检索结果-南通市图书馆

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

引用

World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng Zhou wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu wei-zhong Zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

引用

World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai Huang Yi Hu Xiao-Dong Zhou Cong He Jia-wei zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Betaine combined with traditional Chinese medicine ointment to treat skin wounds in microbially infected diabetic mice

引用

World Journal of Diabetes 2025年第1期16卷 104-120页

作者： Wen-Yan Xu Yuan-Yuan Dai Shi-Xian Yang Hao Chen Yan-Qiang Huang Pei-Pei Luo zhong-Heng wei Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Guangxi Zhuang Autonomous Region Engineering Research Center of Clinical Prevention and Control Technology and Leading Drug for Microorganisms with Drug Resistance in Border Ethnic Areas Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Wujin People’s Hospital Affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina

BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and *** To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic *** By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in *** skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of *** The MICs of betaine against microorganisms such as Staphylococcus aureus(***),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/*** root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of *** 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically *** diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound *** The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensit

关键词： Betaine ointment Staphylococcus aureus Drug resistance Skin infection Diabetes mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

面向可持续雨洪管理的低影响开发措施综合效益评估

引用

天津理工大学学报 2025年第1期41卷 126-133页

作者：訾妍钟炜天津理工大学管理学院

为满足低影响开发(low impact development, LID)组合在城市雨洪管理过程中良好的应用效果和经济效益，应用暴雨洪水管理模型(stormwater management model, SWMM)结果指标和项目全生命周期成本理论，构建不同LID组合方案下的环境-成本... 详细信息

为满足低影响开发(low impact development, LID)组合在城市雨洪管理过程中良好的应用效果和经济效益，应用暴雨洪水管理模型(stormwater management model, SWMM)结果指标和项目全生命周期成本理论，构建不同LID组合方案下的环境-成本效益综合评价系统，并通过数值模拟和数理分析相结合的方法评估各备选方案的综合效益。为验证理论模型的可行性，将9种不同布设比例的LID组合分别嵌入实际项目中进行模拟和评估。结果表明，综合效益最高的LID组合为“45%的绿色屋顶+15%的植草沟+30%的雨水花园+70%的透水铺装”,其径流总量削减率为52.83%、4类污染负荷削减率均为80%以上且每年消耗的总成本费用为22 416 350元。该评价体系为优化城市可持续雨洪管理提供新思路，同时为建设开发海绵城市提供方案指导。

关键词：低影响开发综合效益评估暴雨洪水管理模型可持续雨洪管理海绵城市

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Robust Sure Independence Screening for Ultrahigh Dimensional Non-normal Data

引用

Acta Mathematica Sinica,English Series 2014年第11期30卷 1885-1896页

作者： wei zhong Wang Yanan Institute for Studies in Economics Department of StatisticsSchool of EconomicsXiamen University

Sure independence screening（SIS） has been proposed to reduce the ultrahigh dimensionality down to a moderate scale and proved to enjoy the sure screening property under Gaussian linear ***,the observed response is often skewed or heavy-tailed with extreme values in practice,which may dramatically deteriorate the performance of *** this end,we propose a new robust sure independence screening（RoSIS） via considering the correlation between each predictor and the distribution function of the *** proposed approach contributes to the literature in the following three folds： First,it is able to reduce ultrahigh dimensionality ***,it is robust to heavy tails or extreme values in the ***,it possesses both sure screening property and ranking consistency property under milder ***,we demonstrate its excellent finite sample performance through numerical simulations and a real data example.

关键词： Robustness sure independence screening sure screening property ultrahigh dimensionality variable selection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Portfolio Optimization under Entropic Risk Management

引用

Acta Mathematica Sinica,English Series 2009年第7期25卷 1113-1130页

作者： wei zhong Department of Finance and Control Science School of Mathematical Sciences Fudan University Shanghai 200433 China

framework in the risk uniqueness In this paper, properties of the entropic risk measure are examined rigorously in a general This risk measure is then applied in a dynamic portfolio optimization problem, appearing management constraint. By considering the dual problem, we prove the existence and of the solution and obtain an analytic expression for the solution.

关键词： entropic risk measure portfolio optimization risk management

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Variable Selection for Structural Equation with Endogeneity

引用

Journal of Systems Science & Complexity 2018年第3期31卷 787-803页

作者： FAN Qingliang zhong wei Wang Yanan Institute for Studies in Economics (WISE) Department of StatisticsSchool of Economics and Fujian Key Laboratory of Statistical ScienceXiamen University

This paper studies variable selection problem in structural equation of a two-stage least squares （2SLS） model in presence of endogeneity which is commonly encountered in empirical economic studies. Model uncertainty and variable selection in the structural equation is an important issue as described in Andrews and Lu （2001） and Caner （2009）. The authors propose an adaptive Lasso 2SLS estimator for linear structural equation with endogeneity and show that it enjoys the oracle properties, i.e., the consistency in both estimation and model selection. In Monte Carlo simulations, the authors demonstrate that the proposed estimator has smaller bias and MSE compared with the bridge-type GMM estimator （Caner, 2009）. In a case study, the authors revisit the classic returns to education problem （Angrist and Krueger, 1991） using the China Population census data. The authors find that the education level not only has strong effects on income but also shows heterogeneity in different age cohorts.

关键词： Endogeneity structural equation 2SLS variable selection.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A weighted fuzzy C-means clustering method for hardness prediction

引用

Journal of Iron and Steel Research International 2023年第1期30卷 176-191页

作者： Yuan Liu Shi-zhong wei School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471003HenanChina School of Aerospace Engineering Zhengzhou University of AeronauticsZhengzhou 450015HenanChina National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan University of Science and TechnologyLuoyang 471003HenanChina

The hardness prediction model was established by support vector regression(SVR).In order to avoid exaggerating the contribution of very tiny alloying elements,a weighted fuzzy C-means(WFCM)algorithm was proposed for data clustering using improved Mahalanobis distance based on random forest importance values,which could play a full role of important features and avoid clustering center *** samples were divided into two *** top 10 features of each class were selected to form two feature subsets for better performance of the *** dimension and dispersion of features decreased in such feature *** four machine learning algorithms,SVR had the best performance and was chosen to *** hyper-parameters of the SVR model were optimized by particle swarm *** samples in validation set were classified according to minimum distance of sample to clustering centers,and then the SVR model trained by feature subset of corresponding class was used for *** with the feature subset of original data set,the predicted values of model trained by feature subsets of classified samples by WFCM had higher correlation coefficient and lower root mean square *** indicated that WFCM was an effective method to reduce the dispersion of features and improve the accuracy of model.

关键词： Hardness prediction weighted fuzzy C-means algorithm Feature selection Particle swarm optimization Support vector regression Dispersion reduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Discrete weighted Hardy Inequalities with Different Kinds of Boundary Conditions

引用

Acta Mathematica Sinica,English Series 2016年第9期32卷 993-1013页

作者： zhong wei LIAO School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

This paper studies the weighted Hardy inequalities on the discrete intervals with four different kinds of boundary conditions. The main result is the uniform expression of the basic estimate of the optimal constant with the corresponding boundary condition. Firstly, one-side boundary condition is considered, which means that the sequences vanish at the right endpoint （ND-case）. Based on the dual method, it can be translated into the case vanishing at left endpoint （DN-case）. Secondly, the condition is the case that the sequences vanish at two endpoints （DD-case）. The third type of condition is the generality of the mean zero condition （NN-case）, which is motivated from probability theory. To deal with the second and the third kinds of inequalities, the splitting technique is presented. Finally, as typical applications, some examples are included.

关键词： weighted Hardy inequality one-side boundary condition vanishing at two endpoints,mean zero basic estimates dual method splitting technique

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Composite Quantile Estimation for Kink Model with Longitudinal Data

引用

Acta Mathematica Sinica,English Series 2023年第3期39卷 412-438页

作者： Chuang WAN wei zhong Ying FANG School of Statistics and Data Science Nankai UniversityTianjin 300071P.R.China MOE Key Lab of Econometrics WISEDepartment of Statistics and Data ScienceSchool of EconomicsXiamen UniversityXiamen 361000P.R.China

Kink model is developed to analyze the data where the regression function is two-stage piecewise linear with respect to the threshold covariate but continuous at an unknown kink *** quantile regression for longitudinal data,kink point where the kink effect happens is often assumed to be heterogeneous across different ***,the kink point tends to be the same across different quantiles,especially in a region of neighboring quantile *** such homogeneity information could increase the estimation efficiency of the common kink *** this paper,we propose a composite quantile estimation approach for the common kink point by combining information from multiple neighboring *** normality of the proposed estimator is *** addition,we also develop a sup-likelihood-ratio test to check the existence of the kink effect at a given quantile level.A test-inversion confidence interval for the common kink point is also developed based on the quantile rank score *** simulation studies show that the proposed composite kink estimator is more efficient than the single quantile regression *** also illustrate the proposed method via an application to a longitudinal data set on blood pressure and body mass index.

关键词： Asymptotical normality composite quantile estimation estimation efficiency kink design model longitudinal data

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：