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血清PSA检测在前列腺癌早期诊断中的应用价值

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中国实用医药 2008年第21期3卷 39-40页

作者：钟乔华广东省揭阳市人民医院 522000

目的探索前列腺特异性抗原(PSA)在前列腺癌早期诊断中的应用价值。方法采用电化学发光免疫分析(ECLIA)方法测定30例前列腺癌(PCa),50例良性前列腺增生(BPH)患者的血清总PSA(t-PSA)和游离PSA(f-PSA),并求出f-PSA/t-PSA(f/t)比值,然后进... 详细信息

目的探索前列腺特异性抗原(PSA)在前列腺癌早期诊断中的应用价值。方法采用电化学发光免疫分析(ECLIA)方法测定30例前列腺癌(PCa),50例良性前列腺增生(BPH)患者的血清总PSA(t-PSA)和游离PSA(f-PSA),并求出f-PSA/t-PSA(f/t)比值,然后进行统计学分析。结果受检者血清t-PSA及f-PSA水平随年龄增长而增加;PCa组与BPH组比较,f-PSA及f/t比值均有显著性差异(P<0.01),若以f/t<16%作为鉴别诊断BPH和PCa的界值,敏感性为83.3%,特异性为92.0%。结论在PSA值轻度升高时,根据不同年龄段特异性PSA水平,以f/t<16%为界值,可提高对PCa早期诊断的特异性和敏感性。

关键词：前列腺特异性抗原前列腺癌早期诊断

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian qiao Gao Sheng-Lan Xu hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

某国产肌酐试剂在日立生化分析仪上检测的性能评价

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标记免疫分析与临床 2019年第7期26卷 1219-1223页

作者：钟乔华谢细娜巫娟陈琦邹俊忠卢松耀广东省揭阳市人民医院检验科

目的评价某国产酶法肌酐试剂在日立7600全自动生化分析仪上的分析性能。方法对该试剂进行相关性能验证,并与迈瑞配套肌酐试剂进行比对。结果批内精密度(CV)为0.93%、0.47%,实验室内不精密度(CV)为2.18%、0.78%;正确度验证相对偏倚小于6%... 详细信息

目的评价某国产酶法肌酐试剂在日立7600全自动生化分析仪上的分析性能。方法对该试剂进行相关性能验证,并与迈瑞配套肌酐试剂进行比对。结果批内精密度(CV)为0.93%、0.47%,实验室内不精密度(CV)为2.18%、0.78%;正确度验证相对偏倚小于6%;线性范围为13.16~8206.5μmol/L(R2=0.999≥0.95),最大稀释倍数为16;临床可报告范围为13.16~131304.00μmol/L;与迈瑞BS-800M比对肌酐检测结果具有良好的一致性。结论该国产酶法肌酐试剂在日立7600全自动生化分析仪上的分析性能良好,可满足临床应用需求。

关键词：肌酐酶法全自动生化分析仪性能评价

FCC-to-HCP Phase Transformation in CoCrNi_x Medium-Entropy Alloys

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Acta Metallurgica Sinica(English Letters) 2020年第8期33卷 1151-1158页

作者： Jia-Qi Zhao hua Tian zhong Wang Xue-Jiao Wang Jun-Wei qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Information and Computer Taiyuan University of TechnologyTaiyuan 030024China

A hybrid first-principles/Monte Carlo simulation is combined with experiments to study the structure and elastic properties of CoCrNi_x(x=1-0.5)*** experimental X-ray diffraction patterns show that the structures have changed from the single-phase face-centered cubic(FCC)structure at x=1-0.8 to the coexistence of FCC and the hexagonal close-packed structures at x=0.7-0.5,which is further confirmed by calculations on mixing *** elastic moduli by calculation are basically in agreement with ***-temperature tension shows that the six alloys have a certain plasticity,the strength and plasticity of the alloys have a linear decrease with the decrease in Ni contents,and the plasticity of the alloys drops from 84 to 23%.Furthermore,first-principles density function theory calculations were employed to reveal the electronic and magnetic structures of *** electron density of states for all alloys is asymmetrical,which illustrates that the alloys are *** is found that Cr atoms can suppress the ferromagnetism of alloys,since Cr atoms have both positive and negative magnetic moments in all alloys.

关键词： Hexagonal close-packed(HCP)structure Medium-entropy alloys Magnetic Mechanical properties Phase transformation High-entropy alloys

心肌三项（cTnI、Myo、CK-MB）联合检测对胸痛患者的诊断意义

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智慧健康 2019年第21期5卷 13-14页

作者：钟乔华卢松耀陈琦巫娟黄伟鹏广东省揭阳市人民医院检验科广东揭阳522000 广东省揭阳市人民医院心内二科广东揭阳522000

目的研究胸痛患者肌钙蛋白I(cTnI),肌红蛋白(MYO),肌酸激酶同工酶(CK-MB)联合检测的临床意义。方法选取胸痛患者100例作为观察组,健康体检者100例作为对照组,所有受检者均测量c Tn I,MYO,CK-MB含量,并对胸痛患者血清中含量的变化进行动... 详细信息

目的研究胸痛患者肌钙蛋白I(cTnI),肌红蛋白(MYO),肌酸激酶同工酶(CK-MB)联合检测的临床意义。方法选取胸痛患者100例作为观察组,健康体检者100例作为对照组,所有受检者均测量c Tn I,MYO,CK-MB含量,并对胸痛患者血清中含量的变化进行动态分析。结果观察组胸痛患者各项指标均高于对照组健康体检者(P>0.05),cTnI、MYO、CK-MB的动态检测结果显示cTnI于发病后2h开始明显升高,24h达到峰值,72h仍维持较高水平;MYO于2h水平显著升高,24h出现明显下降,48h恢复基线水平,72h后达到正常水平;CK-MB在2h正常或轻微升高,于24h达到峰值,48h水平明显下降,72h恢复基线水平;观察组胸痛患者联合检测阳性率均显著高于单一检测阳性率,差异有统计学意义(P<0.05);结论胸痛患者实施心肌三项(cTnI、Myo、CK-MB)联合检测,能显著提高检测阳性率,具有显著的诊断价值。

关键词：胸痛肌钙蛋白I 肌红蛋白肌酸激酶同工酶

Self-organized Criticality Behavior in Bulk Metallic Glasses

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Journal of Iron and Steel Research International 2016年第1期23卷 7-13页

作者： Jun-wei qiao zhong WANG Laboratory of Applied Physics and Mechanics of Advanced Materials College of Materials Science and EngineeringTaiyuan University of Technology

Serrated flows are known as repeated yielding of bulk metallic glasses（BMGs）during plastic deformation under different loading conditions,which are associated with the operation of shear *** to the statistics of some parameters,the shear avalanches can display a self-organized critical state,suggesting a large ductility of *** emergence of the self-organized criticality（SOC）behavior in different BMGs is due to the temperature,strain rate,and chemical *** SOC behavior is accompanied with the following phenomena：the interactions occur in the shear bands;the incubation time is longer than the relaxation time;the time interval is lacking of typical time scale;and the spatial or temporal parameters should display apower-law distribution.

关键词： self-organized criticality behavior bulk metallic glass serrated flow power-law distribution

Perturbation of Yamabe Equation on Iwasawa N Groups in Presence of Symmetry

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1575-1590页

作者： qiao hua YANG School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

Let G be a simple Lie group of real rank one and N be in the Iwasawa decomposition of G. Under the assumption of some symmetries, we obtain an existent result for the nonlinear equation △NU ＋（1 ＋ ∈K（x, z））u2＊-1 = 0 on N, which generalizes the result of Malchiodi and Uguzzoni to the Kohn＇s subelliptic context on N in presence of symmetry.

关键词： Heisenberg type groups Yamabe equations simple Lie group of real rank one

Constrained minimum power combination for broadband beamformer design in the STFT domain

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Frontiers of Computer Science 2017年第3期11卷 408-418页

作者： zhong-hua FU School of Computer Science Northwestern Polytechnical University Xi'an 710072 China

Beamforming using sensor array is widely used in spatial signal processing since it offers better spatial focusing capability than single sensor. However, in practical appli- cations for broadband signal, there always exists a trade-off issue between the directivity capability of an array and its robustness on system errors. In this paper, in order to combine merits of different beamformers instead of trade-off their per- formances, we propose a constrained minimum-power com- bination method. We firstly analyze two optimal beamform- ers that maximize Directivity Factor （DF） and White Noise Gain （WNG） respectively. Then we propose a non-linear combination method, which automatically selects the best beamformer that has the minimum output power, so as to control the unwanted white noise amplification and keep the maximum DF if possible. Two solutions to the proposed com- bination strategy are given. They do not need to determine the correct trade-off factor used in linear combination method, and avoid challenge ~stimations on noise and target statistics required in adaptive beamforming. The performance of the proposed beamformer is evaluated in ideal noise fields and complicated noise fields respectively. It is shown that the proposed beamformer integrates merits of different beamform- ers. It always achieves the best speech quality and biggest noise reduction compared to other popular beamformers.

关键词： robust beamforming directivity index white noise gain broadband STFT domain speech enhancement

Analysis of the penalty version of the Arlequin framework for the prediction of structural responses with large deformations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 552-560页

作者： hua qiao Wei-qiu CHEN Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China

The Arlequin framework proposed by Ben Dhia in 1998 is a flexible and robust method for conducting global/local analysis of structures and materials.A penalty version of the Arlequin framework for the study of structural problems involving large deformation is considered *** implementation of the penalty-based Arlequin framework into ABAQUS is then explored and the corresponding Arlequin user element subroutine is *** nonlinear simulations of a cantilever beam and a shallow arch are conducted and the choice of the coupling operator with an appropriate penalty parameter is *** numerical results justify the feasibility of the proposed method,ensuring its further application to more complicated problems involving geometric or material nonlinearities.

关键词： Global/Local analysis Geometric nonlinear analysis Penalty-based Arlequin method User defined element