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Effect of superoxide dismutase and malondialdehyde metabolic changes on carcinogenesis of gastric carcinoma

World Journal of Gastroenterology 2005年第28期11卷 4305-4310页

作者： Shao-Hong wang Jin-Hui Shen Hou-Qiang Zhou Xiao-Yang Qiu yi-zhong wang Ke-yi Zhang Department of Pathology Central Hospital of Shantou City Shantou 515031 Guangdong Province China Department of Laboratory Central Hospital of Shantou City Shantou 515031 Guangdong Province China Department of Surgical Oncology Central Hospital of Shantou City Shantou 515031 Guangdong Province China

AIM： To investigate the relationship between the superoxide dismutase （SOD）, malondialdehyde （MDA） metabolic changes and the gastric carcinogenesis.METHODS： The SOD activity and MDA content were measured in the gastric tissues from the focus center, peripheral and far-end areas of gastric carcinoma （n = 52） arid gastric ulcer （n = 10）. All the tissues were subjected to routine histological examinations and classifications.RESULTS： The SOD activity was greatly reduced but the MDA content was markedly increased in the center areas of the non-mucous gastric carcinoma （non-MGC）; and the poorly differentiated gastric carcinoma varied. The SOD activity was gradually decreased and the MDA content was gradually increased in the tissues from the focus far-end, peripheral to center areas of non-MGC. Both of the SOD activity and the MDA content were significantly declined and were respectively at same low level in the tissues from the focus center, peripheral, and far-end area with the mucous gastric carcinoma （MGC）. In contrast to the gastric ulcer and grade I or II of non-MGC, the same level of the SOD activity and the MDA content were found in the focus center areas. Between non-MGC （groups A-D） and gastric ulcer （group F）, the differences of SOD activity and MDA content were very noticeable in the gastric tissues from the focus peripheral and far-end areas, in which the SOD activity showed noticeable increase and the MDA content showed noticeable decreasein the gastric ulcer.CONCLUSION： The active free radical reaction in the gastric tissues can induce the carcinogenesis of non-MGC. The utmost low ability of antioxidation in the gastric tissues can induce the carcinogenesis of MGC. The metabolic change of the free radicals centralized mostly in the center of ulcerated lesions only, which suggested the ability of antioxidation was declined only in these lesions. However, the metabolism of free radicals varied significantly and the ability of antioxidation declined not

关键词： Gastric carcinoma Free radical Superoxide dismutase

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Formation of hierarchical Co-decorated Mo_(2)C hollow spheres for enhanced hydrogen evolution

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Rare Metals 2021年第10期40卷 2785-2792页

作者： yi-zhong wang yi-Ming Ding Cai-Hong Zhang Bo-Wen Xue Nian-Wu Li Le Yu State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

Water electrolysis has been regarded as a promising technology to produce clean hydrogen fuel with high purity. However, large-scale water electrolysis has been greatly hindered due to the lack of non-noble metal catalysts with high catalytic performance. Benefitting from unique hollow structures with large surface area and adjustable chemical compositions, hollow design plays an important role in improving the electrocatalytic performance for hydrogen evolution reaction(HER). Herein, we report an effective multi-step strategy to prepare hierarchical Co-decorated Mo_(2)C hollow spheres(CMCHSs) as electrocatalyst for HER. To be specific, the preparation process involves a metal-chelated polymerization and a subsequent surface modulation process. Owing to the unique hollow structure and incorporation of Co species,the as-prepared CMCHSs demonstrate largely enhanced HER performance with a low overpotential of 139 mV at the current density of 10 m A·cm^(-2) and good cycling durability in acid. The present research work highlights a new feasible strategy for the design of HER electrocatalyst via hollow designs and surface engineering.

关键词： Mo_(2)C Hollow design Surface modulation Hydrogen evolution reaction

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(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes

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World Journal of Gastroenterology 2017年第32期23卷 5895-5903页

作者： yi-zhong wang Jie-Liang Li Xu wang Ting Zhang Wen-Zhe Ho Department of Infectious Diseases Shanghai Children’s Hospital Shanghai Jiao Tong University Department of Pathology and Laboratory Medicine Temple University Lewis Katz School of Medicine

AIM To investigate the effect of(-)-epigallocatechin-3-gallate(EGCG) on polyinosinic-polycytidylic acid(poly I:C)-triggered intracellular innate immunity against hepatitis C virus(HCV) in hepatocytes. METHODS A cell culture model of HCV infection was generated by infecting a hepatoma cell line, Huh7, with HCV JFH-1 strain(JFH-1-Huh7). Poly I:C with a high molecular weight and EGCG were used to stimulate the JFH-1-Huh7 cells. Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of intracellular m RNAs and of intracellular and extracellular HCV RNA. Enzyme-linked immunosorbent assay was used to evaluate the interferon(IFN)-λ1 protein level in the cell culture supernatant. Immunostaining was used to examine HCV core protein expression in Huh7 *** Our recent study showed that HCV replication could impair poly I:C-triggered intracellular innate immune responses in hepatocytes. In the current study, we showed that EGCG treatment significantly increased the poly I:C-induced expression of Toll-like receptor 3(TLR3), retinoic acid-inducible gene I, and IFN-λ1 in JFH-1-Huh7 cells. In addition, supplementation with EGCG increased the poly I:C-mediated antiviral activity in JFH-1-Huh7 cells at the intracellular and extracellular HCV RNA and protein levels. Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several antiviral IFNstimulated genes, including ISG15, ISG56, myxovirus resistance A, and 2'-5'-oligoadenylate synthetase 1, which encode the key antiviral elements in the IFN signaling pathway. CONCLUSION Our observations provide experimental evidence that EGCG has the ability to enhance poly I:C-induced intracellular antiviral innate immunity against HCV replication in hepatocytes.

关键词： (-)-Epigallocatechin-3-gallate Toll-like receptor 3 Retinoic acid-inducible gene I IFN-λ1 Hepatitis C virus IFN-stimulated genes

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Development of a portable multi-channel system for plant physiological signal recording

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Information Processing in Agriculture 2016年第2期3卷 124-132页

作者： Ting Li Zi-Yang wang Dong-Jie Zhao Lan Huang zhong-yi wang College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Modern Precision Agriculture System Integration Research Key Laboratory of Ministry of Education Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing 100083China

Bioelectrical signals can reflect physiological state of organs or tissues in plants and have a significant potential value in research of plant stress *** order to study the relationship between environment factors and electrical signals in plant,a portable multichannel physiological signal acquisition system which relevant in plant physiology research was *** parameters and electrical signals can be measured in different channels by the acquisition system simultaneously and the measurement data will be displayed in an embedded integrated touch screen which is the system processing *** system was validated to be stable and reliable after the calibration and repeated experiments of recording electrical signals in Helianthus annuus L.

关键词： Bioelectrical signals Acquisition system Multi-channel Portable device

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Dynamic scaling characteristics of single-phase natural circulation based on different strain transformations

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Nuclear Science and Techniques 2023年第9期34卷 128-141页

作者： Jia-Ning Xu Xiang-Bin Li zhong-yi wang Yu-Sheng Liu De-Chen Zhang Qiao Wu School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China Beijing Key Laboratory of Passive Safety Technology for Nuclear Energy Beijing 102206China China Institute of Nuclear Industry Strategy BeijingChina Nuclear and Radiation Safety Center MEEBeijing 100082China Department of Nuclear Engineering Oregon State UniversityCorvallisOR 97331USA

To understand the dynamical system scaling(DSS)analysis theory,the applicability of DSSβ-andω-strain transformation methods for the scaling analysis of complex loops was explored.A simplified model consisting of two loops was established based on the primary and secondary sides of a nuclear reactor,andβ-andω-strain transformation methods were used to ana-lyze the single-phase natural circulation in the primary *** comparison with the traditional method,simplified DSSβ-andω-strain methods were developed based on the standard scaling *** strain parameters in these four methods were modified to form multiple groups of scaled-down *** transient process of the natural circulation was simulated using the Relap5 code,and the variation in the dynamic flow characteristics with the strain numbers was obtained using different scaling *** results show that both the simplified and standard DSS methods can simulate the dynamic characteristics of natural circulation in the primary *** scaled-down cases in the simplified method exhibit the same geometric scaling and correspond to small core power *** contrast,different scaled-down cases in the standard DSS method correspond to different geometric scaling criteria and require more *** dynamic process of natural circula-tion can be simulated more accurately using the standard DSS method.

关键词： Dynamical system scaling analysis β-strain transformation ω-strain transformation Natural circulation

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The calibration model in potassium ion flux non-invasive measurement of plants in vivo in situ

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Information Processing in Agriculture 2016年第2期3卷 76-82页

作者： Lin Xue Dong-jie Zhao Zi-yang wang Xiao-dong wang Cheng wang Lan Huang zhong-yi wang College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China College of Information Technology Beijing Union UniversityBeijing 100101China Modern Precision Agriculture System Integration Research Key Laboratory of Ministry of Education Beijing 100083China Key Laboratory of Agricultural Information Acquisition Technology(Beijing) Ministry of AgricultureBeijing 100083China National Engineering Research Center for Information Technology in Agriculture Beijing 100097China

SIET(Self-referencing Ion Electrode Technique)provides a novel electrophysiological tool which can non-invasively measure the dynamic influxes and effluxes of ions caused by the diffusion along the concentration gradients in ***,in this technique ion fluxes are converted to voltage signals using an ion selective microelectrode at a small amplitude of lV,which is easy to be interfered by the ambient ***,effective solutions to the suppression of noise and calibration of ion flux measurement system are very important for this method.A K^+-selective microelectrode was constructed using liquid ion exchangers(LIX)to investigate ion transport over plant tissue.A standard concentration gradient which simulates plant living cells was produced by an electrode with a certain tip diameter,filled with a solution containing a known K+concentration in 100 mmol/*** ion diffusion simulation model was *** model evaluated the performance of ion flux measurement system in accuracy and reliability by comparing the consistency of the measured value and the predicted curve.K^+fluxes were measured within 25 min at each measuring point of distance 10,20,30,40,50,80,and 100 lm from the K+source,*** can be seen that the K^+fluxes changes little,which indicates that ion flux measurement system has a reliable *** study provides a theoretical basis for a new non-invasive ion flux measurement method creation and a new sensors design.

关键词： SIET Plant K^+flux Calibration In situ

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Congenital hepatic fibrosis in a young boy with congenital hypothyroidism:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1475-1482页

作者： Fang-Fei Xiao yi-zhong wang Fang Dong Xiao-Lu Li Ting Zhang Department of Gastroenterology Hepatology and NutritionShanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China

BACKGROUND Congenital hepatic fibrosis(CHF)is a rare autosomal recessive disorder characterized by variable degrees of periportal fibrosis and malformation of bile *** is generally accompanied by a variety of conditions or syndromes with other organ *** SUMMARY We report a 5-year-4-month-old Chinese boy with congenital hypothyroidism(CH)diagnosed with *** patient was diagnosed with CH by a newborn screening test and has since been taking *** has developed normally without neurocognitive *** liver function was observed in the patient at the age of 4 years and 11 mo,and elevated levels of liver function indices were persistent for 5 *** imaging indicated hepatosplenomegaly without narrowing of the portal vein but dilated splenic vein.A liver biopsy confirmed the pathological features of *** testing revealed two novel homozygous mutations,namely,c.2141-3T>C variant in PKHD1 related to CHF and c.2921G>A(p.R974H)in DUOX2 related to *** patient was treated with compound glycyrrhizin tablet,ursodeoxycholic acid,and levothyroxine after *** patient achieved a favorable clinical outcome during a follow-up period of over 2 *** Herein,we report the first case of a Chinese boy with comorbidity of CHF and CH,carrying both PKHD1 gene and DUOX2 gene novel *** biopsy and genetic testing should be considered for the diagnosis of coexistent liver disease in CH patients with unexplained abnormal liver function.

关键词： Congenital hepatic fibrosis Congenital hypothyroidism Liver biopsy PKHD1 DUOX2 Case report Genetic testing

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Catalytic Asymmetric Cyclopropanation using a New Chiral β-Diketone Cu (Ⅱ) Complex as a Catalyst

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Chinese Chemical Letters 1998年第7期9卷 607-608页

作者： Yu XU zhong yi wang and Tian Pa YOU(Department of Chemistry, University of Science and Technology of China, Hefei 230026) Department of Chemistry Univ. of Sci./Technology of China Hefei 230026 China

A new chiral β-diketone Cu (Ⅱ) catalyst was synthesized and used for the asymmetric cyclopropanation of styrene with diazoester. A high optical yield (~90%) was achieved. The effect of the structure of substrate on the enantioselectivity was studied. Both chendcal yield and optical yield being reduced when the steric bulky substrate was employed. The reaction mechanism and the chiral model of the transition state are under fufther investigation.

关键词： Asymmetric cyclopropanation β-Diketone Cu (Ⅱ) Complex

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Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3-galactosyl epitope-ulsed dendritic cells and cytokine-induced killer cells

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World Journal of Gastroenterology 2011年第48期17卷 5260-5266页

作者： ying Qiu Ming-Bao Xu Mark M Yun yi-zhong wang Rui-Ming Zhang Xing-Kai Meng Xiao-Hui Ou-Yang Sheng Yun The First Teaching Hospital Inner Mongolia Medical College Huhhot 010050 Inner Mongolia Autonomous Region China The Armed Police General Hospital Beijing100036 China Medical School of UCL London WC1E 6BTUnited Kingdom Aerospace Medical College Peking University Beijing 100049 China Department of Clinical Sciences King＇s College Hospital London SE5 9NU United Kingdom Clinical Sciences Centre MRC HammersmithHospital Campus London W12 0NN United Kingdom

AIM： To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal epitope-pulsed dendritic cells （DCs） and cytokine-induced killer cells. METHODS： Freshly collected hepatocellular carcinoma （HCC） tumor tissues were incubated with a mixture of neuraminidase and recombinant αl,3-galactosyltrans- ferase （αI,3GT） to synthesize α-Gal epitopes on car- bohydrate chains of the glycoproteins of tumor mem- branes. The subsequent incubation of the processed membranes in the presence of human natural anti-Gal IgG resulted in the effective phagocytosis to the tumor membrane by DCs. Eighteen patients aged 38-78 years with stage 111 primary HCC were randomly chosen for the study; 9 patients served as controls, and 9 patients were enrolled in the study ***： The evaluation demonstrated that the pro- cedure was safe; no serious side effects or autoimmune diseases were observed. The therapy significantly pro- longed the survival of treated patients as compared with the controls （17.1 ± 2.01 mo vs 10.1 ±4.5 mo, P = 0.00121）. After treatment, all patients in the study group had positive delayed hypersensitivity and robust systemic cytotoxicity in response to tumor lysate as measured by interferon-y-expression in peripheral blood mononuclear cells using enzyme-linked immunosorbent spot assay. They also displayed increased numbers of CD8-, CD45RO- and CD56-positive cells in the peripheral blood and decreased α-fetoprotein level in the se- rum. CONCLUSION： This new tumor-specific immunotherapy is safe, effective and has a great potential for the treat- ment of tumors.

关键词： Hepatocellular carcinoma α-Gal epitope Dendritic cell Tumor-associated antigen Dendritic cell-activated cytokine-induced killer cell

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Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study

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World Journal of Clinical Cases 2018年第16期6卷 1121-1127页

作者： Xin-Yue Zhang yi-zhong wang Xiao-Lu Li Hui Hu Hai-Feng Liu Dan Li Yong-Mei Xiao Ting Zhang Department of Gastroenterology Hepatology and Nutrition Shanghai Children's Hospital Shanghai Jiao Tong University

BACKGROUND Fecal microbiota transplantation(FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection(CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted on FMT in children or on the proper guidelines. Our center first performed FMT to treat a 13-month-old boy with severe CDI in 2013. Until February 2018, our center had performed 114 pediatric FMT procedures in 49 subjects. AIM To investigate the safety of FMT in children. METHODS A retrospective study was conducted on 49 patientswho underwent 114 FMT treatments at our hospital. All FMT processes followed uniform standards. Adverse events(AEs) related to FMT were divided into shortterm(48 h post-FMT) and long-term(3 mo). All potential influencing factors for AEs, such as gender, age, time of FMT infusion, route of administration, disease type, immune function state, and donor relative genetic background, were analyzed as independent factors. The significant independent factors and risk ratio with 95% confidence interval(CI) were assessed by multivariate logistic regression *** Forty-nine patients(mean age 68.1 mo, range 4 to 193 mo) were recruited. Their average follow-up time after the first FMT was 23.1 mo. The incidence of short-term AEs was 26.32%(30/114). The most common shortterm AEs were abdominal pain, diarrhea, fever, and vomiting, which were all self-limited and symptom-free within 48 h. Two severe AEs occurred, and one patient died in the fourth week after FMT. All-cause mortality was 2.04%. As independent factors, age(P = 0.006) and immune state(P = 0.002) had significant effects. Age greater than 72 mo seemed to be correlated with more AEs than age 13 to 36 mo(P = 0.04). In multivariate logistic regression analysis, immune state was an independent risk factor for

关键词： Safety Fecal microbiota transplantation Pediatrics Adverse event Immune system diseases Age factors

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