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Journal of Integrative Agriculture 2024年第9期23卷 2955-2969页

作者： Xin Dong Baole li Zhenzhen Yan ling Guan Shoubing Huang Shujun li zhiyun Qi ling Tang Honglin Tian Zhongjun Fu Hua Yang Chongqing Academy of Agricultural Sciences Chongqing 401329China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Heat stress is a major constraint to current and future maize production at the global *** and female reproductive organs both play major roles in increasing seed set under heat stress at flowering,but their relative contributions to seed set are *** this study,a 2-year field experiment including three sowing dates in each year and 20 inbred lines was *** set,kernel number per ear,and grain yield were all reduced by more than 80%in the third sowing dates compared to the first sowing *** viability,silk emergence ratio,and anthesis-silking interval were the key determinants of seed set under heat stress;and their correlation coefficients were 0.89^(***),0.65^(***),and-0.72^(***),*** pressure deficit(VPD)and relative air humidity(RH)both had significant correlations with pollen viability and the silk emergence *** RH can alleviate the impacts of heat on maize seed set by maintaining high pollen viability and a high silk emergence *** a warming climate from 2020 to 2050,VPD will decrease due to the increased *** on their pollen viability and silk emergence ratios,the 20 genotypes fell into four different *** group with high pollen viability and a high silk emergence ratio performed better under heat stress,and their performance can be further improved by combining the improved flowering pattern traits.

关键词： maize pollen viability silk emergence heat stress relative humidity

Relapse of a cardiac tumor from myxoma to low-grade malignant myofibroblastic sarcoma: malignant transformation or metachronous lesion?

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Journal of Medical Colleges of PLA(China) 2010年第1期25卷 50-53页

作者： Duan lian Xu zhiyun li Zhigang Department of Thoracic and Cardiovascular Surgery Changhai Hospital Shanghai 200433 China

A 47-year-old woman, who had undergone cardiac myxoma removal surgery six years ago, was readmitted due to a 2-week history of chest distress, and dyspnea with the change of body position. Both the examinations and the surgery confirmed a cardiac tumor relapse. Histology demonstrated that the mass resected in surgery had a pathologic change from myxoma to a low-grade malignant myofibroblastic sarcoma. The patient received heart transplantation 2 years later due to tumor recurrence, and finally died of cerebral hemorrhage.

关键词： Neoplasm Myxoma Malignant myofibroblastic sarcoma

Effect of valsartan particle size and morphology on dissolution of valsartan and amlodipine tablet

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Effect of valsartan particle size and morphology on dissolut...

STEAM教育视角下中小学地震科普路径思考

2018年第十二届中国药物制剂大会

作者：程开生臧洪梅 li zhiyun li Chunni CHEN Dengjun Hefei cosource pharmaceuticals inc Anhui Medical University

OBJECTIVE The reason for the significant difference in the dissolution of valsartan and amlodipine tablet prepared from two batches of valsartan was studied. METHODS The dissolution of valsartan and amlodipine tablet was determined by using PBS4.5 as the dissolution medium. The valsartan crystal form was determined by powder X-ray diffraction. The valsartan particle size was determined by laser particle size method. particle morphology of powder valsartan, premixer and valsartan suspension for particle size determination were observed by optical microscope with reflection. The difference between two batches was compared. Sieve mixing, wet granulator shear mixing and pulverization and mixing were employed to premixing process. RESULTS The difference of amlodipine dissolution percentage in 30 min is 15%～25%. The crystal form of two batches valsartan were amorphous, and the particle sizes D50（μm）measured in 1% SDS（77.09 vs. 85.23） and liquid paraffin（9.942 vs. 7.331） were similar. There was no difference between the sieve mixing and the shear mixing process, and the premixing process parameters had no trend effect on the dissolution of valsartan and amlodipine tablet. There were significant differences in the particle morphology of the two batches of valsartan in the powder and the premix. The batch 1 and batch 2 valsartan were dendritic shape and pellet shape, respectively, while the shape in 1% SDS and liquid paraffin was not significantly different. CONCLUSION The pellet shape valsartan results in fast tablet dissolution;but the dendritic shape valsartan is opposite. Control of the valsartan powder particle morphology should be added.

关键词： valsartan particle size particle morphology

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地震科学进展 2024年第4期54卷 278-285页

作者：郑建锋肖萍张玉慧陶思炜段苹丽王锦涛李治云任浩玉溪师范学院云南玉溪653100 玉溪市聂耳小学云南玉溪653100

简要概述了中小学地震科普的重要性、地震科普现状及存在的问题,重点探讨了基于STEAM教育理念的中小学地震科普发展路径。鉴于中小学地震科普教育现状及存在的问题,在明确地震科普教育主旨、服务对象或受众群体及有效科普内容和形式的... 详细信息

简要概述了中小学地震科普的重要性、地震科普现状及存在的问题,重点探讨了基于STEAM教育理念的中小学地震科普发展路径。鉴于中小学地震科普教育现状及存在的问题,在明确地震科普教育主旨、服务对象或受众群体及有效科普内容和形式的基础上,本文运用STEAM教育理念对中小学地震科普有效路径提出思考,并以初中学段为例做具体案例分析,提出构建STEAM视角下地震科普生态体系。STEAM教育是融合了科学、技术、工程、艺术和数学的跨学科教育理念,强调学科融合,并以项目为主线,教师为引领,学生为主体的一种全新的学习形式。本研究认为地震科普宣传需要融入STEAM教育理念、构建高质量科普教育体系,涵盖校内和校外的教育活动和主动学习能力,营造一个适合科普教育发展的生态体系。

关键词：中小学地震科普 STEAM教育生态体系

Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 160-176页

作者： Xilong Cui Fanhui liu Shuang Cai Tingting Wang Sidi Zheng Xinshu Zou linlin Wang Siqi He Yanhua li zhiyun Zhang College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development Harbin 150030China

The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm ***-based nanoplatform is a promising emerging approach for treatment of biofilm ***,their therapeutic efficacy was restricted by the low drug loading capacity and lack of ***,we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin(ISL)loading content for effective treatment of MRSA biofilm.A dimeric ISL prodrug(ISL-G2)bearing a lipase responsive ester bond was synthesized,and then encapsulated into the amphiphilic quaternized *** obtained ISL-G2loaded NPs possessed positively charged surface,which allowed cis-aconityl-D-tyrosine(CA-Tyr)binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr *** NPs maintained their negatively charged surface,thus prolonging the blood circulation *** response to low pH in the biofilms,the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive,which enhanced the accumulation and penetration of NPs in the ***,the pH-triggered release of D-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm *** in vivo study was performed on a MRSA biofilm infected wound *** phytochemical-based system led to~2log CFU(>99%)reduction of biofilm MRSA as compared to untreated wound(Pligible biotoxicity in *** phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.

关键词： MRSA biofilm Isoliquiritigenin Dimer prodrug Charge adaptive Responsive nanoparticles

Deep-reinforcement-learning-based water diversion strategy

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Environmental Science and Ecotechnology 2024年第1期17卷 68-79页

作者： Qingsong Jiang Jincheng li Yanxin Sun Jilin Huang Rui Zou Wenjing Ma Huaicheng Guo zhiyun Wang Yong liu State Environmental Protection Key Laboratory of All Materials Flux in River Ecosystems College of Environmental Sciences and EngineeringPeking UniversityBeijing100871PR China Rays Computational Intelligence Lab Beijing Inteliway Environmental Ltd.Beijing100085PR China Yunnan Key Laboratory of Pollution Process and Management of Plateau Lake-Watershed Yunnan Research Academy of Eco-environmental SciencesKunming650034PR Chin

Water diversion is a common strategy to enhance water quality in eutrophic lakes by increasing available water resources and accelerating nutrient *** effectiveness depends on changes in the source water and lake ***,the challenge of optimizing water diversion remains because it is difficult to simultaneously improve lake water quality and minimize the amount of diverted ***,we propose a new approach called dynamic water diversion optimization(DWDO),which combines a comprehensive water quality model with a deep reinforcement learning *** applied DWDO to a region of Lake Dianchi,the largest eutrophic freshwater lake in China and validated *** results demonstrate that DWDO significantly reduced total nitrogen and total phosphorus concentrations in the lake by 7%and 6%,respectively,compared to previous ***,annual water diversion decreased by an impressive 75%.Through interpretable machine learning,we identified the impact of meteorological indicators and the water quality of both the source water and the lake on optimal water *** found that a single input variable could either increase or decrease water diversion,depending on its specific value,while multiple factors collectively influenced real-time adjustment of water ***,using well-designed hyperparameters,DWDO proved robust under different uncertainties in model *** training time of the model is theoretically shorter than traditional simulation-optimization algorithms,highlighting its potential to support more effective decisionmaking in water quality management.

关键词： Dynamic water diversion optimization Deep reinforcement learning Process-based model Explainable decision-making Parameter uncertainty

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组蛋白密码与胶质母细胞瘤关系的研究进展

中国肿瘤临床 2015年第5期42卷 317-320页

作者：孙红军荔志云兰州军区兰州总医院神经外科兰州市730050

组蛋白密码由组蛋白中被修饰氨基酸的种类、位置和修饰类型构成。目前研究发现组蛋白密码与胶质母细胞瘤(glioblastoma,GBM)密切相关。GBM细胞中各种效应蛋白与组蛋白修饰后相应靶位点的结合效应控制着染色质的状态,进一步影响GBM细胞DN... 详细信息

组蛋白密码由组蛋白中被修饰氨基酸的种类、位置和修饰类型构成。目前研究发现组蛋白密码与胶质母细胞瘤(glioblastoma,GBM)密切相关。GBM细胞中各种效应蛋白与组蛋白修饰后相应靶位点的结合效应控制着染色质的状态,进一步影响GBM细胞DNA复制及基因表达调控等表观遗传现象。GBM组蛋白密码信息存在于包括组蛋白乙酰化、甲基化、磷酸化、泛素化等翻译修饰过程中。组蛋白密码与GBM关系的研究为GBM的发生发展、临床诊断和治疗研究提供了更多分子靶点。

关键词：胶质母细胞瘤组蛋白密码组蛋白修饰表观遗传学

Hemangiopericytoma in the vertebral canal of thoracic segments: report of a rare case

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Oncology and Translational Medicine 2015年第6期1卷 289-290页

作者： Jie Zhou Yong Zhou Hulin Ma zhiyun li Jiaojing He Die Zhu Xiaodong Qu Department of Neurosurgery Lanzhou General Hospital of PLA Health Team 68082 Military of PLA Health Team 68216 Military of PLA

In this paper, we explore the diagnosis and treatment of hemangiopedcytoma （HPC）. A rare case of HPC in the vertebral canal of thoracic segments is reported, and the clinical features as well as treatment approaches of similar cases in the literature are discussed. In the present case, we operatively resected the tumor and performed postoperative radiation therapy, with good treatment results.

关键词： hemangiopencytoma (HPC) vertebral canal therapy

Facies-controlled prediction of dolomite reservoirs in the Middle Permian Qixia Formation in Shuangyushi,northwestern Sichuan Basin

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Energy Geoscience 2024年第2期5卷 21-30页

作者： Chao Zheng Benjian Zhang Rongrong li Hong Yin Yufeng Wang Xin Hu Xiao Chen Ran liu Qi Zeng zhiyun Sun Rui Zhang Xingyu Zhang Weidong Yin Kun Zhang Exploration and Development Research Institute PetroChina Southwest Oil&Gas Field CompanyChengduSichuan610500China Northwest Sichuan Gas Branch PetroChina Southwest Oil&Gas Field CompanyJiangyouSichuan621709China PetroChina Southwest Oil&Gas Field Company ChengduSichuan610500China School of Geosciences and Technology Southwest Petroleum UniversityChengduSichuan610500China

The Middle Permian Qixia Formation in the Shuangyushi area,northwestern Sichuan Basin,develops shoal-facies dolomite *** pinpoint promising reservoirs in the Qixia Formation,deep thin shoal-facies dolomite reservoirs were predicted using the techniques of pre-stack Kirchhoff-Q compensation for absorption,inverse Q filtering,low-to high-frequency compensation,forward modeling,and facies-controlled seismic meme *** results are obtained in six ***,the dolomite reservoirs mainly exist in the middle and lower parts of the second member of Qixia Formation(Qi2 Member),which coincide with the zones shoal cores are ***,the forward modeling shows that the trough energy at the top and bottom of shoal core increases with increasing shoal-core thickness,and weak peak reflections are associated in the middle of shoal ***,five types of seismic waveform are identified through waveform analysis of seismic ***-Ⅰ and Type-Ⅱ waveforms correspond to promising facies(shoal core microfacies).Fourth,vertically,two packages of thin dolomite reservoirs turn up in the sedimentary cycle of intraplatform shoal in the Qi2 Member,and the lower package is superior to the upper package in dolomite thickness,scale and lateral ***,in plane,significantly controlled by sedimentary facies,dolomite reservoirs laterally distribute with consistent thickness in shoal cores at topographical highs and extend toward the ***,the promising prospects are the zones with thick dolomite reservoirs and superimposition of horstegraben structural traps.

关键词： Reservoir prediction Seismic facies Shoal-facies dolomite Qixia formation Shuangyushi Sichuan basin