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重组人抵抗素对TAO患者眼眶前脂肪细胞分化的影响

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眼科研究 2010年第2期28卷 167-170页

作者：刘红霞罗琳吴中耀淄博市中心医院眼科 255036 青岛市市立医院眼科 266011 中山大学中山眼科中心广州510060

目的探讨重组人抵抗素对甲状腺相关眼病(TAO)患者眼眶前脂肪细胞分化的影响及其在TAO发病中的可能作用。方法10例严重TAO患者眼眶脂肪组织来自眼眶减压术中,正常对照组来自各种原因行眼球摘除术者。培养眼眶前脂肪细胞,并诱导分化,在分... 详细信息

目的探讨重组人抵抗素对甲状腺相关眼病(TAO)患者眼眶前脂肪细胞分化的影响及其在TAO发病中的可能作用。方法10例严重TAO患者眼眶脂肪组织来自眼眶减压术中,正常对照组来自各种原因行眼球摘除术者。培养眼眶前脂肪细胞,并诱导分化,在分化液中分别加入0、10、25、50、100μg/L质量浓度的重组人抵抗素,采用逆转录PCR(RT-PCR)法检测分化过程中过氧化物酶增生体激活受体γ(PPARγ)基因的表达,研究重组人抵抗素对前脂肪细胞分化的作用。结果TAO患者及正常对照组眼眶前脂肪细胞在体外均可被诱导分化成脂肪细胞。分化成熟的脂肪细胞可被油红O染成橘红色。重组人抵抗素对眼眶前脂肪细胞的分化有抑制作用,RT-PCR结果显示PPARγ基因的表达随着抵抗素质量浓度的升高而减弱,差异有统计学意义(P<0.05)。结论重组人抵抗素可抑制人眼眶脂肪组织来源前脂肪细胞的分化,脂肪细胞标记性PPARγ基因的表达减弱,有望在TAO治疗方面开创新的研究方向。

关键词：甲状腺相关眼病前脂肪细胞抵抗素

Cavernous Hemangioma of the Bony Orbit

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眼科学报 2005年第3期 19-23页

作者： Jianhua Yan, Yu Cai, zhongyao wu, Ji Han, Youjian Pang Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060 China. Eye Hospital Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060 China

Purpose: To study the clinical features, diagnosis and management of intraosseous cavernous hemangioma of the orbit. Methods: Five cases of intraosseous cavernous hemangioma seen in our hospital from Jan 1, 1986 to Dec 31, 2000 were reviewed. Results: Among all five cases, two were male and three were female. The mean age was 47.6 years old, ranging from 39.0 to 55.0 years. The left orbit was affected in 4 cases and the right one in 1 case. The bony involvement occurred in frontal bone (two cases), zygomatic bone (two cases) and sphenoid bone (one case). A painless, slowly enlarging hard bony mass fixed to the bone with no pulsations was the main clinical sign. The x-ray and CT appearance of intraosseous cavernous hemangioma of the orbit were characteristic and usually diagnostic. The differential diagnosis of it included fibrous dysplasia, eosinophilic granuloma, multiple myeloma and metastatic carcinoma. Treatment is local removal of the bone containing the tumor. Conclusions: Intraosseous cavernous hemangioma is a rare tumor of the orbit and usually has good surgical result. Eye Science 2005;21:147-151.

关键词： orbit bone cavernous hemangiotna orbitotomy

Paracentral Corneal Dellen:A Rare Sign of Graves Ophthalmopathy

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Eye Science 2003年第3期19卷 174-175页

作者： Jianhua Yan, zhongyao wu Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Eye Hospital Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China.

Purpose: To report a rare sign, paracentral corneal dellen that developed in a middleaged female patient with Graves ***:A paracentral corneal dellen developed in the left eye in a 42-year-old woman who was diagnosed as Graves ophthalmopathy. The patient had remarkable upper eyelid retraction, upper eyelid lag and upward motility restriction. The Graves ophthalmopathy was classified as Grade V according to NOSPECS ***:Local artificial tear film and 0.3% Tobramycin eye drops were administered to both ***-four hours later, the left corneal dellen ***:Graves ophthalmopathy can lead to paracentral corneal dellen because of severe upper eyelid retraction and upward motility restriction of the eye in spite of the lack of lagophthalmos. Artificial tear drop and antibiotic eye drop therapy helped even though the patient did not have corneal exposure.

关键词：中心角膜浅凹格雷夫斯眼病临床表现病例报告

Predicting the effect of cooling rates and initial hydrogen concentrations on porosity formation in Al-Si castings

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Materials Genome Engineering Advances 2024年第3期2卷 117-129页

作者： Qinghuai Hou Junsheng Wang Yisheng Miao Xingxing Li Xuelong wu zhongyao Li Guangyuan Tian Decai Kong Xiaoying Ma Haibo Qiao Wenbo Wang Yuling Lang School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijingChina School of Mechanical Engineering Beijing Institute of TechnologyBeijingChina CITIC Dicastal Co. Ltd.QinhuangdaoHebei ProvinceChina

Al-Si alloys are widely used in automotive casting components while microporosity has always been a detrimental defect that leads to property *** this study,a coupled three-dimensional cellular automata(CA)model has been used to predict the hydrogen porosity as functions of cooling rate and initial hydrogen *** quantifying the pore characteristics,it has been found that the average equivalent pore diameter decreases from 40.43 to 23.98μm and the pore number density increases from 10.3 to 26.6 mm^(−3)as the cooling rate changes from 2.6 to 19.4℃/s at the initial hydrogen concentration of 0.25 mL/100 *** is also notable that the pore size increases as the initial hydrogen concentration changes from 0.15 to 0.25 mL/100 g while the pore number remains *** addition,the linear regression between secondary dendrite arm spacing and the equivalent pore diameter has been studied for the first time,matching well with *** work exhibits the application of CA model in future process optimization and robust condition design for advanced automotive parts made of Al-Si alloys.

关键词： Al-Si alloy cellular automata cooling rate microporosity secondary dendrite arm spacing solidification

Amniotic Membrane Transplantation for Conjunctival Tumor

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Eye Science 2003年第3期19卷 165-167,145页

作者： Zhicong Chen, Jianhua Yan, Huasheng Yang, zhongyao wu Youjian Pang, Shiming Ai, Yuxiang Mao Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China.

Purpose: To evaluate the possibility of amniotic membrane transplantation (AMT) for the treatment of conjunctival ***: Preserved AMT was performed in 26 patients (26 eyes) with conjunctival tumor, including 9 eyes (34.62%) with malignant tumor (conjunctival malignant melanoma,corneal and conjunctival squamous cell carcinoma, conjunctival lymphoma), 17 eyes(65.38%) with benign tumor(conjunctival papilloma, conjunctival dermoid tumor, conjunctival nevus, hemangioma etc.).Result: All the patients are followed up for 1 ～53 months. No acute rejection was observed after preserved AMT. Ideal healing was found in conjunctiva ***: Preserved AMT is a very effective method to repair wound after giant conjunctival tumor operation. Complete removal of tumor and perfect fixation are the key of ocular surface reconstruction.

关键词：羊膜移植结膜瘤手术治疗疗效

Inhibition on Telomerase Activity and Cytotoxic Effects by Cisplatin in Cultured Human Choroidal Melanoma Cells

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Eye Science 2003年第1期19卷 54-59页

作者： Hao Cheng, zhongyao wu, Jianliang Zheng, Guilan Lu, Jianhua Yan Min Liu, Danping Huang, Jianxian LinZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China.

Purpose: To study the changes of telomerase activity and cytotoxic effects by Cisplatin;cis-dichlorodiamine platinum (CDDP) in cultured human choroidal *** and Methods: The primary cultured human choroidal melanoma cells werecultured in the presence and absence of CDDP with different concentration and timerespectively. The toxic effects were evaluated by MTT and the level of telormarse wasdetected by PCR-ELISA assay. And the relationship between telomerase activity andcytotoxic effects were analyzed by a correlation ***: Following the increase of the concentration and the time of CDDP, graduallyrepressed telomerase activity was detected in cultured cells. Meanwhile, the restrain rateof the cells increased. The telomerase activity at 24h and 1μg/ml was repressedsignificantly compared with the control cells. However, the appearance of cell deathlagged behind the decreasing of ***: CDDP is an effective telomerase inhibitor in cultured choroidal melanomacells of human eyes, which presents concentration and time dependency and can causethe death of cultured cells.

关键词：端粒酶细胞毒素脉络膜黑色素瘤细胞顺铂细胞培养 PCR-ELISA

Efficacy and safety of anlotinib plus penpulimab as second-line treatment for small cell lung cancer:A multicenter,open-label,single-arm phase II trial

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Cancer Pathogenesis and Therapy 2024年第4期2卷 268-275页

作者： Changgong Zhang Jianhua Chen Huijuan wu Jun Wang Liying Gao Jun Zhao Yan Sun zhongyao Jia Xinlin Mu Chunmei Bai Rui Wang Kailiang wu Qiang Liu Yuankai Shi Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department I of Thoracic Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan 410083China Department of Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenan 450000China Department II of Head and Neck Tumor Gansu Provincial Cancer HospitalLanzhouGansu 730050China Department III of Radiotherapy Gansu Provincial Cancer HospitalLanzhouGansu 730050China Department I of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Department of Oncology Linyi People's HospitalLinyiShandong 276002China Department of Respiratory and Critical Care Medicine Peking University People's HospitalBeijing 100032China Department of Medical Oncology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Thoracic Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebei 050000China Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Cancer HospitalShanghai 200030China Department I of Oncology Shenyang Chest HospitalShenyangLiaoning 110044China

Background:Currently,the need for new therapeutic strategies involving programmed cell death protein-1(PD-1)monoclonal antibodies in the second-line setting of small cell lung cancer(SCLC)is *** study aimed to evaluate the efficacy and safety of anlotinib plus penpulimab as a second-line treatment for patients with SCLC who progressed after first-line platinum-based ***:This study included the patients from Cohort 4 of a single-arm,open-label,multicenter,phase II clinical trial.A safety run-in phase was performed under anlotinib(10/12 mg quaque die[QD],days 1–14)plus penpulimab(200 mg intravenously[IV],day 1)in a 21-day cycle,followed by the formal trial in which the patients received anlotinib(12 mg QD,days 1–14)plus penpulimab(200 mg IV,day 1)in a 21-day *** primary endpoint of the safety run-in phase was *** primary endpoint of the formal trial phase was the objective response rate(ORR).Results:From April 28,2020,to November 24,2020,21 patients were enrolled from 11 hospitals,including 2 in the safety run-in phase and 19 in the formal trial *** the formal trial phase,the ORR was 42.1%(8/19;95%confidence interval[CI]:17.7–66.6%).The median progression-free survival was 4.8 months(95%CI:2.9–11.3 months),and the median overall survival was 13.0 months(95%CI:4.6–not applicable[NA]months).The incidence of grade 3 treatment-related adverse events(TRAEs)was 52.4%(11/21),and the incidence of treatment-related serious adverse events(AEs)was 28.6%(6/21).Two AE-related deaths *** most common AEs were hypertension(57.1%,12/21),hypothyroidism(42.9%,9/21),and hypertriglyceridemia(38.1%,8/21).Conclusions:In patients with SCLC who progressed after first-line platinum-based chemotherapy,the second-line anlotinib plus penpulimab treatment demonstrates promising anti-cancer activity and a manageable safety profile,which warrants further investigation.

关键词： Anlotinib Penpulimab Small cell lung cancer Efficacy Safety Phase II trial

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骨折后肘关节功能障碍两种综合疗法效果比较

第三军医大学学报 1999年第4期21卷 294-295页

作者：周贤丽吴宗耀第三军医大学附属西南医院康复理疗科

目的：比较骨折愈合后肘关节功能障碍两种综合疗法的效果。方法：２０例患者分为关节松动术组和传统体疗组进行综合治疗。结果：平均经过６４．１ｄ的康复治疗，关节松动术组肘关节伸、屈度、关节活动范围（ＲＯＭ）与传统体疗组ＲＯＭ... 详细信息

目的：比较骨折愈合后肘关节功能障碍两种综合疗法的效果。方法：２０例患者分为关节松动术组和传统体疗组进行综合治疗。结果：平均经过６４．１ｄ的康复治疗，关节松动术组肘关节伸、屈度、关节活动范围（ＲＯＭ）与传统体疗组ＲＯＭ均得到明显改善。关节松动术组的康复评定结果、肘关节屈度、ＲＯＭ明显好于传统体疗组。结论：骨折后遗留肘关节功能障碍采用关节松动术及传统体疗法可不同程度地改善肘关节功能，而关节松动术治疗效果明显优于传统体疗法。

关键词：骨折愈合肘关节功能障碍综合疗法

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眼科放弃治疗的伦理学研究

中国医学伦理学 2005年第1期18卷 71-73页

作者：颜建华吴中耀中山大学中山眼科中心广州510060

放弃治疗有广义与狭义之分,广义的放弃治疗在各个专业和轻重不同的疾病中都存在。经济困难仍是眼科放弃治疗的主要问题。部分无光感眼疾患者不要过早放弃治疗,应尽力救治。误诊漏诊致病变由可治变为不可治的放弃治疗要尽量避免。治疗性... 详细信息

放弃治疗有广义与狭义之分,广义的放弃治疗在各个专业和轻重不同的疾病中都存在。经济困难仍是眼科放弃治疗的主要问题。部分无光感眼疾患者不要过早放弃治疗,应尽力救治。误诊漏诊致病变由可治变为不可治的放弃治疗要尽量避免。治疗性放弃对临床医生是一个全新的概念,医生在特殊情况下对某些可治性疾病可采用放弃治疗的方法。

关键词：放弃治疗眼科医学伦理学