph-microvascular density (LMD) and lymph-vascular luminal diameter (LVL). Also, the relations between lymphangiogenesis (measuring by LVA, LMD and LVL) and the size of pterygium (extension, width and area) were explored. RESULTS: There were a few LYVE-1 ((+)) lymphatic vessels in normal epibulbar conjunctiva segments. However, the number of lymphatic vessels slightly increased in primary pterygia and dramatically increased in recurrent pterygia. LVA, LMD and LVL significantly increased in recurrent pterygia in comparison with primary pterygia (all P<0.05). Both LMD and LVA were correlated with the width and area of pterygia (both P<0.05), and LVA was also correlated with the extension of pterygia(P<0.05). CONCLUSION: Lymphangiogenesis is correlated with the size of pterygium. The outgrowth of lymphatic vessels might contribute to the development of pterygia.

关键词： pterygia lymphatic vessel size

Silence of HIN-1 expression through methylation of its gene promoter in gastric cancer

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World Journal of Gastroenterology 2011年第4期17卷 526-533页

作者： Yan Gong Ming-zhou Guo Zhi-jia Ye xiu-Li Zhang Yong-Liang Zhao Yun-Sheng Yang Department of Gastroenterology and Hepatology Chinese PLAGeneral Hospital Beijing 100853 China Department of Genetics Yale Medical School TACS320 1 Gilbert Street New Haven CT 06520 United States Department of General Surgery Southwest Hospital Third Military Medical University Chongqing 400038China

AIM: To clarify the role of high in normal-1 (HIN-1) gene promoter methylation during gastric cancer development. METHODS: Gastric cancer cell lines and tissue specimens were analyzed for expression of HIN-1 mRNA and protein using the semi-quantitative reverse transcription polymerase chain reaction and immunohistochemistry. The methylation of the HIN-1 gene promoter was detected in gastric carcinoma cells and tissues using methylation-specific polymerase chain reaction. The 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium cell viability assay and flow cytometry were used to assess the changes in behaviors of gastric cancer cells with or without 5-aza-2’-deoxycytidine treatment. RESULTS: HIN-1 was not expressed in 4 of 5 gastric cancer cell lines. The demethylation reagent 5-aza-2’-deoxycytidine was able to induce or upregulate HIN-1 expression in gastric cancer cell lines, which is associated with reduction of tumor cell viability. Furthermore, methylation of the HIN-1 gene promoter was shown in 57.8% (26/45) of the primary gastric cancer and 42.1% (17/38) of adjacent tissue samples, but was not shown in normal gastric mucosa (0/10). From the clinicopathological data of the patients, methylation of the HIN-1 gene promoter was found to be associated with tumor differentiation (P = 0.000). CONCLUSION: High methylation of HIN-1 gene promoter results in silence of HIN-1 expression in gastric cancer. 5-aza-2’-deoxycytidine reverses HIN-1 methylation and reduces viability of gastric cancer cells.

关键词： High in normal-1 Gene methylation 5-aza-2’-deoxycytidine Tumor differentiation Gastric cancer

BDNF基因二核苷酸多态性与儿童孤独症的关系

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中国妇幼保健 2007年第11期22卷 1483-1485页

作者：周家秀郭兰婷黄雪竹吴康敏王英成张芳蓉季卫东黄晓琦深圳市儿童医院儿童保健科 518026 四川大学华西医院心理卫生中心

目的:探讨BDNF基因二核苷酸多态性的等位基因及基因型与儿童孤独症的关系。方法:按照ICD-10及CCMD-3的儿童孤独症诊断标准,以儿童孤独症评定量表、孤独症行为检查量表、儿童适应行为评定量表及儿童生长发育调查记录表作为评估、调查工具... 详细信息

目的:探讨BDNF基因二核苷酸多态性的等位基因及基因型与儿童孤独症的关系。方法:按照ICD-10及CCMD-3的儿童孤独症诊断标准,以儿童孤独症评定量表、孤独症行为检查量表、儿童适应行为评定量表及儿童生长发育调查记录表作为评估、调查工具,在华西医院心理卫生中心门诊收集75例儿童孤独症患者的临床资料。根据儿童孤独症的神经发育障碍假说,以儿童孤独症为研究对象,进行神经发育相关的BDNF基因的二核苷酸重复多态性位点的检测,用SPSS11.0进行统计分析。结果:含二核苷酸重复多态性的A1(174bp)等位基因与儿童孤独症的社会交往因子呈负相关,而含A3(170bp)等位基因与之呈正相关,患者的适应水平也受到相应影响。结论:二核苷酸重复多态性的A1等位基因可能对孤独症的症状表达具有抑制作用,而A3等位基因对孤独症的症状表达有促发作用,并且影响儿童孤独症患者的社会适应水平。

关键词：儿童孤独症脑源性神经生长因子多态性

Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas： a multivariate analysis

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Asian Journal of Andrology 2018年第1期20卷 43-49页

作者： Wen-jian-Long zhou Shun-Chang Ma Min Zhao Chang Liu xiu-Dong Guan Zhao-Shi Bao Gui-lun jia Wang jia Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurosurgery Beijing Fuxing Hospital Capital Medical University Beijing 100045 China Department of Neurosurgery Peking University International Hospital Beijing 102206 China Department of Neurosurgery Beijing Huairou Hospital University of Chinese Academy of Sciences Beijing 101400 China

The impact of sexual dysfunction （SD） is distressing to many male patients with pituitary adenomas which affect both physical and psychological health. The research explored to identify risk factors affecting sexual function and the prognosis of male patients with pituitary adenomas. Two hundred and fifty-four male patients, who aged between 18 and 60 （mean ± s.d. ： 44.16 ± 10.14） years and diagnosed with pituitary adenomas, were retrospectively analyzed. One hundred and fifty-nine patients （62.6%） complained of SD prior to surgery. The mean International Index of Erectile Function （IIEF-5） in patients with giant adenomas was 16.13 ± 2.51, much smaller than those with microadenomas or macroadenomas （P 〈 0.05）. All the patients showed significant improvement in terms of erectile dysfunction （ED） following surgery （P 〈 0.05）. In addition, complete resection achieved a higher degree of SD relief than partial resection. The incidence of SD in functioning pituitary adenomas （FPAs） was much higher than that in nonfunctioning pituitary adenomas （NFPAs）（P 〈 0.05）. In addition, compared with NFPAs, males with prolactinomas （82.8%） had the higher prevalence of SD and significantly improvement following surgical intervention （P 〈 0.05）. An inverse relationship was identified between decreasing testosterone levels and increasing incidence of SD before surgery （P 〈 0.05）. There was no significant difference between 6 months and 12 months after surgery in serum testosterone level （P〉 0.05）. Our results indicated that surgical therapy could be optimized for improvements in SD and that testosterone levels can be used as a sensitive indicator to predict the recovery rate of sexual function in patients with pituitary adenomas following surgery and the serum testosterone level will stay stable in 6 months after surgery.

关键词： erectile dysfunction male pituitary adenomas sexual dysfunction testosterone

The in ovo injection of methionine improves intestinal cell proliferation and differentiation in chick embryos by activating the JAK2/STAT3 signaling pathway

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Animal Nutrition 2021年第4期7卷 1031-1038页

作者： Meng-Jie Chen jia-Yi zhou Yi-Jun Chen xiu-Qi Wang Hui-Chao Yan Chun-Qi Gao College of Animal Science South China Agricultural University/Guangdong Provincial Key Laboratory of Animal Nutrition ControlGuangzhou510642China

The intestinal health of chick embryos is vital for their life-long growth,and exogenous nutrition intervention may provide sufficient nutrition for embryonic *** the present study,we investigated the effect of in ovo injection of L-methionine(L-Met)on the intestinal structure and barrier function of chick *** were 4 groups of treatments:the control(CON)group injected with phosphate-buffered saline(PBS)and the other 3 groups injected with 5,10,and 20 mg L-Met/egg,*** injection was performed on embryonic day 9(E9),and intestinal samples were collected on the day of hatching for *** results showed that,compared with the CON group,the groups administered an in ovo injection of L-Met increased relative weights of the duodenum,jejunum,and ileum(P<0.05).Hematoxylin and eosin(H&E)staining showed that the groups injected with 5,10,and 20 mg L-Met significantly increased villus height and crypt depth(P<0.05).Moreover,in ovo injection of 10 mg L-Met also increased the transepithelial electrical resistance(TEER)of the jejunum(P<0.05).Injection with 10 and 20 mg L-Met increased the expression of the tight junction proteins(ZO-1 and claudin-1)and the fluorescence signal intensity of Ki67 and villin proteins(P<0.05).Further,the protein expression of phospho-Janus kinase 2(p-JAK2)and phospho-signal transducer and activator of transcription 3(p-STAT3)was significantly increased by 10 or 20 mg L-Met injection(P<0.05).In conclusion,the injection of L-Met,especially at a dose of 10 mg,showed beneficial effects on the intestinal integrity of chick embryos due to the activation of the JAK2/STAT3 signaling *** results may provide new insights for regulating the intestinal development of embryonic chicks and the rapid growth of chicks after hatching.

关键词： In ovo injection Chick Intestine L-methionine JAK2/STAT3

The clinical significance of bimodal growth pattern in the treatment of hemangiomas in infancy and children

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上海口腔医学 2009年第5期18卷 555-556页

作者： ZHENG jia-wei WANG Yan-an YANG xiu-juan zhou Qin Department of Oral and Maxillofacial Surgery Ninth People's Hospital College of Stomatology Shanghai JiaoTong University School of Medicine. Shanghai 200011 China

Hemangiomas are the most common benign vascular neoplasms of infancy and children, the life cycle of which involves a phase of rapid proliferation in the neonatal period, followed by spontaneous involution, usually du... 详细信息

关键词：血管瘤新生儿临床分析治疗方法

Efficacy of iontophoresis-assisted epithelium-on corneal cross-linking for keratoconus

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 687-694页

作者： Hong-Zhen jia xiu-Jun Peng Department of Ophthalmology Chinese PLA Navy General Hospital

Corneal cross-linking（CXL） is a noninvasive therapeutic procedure for keratoconus that is aimed at improving corneal biomechanical properties by induction of covalent cross-links between stromal proteins. It is accomplished by ultraviolet A（UVA） radiation of the cornea, which is first saturated with photosensitizing riboflavin. It has been shown that standard epithelium-off CXL（S-CXL） is efficacious, and it has been recommended as the standard of care procedure for keratoconus. However, epithelial removal leads to pain, transient vision loss, and a higher risk of corneal infection. To avoid these disadvantages, transepithelial CXL was developed. Recently, iontophoresis has been adopted to increase riboflavin penetration through the epithelium. Several clinical observations have demonstrated the safety and efficacy of iontophoresisassisted epithelium-on CXL（I-CXL） for keratoconus. This review aimed to provide a comprehensive summary of the published studies regarding I-CXL and a comparison between I-CXL and S-CXL. All articles used in this review were mainly retrieved from the Pub Med database. Original articles and reviews were selected if they were related to the I-CXL technique or related to the comparison between I-CXL and S-CXL.

关键词： corneal cross-linking keratoconus iontophoresis riboflavin ultraviolet A

A New Bisesquiterpene from Ligularia macrophylla

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Chinese Chemical Letters 2002年第3期13卷 249-250页

作者： Bo FU Qi xiu ZHU xiu Ping YANG Zhong jian jia Department of Chemistry Lanzhou UniversityLanzhou 730000

From the roots of Ligularia macrophylla, a bisesquiterpene, ligumacrophyllal was isolated and its structure was elucidated on the basis of spectroscopic methods.

关键词： Ligularia macrophylla Compositae bisesquiterpene ligumacrophyllal.

Evaluation of macular vessel density changes after vitrectomy with silicone oil tamponade in patients with rhegmatogenous retinal detachment

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 881-886页

作者： jian jiang Song Chen Ya-Ding jia Rui Li Jin-xiu zhou Rui-Mei Li Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Eye Hospital Tianjin 300020China Taiyuan Aier Eye Hospital Taiyuan 030012Shanxi ProvinceChina

AIM:To evaluate macular microvasculature changes in eyes after pars plana vitrectomy(PPV)and intraocular silicone oil(SO)tamponade for macula-off rhegmatogenous retinal detachment(RRD)using optical coherence tomography angiography(OCTA).METHODS:Totally 19 eyes(19 patients)with maculaoff RRD who underwent PPV and intraocular SO tamponade were retrospectively *** parafoveal superficial capillary plexus(SCP)vessel density(VD),deep capillary plexus(DCP)VD,choriocapillaris plexus(CCP)VD,and foveal macular thickness were evaluated using OCTA throughout 16 wk *** values of healthy fellow eyes were used as ***:The parafoveal SCP,DCP,and CCP VDs were significant increased over time in RRD eyes during the 12 wk postoperatively,then decreased at 16 wk postoperatively(all P0.05).CONCLUSION:The parafoveal SCP,DCP,and CCP VDs gradually recover over time after PPV surgery with SO ***-time SO tamponade might decrease postoperative macular *** to parafoveal CCP VD,the parafoveal SCP and DCP VDs were more vulnerable in RRD eyes postoperatively.

关键词： rhegmatogenous retinal detachment vessel density silicone oil vitrectomy optical coherence tomography angiography