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Magnetic and Transport Properties of Bi_(0.5)Ca_(0.5–x)La_xFe_(0.3)Mn_(0.7)O_3(x=0, 0.05, 0.10, 0.15, 0.20, 0.25) Prepared by Molten Salt Method

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Chemical Research in Chinese Universities 2011年第1期27卷 15-18页

作者： DONG zhong-ping HU Bin chen Yan YUAN Hong-ming FENG Shou-hua State Key Laboratory of Inorganic Synthesis ＆ Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Polycrystallines Bi0.5Ca0.5-xLaxFe0.3Mn0.7O3（x=0, 0,05, 0.10, 0.15, 0.20, 0.25） were prepared by molten salt method and showed perovskite orthorhombic structure with space group Pnma. The magnetic measurements indicate that the compounds exhibit antiferromagnetic behavior in a temperature range of 4-300 K. The measurements of transport properties suggest that the substitution of La for Ca enhanced the conductivity, and a kink appeared on the curve of temperature dependence of resistivity at 275 K, which is related to the spin-reorientation in the samples.

关键词： Perovskite Doping Magnetism Spin-reorientation

Association between glioblastoma cell-derived vessels and poor prognosis of the patients

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Cancer Communications 2020年第5期40卷 211-221页

作者： Xin Mei Yin-Sheng chen Qing-ping Zhang Fu-Rong chen Shao-Yan Xi Ya-Kang Long Ji Zhang Hai-ping Cai Chao Ke Jing Wang zhong-ping chen Department of Neurosurgery/Neuro-oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Neurosurgery Huazhong University of Science and Technology Union Shenzhen HospitalThe 6th Affiliated Hospital of Shenzhen University Health Science Center(Shenzhen Nanshan People’s Hospital)ShenzhenGuangdong 518052P.R.China Department of Molecular Diagnostics State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Neurosurgery Sun Yat-sen Memorial HospitalGuangzhouGuangdong 510235P.R.China

Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)***,details of the microcirculation patterns in GBM remain ***,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December *** microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft *** density assessments and three-dimensional reconstruction were *** promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger *** relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier ***:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft *** were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.

关键词： endothelial differentiation endothelium-dependent vessel extracellular matrix-dependent vessel glioblastoma cell-derived vessel Glioblastoma MGMT promoter methylation microcirculation mosaic vessel prognosis vasculogenic mimicry

Research on the environmental trace elements in permian coals and their ashes from Huainan coalmine area,China

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Journal of Coal Science & Engineering(China) 2010年第3期16卷 306-310页

作者： LIU Wen-zhong chen ping KONG Wei-hui School of Earth and Environment Anhui University of Science and Technology Huainan 232001 China

The contents of environmental trace elements in permian coal from Huainancoalmine area and their combustion products were tested by *** and comparativeresearches on the contents of eighteen environmental trace elements in coal andits combustion product suggest that Se and Cd have a high level of distribution in coals;As, Se, Cd, Sb and As, Se, Cd, Mo, Be, Sb also have a high level of distribution in 815 ℃and 1 100 ℃ coal ashes, *** temperature, thermodynamics featuresof trace elements and ash content in coal are the main factors that influence theabundance of trace elements in coal and ash.

关键词： permian coal coal ash trace element

Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

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Chinese Journal of Cancer 2014年第2期33卷 115-122页

作者： Zhi-Kun Qiu Dong Shen Yin-Sheng chen Qun-Ying Yang cheng-cheng Guo Bing-Hong Feng zhong-ping chen State Key Laboratory of Oncology in South China Department of Neurosurgery/Neuro-oncology Sun Yat-sen University Cancer Center Department of Pharmacology Guangdong Pharmaceutical University Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College

O6-methylguanine DNA methyltransferase(MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contributing to the drug resistance of gliomas to alkylating agents. In addition, glioma stem-like cells(GSCs) have been demonstrated to be involved in the recurrence and treatment resistance of gliomas. In this study, we aimed to investigate MGMT expression and regulatory mechanisms in GSCs and the association of MGMT with temozolomide(TMZ) sensitivity. GSCs were enriched from one MGMT-positive cell line(SF-767) and 7 MGMT-negative cell lines(U251, SKMG-4, SKMG-1, SF295, U87, MGR1, and MGR2) through serum-free clone culture. GSCs from the U251G, SKMG-4G, SF295G, and SKMG-1G cell lines became MGMT-positive, but those from the U87G, MGR1G, and MGR2G cell lines remained MGMT-negative. However, all the GSCs and their parental glioma cell lines were positive for nuclear factor-κB(NF-κB). In addition, GSCs were more resistant to TMZ than their parental glioma cell lines(P 0.05). When we treated the MGMT-positive GSCs with TMZ plus MG-132(an NF-κB inhibitor), the antitumor activity was significantly enhanced compared to that of GSCs treated with TMZ alone(P < 0.05). Furthermore, we found that MGMT expression decreased through the down-regulation of NF-κB expression by MG-132. Our results show that MG-132 may inhibit NF-κB expression and further decrease MGMT expression, resulting in a synergistic effect on MGMT-positive GSCs. These results indicate that enhanced MGMT expression contributes to TMZ resistance in MGMT-positive GSCs.

关键词：神经胶质瘤 MGMT 替莫唑胺干细胞耐药性 DNA甲基转移酶 NF-κB 核因子-κB

Long-term molecular changes in WHO grade II astrocytomas following radiotherapy

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Chinese Journal of Cancer 2012年第3期31卷 159-165页

作者： Wei-Ying Yue Ke Sai Qiu-Liang Wu Yun-Fei Xia Su-Huan Yu zhong-ping chen State Key Laboratory of Oncology in South China Oepartment of Neurosurgery Department of Pathology Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Neurosurgrey Zhongnan Hospital Wuhan University Wuhan Hubei 430077. P. R. China.

Monitoring the long-term radiotherapy-associated molecular changes in low-grade gliomas(LGGs) facilitates the understanding of LGG response to *** this study,we used immunohistochemistry to analyze the expression of Ki-67,tumor protein P53(TP53),P21,and P27 in 8 paired WHO grade II astrocytoma *** interval between radiotherapy(RT) and the second surgery was more than 3 months in all *** average Ki-67 labeling index(LI) was 5.3% in pre-RT samples and 11.54% in post-RT ***-67 LI was higher in the primary tumors that underwent malignant transformation observed at the second surgery after ***-RT Ki-67 LI decreased in 2 cases with an interval of less than 12 months between RT and the second ***53 expression was found in 3 out of 4 pre-RT samples with malignant transformation and in 1 out of 4 pre-RT samples without malignant ***-RT TP53 increased in 2 cases in which increased expression of P21 or P27 was also *** study suggests that radiotherapy can inhibit WHO grade II astrocytoma proliferation as reflected by Ki-67 LI,but the effect attenuates with *** addition,there is a tendency of malignant transformation for WHO grade II astrocytomas with a high Ki-67 level or TP53 expression in initial samples.

关键词：星形细胞放疗世卫组织分子 P53基因二级时间间隔世界卫生组织

Thyroid metastasis from breast cancer presenting with enlarged lateral cervical lymph nodes: A case report

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World Journal of Clinical Cases 2020年第4期8卷 838-847页

作者： Yan-Yan Zhang Shuai Xue Zheng-Min Wang Mei-Shan Jin zhong-ping chen Guang chen Qiang Zhang Department of Thyroid Surgery The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Pathology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Radiology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Secondary malignancy of the thyroid occurs infrequently and mainly originates from malignant tumors of the kidney,gastrointestinal tract,lungs,breast,and *** correct diagnosis is important but ***,there are major differences in the treatment of primary and metastatic thyroid cancer,which has a significant impact on prognosis and ***,how to diagnose thyroid metastasis(TM)correctly before surgery is a major concern for *** SUMMARY We report a 38-year-old woman who presented with palpable cervical lymph nodes after breast cancer(BC)surgery 2 years *** and computed tomography revealed thyroid nodules with irregular margins and enlarged cervical lymph *** was performed for the right largest cervical lymph node,and immunohistochemical analysis revealed negativity for thyroglobulin,estrogen receptor,and progestin receptor and positive for human epidermal growth factor receptor *** diagnosis was TM from BC with cervical lymph node *** thyroidectomy with bilateral central and lateral neck lymph node dissection was *** a 5-mo follow-up,no recurrence or novel distant metastasis was *** TM from BC is a rare secondary *** differential diagnosis by biopsy and immunohistochemical analysis needs to be considered.

关键词： Secondary malignancy Thyroid Breast cancer Metastasis Case report

Magnetic nanocomposites of Fe_3O_4/SiO_2-FITC with pH-dependent fluorescence emission

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Chinese Chemical Letters 2009年第8期20卷 969-972页

作者： Yu Zhang Shang Wen Yan Gong Lu Jin Shuang Man Li zhong ping chen Ming Ma Ning Gu aState Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China Jiangsu Key Laboratory for Biomaterials and Devices Southeast University Nanjing 210096 China

This paper describes the formation of magnetic and fluorescent nanocomposite particles which consist of superparamagnetic Fe3O4 core, SiO2 shell and organic dye （FITC） coating layer on their surface. The obtained nanocomposites possess typical superparamagnetism and exhibit clear green fluorescence image. And their fluorescence emission is pH-dependent, which would be applied to pH sensing. ？2009 Yu Zhang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： Nanocomposites Cote-shell structure Magnetic nanoparticles Fluorescence

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

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Petroleum Science 2024年第04期21卷 2625-2637页

作者： Zhi-Qiang He He-ping Xie Ling chen Jian-ping Yang Bo Yu Zi-Jie Wei Ming-zhong Gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and Hydropower Sichuan University Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green Energy College of Civil and Transportation Engineering Shenzhen University School of Mechanical Engineering Sichuan University College of Polymer Science and Engineering Sichuan University

Deep oil and gas reservoirs are under high-temperature conditions, but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability, resulting in distorted resource assessments. The development of in situ temperaturepreserved coring(ITP-Coring) technology for deep reservoir rock is urgent, and thermal insulation materials are key. Therefore, hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) were proposed as thermal insulation materials. The materials properties under coupled hightemperature and high-pressure(HTHP) conditions were tested. The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased; additionally,increasing temperature accelerated the process. High temperatures directly caused the thermal conductivity of the materials to increase; additionally, the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity. High temperatures weakened the matrix, and high pressures destroyed the HGM, which resulted in a decrease in the tensile mechanical properties of the materials. The materials entered the high elastic state at 150.C, and the mechanical properties were weakened more obviously, while the pressure led to a significant effect when the water absorption was above 10%. Meanwhile, the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86% at 100.C and 100 MPa, respectively, which meet the application requirements of the self-designed coring device. Finally, K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100.C and 100 MPa. To further improve the materials properties, the interface layer and EP matrix should be optimized. The results can provide references for the optimization and engineering application of materials and thus technical su

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring (ITP-Coring) Hollow glass microsphere/epoxy resin thermal insulation materials (HGM/EP materials) High-temperature and high-pressure (HTHP) Physical and mechanical properties

Longest survival with primary intracranial malignant melanoma:A case report and literature review

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World Journal of Clinical Cases 2022年第30期10卷 11162-11171页

作者： Tang-Fai Wong Yin-Sheng chen Xiang-Heng Zhang Wan-Ming Hu Xiao-Shi Zhang Yan-Chun Lv Dong-Cun Huang Mei-Ling Deng zhong-ping chen Department of Neurosurgery Macao Kiang Wu HospitalMacao 999078Sichuan ProvinceChina Department of Neurosurgery/Neuro-Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Biotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Medical Imaging Sun Yat-sen University Cancer CenterCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Department of Radiotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Primary intracranial malignant melanoma(PIMM)is rare,and its prognosis is very *** is not clear what systematic treatment strategy can achieve long-term *** case study attempted to identify the optimal strategy for long-term survival outcomes by reviewing the PIMM patient with the longest survival following comprehensive treatment and by reviewing the related *** SUMMARY The patient is a 47-year-old Chinese man who suffered from dizziness and gait *** underwent surgery for right cerebellum melanoma and was subsequently diagnosed by pathology in June *** the surgery,the patient received three cycles of chemotherapy but relapsed locally within 4 *** the second surgery for total tumor resection,the patient received an injection of Newcastle disease virus-modified tumor vaccine,interferon,andβ-elemene *** patient was tumor-free with a normal life for 21 years before the onset of the recurrence of melanoma without any symptoms in July 2021.A third gross-total resection with adjuvant radiotherapy and temozolomide therapy was *** magnetic resonance imaging showed no residual tumor or recurrence 3 mo after the 3rd operation,and the patient recovered well without neurological dysfunction until the last follow-up in June 2022,which was 22 years following the initial *** It is important for patients with PIMM to receive comprehensive treatment to enable the application of the most appropriate treatment ***-term survival is not impossible in patients with these malignancies.

关键词： Primary intracranial malignant melanoma Immunotherapy Newcastle disease virus-modified tumor vaccine β-elemene Long-term survival Case report