检索结果-南通市图书馆

Genome sequencing provides insights into Caprifoliaceae genome evolution and the mechanism underlying second blooming phenomenon in Heptacodium miconioides

引用

Horticultural Plant Journal 2024年第3期10卷 897-910页

作者： Yueling Li zhongshuai sun Zexin Jin Junmin Li Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation Taizhou UniversityTaizhouZhejiang 318000China Institute of Ecology Taizhou UniversityTaizhouZhejiang 318000China School of Life Sciences Taizhou UniversityTaizhouZhejiang 318000China

Plants of the Caprifoliaceae family are widely cultivated worldwide as ornamental plants owing to their numerous,sweet-smelling,beautiful flowers and *** miconioides Rehd.,a member of the family,is endemic to eastern China and is cultivated as a popular ornamental plant in North America and European *** has a rather novel and beautiful trait of high horticultural value,that is,its sepals persist and enlarge,turning purplish ***,we report the chromosome-level genome assembly of *** to understand its evolution and floral *** 622.28 Mb assembled genome harbored a shared whole-genome duplication with a related species,Lonicera *** genomic analysis suggested that chromosome fission events following genome duplication underlie the unusual chromosome number of these two species,as well as chromosome fission of another five chromosomes in ***,giving rise to a haploid chromosome number of 14(versus 9 in ***).In addition,based on transcriptome and chloroplast genome analysis of 17 representative species in the Caprifoliaceae,we assumed that large structural variations in the chromosomes of *** were not caused by *** in the candidate genes of the MADS-box family were detected in the *** genome,including AP1-,AP3-,and SEPexpanded,which might underlie the sepal elongation and development in this *** current findings provided a critical resource for genome evolution studies in Caprifoliaceae and it was an example of how multi-omics data can elucidate the regulation of important ornamental traits.

关键词： Heptacodium miconioides Genome assembly Caprifoliaceae Chromosome fusion Sepal traits

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Miro2 supplies a platform for Parkin translocation to damaged mitochondria

引用

Science Bulletin 2019年第11期64卷 730-747页

作者： Jiu-Qiang Wang Shu Zhu Yihan Wang Fengli Wang Chaoqiang An Dongfang Jiang Lijie Gao Yingfeng Tu Xuefei Zhu Yun Wang Hongmei Liu Juanjuan Gong zhongshuai sun Xi Wang Leimei Liu Keyan Yang Caixia Guo Tie-Shan Tang State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Key Laboratory of Genomics and Precision Medicine Beijing Institute of GenomicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Department of Foresight and Evaluation Research Chinese Academy of Science and Technology for DevelopmentBeijing 100038China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

PINK1/Parkin-mediated mitophagy is an important process in selective removal of damaged mitochondria, in which translocation of Parkin to damaged mitochondria is recognized as an initiation step. At present, how the damaged mitochondria are selectively recognized and targeted by Parkin is not fully understood. Here we show that Miro2, an outer mitochondrial membrane protein, undergoes demultimerization from a tetramer to a monomer and alteration in mitochondrial localization upon CCCP treatment, suggesting a CCCP-induced realignment of Miro2. The realignment of Miro2 is tightly regulated by PINK1-mediated phosphorylation at Ser325/Ser430 and by Ca^2+binding to EF2 domain, which are both essential for the subsequent Parkin translocation. Interestingly, ablation of Miro2 in mouse causes delayed reticulocyte maturation, lactic acidosis and cardiac disorders. Furthermore, several Miro2 mutations found in the congenital lactic acidosis patients also disable its realignment and Parkin translocation. These findings reveal an important role of Miro2 to mediate Parkin translocation by sensing both depolarization and Ca^2+release from damaged mitochondria to ensure the accuracy of mitophagy.

关键词： Miro2 Parkin Mitochondria Ca^2+ Mitophagy PINK1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国华北地区城市与乡村基督教徒对死亡认识的比较研究

引用

宗教学研究 2010年第4期 108-113页

作者：史宝欣孙中帅天津医科大学临终关怀研究中心

通过对城市和乡村基督教徒关于死亡和濒死态度的比较研究,探索城市和乡村基督教信徒对死亡和濒死态度的差异性及形成原因,为死亡教育和临终关怀服务的开展进行理论探索。本文认为城市教徒在对死亡和濒死的理解和态度方面比张庄地区教徒... 详细信息

通过对城市和乡村基督教徒关于死亡和濒死态度的比较研究,探索城市和乡村基督教信徒对死亡和濒死态度的差异性及形成原因,为死亡教育和临终关怀服务的开展进行理论探索。本文认为城市教徒在对死亡和濒死的理解和态度方面比张庄地区教徒更现实、更世俗化,在思想与行为方面发生一定程度的异化。而乡村教徒对于基督教教义中关于死亡和濒死的论述认可程度较高,在思想和行为上更接近于基督教关于死亡和濒死的论述。

关键词：城市基督教徒乡村基督教徒死亡认识临终关怀

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国鸡皮衣属地衣3新记录种

引用

西北植物学报 2014年第3期34卷 628-630页

作者：赵娜孙中帅周明孙海任强山东师范大学生命科学学院济南250014 浙江大学生命科学学院杭州310058 内蒙古额尔古纳国家级自然保护区内蒙古呼伦贝尔022150

鸡皮衣属(Pertusaria)隶属于子囊菌门(Ascomycota)、茶渍纲(Lecanoromycetes)、鸡皮衣目(Pertusariales)、鸡皮衣科(Pertusariaceae)。在对鸡皮衣属地衣进行研究时,发现3个中国新记录种,即异亚澳鸡皮衣(***),刚硬鸡皮衣(***)和赭色鸡皮... 详细信息

关键词：鸡皮衣科新记录壳状地衣

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TMCO1 functions as an ER Ca2+ load-activated Ca2+(CLAC) release channel

TMCO1 functions as an ER Ca2+ load-activated Ca2+(CLAC) rele...

引用

第十一届全国钙信号和细胞功能研讨会

作者： Qiao-Chu Wang Qiaoxia Zheng Haiyan Tan Bing Zhang Xiaoling Li Yuxiu Yang Jie Yu Yang Liu Hao Chai Xi Wang zhongshuai sun Jiu-Qiang Wang Shu Zhu Fengli Wang Maojun Yang Caixia Guo Heng Wang Qingyin Zheng Yang Li Quan Chen Aimin Zhou Tie-Shan Tang State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Department of Chemistry and GRHD Cleveland State University CAS key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Key Laboratory for Protein Sciences of Ministry of Education Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Key Laboratory of Genomics and Precision Medicine China Gastrointestinal Cancer Research Center Beijing Institute of Genomics Chinese Academy of Sciences

Endoplasmic reticulum(ER) Ca store homeostasis is crucial for the proper Ca signaling and cellular functions. It has been established that Ca-release-activated Ca(CRAC) channel is responsible for the Ca influx and Ca store refilling after store depletion. However, it is unclear whether the ER Ca store can expel the excess Ca when the store gets overloaded. Here we show that TMCO1 is an ER transmembrane protein that actively prevents Ca store from overfilling. TMCO1 undergoes reversible homo-tetramerization/disassembly in response to ER Ca overloading/depletion, and forms a Ca selective ion channel on giant-liposomes. TMCO1-knockout mice reproduce the main clinical features of human cerebrofaciothoracic(CFT) dysplasia spectrum and exhibit a severe mishandling of ER Ca in cells. These findings reveal TMCO1 to be a novel Ca channel for ER Ca homeostatic maintenance. We name this Ca load-activated Ca channel "CLAC" channel, a function disrupted by human CFT dysplasia spectrum mutations.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

An optimization method of fidelity parameters of formation fluid sampling cylinder while drilling

引用

Petroleum Exploration and Development 2022年第2期49卷 458-467页

作者： JIANG Chuanlong YAN Tingjun ZHANG Yang sun Tengfei CHEN zhongshuai sun Haoyu College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China Drilling Technology Research Institute of Shengli Oilfield Service Corporation SinopecDongying 257000China

A design idea of fidelity sampling cylinder while drilling based on surface nitrogen precharging and supplemented by downhole pressurization was proposed, and the working mode and optimization method of sampling parameters were discussed. The nitrogen chamber in the sampling cylinder functions as an energy storage air cushion, which can supplement the pressure loss caused by temperature change in the sampling process to some extent. The downhole pressurization is to press the sample into the sample chamber as soon as possible, and further increase the pressure of sample to make up for the pressure that the nitrogen chamber cannot provide. Through the analysis of working mode of the sampling fidelity cylinder, the non-ideal gas state equation was used to deduce and calculate the optimal values of fidelity parameters such as pre-charged nitrogen pressure, downhole pressurization amount and sampling volume according to whether the bubble point pressure of the sampling fluid was known and on-site emergency sampling situation. Besides, the influences of ground temperature on fidelity parameters were analyzed, and corresponding correction methods were put forward. The research shows that the fidelity sampling cylinder while drilling can effectively improve the fidelity of the sample. When the formation fluid sample reaches the surface, it can basically ensure that the sample does not change in physical phase state and keeps the same chemical components in the underground formation.

关键词： sampling while drilling formation fluid sample fidelity bubble point pressure nitrogen pre-charge downhole pressurization parameter optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and interface modification of Si3N4f/SiO2 composites

引用

Journal of Materials Science & Technology 2019年第12期35卷 2767-2771页

作者： Yubo Houa Xuejin Yang Bin Li Duan Li Shitao Gao zhongshuai Wu Science and Technology on Advanced Ceramic Fibers and Composites Laboratory National University of Defense TechnologyChangsha410073China School of Materials Sun Yat-sen UniversityGuangzhou510275China

In order to modify the interface, Si ON coating was introduced on the surface of silicon nitride fiber by perhydropolysilazane conversion method. Si-3N4f/SiO2 and Si-3N4f/Si ONc/SiO2 composites were prepared by sol-gel method to explore the influence of Si ON coating on the mechanical properties of *** results show that with the protection of Si ON coating, Si-3N4fiber enjoys a strength increase of up to 24.1% and Si-3N4f/Si ONc/SiO2 composites have a tensile strength of 170.5 MPa and a modulus of26.9 GPa, respectively. After 1000℃ annealing in air for 1 h, Si-3N4f/Si ONc/SiO2 composites retain 65.0%of their original strength and show a better toughness than Si-3N4f/SiO2 composites. The improvement of mechanical properties is attributing to the healing effect of Si ON coating as well as its intermediate coefficient of thermal expansion between Si-3N4fiber and SiO2 matrix.

关键词： Si3N4 fiber Perhydropolysilazane SiON coating Interface Mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TMCO1是内质网钙离子过载激活的钙离子通道

引用

科学新闻 2017年第4期 34-34页

文章简介钙信号是重要的细胞内离子信号,其在胞内的浓度必须被精确地调控,以达到信号传递的忠实性和准确性。内质网是细胞内的重要钙库,保持内质网(ER)中钙离子浓度的平衡对于触发准确的钙信号和行使正常的细胞功能至关重要。经过近三... 详细信息

文章简介钙信号是重要的细胞内离子信号,其在胞内的浓度必须被精确地调控,以达到信号传递的忠实性和准确性。内质网是细胞内的重要钙库,保持内质网(ER)中钙离子浓度的平衡对于触发准确的钙信号和行使正常的细胞功能至关重要。经过近三十年的研究,目前人们已经知道当内质网中的

关键词：内质网钙库钙离子凝血因子Ⅳ TMCO1

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于局部信息的LNS-PCA的多模态过程故障监测

引用

过程工程学报 2023年第5期23卷 790-798页

作者：苑忠帅孙四通青岛科技大学自动化与电子工程学院山东青岛266061

为了满足各种不同的企业生产需求,在实际化工过程中往往包括许多不同的运行模态。因为涉及内部各种反应的复杂性和微妙性,且各个环节相互联系,导致化工过程数据呈现高斯与非高斯数据相互混合的情况,传统多元统计监控(Multivariate Stati... 详细信息

为了满足各种不同的企业生产需求,在实际化工过程中往往包括许多不同的运行模态。因为涉及内部各种反应的复杂性和微妙性,且各个环节相互联系,导致化工过程数据呈现高斯与非高斯数据相互混合的情况,传统多元统计监控(Multivariate Statistical Process Monitoring, MSPM)在多模态数据故障检测领域精确度较低。因此进行准确的复杂化工过程故障检测仍然是一大难题。针对这一类问题,本工作提出了一种新的基于局部信息的近邻标准化和主成分分析(Local Information Local Neighbor Standardization and Principal Component Analysis, LLNS-PCA)的方法建立高精确度的故障诊断模型。首先对样本利用高斯混合模型(Gaussian Mixture Model, GMM)方法分解成多个局部样本,应用每一个局部样本的平均值和方差进行近邻标准化,再使用主元分析进行故障监测。基于PCA监测模型,采用T2和SPE两种监测统计量对多模态过程进行监测。最后通过数值例子和青霉素生产过程验证其有效性。结果表明,相对于PCA, KPCA, LNS-PCA等方法,LLNS-PCA在多模态故障检测领域有更加迅速的反应率和更高的准确率,因此能够保障多模态生产过程的安全性和产品的高品质。

关键词：青霉素生产过程多模态故障监控主成分分析高斯分布模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

随钻地层流体保真取样筒保真参数优化方法

引用

石油勘探与开发 2022年第2期49卷 403-410页

作者：姜传隆颜廷俊张杨孙腾飞陈忠帅孙浩玉北京化工大学机电工程学院北京100029 中国石化胜利石油工程有限公司钻井工艺研究院山东东营257000

提出以地面预充氮气方法为主、井下增压方法为辅的随钻取样保真筒的设计思路,对其工作方式、取样参数优化方法进行讨论。取样筒中氮气腔的作用相当于储能气垫,可在一定程度上补充取样过程中因温度变化带来的压力损失,井下增压则是将样... 详细信息

提出以地面预充氮气方法为主、井下增压方法为辅的随钻取样保真筒的设计思路,对其工作方式、取样参数优化方法进行讨论。取样筒中氮气腔的作用相当于储能气垫,可在一定程度上补充取样过程中因温度变化带来的压力损失,井下增压则是将样品尽快地压入样品腔,并进一步提高样品压力来弥补氮气腔无法提供的压力补偿。通过对取样保真筒工作方式的分析,引入非理想气体状态方程,根据取样流体泡点压力是否已知、现场应急取样等情况,对预充氮气压力、井下增压量和取样体积等保真参数的优化取值进行了推导和计算,同时分析了地面温度对保真参数的影响并提出了相应的校正方法。研究表明,地面预充氮气与井下增压随钻取样保真筒,可有效提高样品保真程度,地层流体样品到达地面时,可基本保证样品不发生物理相变现象,进而保证其具有在地层中原有的化学组分。

关键词：随钻取样地层流体样品保真泡点压力预充氮气井下增压参数优化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：