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Mining Sensor Data in Cyber-Physical Systems

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Tsinghua Science and Technology 2014年第3期19卷 225-234页

作者： Lu-An Tang Jiawei Han Guofei jiang the NEC Laboratory America the Department of Computer Science University of Illinois at Urbana-Champaign

A Cyber-Physical System （CPS） integrates physical devices （i.e.,sensors） with cyber （i.e.,informational） components to form a context sensitive system that responds intelligently to dynamic changes in real-world *** a system has wide applications in the scenarios of traffic control,battlefield surveillance,environmental monitoring,and so on.A core element of CPS is the collection and assessment of information from noisy,dynamic,and uncertain physical environments integrated with many types of cyber-space *** potential of this integration is *** achieve this potential the raw data acquired from the physical world must be transformed into useable knowledge in ***,CPS brings a new dimension to knowledge discovery because of the emerging synergism of the physical and the *** various properties of the physical world must be addressed in information management and knowledge *** paper discusses the problems of mining sensor data in CPS：With a large number of wireless sensors deployed in a designated area,the task is real time detection of intruders that enter the area based on noisy sensor *** framework of IntruMine is introduced to discover intruders from untrustworthy sensor *** first analyzes the trustworthiness of sensor data,then detects the intruders＇ locations,and verifies the detections based on a graph model of the relationships between sensors and intruders.

关键词： cyber-physical system sensor network data trustworthiness

L^p(R^n)-Boundedness of certain commutators

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 185-191页

作者： DI Yan-mei jiang Li-ya Department of Mathematics Zhejiang University of Technology Hangzhou 310023 China

In this paper, the LP（Rn）-boundedness of the commutators generalized by BMO（Rn） function and the singular integral operator T with rough kernel Ω∈ L log＋ L（Sn-1）is proved by using the Bony＇s formula for the... 详细信息

关键词： Commutators paraproduct Littlewood-Paley theory.

The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance

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Nano Research 2018年第10期11卷 5615-5628页

作者： Huahua Song Xinyi Ma Jianrong Xu Qingxiang Song Meng Hu Xiao Gu Qian Zhang Lina Hou Lepei Chen Yukun Huang ping Yu Dayuan Wang Gan jiang Meng Huang Jun Chen Hongzhuan Chen Xiaoling Gao Department of Pharmacology and Chemical Biology Faculty of Basic Medicine School of Medicine Shanghai.liao Tong University Shanghai 200025 China Key Laboratory of Smart Drug Delivery Ministry of Education School of Pharmacy Fudan University Lane 826 Zhangheng Road Shanghai 201203 China Department of Pharmacy Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Accumulation of extracellular β-amyloid （Aβ） is crucial for the pathogenesis of Alzheimer＇s disease （AD）, and the development of novel therapeutic agents that can both accelerate Aβ clearance and inhibit the subsequent pathological cascades is regarded as a promising strategy for AD management. In our previous study, we have constructed discoidal apolipoprotein E3-reconstituted high-density lipoprotein （ApoE3-rHDL） as an efficient nanoplatform that can penetrate the blood-brain barrier and accelerate Aβ clearance for a combination treatment of AD. To further improve its drug loading capacity, we hypothesized that spherical rHDL might serve as a more powerful nanocarrier if it has the same brain delivery and Aβ clearance abilities as the discoidal rHDL does. To evaluate the potential of spherical rHDL as a promising alternative for the combination therapy for AD, here, we investigated the effect of the shape of rHDL on its brain delivery, Aβ clearance, and anti-AD efficacy. We found that spherical rHDL had stronger Aβ-binding affinity than discoidal rHDL did, more effectively facilitated microglial uptake and degradation of Aβ-42, achieved better brain distribution after intravenous administration, and more powerfully reduced Aβ deposition, decreased microglia activation, attenuated neurological damage, and rescued memory deficits in a mouse model of AD. Among the rHDLs evaluated, monosialotetrahexosyl ganglioside-incorporated spherical rHDL exerted the best effect. The findings of this study for the first time show a shape effect of an rHDL nanocarrier on its biological functions and suggest that a spherical lipoprotein-mimic nanocarrier may serve as a more efficient multifunctional nanoplatforrn for AD therapy.

关键词： reconstituted high density lipoprotein β-amyloid apolipoprotein E spherical discoidal Alzheimer's disease

Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients： new insights based on peritoneal inflammation and angiogenesis

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Frontiers of Medicine 2017年第3期11卷 349-358页

作者： Zhen Zhang Na jiang Zhaohui Ni Department of Nephrology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Peritoneal dialysis （PD） is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane （PM）, which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-lp, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.

关键词： peritoneal dialysis peritoneal fibrosis inflammation angiogenesis

Thermally controlled large deformation in temperaturesensitive hydrogels bilayers

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International Journal of Smart and Nano Materials 2021年第4期12卷 450-471页

作者： Jianying Hu Nan jiang Jianke Du Department of Mechanics and Engineering Science Smart Materials and Advanced Structure LaboratorySchool of Mechanical Engineering and MechanicsNingbo UniversityNingboChina State Key Laboratory for Strength and Vibration of Mechanical Structures Xi’an Jiaotong UniversityXi’anChina

The present work investigates the thermally controlled deformation characteristics in temperature-sensitive hydrogels *** free energy density for temperature-sensitive hydrogels is modified,upon which the finite element model is developed and implemented through user-defined material subroutine UHYPER in the commercial software *** modified UHYPER implementation allows for more vividly depicting the continuous deformation in phase temperature region for temperature-sensitive *** thermally controlled cases of temperature-sensitive hydrogel including grippers,self-folding boxes,thermally driven origami are presented to illustrate a wide array of complex interesting applications or ***,we develop a simple model to theoretically calculate the bending angle of the temperature-sensitive hydrogel bilayers,which has been validated by the finite element simulation *** study can provide more insights for optimal design in thermally controlled hydrogels structures.

关键词： Temperature-sensitive hydrogels thermally controlled deformation swelling-induced bending

EQUIVALENT MODEL OF EXPANSION OF CEMENT MORTAR UNDER SULPHATE EROSION

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Acta Mechanica Solida Sinica 2008年第4期21卷 327-332页

作者： Jue Zhu Minqiang jiang Jiankang Chen Mechanics and Materials Science Research Center Ningbo University Ningbo 315211 China State Key Laboratory of Nonlinear Mechanics （LNM） Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

The expansion property of cement mortar under the attack of sulfate ions is studied by experimental and theoretical methods. First, cement mortars are fabricated with the ratio of water to cement of 0.4, 0.6, and 0.8. Secondly, the expansion of specimen immerged in sulphate solution is measured at different times. Thirdly, a theoretical model of expansion of cement mortar under sulphate erosion is suggested by virtue of represent volume element method. In this model, the damage evolution due to the interaction between delayed ettringite and cement mortar is taken into account. Finally, the numerical calculation is results indicate that the model perfectly describes performed. The numerical and experimental the expansion of the cement mortar.

关键词： size effect microvoids expansion sodium sulfate attack

A comparative study of tactile paving design standards in different countries

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通讯和计算机（中英文版） 2009年第3期6卷 47-54页

作者： L U jiang-yan SIU Kin Wai Michaele XU ping Art and Design Institute Wuhan University of Technology Wuhan China School of Design The Hong Kong Polytechnic University Hong Kong China School of Design Central Academy of Fine Art Beijing China

Fast,Exact and Robust Set Operations on Polyhedrons Using Localized Constructive Solid Geometry Trees

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ZTE Communications 2015年第3期13卷 57-66页

作者： ping Lu Xudong jiang Wei Lu Ran Wei Bin Sheng ZTE Corporation Autodesk China Research & Development Center Shanghai Jiao Tong University

Regularized Boolean operations have been widely used in 3D modeling systems. However, evaluating Boolean operations may be quite numerically unstable and time consuming, especially for iterated set operations. A novel and unified technique is proposed in this paper for computing single and iterated set operations efficiently, robustly and exactly. An adaptive octree is combined with a nested constructive solid geometry （CSG） tree by this technique. The intersection handling is restricted to the cells in the octree where intersection actually occurs. Within those cells, a CSG tree template is instanced by the surfaces and the tree is converted to planebased binary space partitioning （BSP） for set evaluation; Moreover, the surface classification is restricted to the ceils in the octree where the surfaces only come from a model and are within the bounding-boxes of other polyhedrons. These two ways bring about the efficiency and scalability of the operations, in terms of runtime and memory. As all surfaces in such a cell have the same classification relation, they are classified as a whole. Robustness and exactness are achieved by integrating plane-based geometry representation with adaptive geometry predicate technique in intersection handling, and by applying divide-and-conquer arithmetic on surface classification. Experimental results demonstrate that the proposed approach can guarantee the robustness of Boolean computations and runs faster than other existing approaches.

关键词： Boolean operations polyhedrons constructive solid geometry binary space partitioning tree

Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons

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Neural Regeneration Research 2013年第29期8卷 2744-2753页

作者： Yue He Ailing Zhou Wei jiang Department of Pathophysiology Medical CollegeNantong University Department of Neurology Affiliated Hospital of Nantong University Department of Scientific Technology and Property Nantong University

The phosphatidylinositol 3 kinase （PI3K）/protein kinase B （AKT） signaling pathway is considered important for cell survival and has been shown to mediate various anti-apoptotic biological effects. This study explored the role of the Toll-like receptor 4 （TLR4）-mediated PI3K/AKT-glycogen syn-thase kinase 3β （GSK-3β） signaling pathways in lipopolysaccharide-induced apoptosis in a primary culture of hippocampal neurons. Results demonstrated that the apoptotic ratio of hippocampal neurons stimulated by lipopolysaccharide was significantly higher compared with the control group. Both the expression of P-AKTser473 and P-GSK-3βSserg in hippocampal neurons stimulated by lipopolysaccharide decreased compared with the control, while the level of active Caspase-3 and the ratio of Bax/Bcl-2 were significantly increased. The level of active Caspase-3 and the ratio of Bax/Bcl-2 in hippocampal neurons treated with TLR4 antibody or the GSK-3β inhibitor, LiCl, de-creased before intervention with lipopolysaccharide, but increased after treatment with the AKT in-hibitor, LY294002. These findings suggest that the TLR4-PI3K/AKT-GSKβ signaling pathway may be involved in lipopolysaccharide-induced apoptosis of hippocampal neurons.

关键词： neural regeneration brain injury hippocampus neurons Toll like receptor 4 phosphatidylinositol 3kinase/protein kinase B-glycogen synthase kinase 3β apoptosis grants-supported paper neu-roregeneration