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Hepatitis C virus vaccine development: old challenges and new opportunities

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National Science Review 2015年第3期2卷 285-295页

作者： Dapeng Li zhong huang Jin zhong Key Laboratory of Molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological SciencesChinese Academy of Sciences Institute Pasteur of Shanghai Chinese Academy of Sciences

Hepatitis C virus(HCV), an enveloped positive-sense single-stranded RNA virus, can cause chronic and end-stage liver diseases. Approximately 185 million people worldwide are infected with HCV. Tremendous progress has been achieved in the therapeutics of chronic hepatitis C thanks to the development of direct-acting antiviral agents(DAAs), but the worldwide use of these highly efective DAAs is limited due to their high treatment cost. In addition, drug-resistance mutations remain a potential problem as DAAs are becoming a standard therapy for chronic hepatitis C. Unfortunately, no vaccine is available for preventing new HCV infection. herefore, HCV still imposes a big threat to human public health, and the worldwide eradication of HCV is critically dependent on an efective HCV vaccine. In this review, we summarize recent progresses on HCV vaccine development and present our views on the rationale and strategy to develop an efective HCV vaccine.

关键词： hepatitis C virus vaccine prophylactic vaccine therapeutic vaccine neutralizing antibody

Strong Coupling of Light with Extremely Thin Non-Close-Packing Colloidal Crystals:Experimental and Theoretical Studies

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Chinese Physics Letters 2013年第4期30卷 217-220页

作者： huang zhong DONG Wen Department of Physics and Jiangsu Key Laboratory of Thin Films Soochow UniversitySuzhou 215006

Single and double layers of non-close-packing silica colloidal crystals are prepared using the self-assembly and chemical etching methods.A modulation of size reduction of 21%of silica particles is reported while sustaining the ordering of the *** a result of the coupling between light and the two-dimensional(2D)photonic structures,several dips are clearly observed in the measured optical transmission *** decreasing the dielectric particle size,the transmission dips undergo blue shifts and simultaneously become *** measured transmission spectra are in good agreement with the theoretical calculations by taking the energy dissipation of the semi-infinite dielectric substrate for the 2D photonic crystals.

关键词： spectra. methods. dielectric

Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistula

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World Journal of Stem Cells 2023年第8期15卷 866-875页

作者： Fang Cheng huang zhong zhong huang Zhi Li Division of Gastroenterology Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina Department of Gastroenterology Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Local mesenchymal stem cell(MSC)therapy for complex perianal fistulas(PFs)has shown considerable ***,the long-term safety and efficacy of MSC therapy in complex PFs remain *** To explore the long-term effectiveness and safety of local MSC therapy for complex *** Sources included the PubMed,EMBASE,and Cochrane Library databases.A standard meta-analysis was performed using RevMan *** After screening,6 studies met the inclusion *** therapy was associated with an improved long-term healing rate(HR)compared with the control condition[odds ratio(OR)=2.13;95%confidence interval(95%CI):1.34 to 3.38;P=0.001].Compared with fibrin glue(FG)therapy alone,MSC plus FG therapy was associated with an improved long-term HR(OR=2.30;95%CI:1.21 to 4.36;P=0.01).When magnetic resonance imaging was used to evaluate fistula healing,MSC therapy was found to achieve a higher long-term HR than the control treatment(OR=2.79;95%CI:1.37 to 5.67;P=0.005).There were no significant differences in long-term safety(OR=0.77;95%CI:0.27 to 2.24;P=0.64).CONCLUSION Our study indicated that local MSC therapy promotes long-term and sustained healing of complex PFs and that this method is safe.

关键词： Complex perianal fistula Mesenchymal stem cells Long-term evaluation Meta-analysis

TAILORED FINITE CELL METHOD FOR SOLVING HELMHOLTZ EQUATION IN LAYERED HETEROGENEOUS MEDIUM

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Journal of Computational Mathematics 2012年第4期30卷 381-391页

作者： zhong-yi huang Xu Yang Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematics Courant Institute of Mathematical Sciences New York UniversityNew York NY 10012 USA

In this paper, we propose a tailored finite cell method for the computation of two- dimensional Helmholtz equation in layered heterogeneous medium. The idea underlying the method is to construct a numerical scheme based on a local approximation of the solution to Helmholtz equation. This provides a computational tool of achieving high accuracy with coarse mesh even for large wave number （high frequency）. The stability analysis and error estimates of this method are also proved. We present several numerical results to show its efficiency and accuracy.

关键词： Tailored finite cell method Helmholtz equation Heterogeneous media Som-merfeld condition.

Experimental investigation on the cuttings formation process and its relationship with cutting force in single PDC cutter tests

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Petroleum Science 2023年第3期20卷 1779-1787页

作者： Xian-Wei Dai zhong-Wei huang Tao huang Peng-Ju Chen Huai-zhong Shi Shuang Yan State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanPR China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum-BejingBeijing102249PR China PetroChina Southwest Oil and Gasfield Company Northeast Sichuan Gas District PR China

The single polycrystalline diamond compact(PDC)cutter test is widely used to investigate the mecha-nism of *** generated cuttings and cutting force are important indexes reflecting the rock failure ***,they were treated as two separate parameters in previous *** this study,through a series of rock block cutting tests,the relationship between them was investigated to obtain an in-depth understanding of the formation of *** addition,to validate the standpoints obtained in the aforementioned experiments,rock sheet cutting tests were conducted and the rock failure process was monitored by a high-speed camera frame by *** cutting force was recorded with the same sampling rate as the *** this design,every sampled point of cutting force can match a picture captured by the camera,which reflects the interaction between the rock and the *** results indicate that the increase in cutting depth results in a transition of rock failure *** shallow cutting depth,ductile failure dominates and all the cuttings are produced by the compression of the *** corresponding cutting force fluctuates ***,beyond the critical depth,brittle failure occurs and chunk-like cuttings appear,which leads to a sharp decrease in cutting *** that,the generation of new surface results in a significant decrease in actual cutting depth,a parameter proposed to reflect the interaction between the rock and the ***,ductile failure dominates again and a slight fluctuation of cutting force can be *** the cutter moves to the rock,the actual cutting depth gradually increases,which results in the subsequent generation of chunk-like *** is accompanied by an obvious cutting force *** is,ductile failure and brittle failure,one following another,present at large cutting *** transition of rock failure mode can be correlated with the variation of cutting *** on the results of

关键词： Rock breaking Cutting force PDC cutter Cuttings

Synthesis of Poly(p-phenyleneethynylene)s with Crosslinkable End or Side Groups and Its Solid State Structure and Optical Properties Before and after Crosslinking

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Chemical Research in Chinese Universities 2009年第5期25卷 767-772页

作者： WANG Wen-zhong LIU zhong-yi huang Peng-cheng Department of Polymer Materials and Composites School of Materials Science and Engineering Beihang University Beijing 100083 P. R. China

Two crosslinkable poly（p-phenyleneethynylene）s（PPEs）： poly[2,5-di（2＇-ethyl-hexyloxy）-1,4-phenylenecthynylene] with end-capped vinyl（PPE1） and poly[2,5-di（allyloxy）-1,4-phenyleneethynylene-2,5-di（2＇-ethyl-hexyloxy）-1,4-phenyleneethynylene]（PPE2） were synthesized. Via the thermal addition reactions of vinyl end groups of PPE1 and allyloxy side groups of PPE2, crosslinked polymers C-PPE1 and C-PPE2 were obtained, respectively. The two polymers were characterized by wide-angle X-ray diffraction（WXRD）, ultraviolet-visible（UV-Vis） absorption, and photoluminescence（PL）. The results indicate that in the solid state, the polymer chains of PPE1 were packed with a low degree of crystallinity because of the sterically hindered（2＇-ethyl-hexyl）oxy branched side chains, but, because of the introduction of allyloxy side chains, the polymer chains of PPE2 were packed in an order fashion with a high degree of crystallinity. Because of the high crosslinking density in C-PPE2, the formation of aggregates and excimer was hampered by the formed crosslinking network more effectively in C-PPE2 film than in C-PPE1 film.

关键词： Poly(p-phenyleneethynylene) Crosslinkable polymer Optical property Packing fashion

Energy identity of the heat flow of H-systems at finite singular time

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Science China Mathematics 2007年第11期50卷 1571-1582页

作者： Tao huang zhong TAN School of Mathematical Sciences Xiamen UniversityXiamen 361005China School of Mathematical SciencesXiamen UniversityXiamen 361005China

It is well known that there exists a global solution to the heat flow of *** the solution satisfies a certain energy inequality,it is global regular with at most finitely many *** the same energy inequality,we can show the energy identity of the heat flow of H-systems at finite singular *** most interesting thing in our proof is that we find the singular points can only occur in the interior of the set in some sense.

关键词： H-systems heat flow singularity energy identity regularity

Analyticity of the Sine Family with L^P-Maximal Regularity for Second Order Cauchy Problems

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Acta Mathematica Sinica,English Series 2010年第3期26卷 561-568页

作者： Yong zhong huang Meng Cheng WANG School of Mathematics and Statistics Huazhong University of Science and Technology Wuhan 430074 P. R. China

If the second order problem u（t）＋ Bu（t）＋ Au（t） = f（t）, u（0） =u（0） = 0 has L^p-maximal regularity, 1 〈 p 〈 ∞, the analyticity of the corresponding propagator of the sine type is shown by obtaining the estimates of ‖λ（λ^2 ＋ λB ＋ A）^-1‖ and ‖B（λ^2 ＋ λB ＋ A）^-1‖ for λ∈ C with Reλ 〉 ω, where the constant ω≥ 0.

关键词： analyticity second order Cauchy problem maximal regularity propagator

Semidifferential Electroanalysis of Aqueous Triton X-100/Toluene/H2O Microemulsion

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Chinese Chemical Letters 2002年第4期13卷 371-374页

作者： Chun Sheng MO Zhen zhong huang Ming Hua zhong Department of Chemistry Jiangxi Normal UniversityNanchang 330027

Semidifferential electroanalysis is used as an effective method for investigating microstructure and structural transition of Triton X-100 microemulsions.

关键词： Semidifferential electroanalysis Triton X-100 microemulsion.