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Malignant tumors associated with Peutz-Jeghers syndrome: Five cases from a single surgical unit

World Journal of Clinical Cases 2020年第2期8卷 264-275页

作者： Zhi Zheng Rui Xu Jie Yin Jun Cai Guang-Yong Chen Jun Zhang zhong-tao Zhang Department of General Surgery Beijing Friendship Hospital Capital Medical University

BACKGROUND Peutz-Jeghers syndrome(PJS) is an autosomal dominant inherited disease easily causing secondary malignant changes without effective *** To assess the clinical characteristics, diagnosis, and treatment of malignant changes secondary to *** The clinical data of five patients with malignant changes secondary to PJS diagnosed and treated at Beijing Friendship Hospital from June 2014 to January 2017 were retrospectively analyzed;the follow-up ended in May *** There were three male and two female patients with an average age of 43.6 *** obstruction, intussusception, and abdominal pain were the first symptoms. Computed tomography and gastrointestinal imaging combined with endoscopy helped evaluate the depth of tumor infiltration and determine the need for radical resection. Three patients underwent surgery. Postoperative pathology confirmed adenocarcinoma, genetic test indicated STK11 mutation,and the patients received chemotherapy, including one who succumbed to tumor progression 6 months post-surgery. Other two patients underwent endoscopic resection, and postoperative pathology confirmed high grade intraepithelial neoplasia. The surviving patients had no recurrence by May *** Endoscopy combined with computed tomography and gastrointestinal imaging is of great significance in the diagnosis and treatment of PJS, and pathological examination and gene detection are the gold standards for detecting malignant changes secondary to PJS. Some malignant polyps can be removed under endoscopy, and surgery is feasible when malignant polyps cannot be remove dunder an endoscope. For patients unable to achieve R0 resection, clinical symptoms should be relieved, and postoperative adjuvant chemotherapy could improve long-term prognosis. Meanwhile, close and regular surveillance should be conducted to prevent severe complications.

关键词： Peutz-Jeghers syndrome Malignant Diagnosis Surgery Treatment

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Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum

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Chinese Journal of Natural Medicines 2018年第11期16卷 866-870页

作者： SHU Yan YIN Tian-Peng WANG Jia-Peng GAN Dong ZHANG Qin-Yan CAI Le DING zhong-tao Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province School of Chemical Science and Technology Yunnan University Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine Zunyi Medical University Zhuhai Campus

In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A–C(1–3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses(IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl_3 were also measured.

关键词： Aconitum brevicalcaratum Ranunculaceae Diterpenoid alkaloid Brochyponine

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Evolutionary analysis of allotetraploid hybrids of red crucian carp×common carp,based on ISSR,AFLP molecular markers and cloning of cyclins genes

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Chinese Science Bulletin 2009年第16期54卷 2849-2861页

作者： LIU LiangGuo YAN JinPeng LIU ShaoJun LIU Dong YOU CuiPing zhong Huan tao Min LIU Yun Key Laboratory of Protein Chemistry and Fish Developmental Biology of Ministry of Education College of Life Sciences HunanNormal University Changsha 410081 China

The allotetraploid hybrids of red crucian carp × common carp are the first reported artificially cultured polyploid fish with bisexual fertility and stable inheritance in vertebrate. Using ISSR and AFLP markers and the cyclins genes, the genomes and cyclin gene sequence changes were analyzed between the allotetraploid hybrids and their parents. The results indicated that the allotetraploids inherited many genetic characteristics from their parents and the genetic characteristics were stable after 15 generations. However, the allotetraploids had a closer genetic relationship with their original female parents and represented a bias toward the maternal progenitor. DNA fingerprinting analysis showed that the allotetraploids had undergone sequences deletion from their original parents and that the deleted sequences were mostly from the male parent's genome. Some non-parental bands were found in the allotetraploid hybrids. Sequences analysis of the cyclin A1 and B1 genes showed nonsynonymous substitutions of single nucleotides in codons that were different from their original parents, leading to non-parental amino acid loci. We speculate that the non-additivity in the allotetraploids, compared with their progenitors, could be an adjustment to the genomic shock from heterozygosity and polyploidy, allowing maintenance of genetic stability.

关键词：异源四倍体鲫鲤细胞周期蛋白基因克隆 AFLP分子标记 ISSR 杂交种 DNA指纹图谱分析进化

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A new cyclopeptide from Dianthus caryophyllus

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Chinese Chemical Letters 2008年第2期19卷 193-195页

作者： Fei Li Feng Mei Zhang Ya Bin Yang Xue Qiong Yang Qiu E. Cao zhong tao Ding Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of Education School of Chemical Science and Technology Yunnan University # 2 Green Lake North Road Kunming 650091 China

A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo （-Thr-Gly-Pro-Tyr-Phe-）（1） and cyclo （-Ala-Gly-Ser-IIe-P... 详细信息

关键词： Caryophyllaceae Dianthus caryophyllus Cyclopeptide Caryophllusin A

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Interfacial reaction between AZ91D magnesium alloy melt and mild steel under high temperature

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China Foundry 2024年第2期21卷 159-167页

作者： Jia-hong Dai Jian-yue Zhang Bin Jiang Xiang-jun Xu zhong-tao Jiang Hong-mei Xie Qing-shan Yang Guo-qing Zhang College of Materials Science and Engineering Yangtze Normal UniversityChongqing 408100China National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Chongqing Jiulongyuan High-tech Industry Group Co. Ltd.Chongqing 400080China Loncin Industry Co. Ltd.Chongqing 400080China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing University of Arts and SciencesChongqing 402160China School of Metallurgy and Material Engineering Chongqing University of Science and TechnologyChongqing 401331China

The metallurgical quality control of magnesium(Mg)and Mg alloys in melting process is required to ensure a satisfied mechanical and corrosion performance,while the typical used steel crucible introduces impurities and interfacial interaction during melting ***,a systematic study about impurities diffusion and interfacial interaction between molten Mg and steel is *** the present study,the interfacial reaction between molten AZ91D Mg alloy and mild steel during melting process was investigated with the melting temperatures of 700℃,750℃ and 800℃.The results show that Al(Fe,Mn)intermetallic layer is the intermetallic primarily formed at the interfaces of AZ91D melt and mild ***,Al_(8)(Mn,Fe)5is indexed between Al(Fe,Mn)and ***_(3)C appears between the mild steel and Al(Fe,Mn)at 700℃ and 750℃,but absent at 800℃ due to the increased solubility of carbon in Mg *** is found that the growth of the intermetallic layer is controlled by diffusion mechanism,and Al and Mn are the dominant diffusing species in the whole interfacial reaction *** measuring the thickness of different layers,the growth constant was *** increases from 1.89(±0.03)×10^(-12)m^(2)·s^(-1)at 700℃ to 3.05(±0.05)×10^(-12)m^(2)·s^(-1)at 750℃,and 5.18(±0.05)×10^(-12)m^(2)·s^(-1)at 800℃.Meanwhile,the content of Fe is linearly increased in AZ91D with the increase of holding time at 700℃ and 750℃,while it shows a significantly increment after holding for 8 h at 800℃,indicating holding temperature is more crucial to determine the Fe content of AZ91D than holding time.

关键词： AZ91D mild steel interface reaction intermetallic growth kinetics

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复杂地形地质条件岩土工程勘察实践与探索

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岩土工程学报 2007年第8期29卷 1178-1183页

作者：陶忠平云南省水利水电勘测设计研究院云南昆明650021

在复杂的地形地质条件下,搞水利水电工程建设,面临的就是难字,特别是在勘测设计初期,更是困难重重,然而,查明工程区复杂的工程地质条件及水文地质条是勘测人员的主要任务,也是工程建设项目是否可行的重要基础工作。如何在复杂的地形地... 详细信息

在复杂的地形地质条件下,搞水利水电工程建设,面临的就是难字,特别是在勘测设计初期,更是困难重重,然而,查明工程区复杂的工程地质条件及水文地质条是勘测人员的主要任务,也是工程建设项目是否可行的重要基础工作。如何在复杂的地形地质条件下查明工程区工程地质、水文地质条件,是地质工作者一直潜心研究的一个重要课题。本文就复杂的地形地质环境中水利水电工程地质勘察方法、分析与评价或探索性的工作思路作一简要的论述。

关键词：地形地质环境工程勘察实践与探索

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Laparoscopic surgery in the mainland of China

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Chinese Medical Journal 2009年第19期122卷 2226-2228页

作者： GUO Wei ZHANG zhong-tao Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Laparoscopic surgery in the mainland of China began ,in 1991, when Dr. XUN Zu-wu from the Second Hospital of Qujing City in Yunnan Province successfully performed the first laparoscopic cholecystectomy （LC）. From then on, the implementation of laparoscopic techniques has been increased rapidly all over China. These techniques have been used nearly in all fields of general surgery including colorectal, gastric, hepatic, pancreatic, thyroid and mammary surgeries.

关键词： laparoscopic cholecystectomy Yunnan Province implementation techniques China

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Impact of interest rate changes on Chinese consumer behavior

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Ecological Economy 2018年第3期11卷 236-240页

作者： WEN zhong-tao School of Economics Tianjin University of Commerce

In 2015, The Central Bank cut interest rates six times in a row. There are two main purposes: one is to reduce the interest burden on corporate loans, and stimulate corporate investment. Second, to reduce interest income on residential deposits, and stimulate residents to increase current consumption. However, many empirical data prove that although the effect of interest rate decline on stimulating corporate investment is more obvious, the effect of stimulating residents to increase current consumption is not obvious, and household savings continue to grow rapidly. This shows that the main factor affecting the current consumption of residents is no longer the bank's deposit interest rate, but the irreplaceability of future consumer goods for current consumer goods, income restrictions and other economic factors that can affect cross-time consumption. This paper is based on the theory of intertemporal utility maximization. The empirical analysis of the impact of the rate change on China's residents' consumption, looking for the reasons why residents' consumption is not sensitive to changes in the rate, and put forward corresponding countermeasures and suggestions.

关键词： intertemporal choice rate change resident consumption

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Study on dynamic mechanical properties of high nitrogen steels

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Defence Technology（防务技术） 2018年第5期14卷 496-502页

作者： Cheng Miao tao zhong Hai-ling Wu Li-hong Bai Wei Yuan Lin Yang Yan-li Wang Lin-yang Guo No.52 Institute of China Ordnance Industries Yantai264003China National Key Laboratory of Science and Technology on Materials Under Shock and Impact Yantai264003China Jiangsu Shuguang Opto-electronics Co. LTDYangzhou225009China

Reliable dynamic mechanical properties of high nitrogen steels are necessary for the design and assessment of armor structures subject to impact and blast. A series of experiments, based on Hopkinson bar techniques, were conducted and described in this study. The dynamic compression, tensile and shear properties of high nitrogen steel had been tested, and the stress-strain curves under high strain rates were obtained. The results have been showed as follows: High nitrogen steel has a remarkable strain rate strengthening effect. Compared to the static curves, the constitutive curves of dynamic tension and compression move upper. The dynamic compressive yield strength of high nitrogen steel increases first and then decreases with the increase of strain rate, and the yield strength varies in the range of 1465-1549 MPa within the range of 1147-2042 s^(-1) strain rate; The tensile strength of high nitrogen steel increases with the increase of strain rate. When the strain rate is greater than 1341 s^(-1), the tensile strength will not increase and the curve tends to be gentle. The pure shear yield strength of the high nitrogen steel is above 800 MPa.

关键词： High nitrogen steels Hopkinson bar Dynamic compression Dynamic tension Dynamic shear

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Synthesis and Anticancer Activity of 4b-Triazolepodophyllotoxin Glycosides

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Natural Products and Bioprospecting 2015年第2期5卷 83-90页

作者： Cheng-Ting Zi Gen-tao Li Yan Li Jun Zhou zhong-tao Ding Zi-Hua Jiang Jiang-Miao Hu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Key Laboratory of Medicinal Chemistry for Nature Resource Ministry of EducationSchool of Chemical Science and TechnologyYunnan UniversityKunming 650091China Department of Chemistry Lakehead University955 Oliver RoadThunder BayON P7B 5E1Canada

A series of novel 4b-triazole-podophyllotoxin glycosides were synthesized by utilizing the Click *** of cytotoxicity against a panel of five human cancer cell lines(HL-60,SMMC-7721,A-549,MCF-7,SW480)using MTT assay shows that most of these compounds show weak *** was observed that compound 16 shows the highest activity with IC50 values ranging from 2.85 to 7.28 lM,which is more potent than the control drugs etoposide and cisplatin against four of five cancer cell lines *** 16 is characterized with an a-D-galactosyl residue directly linked to the triazole ring and a 40-OH group on the E ring of the podophyllotoxin *** investigation of representative compound indicates that incorporation of a sugar moiety seems to improve the chemical stability of the podophyllotoxin scaffold.

关键词： Podophyllotoxin 4b-Triazole-podophyllotoxin Glycosides Click reaction Anticancer Synthesis

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