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Rise and Fall of the First Financial Futures Market in China: The Case of Chinese Government Bond Futures

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China & World Economy 2009年第2期17卷 110-124页

作者： Chao Chen zhong- guo zhou Professor Fudan University Shanghai China. Associate Professor California State University Northridge USA.

This paper studies the rise and fall of the first financial futures market in China. We compare the characteristics in the Chinese Government bond futures market with those in the US T-bond futures market. They differ in market design and structure, market governance, margin requirements, position limits, delivery process, and the way in which the settlement price is calculated. Furthermore, with a unique dataset, we show that prior to maturities of government bond futures, traders began to accumulate significant amounts of long positions for several selected contracts without the intention to offset, forcing short position holders to either purchase deliverable bonds or offset futures at highly inflated prices, causing higher market volatility and price disequilibrium in both spot and futures markets. Arbitrage opportunity arises and the market eventually collapses. The lessons learned from the suspension of the Chinese Government bond futures market offer an invaluable learning experience.

关键词： arbitrage volatility Government bond futures price distortion short-selling restriction

Indoleamine-2,3-dioxygenase 1/cyclooxygenase 2 expression prediction for adverse prognosis in colorectal cancer

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World Journal of Gastroenterology 2018年第20期24卷 2181-2190页

作者： Wen-Juan Ma Xing Wang Wen-Ting Yan zhong-guo zhou Zhi-zhong Pan Gong Chen Rong-Xin Zhang State Key Laboratory of Oncology in South China Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Collaborative Innovation Center of Cancer Medicine Guangzhou 510060Guangdong ProvinceChina Tongji Medical College Huazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Hepatobiliary Surgery Cancer CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Department of Colorectal Surgery Cancer CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM To evaluate indoleamine-2,3-dioxygenase 1/cyclooxygenase 2(IDO1/COX2) expression as an independent prognostic biomarker for colorectal cancer(CRC) *** We retrospectively studied the medical records of 95 patients who received surgical resection from August 2008 to January 2010. All patients were randomly assigned to adjuvant treatment with or without celecoxib groups after surgery. We performed standard immunohistochemistry to assess the expression levels of IDO1/COX2 and evaluated the correlation of IDO1/COX2 with clinicopathological factors and overall survival(OS) *** The expression of nuclear IDO1 was significantly correlated with body mass index(P < 0.001), and IDO1 expression displayed no association with sex, age, tumor differentiation, T stage, N stage, carcinoembryonic antigen, cancer antigen 19-9, CD3+ and CD8+ tumor infiltrating lymphocytes, and COX2. In univariate analysis, we found that nuclear IDO1(P = 0.039), nuclear/cytoplasmic IDO1 [hazard ratio(HR) = 2.044, 95% confidence interval(CI): 0.871-4.798, P = 0.039], nuclear IDO1/COX2(HR = 3.048, 95%CI: 0.868-10.7, P = 0.0049) and cytoplasmic IDO1/COX2(HR = 2.109, 95%CI: 0.976-4.558, P = 0.022) all yielded significantly poor OS outcomes. Nuclear IDO1(P = 0.041), nuclear/cytoplasmic IDO1(HR = 3.023, 95%CI: 0.585-15.61, P = 0.041) and cytoplasmic IDO1/COX2(HR = 2.740, 95%CI: 0.764-9.831, P = 0.038) have significantly poor OS outcomes for the CRC celecoxib subgroup. In our multivariate Cox model, high coexpression of cytoplasmic IDO1/COX2 was found to be an independent predictor of poor outcome in CRC(HR = 2.218, 95%CI: 1.011-4.48, P = 0.047) and celecoxib subgroup patients(HR = 3.210, 95%CI: 1.074-9.590, P = 0.037).CONCLUSION Our results showed that cytoplasmic IDO1/COX2 coexpression could be used as an independent poor predictor for OS in CRC.

关键词： Prognosis Indoleamine-2,3-dioxygenase 1 Cyclooxygenase 2 Colorectal cancer

Risk factor analysis and clinical decision tree model construction for diabetic retinopathy in Western China

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World Journal of Diabetes 2022年第11期13卷 986-1000页

作者： Yuan-Yuan zhou Tai-Cheng zhou Nan Chen guo-zhong zhou Hong-Jian zhou Xing-Dong Li Jin-Rui Wang Chao-Fang Bai Rong Long Yu-Xin Xiong Ying Yang Department of Endocrinology and Metabolism The Sixth Affiliated Hospital of Kunming Medical UniversityThe People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina Department of Endocrinology and Metabolism Affiliated Hospital of Yunnan UniversityThe Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and Metabolism The Frist People’s Hospital of Anning CityAnning City 650300Yunnan ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is the driving force of blindness in patients with type 2 diabetes mellitus(T2DM).DR has a high prevalence and lacks effective therapeutic strategies,underscoring the need for early prevention and *** province,located in the southwest plateau of China,has a high prevalence of DR and an underdeveloped *** To build a clinical prediction model that will enable early prevention and treatment of *** In this cross-sectional study,1654 Han population with T2DM were divided into groups without(n=826)and with DR(n=828)based on fundus *** DR group was further subdivided into non-proliferative DR(n=403)and proliferative DR(n=425)groups.A univariate analysis and logistic regression analysis were conducted and a clinical decision tree model was *** Diabetes duration≥10 years,female sex,standing-or supine systolic blood pressure(SBP)≥140 mmHg,and cholesterol≥6.22 mmol/L were risk factors for DR in logistic regression analysis(odds ratio=2.118,1.520,1.417,1.881,and 1.591,respectively).A greater severity of chronic kidney disease(CKD)or hemoglobin A 1c increased the risk of DR in patients with *** the decision tree model,diabetes duration was the primary risk factor affecting the occurrence of DR in patients with T2DM,followed by CKD stage,supine SBP,standing SBP,and body mass index(BMI).DR classification outcomes were obtained by evaluating standing SBP or BMI according to the CKD stage for diabetes duration<10 years and by evaluating CKD stage according to the supine SBP for diabetes duration≥10 *** Based on the simple and intuitive decision tree model constructed in this study,DR classification outcomes were easily obtained by evaluating diabetes duration,CKD stage,supine or standing SBP,and BMI.

关键词： Diabetic retinopathy Type 2 diabetes Western China Decision tree

Expression of CC Chemokine Ligand 5 in Patients with Rheumatoid Arthritis and Its Correlation with Disease Activity and Medication

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Chinese Medical Sciences Journal 2009年第1期24卷 50-54页

作者： Ming-hui Yang Feng-xia Wu Chuan-mei Xie Yu-feng Qing Guang-rong Wang Xiao-lan guo zhong Tang Jing-guo zhou guo-hua Yuan Institute of Rheumatology and Immunology Affiliated Hospital of North Sichuan Medical College Nanchong Sichuan 637000 China

Objective To determine the levels of CC chemokine ligand 5 (CCL5) in serum and synovial fluid (SF) from patients with rheumatoid arthritis (RA) and their relations with disease activity and medication. Methods CCL5 in serum and SF was quantified by enzyme-linked immunosorbent assay (ELISA) in 28 RA patients and 21 osteoarthritis (OA) patients. In RA patients, the correlations of CCL5 levels in serum and SF with disease activity were analyzed. Meanwhile, the serum CCL5 levels among RA patients treated with disease-modifying antirheumatic drugs (DMARDs), Tripterygium Glucosides, and other Chinese herbs without disease-modifying effects were also compared. Results CCL5 levels in both serum and SF of RA patients were significantly higher than those of OA patients (P<0.05). Moreover, the level of CCL5 was higher in SF than that in serum of RA patients (P<0.01). Serum CCL5 level was correlated significantly with the number of swollen joints (r=0.3329, P<0.05), erythrocyte sedimentation rate (r=0.4001, P<0.05), and C reactive protein (r=0.3735, P<0.01). In addition, the level of CCL5 had a trend of lower in patients treated with DMARDs or Tripterygium Glucosides than those treated with other Chinese herbs, although the difference was not significant among those patients due to the small number of patients in each group. Conclusions In RA patients, the expression of CCL5 increases and correlates with some clinical and laboratory parameters of RA, which indicate that CCL5 plays an important role in RA and may serve as a useful marker of disease activity. DMARDs and Tripterygium Glucosides might exert their clinical effects through reducing CCL5 production in RA.

关键词： rheumatoid arthritis chemokine CC chemokine ligand 5

Left jackknife position:a novel position for laparoscopic hepatectomy

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Chinese Journal of Cancer 2017年第8期36卷 380-383页

作者： Jian-Cong Chen Rong-Xin Zhang Min-Shan Chen Li Xu Jin-Bin Chen Ke-Li Yang Yao-Jun Zhang zhong-guo zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hepatobiliary Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment Ⅵ, Ⅶ, or Ⅷ.Methods: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife *** located in segment Ⅵ, Ⅶ, or Ⅷ were assessed by preoperative dynamic computed tomography or magnetic resonance imaging. Operation time, intraoperative blood loss, postoperative fasting time, postoperative drainage time, major postoperative complications, and duration of postoperative hospital stay were ***: All surgeries were successfully completed. None of the patients required conversion to open surgery during the procedure, and no serious postoperative complications were *** median tumor size was 31 mm(range 23-41 mm) in diameter, the mean operation time was 166 ± 38 min, the mean intraoperative blood loss was220 ± 135 mL, and the median postoperative hospital stay was 4 days(range 2-7 days).Conclusions: For HCC located in segment Ⅵ, Ⅶ, or Ⅷ, laparoscopic hepatectomy with this novel position—the left jackknife position—is safe and effective during tumor resection by exposing a sufficient operating *** registration *** ID:

关键词： Laparoscopic hepatectomy Hepatocellular carcinoma Segment VI VII or VIII Left jackknife position

Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3240-3243页

作者： Yi-Hong Ling Meng-Ni Liu Yi-Xin Yin zhong-guo zhou Jie-Wei Chen Wei Wei Jing-Ping Yun Dan Xie Rong-Ping guo Mu-Yan Cai State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina Clinical Big Data Research Center Scientific Research CenterThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina

Dear Editor,Hepatocellular carcinoma(HCC)ranks the fourth most lethal cancer worldwide and over 50%of cases are diagnosed as multifocal HCC(mHCC)with dismal prognosis.1 mHCC displays more complicated intratumor hetero... 详细信息

关键词： alterations multifocal clinical

Tescalcin is an unfavorable prognosis factor that regulats cell proliferation and survival in hepatocellular carcinoma patients

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Cancer Communications 2020年第8期40卷 355-369页

作者： zhong-guo zhou Jin-Bin Chen Rong-Xin Zhang Ling Ye Jun-ChengWang Yang-Xun Pan Xiao-HuiWang Wen-Xuan Li Yao-Jun Zhang Li Xu Min-Shan Chen State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Oncology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong 510630P.R.China

Background:Hepatocellular carcinoma(HCC)is a major health problem and a primary cause of cancer-related death *** great advances have achieved recently by large-scale high-throughput analysis,the precise molecular mechanism underlying HCC progression remains to be clearly *** investigated the relationship between Tescalcin(TESC),a candidate oncogene,and clinicopathological features of HCC patients and explored the role of TECS in HCC ***:To identify new genes involved in HCC development,we analyzed The Cancer Genome Atlas liver cancer database,and TESC was selected for further *** tissue microarray analysis for TESC and its association with clinicopathological features were performed to investigate its clinical *** was knocked down by using short-hairpin *** proliferation was analyzed by WST-1 assay and cell *** apoptosis was tested by fluorescence-activated cell sorting.A subcutaneous xenograft tumor model in nude mice was established to determine the in vivo function of *** microarray was used to identify its molecular ***:TESC was significantly increased in HCC tissues compared with the adjacent normal liver *** expression of TESC was detected in 61 of 172 HCC patients by tissue *** tumor(>5 cm)and elevated total bilirubin were associated with high TESC expression(both P<0.050).In multivariate analysis,TESC was identified as an independent prognostic factor for short overall survival of HCC *** knockdown impaired HCC cell growth in vitro and in *** knockdown significantly increased cell apoptosis in HCC cell ***,Affymetrix microarray analysis revealed that TESC knockdown inhibited tumor proliferation-related pathways while activated cell death-related ***:TESC was identified as an independent prognostic factor for short overall survival of HCC patients,and was critical for HCC cell proli

关键词： Apoptosis Cell proliferation Hepatocellular carcinoma Oncogene Tescalcin

Impact of oral anti-hepatitis B therapy on the survival of patients with hepatocellular carcinoma initially treated with chemoembolization

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Chinese Journal of Cancer 2015年第5期34卷 205-216页

作者： zhong-guo zhou Xing-Rong Zheng Qian zhou Ming Shi Yao-Jun Zhang Rong-Ping guo Yun-Fei Yuan Min-Shan Chen Xiao-Jun Lin Xiang-Ming Lao Sheng-Ping Li Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen University Epidemiology Research Unit Translational Medicine Research CenterThe First Affiliated Hospital of Sun Yat-sen University

Introduction:Most hepatocellular carcinomas(HCC) develop in a background of underlying liver disease including chronic hepatitis ***,the effect of antiviral therapy on the long-term outcome of patients with hepatitis B virus(HBV)-related HCC treated with chemoembolization is *** study aimed to evaluate the survival benefits of anti-HBV therapy after chemoembolization for patients with HBV-related ***:A total of 224 HCC patients who successfully underwent chemoembolization were identified,and their survival and other relevant clinical data were ***-Meier and Cox regression analyses were performed to validate possible effects of antiviral treatment on overall survival(OS).Results:The median survival time(MST) was 15.9(95%confidence interval[CI],9.5-27.7) months in the antiviral group and 9.6(95%CI,7.8-13.7) months in the non-antiviral group(log-rank test,P = 0.044).Cox multivariate analysis revealed that antiviral treatment was a prognostic factor for OS(P = 0.008).Additionally,a further analysis was based on the stratification of the TNM tumor *** the subgroup of early stages,MST was significantly longer in the antiviral-treatment group than in the non-antiviral group(61.8 months[95%CI,34.8 months to beyond the follow-up period]versus 26.2[95%CI,14.5-37.7]months,P= 0.012).Multivariate analysis identified antiviral treatment as a prognostic factor for OS in the early-stage subgroup(P = 0.006).However,in the subgroup of advanced stages,MST of the antiviral-treated group was comparable to that of the non-antiviral group(8.4[95%CI,5.2-13.5]months versus 7.4[95%CI,5.9-9.3]months,P = 0.219).Multivariate analysis did not indicate that antiviral treatment was a significant prognostic factor in this ***:Antiviral treatment is associated with prolonged OS time after chemoembolization for HCC,especially in patients with early-stage tumors.

关键词：抗病毒治疗原发性肝癌乙肝病毒生存期肝细胞癌乙型肝炎病毒多因素分析肿瘤患者

Prospective,single-center cohort studyanalyzing the efficacy of complete laparoscopic resection on recurrent hepatocellular carcinoma

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Chinese Journal of Cancer 2016年第5期35卷 229-235页

作者： Jie Zhang zhong-guo zhou zhong-Xi Huang Ke-Li Yang Jian-Cong Chen Jin-Bin Chen Li Xu Min-Shan Chen Yao-Jun Zhang Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine

Background:Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma(HCC).However,few studies have examined the treatment of recurrent HCC in patients who received a prior *** present prospective study compared the clinical efficacy of laparoscopic surgery with conventional open surgery in HCC patients with postoperative tumor ***:We conducted a prospective study of 64 patients,all of whom had undergone open surgery once before,who were diagnosed with recurrent HCC between June 2014 and November *** laparoscopic group(n = 31)underwent laparoscopic hepatectomy,and the control group(n = 33) underwent conventional open *** time,intraoperative blood loss,surgical margins,postoperative pain scores,postoperative time until the patient could walk,anal exsufflation time,length of hospital stay,and inpatient costs were compared between the two *** patients were followed up for 1 year after surgery,and relapse-free survival was compared between the two ***:All surgeries were successfully *** conversion to open surgery occurred in the laparoscopic group,and no serious postoperative complications occurred in either *** significant difference in inpatient costs was found between the laparoscopic group and the control group(P = 0.079),but significant differences between the two groups were observed for operation time(116.7 ± 37.5 vs.148.2 ± 46.7 min,P = 0.031),intraoperative blood loss(117.5 ± 35.5 vs.265.9 ± 70.3 mL,P = 0.012),postoperative time until the patient could walk(1.6 ± 0.6vs.2.2 ± 0.8 days,P < 0.05),anal exsufflation time(2.1 ± 0.3 vs.2.8 ± 0.7 days,P = 0.041),visual analogue scale pain score(P < 0.05),postoperative hepatic function(P < 0.05),and length of hospital stay(4.5 ± 1.3 vs.6.0 ± 1.2 days,P = 0.014).During the 1-year postoperative follow-up period,6 patients in each group had recurrent HCC on the side of the initial operation,but no significant difference

关键词：英语教学教学理念英语阅读