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Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety:A network pharmacology and molecular docking study

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World Journal of Clinical Cases 2022年第33期10卷 12104-12115页

作者： zhong-hui li Guo-Hua Yang Fang Wang Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102China

BACKGROUND The therapeutic effects of a combination of Chinese medicines called Baihedihuang decoction(BD)have been clinically verified,although its molecular targets in breast cancer related anxiety remain *** To explore the molecular mechanisms of BD for breast cancer related anxiety *** We used the Traditional Chinese Medicine Systems Pharmacology database to screen the active ingredients and potential targets of BD,and constructed the"drug-ingredient-target"network map with the help of Cytoscape 3.8 ***,we used the Online Mendelian Inheritance in Man,DrugBank,and Gencards databases to collect the disease targets of breast cancer related anxiety,and used the STRING platform to perform protein interaction analysis and construct the protein-protein interaction *** platform was used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key *** docking technology was used to verify the drug component/target disease *** We screened 16 active ingredients of BD for breast cancer related anxiety,with 113 target *** are 931 disease targets of breast cancer related anxiety,and finally,43 key targets and 305 Kyoto Encyclopedia of Genes and Genomes pathways were *** main active ingredients of BD for breast cancer related anxiety are verbascoside,β-sitosterol,stigmasterol,catalpol,***2,TP53,HTR2A,ESR1,*** its key targets,and the main involved signaling pathways may include neuroactive ligand-receptor interaction pathway,5-hydroxytryptaminergic synapse,P53 signaling pathway,cGMP-PKG signaling pathway,the cAMP signaling pathway,***,molecular docking was performed with Vina software to validate the key active ingredients in BD with the selected key action *** molecular docking results showed that verbascoside,β-sitosterol,stigmasterol and CDK2 could stably bind and interact through amino acid residues SER249,ARG260,PRO228,ALA

关键词： Network pharmacology Molecular docking Baihedihuang decoction Breast cancer related anxiety Mechanism of action

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In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He Jun Guo hui Huang zhong-Cheng Guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

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Super-high bed sintering for iron ores:behaviors,causes and solutions of horizontal segregation on strand

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1590-1596页

作者： liang-ping Xu hui-bo liu zhong-lin Dong Qiang zhong Yu-chao Zhao Guang-hui li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Horizontal segregation has been a constraint to the development and application of super-high bed *** eliminate the horizontal segregation of super-high bed sintering,several typical sintering machines were sampled and analyzed,and theoretical calculation was made to compare the bed depth and their differences in different areas within the mixture ***,solutions were proposed and applied to a 265 m^(2) sintering *** results showed that the horizontal seg-regation of the 265 m^(2) sintering machine was dominated by particles larger than 8 mm with horizontal segregation degree of 0.48,while 360 and 550 m^(2) sintering machines were affected by 5-8 mm and 1-3 mm particles with horizontal segregation degree of 0.27 and 0.31,*** analysis indicated the different segregation distribution results from the matching of the bed depth of each area within the mixture ***,the horizontal segregation degree not larger than 0.06 was achieved by optimizing the time parameters and the division of three zones on the 265 m^(2) sintering machine.

关键词： Super-high bed sintering Horizontal segregation Feeder Particle distribution Agglomeration

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Diagnosis and guidance of treatment of breast cancer cutaneous metastases by multiple needle biopsy: A case report

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World Journal of Clinical Cases 2022年第1期10卷 345-352页

作者： zhong-hui li Fang Wang Ping Zhang Peng Xue Shi-Jie Zhu Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102Beijing ProvinceChina Department of Pathology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102Beijing ProvinceChina

BACKGROUND Breast cancer patients have a high skin metastasis ***,reports on treatment of cutaneous metastases of breast cancer are *** SUMMARY We report the treatment process for one breast cancer case with bone,lung,and skin *** patient was a 43-year-old woman with advanced breast cancer and skin *** underwent pathological diagnosis by needle biopsy to guide the *** the disease progressed,a new pathological diagnosis was determined by needle biopsy to guide the *** patient received chemotherapy,endocrine therapy,and photodynamic dynamic therapy,followed by sonodynamic *** Repeated puncture should be performed for advanced breast cancer with skin metastasis,in order to obtain the pathology and directly determine diagnosis when the disease *** treatment should focus on controlling the systemic metastasis,rather than the local disease.

关键词： Breast cancer Cutaneous metastases Needle biopsy Exemestane and everolimus Case report

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SEI/dead li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu li Hongzhang Zhang Guiming zhong Xiaofei Yang Xianfeng li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical liPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead li

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不同灌溉方式对西北干旱区紫花苜蓿生产性能的影响

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节水灌溉 2024年第3期 56-61,67页

作者：刘兴成甘吉元钟辉丽张田米胡健泰朱明敏于栋张涛方梦琪武威市农业技术推广中心甘肃武威733000 河西学院农业与生态工程学院甘肃张掖734000

为了明确紫花苜蓿品质形成差异的水分生理特征,探索因地制宜、节水高效的灌溉模式,以河西地区为例,以不灌水(CK)为对照,对比分析了常规畦灌(M)、交替灌溉(T)和隔沟灌溉(G)等3种不同灌溉方式分别在灌底墒水、越冬水、返青水和现蕾水不同... 详细信息

为了明确紫花苜蓿品质形成差异的水分生理特征,探索因地制宜、节水高效的灌溉模式,以河西地区为例,以不灌水(CK)为对照,对比分析了常规畦灌(M)、交替灌溉(T)和隔沟灌溉(G)等3种不同灌溉方式分别在灌底墒水、越冬水、返青水和现蕾水不同灌溉量下对“三得利”紫花苜蓿产量和品质的影响。结果表明:(1)不同灌水方式下株高与灌水次数呈正相关,分支数与灌水量呈负相关;交替灌溉在灌底墒水、越冬水、返青水和现蕾水条件下株高三茬平均值最高为91.92 cm。(2)各灌水模式下,紫花苜蓿净光合速率、蒸腾速率随灌水量的增大表现出增高的趋势,其中交替灌溉的净光合速率随灌水量的增大提高了15.64%,且均高于常规畦灌和隔沟灌溉在同等灌水量下净光合速率。(3)不同处理紫花苜蓿的产量随灌水量的增加而增加,漫灌处理紫花苜蓿的三茬总产量显著高于交替灌溉与隔沟灌溉在相同灌水量下苜蓿产量,在灌底墒水、越冬水、返青水和现蕾水条件下三茬总产最高达49447.6 kg/hm^(2)。(4)不同灌水方式紫花苜蓿粗蛋白含量和中性洗涤纤维含量显著高于无灌水(CK)处理,且随着灌水量的增加有不同程度的提高。河西地区地处干旱和半干旱区,以节水灌溉的角度出发,可以选择交替灌溉灌底墒水、越冬水、返青水和现蕾水的灌溉模式能够在保证高产的同时,达到节水的目的。

关键词：紫花苜蓿干旱区灌溉方式光合生长产量品质水分利用率

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Super-high bed sintering for iron ores:problems ascertainment

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1063-1070页

作者： liang-ping Xu hui-bo liu Yu-chao Zhao Qiang zhong zhong-lin Dong Guang-hui li Tao Jiang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina

Super-high bed sintering process is an important development direction of iron ore sintering for its lower emission and higher ***,there is a lack of deep understanding of the uneven quality of super-high bed sintering products,and the deterioration of reduction disintegration performance,the thickening of hearth layer and the reduction in energy-saving effect are perplexing enterprises and *** ascertain the problems of super-high bed sintering,ten sintering machines with the areas of 265,280,360,550 and 660 m^(2)and bed depth above 900 mm were sampled and *** results showed that problems were mainly shown in the unevenness of chemical composition,macrostructure,mechanical strength and metallurgical *** chemical composition exhibits severe segregation in both horizontal and vertical directions,with basicity segregation reaching as high as *** uneven macrostructure of sinter is reflected in a 10%difference in porosity and mechanical strength increase in 16%–19%along the vertical *** reducibility and reduction disintegration performance gradually deteriorate along the bed depth,with a difference of 10.5%in reducibility and 7.3%in RDI−0.5 mm(reduction disintegration index of sinter with size smaller than 0.5 mm).

关键词： Super-high bed sintering Uneven sinter performance Segregation Agglomeration Iron ore

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Effect of forging on the microstructure and texture of a high Nb containing γ-TiAl alloy

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Journal of Central South University 2024年第6期31卷 1763-1773页

作者： TAO hui li hui-zhong WANG li ZHOU Rui CHE Yi-xuan CHEN Yong-hui liANG Xiao-peng School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Key Laboratory of Nonferrous Metal Materials Science and Engineering Central South UniversityChangsha 410083China Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina

The effect of forging on the microstructure and texture evolution of a high Nb containing Ti-45Al-7Nb-0.3W(at.%)alloy was investigated by X-ray diffractometer(XRD),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).The results show that the as-cast alloy is mainly composed of α_(2)/γ lamellar colonies with a mean size of 70μm,but the hot-forged pancake displays a near duplex microstructure(DP).Kinking and bending of lamellar colonies,deformation twinning and dynamic recrystallization(DRX)occur during hot ***,dense dislocations in theβphase after forging suggest that the high-temperature β phase with a disordered structure is favorable for improving the hot-workability of the *** the common TiAl casting texture,the solidification process of the investigated as-cast alloy with high Nb content is completely via the β phase region,resulting in the formation of aγ fiber texture where theγ aligns parallel to the heat-flow *** comparison,the relatively strongand weaktexture components in the as-forged alloy are attributed to the deformation *** annealing,static recrystallization occurs at the twin boundary and intersections,which weakens the deformation texture.

关键词： high Nb containing γ-TiAl alloy forging microstructure texture β phase

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Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

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Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： Dan li Jinning Jia Haibo Zeng Xiaoyan zhong hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

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血栓弹力图与FIB联合预测普外科患者围术期大量输血的效能评价

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海南医学 2024年第10期35卷 1435-1439页

作者：邵方真闫优萍朱俊常圣雅钟丽慧驻马店市中心医院输血科河南驻马店463000 驻马店市中医院检验科河南驻马店463000 驻马店市中心医院检验科河南驻马店463000

目的探讨血栓弹力图(TEG)与纤维蛋白原(FIB)联合预测普外科患者围术期大量输血的效能,以期为临床尽早制定合理用血方案提供参考依据。方法回顾性选取2021年9月1日至2023年9月1日驻马店市中心医院收治的182例普外科患者,根据围术期是否... 详细信息

目的探讨血栓弹力图(TEG)与纤维蛋白原(FIB)联合预测普外科患者围术期大量输血的效能,以期为临床尽早制定合理用血方案提供参考依据。方法回顾性选取2021年9月1日至2023年9月1日驻马店市中心医院收治的182例普外科患者,根据围术期是否大量输血分为大量输血组(输血量≥18 U)(n=45)与非大量输血组(输血量<18 U)(n=137)。比较两组患者的临床资料、TEG参数[凝血时间指数(R)、凝固时间(K)、凝血形成速率(α角)、血栓最大幅度(MA)]和FIB水平,采用Pearson相关系数模型分析TEG参数与FIB的相关性,采用受试者工作特征曲线(ROC)及曲线下面积(AUC)评价TEG参数、FIB对普外科患者围术期大量输血的预测效能。结果大量输血组患者的R、K[(8.57±2.31)min、(3.72±0.68)min]明显高于非大量输血组[(6.68±1.75)min、(3.15±0.50)min],α角、MA、FIB[(44.88±4.17)°、(43.85±5.58)mm、1.(21±0.30)g/L]明显低于非大量输血组[(48.96±5.02)°、(49.76±6.41)mm、1.68±0.52g/L)],差异均具有统计学意义(P<0.05);经Pearson相关性分析结果显示,R、K与FIB呈负相关(r=-0.603、-0.6015,P<0.01),α角、MA与FIB呈显著正相关(r=0.589、0.622,P<0.01);R、K、α角、MA、FIB预测普外科患者围术期大量输血的AUC分别为0.755(95%CI:0.686~0.816)、0.806(95%CI:0.741~0.861)、0.752(95%CI:0.683~0.813)、0.789(95%CI:0.723~0.846)、0.807(95%CI:0.742~0.861),约登指数分别为0.449、0.493、0.399、0.484、0.590,最佳截断值为7.45 min、3.41 min、47.62°、45.86 mm、1.46 g/L,敏感度分别为73.33%、77.78%、80.00%、66.67%、91.11%,特异度分别为71.53%、71.53%、59.85%、81.75%、67.88%,各指标联合预测普外科患者围术期大量输血的AUC为0.924(95%CI:0.875~0.958),优于各指标单独预测;R、K高值的普外科患者围术期大量输血风险是低值患者的4.201倍(95%CI:2.329~7.580)、5.108倍(95%CI:2.700~9.663);α角、MA、FIB低值的普外科患者围术期输血风险是高值患者的4.000倍(95%CI:2.047~7.818)、4.618倍(95%CI:2.710~7.869)、11.697倍(95%CI:4.370~31.307)。结论TEG与FIB联合应用可用于普外科患者围术期输血效能预测中,为临床术前预测大量输血提供参考依据,以尽早制定相应输血方案,改善预后。

关键词：血栓弹力图纤维蛋白原围术期输血预测价值

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