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Association between serum estradiol level and appendicular lean mass index in middle-aged postmenopausal women

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World Journal of Orthopedics 2024年第1期15卷 45-51页

作者： Fang Jin Yan-Fei Wang zhong-Xin zhu Department of Osteoporosis Care and Control Xiaoshan Affiliated Hospital of Wenzhou Medical UniversityHangzhou 311200Zhejiang ProvinceChina

BACKGROUND Previous studies investigating the association between loss of estrogen at menopause and skeletal muscle mass came to contradictory *** To evaluate the association between serum estradiol level and appendicular lean mass index in middle-aged postmenopausal women using population-based *** This study included 673 postmenopausal women,aged 40-59 years,from the National Health and Nutrition Examination Survey between 2013 and *** multivariable linear regression models were used to evaluate the association between serum E2 Level and appendicular lean mass index(ALMI).When non-linear associations were found by using weighted generalized additive model and smooth curve fitting,two-piecewise linear regression models were further applied to examine the threshold *** There was a positive association between serum E2 level and *** to individuals in quartile 1 group,those in other quartiles had higher ALMI *** inverted U-shaped curve relationship between serum E2 Level and ALMI was found on performing weighted generalized additive model and smooth curve fitting,and the inflection point was identified as a serum E2 level of 85 pg/*** Our results demonstrated an inverted U-shaped curve relationship between serum E2 levels and ALMI in middle-aged postmenopausal women,suggesting that low serum E2 levels play an important in the loss of muscle mass in middleaged postmenopausal women.

关键词： Estradiol Skeletal muscle Menopause Health The National Health and Nutrition Examination Survey

Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2380-2393页

作者： Qi-Feng Wang Zong-Wei Li Hai-Feng Zhou Kun-zhong zhu Ya-Jing Wang Ya-Qin Wang Yue-Wei Zhang Department of Hepatobiliary Pancreatic Center Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua UniversityBeijing 102218China Department of Hepatobiliary and Pancreatic Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina

Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy *** review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical *** of October 25,2023,51 articles have been retrieved based on keyword predictions and *** eligible articles were selected for inclusion in this *** literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging *** above indicators and their combined forms showed excellent predictive effects in retrospective *** review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Prediction Prognosis Imaging Biomarkers Genomics

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谷氨酰胺代谢抑制剂调节肿瘤免疫的研究进展

中国新药与临床杂志 2024年第8期43卷 568-573页

作者：朱仲玲史业辉天津医科大学肿瘤医院药理研究室/国家恶性肿瘤临床医学研究中心/天津市恶性肿瘤临床医学研究中心/天津市肿瘤防治重点实验室天津300060

谷氨酰胺(Gln)是机体关键的碳元素和氮元素供体以及能量来源,不仅对肿瘤的发生发展至关重要,还参与调节免疫细胞的发育和活化。快速增殖的肿瘤细胞会从肿瘤微环境中大量摄取营养物质,由此导致的Gln匮乏会显著抑制T细胞的活性和功能,诱导... 详细信息

谷氨酰胺(Gln)是机体关键的碳元素和氮元素供体以及能量来源,不仅对肿瘤的发生发展至关重要,还参与调节免疫细胞的发育和活化。快速增殖的肿瘤细胞会从肿瘤微环境中大量摄取营养物质,由此导致的Gln匮乏会显著抑制T细胞的活性和功能,诱导T细胞耗竭。Gln抗代谢物、谷氨酰胺酶抑制剂、Gln摄取抑制剂等Gln代谢抑制剂能够显著抑制肿瘤细胞的生长增殖,同时不会加剧T细胞耗竭,反而可通过调控免疫检查点表达、细胞外基质结构重塑、肿瘤相关巨噬细胞极化等多重机制改善肿瘤微环境,增强抗肿瘤免疫反应。Gln代谢抑制剂与免疫检查点抑制剂联合使用还可发挥协同增效的作用。

关键词：谷氨酰胺肿瘤微环境免疫靶向药物

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乡村小规模学校空间的教育价值及其实现

教学与管理 2024年第17期 6-9页

作者：朱忠琴山东师范大学教育学部

乡村小规模学校有着丰富的乡村自然资源、文化资源可用于学校教育生产。从空间社会学视角审视乡村小规模学校面临的空间环境与发展路径具有很强的现实性。乡村小规模学校的物理空间位置不合理,办学空间封闭,与乡村融合不足,学校特色不明... 详细信息

乡村小规模学校有着丰富的乡村自然资源、文化资源可用于学校教育生产。从空间社会学视角审视乡村小规模学校面临的空间环境与发展路径具有很强的现实性。乡村小规模学校的物理空间位置不合理,办学空间封闭,与乡村融合不足,学校特色不明显;课程与教学设置方面未能充分利用校内外教育资源和教学空间场所;学校师生并未与学校、村落形成紧密的人际空间。乡村小规模学校发展需要充分审视学校与乡村的关系,充分开发乡村学校的特有空间资源,增强乡村师生与乡村学校以及乡村的亲密关系。

关键词：乡村小规模学校空间社会学空间生产乡土文化

Velocity analysis of supersonic jet flow in double-cone ignition scheme

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Chinese Physics B 2024年第6期33卷 460-465页

作者：朱仲源张成龙李英骏 School of Science China University of Mining and TechnologyBeijing 100083China State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China Double-cone ignition(DCI)joint team State Key Laboratory for Geomechanics and Deep Underground EngineeringChina University of Mining and TechnologyBeijing 100083China

In the double-cone ignition schemes(DCIS), the deuterium–tritium target shell is ablated and compressed by a highpower nanosecond laser in Au-cones to generate plasmas. Under the actions of spherically symmetric compression and acceleration along the Au cone, they will be ejected out of the cone mouth and collide with each other. The plasmas experience conversion from kinetic energy to internal energy at the vertex of the geometric center of two Au cones that are symmetric to each other, because of which high-density fusion plasmas are preheated. This key physical process has undergone experimental verification on the Shenguang-II upgraded facility in China. Apparently, the improvement and optimization of the velocity of plasmas in hypersonic jet flow at the cone mouth are crucial for the success of the DCIS. In the DCIR7 experiment of the Shenguang-II upgraded facility, a velocity yield of approximately 130–260 km/s was achieved for the plasmas at the cone mouth, with a result of nearly 300 km/s based on numerical simulation. In this paper, theoretical analysis is performed as regards the process, in which target shells are ablated and compressed by laser to generate highvelocity plasmas ejected through jet flow. Based on this analysis, the formula for the velocity of plasmas in supersonic jet flow at the cone mouth is proposed. This study also provides measures that are more effective for improving the kinetic energy of plasmas and optimizing energy conversion efficiency, which can serve as theoretical references for the adjustment and optimization of processes in subsequent experiments.

关键词： double-cone ignition(DCI) plasma hydrodynamics laser fusion

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正融冰川碎屑冰冻体剪切强度劣化机制研究

岩土力学 2024年第1期45卷 197-212页

作者：孟秋杰宋宜祥黄达马文钟助岑夺丰河北工业大学土木与交通学院天津300401 长安大学地质工程与测绘学院陕西西安710064 北京科技大学土木与资源工程学院北京100083

受到气候变暖的影响,青藏高原冰川剪切滑动带中的碎屑冰冻体存在融化风险,这严重影响了冰川的抗剪强度和稳定性。为了研究融化过程对碎屑冰冻体剪切力学特性的影响,引入融冰率定量评估融化程度,对正融碎屑冰冻体试样开展了室内直剪试验... 详细信息

受到气候变暖的影响,青藏高原冰川剪切滑动带中的碎屑冰冻体存在融化风险,这严重影响了冰川的抗剪强度和稳定性。为了研究融化过程对碎屑冰冻体剪切力学特性的影响,引入融冰率定量评估融化程度,对正融碎屑冰冻体试样开展了室内直剪试验。基于试验结果提出了正融碎屑冰冻体的有限-离散元数值模型并进行了对比验证,研究了融冰率和碎石含量对碎屑冰冻体剪切力学行为的影响规律。结果表明:融化过程显著降低了峰值剪切强度、黏聚力和内摩擦角;强度参数与融冰率的关系可用线性准则表达;正碎屑冰冻体剪切强度急剧劣化的主因是孔隙冰融化导致的冻土-孔隙冰界面黏聚力降低;当融冰率从2%增加到4%,试样变形模式由应变软化过渡为应变硬化,破坏模式由粗糙的“锯齿状”过渡为平滑的“圆弧状”;随着碎石含量增加,碎屑冰冻体剪切强度明显降低,降低幅度随融冰率的增加而减小。该研究可作为冰川稳定性评价的有益补充。

关键词：碎屑冰冻体融化直剪试验剪切力学行为有限-离散元

Paragonimiasis misdiagnosed as liver abscess:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4807-4812页

作者： Ying-Qi Zheng Gong-Bing Guo Mei-Fang Wang He-zhong zhu Chan Zhou Lin-Hong Li Lu Zhang Yu-Quan Liu Department of General Practice Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Pulmonary and Critical Care Medicine Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUNDParagonimiasis is a typical food-borne zoonotic disease. Hosts acquire Paragonimusinfection through the ingestion of raw or undercooked crayfish and *** clinical manifestations of the disease are varied, and it is often misdiagnosedor missed. The diagnosis of paragonimiasis should be considered *** is the first choice for treatment, and albendazole can beused in combination with repeated courses in severe *** SUMMARYWe report a case of liver paragonimiasis that was misdiagnosed as an abscess. Thepatient presented with fatigue and poor appetite for 2 months, and was diagnosedwith liver abscess in the local hospital. After 6 months, the patient visited ourhospital because of recurrent abdominal pain and was diagnosed with liverparagonimiasis based on epidemiological history, clinical presentations, andlaboratory findings. He was treated with praziquantel (25 mg/kg) three times aday for 3 days;however, the symptoms still presented after treatment. He wastreated with oral praziquantel and albendazole for one further course. Follow-upsuggested that the treatment was effective and the symptoms *** combination of albendazole and praziquantel may improve the therapeuticefficacy of paragonimiasis.

关键词： Liver paragonimiasis Liver abscess Misdiagnosis Albendazole Praziquantel Case report

水稻OsCNGC10基因抗倒伏性以及抗旱性功能研究

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作物学报 2024年第5期50卷 1351-1360页

作者：朱忠林文月周棋巫燕飞杜雪竹盛锋湖北大学生命科学学院/省部共建生物催化与酶工程国家重点实验室湖北武汉430062 湖北洪山实验室湖北武汉430062

环核苷酸门控离子通道是一种配体门控的阳离子通道,存在于动物和植物体内,是真核生物信号级联反应的重要组成部分。本研究利用水稻环核苷酸门控离子通道(cyclic nucleotide-gated channel,OsCNGC10)基因,构建了超表达载体pU1301-CNGC10-... 详细信息

环核苷酸门控离子通道是一种配体门控的阳离子通道,存在于动物和植物体内,是真核生物信号级联反应的重要组成部分。本研究利用水稻环核苷酸门控离子通道(cyclic nucleotide-gated channel,OsCNGC10)基因,构建了超表达载体pU1301-CNGC10-Flag和双靶点敲除载体pRGEB32-CRISPR/cas9-cngc10,通过农杆菌介导的遗传转化法获得敲除和过表达材料,并从T2代中分离到纯合植株oscngc10-2及OE-CNGC10-6。转基因植株茎秆特性以及抗倒伏性分析表明,突变体oscngc10-2茎秆强度和抗倒伏性增强;茎秆细胞壁组织切片以及组织成分分析则表明突变体oscngc10-2植株抗倒伏性增强是由于茎秆细胞壁茎壁厚度、薄壁组织细胞丰度以及木质素含量增加所致;过表达OsCNGC10降低了茎秆壁厚、茎秆木质素含量以及茎秆细胞壁细胞丰度,敲除OsCNGC10增加了茎秆木质素含量且增加了茎秆细胞壁薄壁细胞丰度,初步证明OsCNGC10与水稻茎秆细胞壁成分合成相关,负调控水稻抗倒伏性;T2代田间试验结果表明,与野生型相比,突变体oscngc10-2植株的株高、有效穗、穗长、穗粒数、结实率、千粒重和单株产量等农艺性状显著提升;苗期干旱胁迫实验结果表明,在干旱胁迫下,OsCNGC10基因缺陷型植株体内丙二醛(MDA)含量积累速度加快,且无法形成足够的游离脯氨酸,而过表达OsCNGC10植株在遭受干旱胁迫时,体内游离脯氨酸(Pro)含量大量升高,且MDA积累速度相对变慢,初步说明OsCNGC10正向调控水稻苗期抗旱性。本研究结果表明水稻OsCNGC10可能在水稻抗倒伏及抗旱方面有潜在功能,为培育抗倒伏且高产的水稻新品种提供了理论基础和新的种质资源。

关键词：水稻 OsCNGC10 抗倒伏抗旱细胞壁

TIMSS 2023数学测评:“特点”“框架内容”与“启示”

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数学教育学报 2024年第3期33卷 77-81页

作者：朱忠明张令伟上海师范大学教育学院上海200234 石家庄学院理学院河北石家庄050035

TIMSS是IEA组织的测评参与国与地区学生数学与科学学业成就趋势的一项重要国际比较项目.分析TIMSS 2023数学测评,发现其“变”与“不变”:在测评方式上,采取全数字化测评;在测评设计上,引入群体适应性测试设计;在测评基调上,更加重视问... 详细信息

TIMSS是IEA组织的测评参与国与地区学生数学与科学学业成就趋势的一项重要国际比较项目.分析TIMSS 2023数学测评,发现其“变”与“不变”:在测评方式上,采取全数字化测评;在测评设计上,引入群体适应性测试设计;在测评基调上,更加重视问题解决的情境及过程;在测评维度上,仍综合考查内容和认知两个维度,稳中微调.这对中国中小学数学学业质量监测乃至教学实践都具有一定的启示:在借鉴国际共识,凸显时代诉求的理念下,丰富测评方式和测评内涵,迈向多模态信息化方向;关注问题情境和解决过程,落实学生发展核心素养;立足课程模型和知识技能,关注学生高阶思维发展.

关键词： TIMSS 2023 数学测评全数字化测评群体适应性测试问题解决情境