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基于改进DATA-SSI和聚类分析的桥梁结构模态参数识别

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公路交通科技 2017年第9期34卷 76-85页

作者：陈永高钟振宇浙江工业职业技术学院浙江绍兴312000

桥梁结构的模态参数主要用于桥梁结构损伤识别及使用性能评估,在桥梁健康监测系统中具有十分重要的意义。目前较为常用的模态参数识别算法是随机子空间识别算法,主要包括协方差驱动的随机子空间识别算法和数据驱动的随机子空间识别算法... 详细信息

桥梁结构的模态参数主要用于桥梁结构损伤识别及使用性能评估,在桥梁健康监测系统中具有十分重要的意义。目前较为常用的模态参数识别算法是随机子空间识别算法,主要包括协方差驱动的随机子空间识别算法和数据驱动的随机子空间识别算法。在利用随机子空间算法识别桥梁结构的模态参数时,首先需人为依据稳定图来进行系统阶次的确定,通过对稳定图定阶的不断研究,发现其依然存在模态失真和计算量大这两方面的缺陷,为此提出了新的定阶算法以实现系统阶次的自适应确定。其次需要人为参与稳定图中真实模态的辨识,这不仅降低参数识别效率,还导致筛选的结果带有一定主观性。为了避免人为参与定阶和真实模态的筛选,提高模态参数识别的效率,在现有随机子空间算法的基础上引入聚类分析算法,提出了一种改进的模态参数自动化识别算法,以实现系统阶次的自动化确定和稳定图中真实模态的自动化筛选。再通过一座试验桥验证了真实模态存在的规律。最后将改进算法运用于识别实际大型斜拉桥的结构参数。结果表明:改进算法能够实现实际桥梁结构的模态参数自动化识别,且识别结果具有可靠性。

关键词：桥梁工程模态参数识别随机子空间识别稳定图系统阶次聚类分析

Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension

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World Journal of Gastroenterology 2024年第31期30卷 3668-3679页

作者： Hong-Wei Zhao Jin-Long Zhang Fu-Quan Liu zhen-Dong yue Lei Wang yu Zhang Cheng-Bin Dong zhen-Chang Wang Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Radiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Interventional Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Gut microbiota(GM)affects the progression and response to treatment in liver *** GM composition is diverse and associated with different etiologies of liver ***,alterations in GM alterations are observed in patients with portal hypertension(PH)secondary to cirrhosis,with hepatitis B virus(HBV)infection being a major cause of cirrhosis in ***,understanding the role of GM alterations in patients with HBV infection-related PH is *** To evaluate GM alterations in patients with HBV-related PH after transjugular intrahepatic portosystemic shunt(TIPS)*** This was a prospective,observational clinical *** were 30 patients(with a 100%technical success rate)recruited in the present *** with esophagogastric variceal bleeding due to HBV infection-associated PH who underwent TIPS were *** samples were obtained before and one month after TIPS treatment,and GM was analyzed using 16S ribosomal RNA amplicon *** One month after TIPS placement,8 patients developed hepatic encephalopathy(HE)and were assigned to the HE group;the other 22 patients were assigned to the non-HE *** was no substantial disparity in the abundance of GM at the phylum level between the two groups,regardless of TIPS treatment(all,P>0.05).However,following TIPS placement,the following results were observed:(1)The abundance of Haemophilus and Eggerthella increased,whereas that of Anaerostipes,Dialister,Butyricicoccus,and Oscillospira declined in the HE group;(2)The richness of Eggerthella,Streptococcus,and Bilophila increased,whereas that of Roseburia and Ruminococcus decreased in the non-HE group;and(3)Members from the pathogenic genus Morganella appeared in the HE group but not in the non-HE *** Intestinal microbiota-related synergism may predict the risk of HE following TIPS placement in patients with HBVrelated *** microbiome therapies may be useful for preventing and trea

关键词： Transjugular intrahepatic portosystemic shunt Hepatic encephalopathy Gut microbiota Hepatitis B virus Portal hypertension

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基于非结构网格的螺旋桨周围流场大涡模拟

水动力学研究与进展（A辑） 2008年第4期23卷 419-425页

作者：韦喜忠黄振宇洪方文中国船舶科学研究中心江苏无锡214082

采用基于非结构网格的有限体积法对螺旋桨的水动力性能和周围黏性流场进行了大涡模拟,在加权最小二乘法重构流动物理量梯度的基础上,分别以三阶精度的UMUSCL(Unstructured Monotonic Upstream-centered Schemes for Conversation Law)... 详细信息

采用基于非结构网格的有限体积法对螺旋桨的水动力性能和周围黏性流场进行了大涡模拟,在加权最小二乘法重构流动物理量梯度的基础上,分别以三阶精度的UMUSCL(Unstructured Monotonic Upstream-centered Schemes for Conversation Law)插值方法和方向导数法离散控制方程的对流项和亚格子应力项,计算得到的螺旋桨的定常水动力性能、叶片表面压力和尾流场速度与试验吻合很好。

关键词：大涡模拟有限体积法非结构网格螺旋桨

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儿童白癜风及其治疗进展

中国皮肤性病学杂志 2014年第8期28卷 855-858页

作者：钟震宇傅雯雯复旦大学附属华山医院皮肤科上海200040

白癜风是一种常见的色素脱失性疾病,近半数患者20岁前起病。本病因影响美容,为许多患者造成不同程度的精神心理影响。近年来随着对白癜风的认识不断深入,钙调神经蛋白免疫抑制剂、308nm准分子激光及窄波UVB光疗等新的治疗方法不断发展普... 详细信息

白癜风是一种常见的色素脱失性疾病,近半数患者20岁前起病。本病因影响美容,为许多患者造成不同程度的精神心理影响。近年来随着对白癜风的认识不断深入,钙调神经蛋白免疫抑制剂、308nm准分子激光及窄波UVB光疗等新的治疗方法不断发展普及,儿童白癜风的治疗取得了很大进步。而如何从现有治疗手段中为儿童患者选择最佳治疗方案成为临床上的重要问题。本篇综述将着重介绍儿童白癜风及其治疗新进展。

关键词：白癜风儿童治疗进展

Crossed renal ectopia with rectal cancer:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2122-2127页

作者： zhen-Wei Tang Hui-Feng Yang Zhao-yu Wu Chang-You Wang Department of General Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Crossed renal ectopia(CRE)occurs when one kidney crosses the midline from the primary side to the contralateral side while the ureter remains on the primary *** cancer,one of the most common malignant tumors of the digestive tract,refers to cancer from the dentate line to the rectosigmoid *** concurrent presentation of CRE alongside rectal cancer is an uncommon clinical *** SUMMARY Herein,we report a 69-year-old male patient with rectal cancer who was diagnosed with CRE via computed tomography during *** thorough preoperative evaluations,the patient underwent Dixon *** We performed laparoscopic radical resection of rectal cancer and adequate lymph node removal in a patient with CRE with no postoperative discomfort.

关键词： Rectal cancer Crossed renal ectopia Anatomy Laparoscopic surgery Case report

Heterochronous multiple primary prostate cancer and lymphoma:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1333-1338页

作者： Jin-Long Liang yu-Qing Bu Li-Li Peng Hong-zhen Zhang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Multiple primary malignant tumors(MPMTs)are rare type of cancer,especially when solid tumors are the first and lymphoma is the second primary *** report a patient with heterochronous MPMTs consisting of prostate cancer and rectal diffuse large B-cell lymphoma(DLBCL).CASE SUMMARY We report a 77-year-old male patient diagnosed with prostate cancer who was treated with radiation therapy and one year of endocrine therapy with bicalutamide(50 mg per day)and an extended-release implant of goserelin(1/28 d).Seven years later,rectal DLBCL with lung metastases was *** Although rare,the possibility of prostate cancer combined with a double primary cancer of DLBCL can provide a deeper understanding.

关键词： Multiple primary malignant tumors Radiation therapy Diffuse large B-cell lymphoma Prostate cancer Non-Hodgkin lymphoma Case report

Monotonic mechanical behaviour of compacted completely decomposed granite with various inclusion levels of incineration bottom ash

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 670-679页

作者： Han-Lin WANG Cheng-Shuang YIN Qian-Yi ZHANG Qi-Wei LIU zhen-yu YIN Dong-Xing XUAN Askar KHASANOV Research Center for Advanced Underground Space Technologies of Hunan University Changsha 410082China Key Laboratory of Building Safety and Energy Efficiency of the Ministry of Education Hunan UniversityChangsha 410082China College of Civil Engineering Hunan UniversityChangsha 410082China School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Applied and Theoretical Mechanics Samarkand State UniversitySamarkandUzbekistan

1 Introduction Completely decomposed granite(CDG)is widely distributed in South China(Xu et al.,2022;Wang et al.,2023).The parent granite rock mass gradually loses features during the weathering process,and thus needs to be reinforced when used(Lan et al.,2003;Dassekpo et al.,2017;Alamanis et al.,2021).On the other hand,considering the huge demand for construction materials and limited natural resources,it is increasingly important to fully utilize solid waste(Gruhler et al.,2019;Anagnostopoulos et al.,2020;Jiang et al.,2022,2023a,2023b).With high strength and environment-friendly characteristics,incineration bottom ash(IBA)seems to be a suitable reinforcement material for CDG(Ahmed and Khalid,2011;Alhassan and Tankó,2012;Toraldo et al.,2013;Lynn et al.,2017;Xuan et al.,2018;Tang et al.,2020).

关键词： incineration behaviour utilize

Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： Hua-yang Fan Ming-da Zhao Hong-jie Jiang zhen-wei yu yu-jiang Fan Xin-hua Liang Ya-ling Tang Yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1,a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1,which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

Strategies for improving extraction capacity through preorganization structure:A novel 5,6-bicyclicmalonamide extractant(THPPD)

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Journal of Rare Earths 2024年第4期42卷 768-774页

作者： Miaomiao Zhang zhen Yang yuhua Cui Jianhui Su Heng Zhao Chengjin Xu Xiaolei Liu Guoxin Sun Xiujing Peng yu Cui School of Chemistry and Chemical Engineering University of JinanJinan250022China Institute for Smart Materials&Engineering University of JinanJinan250022China Shandong Institute for Food and Drug Control Jinan250101China

Rational design of extractant structure to improve the extraction and separation capacity of rare earth elements(REEs)is a long-standing ***,a new strategy was proposed to improve the stability of the chelating structure formed by malonamide and *** stability of the chelating structure is greatly improved by using a double-ring framework structure which makes the two carbonyl groups of malonamide unable to rotate freely and both of them point to the metal ion *** benzyl groups were used to construct the hydrophobicity of the extractant and the organic shell of the extracted ***-pyrrolo-pyridine-dione(THPPD)was designed and *** structure reduces the energy consumed by rotating carbonyl group in the coordination with metal ions and then improves the extraction ability of *** crystal structure was preorganized as expected,with the two carbonyls pointing in a favorable coordination direction to the structural complement of the metal *** extraction behaviors of REEs with THPPD in a nitric acid medium were *** with N,N’-dibenzyl-N,N’-dimethylmalonamide(DBDM-MA)with a chain structure,the extraction capacity of THPPD is 360 times higher than that of DBDM-MA at 5.0 mol/L sodium ***,the binding energy and Gibbs free energy were investigated by density functional theory(DFT)in conjunction with the *** theoretical results show that THPPD has more effective interaction with Pr(NO_(3))3 than *** construction of chelating groups conformation is a worthy direction to improve the coordination ability and even selectivity of extractant.

关键词： Rare earth elements Extraction separation 5,6-bicyclicdiamide extractant