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Complex genesis of multiperiod fractures in the Middle Triassic Leikoupo Formation in the Pengzhou gas field, western Sichuan Basin, China

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Petroleum Science 2023年第1期20卷 161-176页

作者： Xiao-Fei Hu Hu-Cheng Deng Jian-Hua He zhong-Min Shen Xian-Feng Peng College of Energy Chengdu University of TechnologyChengduSichuan 610059China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) ChengduSichuan 610059China

The cumulative expression of multistage deformation is complex multiperiod fractures,which are commonly seen in tectonic zones.The Middle Triassic Leikoupo Formation in the western Sichuan Basin Depression,China,is a typical marine carbonate reservoir with natural fractures caused mainly by tectonic movements.According to outcrops,drill cores,image logging,and fluid inclusions,the fracture characteristics,types of natural fractures,and interactions of fractures are determined.In total,419 natural fractures in 493.2 m of cores from 7 wells are investigated,which are mainly shear and tensile fractures with a small number of weathering generated fractures.Meanwhile,the results of the stable isotope analysis of δ13C and δ18O,as well as the flow fluid inclusion data,reveal four tectonic periods of fractures with different occurrences.Based on the history of regional tectonic evolution,indicating one period of weathering fractures ascribable to stratal uplift and three periods of structural fractures related to the sequential tectonic movements of the Longmenshan fault belt.By analyzing the interaction relationships of fractures,three types of fracture interaction relationships are observed:cutting,restraining,and overlapping.The four stages fractures are chronologically assigned to(1)the early Indosinian N-S trending compression,(2)the late Indosinian NW-SE compression,(3)the middle Yanshanian NE-SE compression,and(4)the early Himalayan E-W compression.The influence of natural fractures on gas migration and well production in marine carbonates is discussed,and indicates that tectonic fractures could provide seepage channels for gas migration and accumulation from near or distant hydrocarbon source rocks into the Middle Triassic Leikoupo Formation.This study utilizes a pragmatic approach for understanding the fracture genesis mechanism in oil and gas field with multiperiod fractures.

关键词： Multiperiod fractures Interaction relationships Genesis mechanism Gas migration Leikoupo formation Sichuan basin

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On Randers Metrics with Isotropic S-Curvature

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Acta Mathematica Sinica,English Series 2008年第5期24卷 789-796页

作者： zhong min shen Hao XING Department of Mathematics IUPUI Indianapolis IN 46202-3216 USA Department of Mathematics University of Michigan Ann Arbor MI 48109 USA

In this paper, we study a class of Finsler metrics defined by a vector field on a Riemannian space form. We give an explicit formula for those with isotropic S-curvature. This class contains all Randers metrics of con... 详细信息

关键词： Randers metrics S-curvature

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Characterization of chromatin accessibility in psoriasis

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Frontiers of Medicine 2022年第3期16卷 483-495页

作者： Zheng Zhang Lu Liu Yanyun shen Ziyuan Meng min Chen zhong Lu Xuejun Zhang Department of Dermatology Huashan HospitalFudan University.Shanghai 200040China Department of Dermatology No.1 Hospital and Key Laboratory of DermatologyMinistry of EducationAnhui Medical UniversityHefei 230032China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215123China

The pathological hallmarks of psoriasis involve alterations in T cell genes associated with transcriptional levels,which are determined by chromatin accessibility.However,to what extent these alterations in T cell transcriptional levels recapitulate the epigenetic features of psoriasis remains unknown.Here,we systematically profiled chromatin accessibility on Th1,Th2,Th1-17,Th17,and Treg cells and found that chromatin remodeling contributes significantly to the pathogenesis of the disease.The chromatin remodeling tendency of different subtypes of Th cells were relatively consistent.Next,we profiled chromatin accessibility and transcriptional dynamics on memory Th/Treg cells.In the memory Th cells,803 increased and 545 decreased chromatin-accessible regions were identified.In the memory Treg cells,713 increased and 1206 decreased chromatin-accessible regions were identified.A total of 54 and 53 genes were differentially expressed in the peaks associated with the memory Th and Treg cells.FOSL1,SPI1,ATF3,NFKB1,RUNX,ETV4,ERG,FLI1,and ETC1 were identified as regulators in the development of psoriasis.The transcriptional regulatory network showed that NFKB1 and RELA were highly connected and central to the network.NFKB1 regulated the genes of CCL3,CXCL2,and IL1RN.Our results provided candidate transcription factors and a foundational framework of the regulomes of the disease.

关键词： psoriasis ATAC-seq epigenetics transcription factor

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An improved LuGre model for calculating static steering torque of rubber tracked chassis

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Defence Technology（防务技术） 2022年第5期18卷 797-810页

作者： Kang Liang Qun-zhang Tu Xin-min shen zhong-hang Fang Xuan Yang Yong Zhang Hui-yu Xiang College of Field Engineering Army Engineering University of PLANanjing210007China State Key Laboratory of Intelligent Manufacturing of Advanced Construction Machinery Xuzhou Construction Machinery GroupXuzhou221004China

Tire and rubber track interchangeable chassis combines the advantages of tire and rubber track,which can greatly improve the maneuverability of military construction machinery.However,there is almost no effective calculation model for the real-time static steering torque.When the relative sliding speed is greater than 0.01 m/s,the influence of friction heating can not be ignored.An improved LuGre model is established to calculate the static real-time steering torque of tire and rubber track interchangeable chassis.Firstly,the friction heating model between rubber and ground is established.Combined with the influence of temperature on the dynamic performance of rubber material,the influence of friction heating on the stiffness and friction coefficient of rubber track is analyzed,and the improved LuGre friction model is established.The steering torque of tire and rubber track interchangeable chassis is affected by rubber material properties,steering speed,pavement type,and ambient temperature.Compared with the original Lu Gre model,the improved LuGre model captures the change in friction torque during multiple in-situ turns due to frictional heating.The error with the experimental data is small,which verifies the effectiveness of the improved LuGre model.

关键词： Rubber track Static steering torque Friction model Chassis Maneuverability Vehicle

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The key role of inoculated sludge in fast start-up of sequencing batch reactor for the domestication of aerobic granular sludge

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Journal of Environmental Sciences 2019年第4期31卷 127-136页

作者： Xiao-chun Wang zhong-lin Chen Jing Kang Xia Zhao Ji-min shen Liu Yang State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of Technology College of Petrochemical Technology Lanzhou University of Technology

Two types of inoculated sludges, granular sludge that had been stored at-20°C and activated sludge, were investigated for the domestication of aerobic granular sludges(AGSs in sequencing batch reactors(SBRs). The results showed that using the stored granular sludge as inoculation sludge could effectively shorten the domestication time of AGS and yielded mature granular sludge after 22 days of operation. The AGS domesticated by stored granular sludge had better biomass and sedimentation properties; its MLSS and SVI reached8.55 g/L and 35.27 mL/g, respectively. The removal efficiencies for chemical oxygen demand(COD), ammonium nitrogen(NH_4^+-N) and total phosphorus(TP) reached 90.76%, 97.39% and 96.40%, respectively. By contrast, 54 days were needed to obtain mature granules using activated sludge. The microbial community structure was probed by using scanning electron microscopy(SEM) and high-throughput sequencing. The results showed that the diversity of the microbial community in mature granules was reduced when stored granular sludge rather than activated sludge was employed as inoculation sludge, and the dominant microbes were changed. The dominant species in mature granules domesticated using stored granular sludge were Zoogloea, Acidovorax and Tolumonas at the genus classification level, while the dominant species were Zoogloea and TM7-genera in granules developed from activated sludge.

关键词： Aerobic granular sludge Microbial community Sequencing batch reactor Stored granular sludge

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Effectiveness and tolerability of programmed cell death protein-1 inhibitor+chemotherapy compared to chemotherapy for upper gastrointestinal tract cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1613-1625页

作者： Xiao-min Zhang Ting Yang Ying-Ying Xu Bao-zhong Li Wei shen Wen-Qing Hu Cai-Wen Yan Liang Zong Department of Central Laboratory Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastrointestinal Surgery Yizheng People’s HospitalThe Affiliated Hospital of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina Department of General Surgery Anyang Tumor HospitalAnyang 455000Henan ProvinceChina Department of General Surgery Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina Department of Gastroenterology Changzhi People’s HospitalThe Affiliated Hospital of Changzhi Medical CollegeChangzhi 046000Shanxi ProvinceChina

BACKGROUND The combination of programmed cell death protein-1(PD-1)inhibitor and che-motherapy is approved as a standard first-or second-line treatment in patients with advanced oesophageal or gastric cancer.However,it is unclear whether this combination is superior to chemotherapy alone.AIM To assess the comparative effectiveness and tolerability of combining PD-1 inhibitors with chemotherapy vs chemotherapy alone in patients with advanced gastric cancer,gastroesophageal junction(GEJ)cancer,or oesophageal carcinoma.METHODS We searched the PubMed and Embase databases for studies that compared the efficacy and tolerance of PD-1 inhibitors in combination with chemotherapy vs chemotherapy alone in patients with advanced oesophageal or gastric cancer.We employed either random or fixed models to analyze the outcomes of each clinical trial,en-compassing data on overall survival(OS),progression-free survival(PFS),objective response rate,and adverse events(AEs).RESULTS Nine phase 3 clinical trials(7016 advanced oesophageal and gastric cancer patients)met the inclusion criteria.Our meta-analysis demonstrated that the pooled PD-1 inhibitor+chemotherapy group had a significantly longer OS than the chemotherapy-alone group[hazard ratio(HR)=0.76,95%confidence interval(CI):0.71-0.81];the pooled PFS result was consistent with that of OS(HR=0.67,95%CI:0.61-0.74).The count of patients achieving an objective response in the PD-1 inhibitor+chemotherapy group surpassed that of the chemotherapy-alone group[odds ratio(OR)=1.86,95%CI:1.59-2.18].AE incidence was also higher in the combination-therapy group than in the chemotherapy-alone group,regardless of whether≥grade 3 only(OR=1.30,95%CI:1.07-1.57)or all AE grades(OR=1.88,95%CI:1.39-2.54)were examined.We performed a subgroup analysis based on the programmed death-ligand 1(PD-L1)combined positive score(CPS)and noted extended OS and PFS durations within the CPS≥1,CPS≥5,and CPS≥10 subgroups of the PD-1 inhibitor+chemotherapy group.CONCLUSION In contrast to chemotherapy alone,the combina

关键词： Programmed cell death protein-1 inhibitor Chemotherapy Oesophageal squamous cell carcinoma Gastric/gastroesophageal junction adenocarcinoma Overall survival Progression-free survival Objective response rate Adverse event

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Torque characteristics in a large permanent magnet synchronous generator with stator radial ventilating air ducts

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Frontiers of Information Technology & Electronic Engineering 2016年第8期17卷 814-824页

作者： He HAO Wei-zhong FEI Dong-min MIAO Meng-jia JIN Jian-xin shen College of Electrical Engineering Zhejiang University Hangzhou 310027 China Power Engineering Centre Cranfield University Cranfield MK43 OAL UK

目的:针对应用于海上风电的大型低速直驱型永磁同步发电机,研究具有径向通风风道定子和分段斜极的转子对于电机转矩特性的影响。创新点:利用二维和三维有限元分析,得到定子通风孔的存在对于电机转矩特性的影响,并且通过对永磁体结构和... 详细信息

目的:针对应用于海上风电的大型低速直驱型永磁同步发电机,研究具有径向通风风道定子和分段斜极的转子对于电机转矩特性的影响。创新点:利用二维和三维有限元分析,得到定子通风孔的存在对于电机转矩特性的影响,并且通过对永磁体结构和转子分段斜极的优化,得到其对电机转矩特性的影响,提高电机转矩性能,降低了对机械齿轮的要求。方法:首先,考虑到大型直驱型永磁同步发电机采用的机械齿轮的机械忍耐性受到限制,因此减少电机的转矩脉动具有非常重要的意义,对于海上工作的风力发电机来说尤为如此。接着,针对现有风力发电机,在具有定子通风孔条件下提出了对于电机永磁体形状的优化,并通过二维和三维的有限云分析,得到了其对电机转矩特性的影响。然后,通过提出对电机转子的分段斜极的优化,同样利用二维和三维的有限元分析得到不同转子结构对电机转矩特性的影响。最后,通过分析比较得到不同结构对电机平均转矩、转矩脉动等的影响。结论:针对大容量永磁同步发电机,我们发现定子通风孔不仅会降低电机的平均转矩,还会增加电机的转矩脉动,且电枢电流和转子分段斜极对减少电机的转矩脉动具有非常大的影响。

关键词：永磁同步发电机转矩特性径向通风通风管道定子二维有限元分析三维有限元分析海上风力发电

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A Potential Alternative to Polystyrene: Ring-opening Terpolymerization of Different Epoxides with Phthalic Anhydride Using Metal-free Dual Catalysts

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Chinese Journal of Polymer Science 2021年第3期39卷 337-343,I0006页

作者： Li-Miao Lin Yong-Hang Xu Man shen Jia-Xin Liang Shuan-Jin Wang min Xiao Yue-zhong Meng The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China School of Environmental and Chemical Engineering Foshan UniversityFoshan 528000China School of Materials Science&Energy Engineering Foshan UniversityFoshan 528000China

A series of semi-aromatic polyesters named as Poly(PO-CHO-PA) were facilely synthesized via ring-opening terpolymerization of biobased cyclohexane oxide(CHO)/propylene oxide(PO)/phthalic anhydride(PA) using economical U1/PPNCl as dual catalyst. The proportion of CHO-PA and PO-PA segments in polymer can be readily altered by changing the feed ratio of CHO/PO because the reactivity ratios of CHO and PO with PA calculated by Fineman-Ross method are comparable. All synthesized amorphous polyesters with various compositions show one Tg ranging from 62 ℃ to 133 ℃. Significantly, the mechanical, thermal and barrier properties of these amorphous semi-aromatic polyesters are also adjustable and investigated for the first time. The results indicate the semi-polyesters exhibit superior thermostability(T5% ranging from 306 ℃ to323 ℃) and high tensile strength(40.21-55.7 MPa) that is comparable with polystyrene(PS). Furthermore, Poly(PO-CHO-PA) films possess a promising prospect as packaging materials because of its colorless and highly transparent nature, along with low oxygen and water vapor transmission rate. All above performances may guarantee its potential alternative to commercial PS.

关键词： Aromatic polyester Ring-opening polymerization Metal-free catalyst Polystyrene Barrier properties

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A “Stem Cells in Cancer” special issue in Translational Cancer Research

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Chinese Journal of Cancer Research 2013年第6期25卷 781-781页

作者： Nancy Q.zhong min shen Editorial Office Translational Cancer Research

Somatic stem cells （SSCs）, being essential in maintaining homeostasis of normal tissue, replenish dying cells and regenerate damaged tissues for organism. On the other hand, with the self-renewed ability, SSCs are ideal cellular targets to be acquired in multiple mutations transforming SSCs to cancer stem cells （CSCs） which cause malignancies and even recurrence after cancer treatment if CSCs fail to be eradicated （1）.

关键词： special issue in Translational Cancer Research Stem Cells in Cancer

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A retrospective study of the occurrence of ischemic-type biliary lesions post liver transplantation

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Science China(Life Sciences) 2016年第5期59卷 529-531页

作者： Rui Shi Ya-min Zhang Yong-Lin Deng Hong Zheng Cheng Pan zhong-Yang shen Tianjin Key Laboratory of Organ Transplantation Department of Hepatobiliary Surgery First Center Hospital Clinic Institute Tianjin Medical University

Dear Editors,Ischemic-type biliary lesions(ITBLs)significantly reduce patient and graft survival rates.Research data regarding the causes of ITBL are rare.ITBLs is an important cause of post liver transplantation graft loss and patient death.The exact cause of this type of biliary complication remains unclear.To establish strategies for ITBL treatment or prevention,the risk factors of ITBL must be elucidated.The objective of this single-center retrospective study was to investigate the risk factors of ITBL in orthotopic liver transplantation(OLT)patients.

关键词：肝移植胆道病变血型预防方法风险因素危险因素存活率

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